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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for SOX17
Z-value: 0.82
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Transcription factors associated with SOX17
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX17 | hg19_v2_chr8_+_55370487_55370503 | -0.68 | 1.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_19739321 Show fit | 0.71 |
ENST00000588461.1
|
lysophosphatidic acid receptor 2 |
|
| chr2_-_114205429 Show fit | 0.62 |
ENST00000440617.1
|
HDCMB45P; Uncharacterized protein |
|
| chr9_-_70866572 Show fit | 0.62 |
ENST00000417734.1
|
HDCMB45P; Uncharacterized protein |
|
| chr1_+_227751231 Show fit | 0.60 |
ENST00000343776.5
ENST00000608949.1 ENST00000397097.3 |
zinc finger protein 678 |
|
| chr10_-_112255945 Show fit | 0.59 |
ENST00000609514.1
ENST00000607952.1 |
RP11-525A16.4 |
|
| chr16_-_71523236 Show fit | 0.55 |
ENST00000288177.5
ENST00000569072.1 |
zinc finger protein 19 |
|
| chr2_+_187371440 Show fit | 0.54 |
ENST00000445547.1
|
zinc finger CCCH-type containing 15 |
|
| chr11_-_118122996 Show fit | 0.46 |
ENST00000525386.1
ENST00000527472.1 ENST00000278949.4 |
myelin protein zero-like 3 |
|
| chr1_+_227751281 Show fit | 0.45 |
ENST00000440339.1
|
zinc finger protein 678 |
|
| chr11_+_65266507 Show fit | 0.44 |
ENST00000544868.1
|
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX17
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0030490 | maturation of SSU-rRNA(GO:0030490) |
| 0.0 | 0.7 | GO:0007202 | activation of phospholipase C activity(GO:0007202) |
| 0.1 | 0.6 | GO:0019255 | glucose 1-phosphate metabolic process(GO:0019255) |
| 0.0 | 0.6 | GO:0070933 | histone H4 deacetylation(GO:0070933) |
| 0.0 | 0.6 | GO:0045947 | negative regulation of translational initiation(GO:0045947) |
| 0.0 | 0.5 | GO:0015986 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.0 | 0.4 | GO:0034393 | positive regulation of smooth muscle cell apoptotic process(GO:0034393) |
| 0.1 | 0.3 | GO:0032972 | regulation of muscle filament sliding speed(GO:0032972) |
| 0.1 | 0.3 | GO:0071684 | blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684) |
| 0.1 | 0.3 | GO:0006789 | bilirubin conjugation(GO:0006789) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.1 | 0.6 | GO:0034457 | Mpp10 complex(GO:0034457) |
| 0.1 | 0.3 | GO:0098592 | cytoplasmic side of apical plasma membrane(GO:0098592) |
| 0.1 | 0.3 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.0 | 0.3 | GO:0000275 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) |
| 0.0 | 0.3 | GO:0071986 | Ragulator complex(GO:0071986) |
| 0.0 | 0.3 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 0.2 | GO:0002079 | inner acrosomal membrane(GO:0002079) |
| 0.0 | 0.2 | GO:0000801 | central element(GO:0000801) |
| 0.0 | 0.2 | GO:0031466 | Cul5-RING ubiquitin ligase complex(GO:0031466) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
| 0.1 | 0.6 | GO:0051748 | UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748) |
| 0.0 | 0.4 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.0 | 0.3 | GO:0031013 | troponin I binding(GO:0031013) |
| 0.0 | 0.3 | GO:0030613 | oxidoreductase activity, acting on phosphorus or arsenic in donors(GO:0030613) oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor(GO:0030614) |
| 0.0 | 0.3 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.0 | 0.3 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
| 0.0 | 0.3 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 0.0 | 0.3 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.1 | 0.2 | GO:0005365 | myo-inositol transmembrane transporter activity(GO:0005365) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.1 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 0.3 | REACTOME MEIOSIS | Genes involved in Meiosis |
| 0.0 | 0.2 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.0 | 0.2 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 0.1 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |