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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for SOX13_SOX12
Z-value: 1.09
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Transcription factors associated with SOX13_SOX12
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX12 | hg19_v2_chr20_+_306221_306239 | -0.36 | 4.9e-01 | Click! |
| SOX13 | hg19_v2_chr1_+_204042723_204042784 | -0.30 | 5.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_174818390 Show fit | 0.82 |
ENST00000509968.1
ENST00000512263.1 |
RP11-161D15.1 |
|
| chr21_+_35553045 Show fit | 0.77 |
ENST00000416145.1
ENST00000430922.1 ENST00000419881.2 |
long intergenic non-protein coding RNA 310 |
|
| chr2_+_102927962 Show fit | 0.72 |
ENST00000233954.1
ENST00000393393.3 ENST00000410040.1 |
interleukin 1 receptor-like 1 interleukin 18 receptor 1 |
|
| chr7_-_81635106 Show fit | 0.57 |
ENST00000443883.1
|
calcium channel, voltage-dependent, alpha 2/delta subunit 1 |
|
| chr4_+_95128748 Show fit | 0.56 |
ENST00000359052.4
|
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 |
|
| chr9_+_26746951 Show fit | 0.55 |
ENST00000523363.1
|
RP11-18A15.1 |
|
| chr17_-_38821373 Show fit | 0.54 |
ENST00000394052.3
|
keratin 222 |
|
| chr21_+_38593701 Show fit | 0.53 |
ENST00000440629.1
|
AP001432.14 |
|
| chr8_+_32579271 Show fit | 0.53 |
ENST00000518084.1
|
neuregulin 1 |
|
| chr20_-_5426380 Show fit | 0.52 |
ENST00000609252.1
ENST00000422352.1 |
long intergenic non-protein coding RNA 658 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX13_SOX12
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.5 | GO:0070933 | histone H4 deacetylation(GO:0070933) |
| 0.0 | 1.3 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.1 | 0.7 | GO:0038129 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) ERBB3 signaling pathway(GO:0038129) |
| 0.0 | 0.7 | GO:0070257 | positive regulation of mucus secretion(GO:0070257) |
| 0.0 | 0.7 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.1 | 0.6 | GO:0086048 | membrane depolarization during bundle of His cell action potential(GO:0086048) |
| 0.0 | 0.6 | GO:2000659 | regulation of interleukin-1-mediated signaling pathway(GO:2000659) |
| 0.1 | 0.5 | GO:0007352 | zygotic specification of dorsal/ventral axis(GO:0007352) |
| 0.0 | 0.5 | GO:2000772 | regulation of cellular senescence(GO:2000772) |
| 0.1 | 0.4 | GO:0038172 | interleukin-33-mediated signaling pathway(GO:0038172) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | GO:0043596 | nuclear replication fork(GO:0043596) |
| 0.0 | 1.3 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 0.7 | GO:0031673 | H zone(GO:0031673) |
| 0.0 | 0.7 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 0.5 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.0 | 0.5 | GO:0070938 | contractile ring(GO:0070938) |
| 0.0 | 0.4 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.0 | 0.4 | GO:0045263 | proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263) |
| 0.0 | 0.3 | GO:0005583 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.0 | 0.3 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 1.0 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.1 | 0.7 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.2 | 0.6 | GO:0086057 | voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057) |
| 0.0 | 0.5 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.0 | 0.5 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.1 | 0.4 | GO:0002113 | interleukin-33 binding(GO:0002113) |
| 0.0 | 0.4 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 0.0 | 0.4 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 0.0 | 0.4 | GO:0042043 | neurexin family protein binding(GO:0042043) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 0.8 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.7 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.2 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 0.4 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 0.3 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.0 | 0.3 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 0.3 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 0.2 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.0 | 0.2 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.0 | 0.1 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.0 | 0.1 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.0 | 0.1 | REACTOME HORMONE LIGAND BINDING RECEPTORS | Genes involved in Hormone ligand-binding receptors |