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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for SMAD4
Z-value: 2.30
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Transcription factors associated with SMAD4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SMAD4 | hg19_v2_chr18_+_48494361_48494426 | -0.80 | 5.5e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_+_30752606 Show fit | 2.12 |
ENST00000399824.2
ENST00000405659.1 ENST00000338306.3 |
coiled-coil domain containing 157 |
|
| chr1_-_32827682 Show fit | 1.96 |
ENST00000432622.1
|
family with sequence similarity 229, member A |
|
| chr11_+_117070037 Show fit | 1.72 |
ENST00000392951.4
ENST00000525531.1 ENST00000278968.6 |
transgelin |
|
| chr12_+_48147699 Show fit | 1.55 |
ENST00000548498.1
|
solute carrier family 48 (heme transporter), member 1 |
|
| chr5_-_151066514 Show fit | 1.54 |
ENST00000538026.1
ENST00000522348.1 ENST00000521569.1 |
secreted protein, acidic, cysteine-rich (osteonectin) |
|
| chr6_-_31651817 Show fit | 1.53 |
ENST00000375863.3
ENST00000375860.2 |
lymphocyte antigen 6 complex, locus G5C |
|
| chr12_-_53207842 Show fit | 1.29 |
ENST00000458244.2
|
keratin 4 |
|
| chr9_+_140119618 Show fit | 1.22 |
ENST00000359069.2
|
chromosome 9 open reading frame 169 |
|
| chr19_-_49522727 Show fit | 1.21 |
ENST00000600007.1
|
CTB-60B18.10 |
|
| chr11_+_115498761 Show fit | 1.20 |
ENST00000424313.2
|
AP000997.1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SMAD4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.8 | GO:1901750 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
| 0.0 | 2.1 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.3 | 1.8 | GO:2000035 | regulation of stem cell division(GO:2000035) |
| 0.1 | 1.8 | GO:0015886 | heme transport(GO:0015886) |
| 0.1 | 1.7 | GO:0015889 | cobalt ion transport(GO:0006824) cobalamin transport(GO:0015889) |
| 0.1 | 1.6 | GO:0046339 | diacylglycerol metabolic process(GO:0046339) |
| 0.3 | 1.5 | GO:0033591 | response to L-ascorbic acid(GO:0033591) |
| 0.1 | 1.5 | GO:0043949 | regulation of cAMP-mediated signaling(GO:0043949) |
| 0.0 | 1.5 | GO:0006893 | Golgi to plasma membrane transport(GO:0006893) |
| 0.1 | 1.2 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 2.4 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 2.0 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 1.9 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 1.5 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 1.5 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.0 | 1.4 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.0 | 1.3 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 1.3 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 1.2 | GO:0043034 | costamere(GO:0043034) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.7 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.2 | 2.8 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 0.0 | 2.4 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.1 | 2.1 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.0 | 2.1 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.0 | 2.0 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 1.9 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.1 | 1.8 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.1 | 1.7 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.0 | 1.7 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.0 | 1.9 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.0 | 1.9 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.8 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 1.7 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.7 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 1.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 1.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.5 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.0 | 1.3 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 1.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 1.9 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.6 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 1.6 | REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS | Genes involved in Post NMDA receptor activation events |
| 0.0 | 1.4 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.0 | 1.2 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 1.2 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.0 | 1.1 | REACTOME P38MAPK EVENTS | Genes involved in p38MAPK events |
| 0.0 | 1.1 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |