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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SMAD2

Z-value: 1.13

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Transcription factors associated with SMAD2

Gene Symbol Gene ID Gene Info
SMAD2
ENSG00000175387.11 SMAD family member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SMAD2hg19_v2_chr18_-_45456930_45456970-0.891.8e-02Click!

Activity profile of SMAD2 motif

Sorted Z-values of SMAD2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_+_20715416 1.58 ENST00000580153.1
CABLES1
Cdk5 and Abl enzyme substrate 1
chr7_-_155601766 1.28 ENST00000430104.1
SHH
sonic hedgehog
chr19_-_49522727 1.15 ENST00000600007.1
CTB-60B18.10
CTB-60B18.10
chr5_-_151066514 0.94 ENST00000538026.1
ENST00000522348.1
ENST00000521569.1
SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr12_-_53207842 0.91 ENST00000458244.2
KRT4
keratin 4
chr6_-_152489484 0.67 ENST00000354674.4
ENST00000539504.1
SYNE1
spectrin repeat containing, nuclear envelope 1
chr12_-_6740802 0.66 ENST00000431922.1
LPAR5
lysophosphatidic acid receptor 5
chr2_-_228028829 0.56 ENST00000396625.3
ENST00000329662.7
COL4A4
collagen, type IV, alpha 4
chr15_-_82338460 0.49 ENST00000558133.1
ENST00000329713.4
MEX3B
mex-3 RNA binding family member B
chr17_+_73629500 0.49 ENST00000375215.3
SMIM5
small integral membrane protein 5
chr12_-_120241187 0.49 ENST00000392520.2
CIT
citron (rho-interacting, serine/threonine kinase 21)
chr11_-_75379479 0.44 ENST00000434603.2
MAP6
microtubule-associated protein 6
chr8_-_130587237 0.40 ENST00000520048.1
CCDC26
coiled-coil domain containing 26
chr7_+_69064566 0.39 ENST00000403018.2
AUTS2
autism susceptibility candidate 2
chr1_+_33722080 0.38 ENST00000483388.1
ENST00000539719.1
ZNF362
zinc finger protein 362
chr1_-_149783914 0.37 ENST00000369167.1
ENST00000427880.2
ENST00000545683.1
HIST2H2BF
histone cluster 2, H2bf
chr3_+_111393659 0.37 ENST00000477665.1
PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr3_+_195447738 0.36 ENST00000447234.2
ENST00000320736.6
ENST00000436408.1
MUC20
mucin 20, cell surface associated
chr11_-_117166201 0.35 ENST00000510915.1
BACE1
beta-site APP-cleaving enzyme 1
chr14_+_70078303 0.35 ENST00000342745.4
KIAA0247
KIAA0247
chr17_-_7297833 0.35 ENST00000571802.1
ENST00000576201.1
ENST00000573213.1
ENST00000324822.11
TMEM256-PLSCR3
TMEM256-PLSCR3 readthrough (NMD candidate)
chr10_+_80027105 0.34 ENST00000461034.1
ENST00000476909.1
ENST00000459633.1
LINC00595
long intergenic non-protein coding RNA 595
chr5_+_14143728 0.34 ENST00000344204.4
ENST00000537187.1
TRIO
trio Rho guanine nucleotide exchange factor
chr8_+_95907993 0.34 ENST00000523378.1
NDUFAF6
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chr12_-_108991778 0.33 ENST00000549447.1
TMEM119
transmembrane protein 119
chr19_+_50094866 0.32 ENST00000418929.2
PRR12
proline rich 12
chr20_+_1875942 0.32 ENST00000358771.4
SIRPA
signal-regulatory protein alpha
chr12_+_122516626 0.32 ENST00000319080.7
MLXIP
MLX interacting protein
chr17_+_65375082 0.32 ENST00000584471.1
PITPNC1
phosphatidylinositol transfer protein, cytoplasmic 1
chr16_+_28889801 0.32 ENST00000395503.4
ATP2A1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr9_+_140145713 0.31 ENST00000388931.3
ENST00000412566.1
C9orf173
chromosome 9 open reading frame 173
chr19_-_51587502 0.31 ENST00000156499.2
ENST00000391802.1
KLK14
kallikrein-related peptidase 14
chr17_-_3571934 0.30 ENST00000225525.3
TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr11_+_64808675 0.30 ENST00000529996.1
SAC3D1
SAC3 domain containing 1
chr19_+_50148087 0.30 ENST00000601038.1
ENST00000595242.1
SCAF1
SR-related CTD-associated factor 1
chr19_+_10527449 0.30 ENST00000592685.1
ENST00000380702.2
PDE4A
phosphodiesterase 4A, cAMP-specific
chr16_-_87417351 0.29 ENST00000311635.7
FBXO31
F-box protein 31
chr1_-_44482979 0.29 ENST00000360584.2
ENST00000357730.2
ENST00000528803.1
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr16_-_70719925 0.29 ENST00000338779.6
MTSS1L
metastasis suppressor 1-like
chr19_-_3551043 0.29 ENST00000589995.1
MFSD12
major facilitator superfamily domain containing 12
chr20_-_56284816 0.28 ENST00000395819.3
ENST00000341744.3
PMEPA1
prostate transmembrane protein, androgen induced 1
chr6_-_143771799 0.28 ENST00000237283.8
ADAT2
adenosine deaminase, tRNA-specific 2
chrX_+_48660107 0.28 ENST00000376643.2
HDAC6
histone deacetylase 6
chr19_-_6481776 0.27 ENST00000543576.1
ENST00000590173.1
ENST00000381480.2
DENND1C
DENN/MADD domain containing 1C
chr5_-_172755056 0.27 ENST00000520648.1
STC2
stanniocalcin 2
chr19_-_55580838 0.27 ENST00000396247.3
ENST00000586945.1
ENST00000587026.1
RDH13
retinol dehydrogenase 13 (all-trans/9-cis)
chr1_-_1243252 0.27 ENST00000353662.3
ACAP3
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
chr17_-_40761375 0.27 ENST00000543197.1
ENST00000309428.5
FAM134C
family with sequence similarity 134, member C
chr16_+_28889703 0.25 ENST00000357084.3
ATP2A1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr22_-_43567750 0.25 ENST00000494035.1
TTLL12
tubulin tyrosine ligase-like family, member 12
chr22_+_22673051 0.25 ENST00000390289.2
IGLV5-52
immunoglobulin lambda variable 5-52
chr21_-_36259445 0.25 ENST00000399240.1
RUNX1
runt-related transcription factor 1
chr3_-_195603566 0.24 ENST00000424563.1
ENST00000411741.1
TNK2
tyrosine kinase, non-receptor, 2
chrX_+_48660287 0.24 ENST00000444343.2
ENST00000376610.2
ENST00000334136.5
ENST00000376619.2
HDAC6
histone deacetylase 6
chr10_+_105314881 0.24 ENST00000437579.1
NEURL
neuralized E3 ubiquitin protein ligase 1
chr1_-_44497118 0.23 ENST00000537678.1
ENST00000466926.1
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr20_+_44098385 0.23 ENST00000217425.5
ENST00000339946.3
WFDC2
WAP four-disulfide core domain 2
chr1_-_149908710 0.22 ENST00000439741.2
ENST00000361405.6
ENST00000406732.3
MTMR11
myotubularin related protein 11
chr11_-_118789613 0.22 ENST00000532899.1
BCL9L
B-cell CLL/lymphoma 9-like
chr16_+_31483374 0.22 ENST00000394863.3
TGFB1I1
transforming growth factor beta 1 induced transcript 1
chr11_+_2923423 0.21 ENST00000312221.5
SLC22A18
solute carrier family 22, member 18
chr7_+_99905325 0.21 ENST00000332397.6
ENST00000437326.2
SPDYE3
speedy/RINGO cell cycle regulator family member E3
chr3_+_50316458 0.21 ENST00000316436.3
LSMEM2
leucine-rich single-pass membrane protein 2
chr22_-_37823468 0.20 ENST00000402918.2
ELFN2
extracellular leucine-rich repeat and fibronectin type III domain containing 2
chr1_-_935491 0.20 ENST00000304952.6
HES4
hes family bHLH transcription factor 4
chr6_+_32938665 0.20 ENST00000374831.4
ENST00000395289.2
BRD2
bromodomain containing 2
chr11_+_75273101 0.20 ENST00000533603.1
ENST00000358171.3
ENST00000526242.1
SERPINH1
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
chr17_+_30593195 0.20 ENST00000431505.2
ENST00000269051.4
ENST00000538145.1
RHBDL3
rhomboid, veinlet-like 3 (Drosophila)
chr8_+_144373550 0.20 ENST00000330143.3
ENST00000521537.1
ENST00000518432.1
ENST00000520333.1
ZNF696
zinc finger protein 696
chr8_+_11561660 0.20 ENST00000526716.1
ENST00000335135.4
ENST00000528027.1
GATA4
GATA binding protein 4
chr11_-_3859089 0.20 ENST00000396979.1
RHOG
ras homolog family member G
chr12_+_47473369 0.19 ENST00000546455.1
PCED1B
PC-esterase domain containing 1B
chr12_-_6798523 0.19 ENST00000319770.3
ZNF384
zinc finger protein 384
chr19_+_56186557 0.19 ENST00000270460.6
EPN1
epsin 1
chr1_+_44412577 0.19 ENST00000372343.3
IPO13
importin 13
chr1_+_174933899 0.19 ENST00000367688.3
RABGAP1L
RAB GTPase activating protein 1-like
chr7_+_150758642 0.19 ENST00000488420.1
SLC4A2
solute carrier family 4 (anion exchanger), member 2
chrX_-_154688276 0.18 ENST00000369445.2
F8A3
coagulation factor VIII-associated 3
chr9_-_140513231 0.18 ENST00000371417.3
C9orf37
chromosome 9 open reading frame 37
chr17_-_46623441 0.18 ENST00000330070.4
HOXB2
homeobox B2
chr2_-_72375167 0.18 ENST00000001146.2
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr1_+_16693578 0.18 ENST00000401088.4
ENST00000471507.1
ENST00000401089.3
ENST00000375590.3
ENST00000492354.1
SZRD1
SUZ RNA binding domain containing 1
chr7_+_155250824 0.18 ENST00000297375.4
EN2
engrailed homeobox 2
chr20_+_34680620 0.18 ENST00000430276.1
ENST00000373950.2
ENST00000452261.1
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr17_-_7297519 0.18 ENST00000576362.1
ENST00000571078.1
TMEM256-PLSCR3
TMEM256-PLSCR3 readthrough (NMD candidate)
chr12_-_6798025 0.18 ENST00000542351.1
ENST00000538829.1
ZNF384
zinc finger protein 384
chr1_-_149908217 0.18 ENST00000369140.3
MTMR11
myotubularin related protein 11
chr12_-_6798410 0.18 ENST00000361959.3
ENST00000436774.2
ENST00000544482.1
ZNF384
zinc finger protein 384
chr2_+_191045656 0.17 ENST00000443551.2
C2orf88
chromosome 2 open reading frame 88
chr6_+_143771934 0.17 ENST00000367592.1
PEX3
peroxisomal biogenesis factor 3
chr22_+_24891210 0.17 ENST00000382760.2
UPB1
ureidopropionase, beta
chr20_-_48532046 0.17 ENST00000543716.1
SPATA2
spermatogenesis associated 2
chr12_-_6798616 0.17 ENST00000355772.4
ENST00000417772.3
ENST00000396801.3
ENST00000396799.2
ZNF384
zinc finger protein 384
chr10_+_72972281 0.17 ENST00000335350.6
UNC5B
unc-5 homolog B (C. elegans)
chr4_-_185139062 0.17 ENST00000296741.2
ENPP6
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr22_+_22676808 0.17 ENST00000390290.2
IGLV1-51
immunoglobulin lambda variable 1-51
chr20_+_35974532 0.17 ENST00000373578.2
SRC
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr22_-_24641027 0.17 ENST00000398292.3
ENST00000263112.7
ENST00000418439.2
ENST00000424217.1
ENST00000327365.4
GGT5
gamma-glutamyltransferase 5
chr20_+_44098346 0.17 ENST00000372676.3
WFDC2
WAP four-disulfide core domain 2
chr12_+_110338323 0.17 ENST00000312777.5
ENST00000536408.2
TCHP
trichoplein, keratin filament binding
chr20_+_42143053 0.16 ENST00000373135.3
ENST00000444063.1
L3MBTL1
l(3)mbt-like 1 (Drosophila)
chr16_+_53164956 0.16 ENST00000563410.1
CHD9
chromodomain helicase DNA binding protein 9
chr4_-_103749179 0.16 ENST00000502690.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chrX_-_30595959 0.16 ENST00000378962.3
CXorf21
chromosome X open reading frame 21
chr7_-_130080977 0.16 ENST00000223208.5
CEP41
centrosomal protein 41kDa
chr6_+_31730773 0.16 ENST00000415669.2
ENST00000425424.1
SAPCD1
suppressor APC domain containing 1
chr3_-_49761337 0.16 ENST00000535833.1
ENST00000308388.6
ENST00000480687.1
ENST00000308375.6
AMIGO3
GMPPB
adhesion molecule with Ig-like domain 3
GDP-mannose pyrophosphorylase B
chrX_-_107018969 0.16 ENST00000372383.4
TSC22D3
TSC22 domain family, member 3
chr11_+_74204395 0.16 ENST00000526036.1
AP001372.2
AP001372.2
chr1_-_207119738 0.16 ENST00000356495.4
PIGR
polymeric immunoglobulin receptor
chr5_+_133861339 0.15 ENST00000282605.4
ENST00000361895.2
ENST00000402835.1
PHF15
jade family PHD finger 2
chr19_-_42636617 0.15 ENST00000529067.1
ENST00000529952.1
ENST00000533720.1
ENST00000389341.5
ENST00000342301.4
POU2F2
POU class 2 homeobox 2
chr20_-_48532019 0.15 ENST00000289431.5
SPATA2
spermatogenesis associated 2
chr19_+_49128209 0.15 ENST00000599748.1
ENST00000443164.1
ENST00000599029.1
SPHK2
sphingosine kinase 2
chr6_+_30853002 0.15 ENST00000421124.2
ENST00000512725.1
DDR1
discoidin domain receptor tyrosine kinase 1
chr7_-_130080818 0.15 ENST00000343969.5
ENST00000541543.1
ENST00000489512.1
CEP41
centrosomal protein 41kDa
chr6_+_32938692 0.14 ENST00000443797.2
BRD2
bromodomain containing 2
chr3_-_71179699 0.14 ENST00000497355.1
FOXP1
forkhead box P1
chr12_+_93965609 0.14 ENST00000549887.1
ENST00000551556.1
SOCS2
suppressor of cytokine signaling 2
chr15_+_74509530 0.14 ENST00000321288.5
CCDC33
coiled-coil domain containing 33
chr12_+_53443963 0.14 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr17_+_36508826 0.14 ENST00000580660.1
SOCS7
suppressor of cytokine signaling 7
chr17_+_40761660 0.14 ENST00000251413.3
ENST00000591509.1
TUBG1
tubulin, gamma 1
chr19_-_46288917 0.14 ENST00000537879.1
ENST00000596586.1
ENST00000595946.1
DMWD
AC011530.4
dystrophia myotonica, WD repeat containing
Uncharacterized protein
chr18_+_3448455 0.13 ENST00000549780.1
TGIF1
TGFB-induced factor homeobox 1
chr9_-_136006496 0.13 ENST00000372062.3
RALGDS
ral guanine nucleotide dissociation stimulator
chr19_-_14606900 0.13 ENST00000393029.3
ENST00000393028.1
ENST00000393033.4
ENST00000345425.2
ENST00000586027.1
ENST00000591349.1
ENST00000587210.1
GIPC1
GIPC PDZ domain containing family, member 1
chr5_-_64064508 0.13 ENST00000513458.4
SREK1IP1
SREK1-interacting protein 1
chr19_+_56186606 0.13 ENST00000085079.7
EPN1
epsin 1
chr1_-_94586651 0.13 ENST00000535735.1
ENST00000370225.3
ABCA4
ATP-binding cassette, sub-family A (ABC1), member 4
chr12_-_120663792 0.12 ENST00000546532.1
ENST00000548912.1
PXN
paxillin
chr19_+_49977818 0.12 ENST00000594009.1
ENST00000595510.1
FLT3LG
fms-related tyrosine kinase 3 ligand
chr2_+_74881398 0.12 ENST00000339773.5
ENST00000434486.1
SEMA4F
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
chr7_+_102004322 0.12 ENST00000496391.1
PRKRIP1
PRKR interacting protein 1 (IL11 inducible)
chr12_-_71003568 0.12 ENST00000547715.1
ENST00000451516.2
ENST00000538708.1
ENST00000550857.1
ENST00000261266.5
PTPRB
protein tyrosine phosphatase, receptor type, B
chr5_+_139493665 0.12 ENST00000331327.3
PURA
purine-rich element binding protein A
chr6_+_4087664 0.11 ENST00000430835.2
C6orf201
chromosome 6 open reading frame 201
chr11_-_75380165 0.11 ENST00000304771.3
MAP6
microtubule-associated protein 6
chr3_-_49131013 0.11 ENST00000424300.1
QRICH1
glutamine-rich 1
chr3_-_150320937 0.11 ENST00000479209.1
SERP1
stress-associated endoplasmic reticulum protein 1
chr9_+_5890802 0.11 ENST00000381477.3
ENST00000381476.1
ENST00000381471.1
MLANA
melan-A
chr12_+_7037461 0.11 ENST00000396684.2
ATN1
atrophin 1
chr19_-_46272462 0.11 ENST00000317578.6
SIX5
SIX homeobox 5
chr9_-_28670283 0.11 ENST00000379992.2
LINGO2
leucine rich repeat and Ig domain containing 2
chr12_-_120554534 0.10 ENST00000538903.1
ENST00000534951.1
RAB35
RAB35, member RAS oncogene family
chr21_-_38639813 0.10 ENST00000309117.6
ENST00000398998.1
DSCR3
Down syndrome critical region gene 3
chr6_+_30689401 0.10 ENST00000396389.1
ENST00000396384.1
TUBB
tubulin, beta class I
chr17_-_1389419 0.10 ENST00000575158.1
MYO1C
myosin IC
chr9_+_34990219 0.10 ENST00000541010.1
ENST00000454002.2
ENST00000545841.1
DNAJB5
DnaJ (Hsp40) homolog, subfamily B, member 5
chrX_+_38420783 0.10 ENST00000422612.2
ENST00000286824.6
ENST00000545599.1
TSPAN7
tetraspanin 7
chr17_+_40440094 0.10 ENST00000546010.2
STAT5A
signal transducer and activator of transcription 5A
chr16_+_2286726 0.10 ENST00000382437.4
ENST00000569184.1
DNASE1L2
deoxyribonuclease I-like 2
chr20_+_30598231 0.10 ENST00000300415.8
ENST00000262659.8
CCM2L
cerebral cavernous malformation 2-like
chr16_+_30406423 0.10 ENST00000524644.1
ZNF48
zinc finger protein 48
chr18_-_24237339 0.10 ENST00000580191.1
KCTD1
potassium channel tetramerization domain containing 1
chr12_-_22094336 0.09 ENST00000326684.4
ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr19_-_14224969 0.09 ENST00000589994.1
PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr16_-_67997947 0.09 ENST00000537830.2
SLC12A4
solute carrier family 12 (potassium/chloride transporter), member 4
chr9_+_125273081 0.09 ENST00000335302.5
OR1J2
olfactory receptor, family 1, subfamily J, member 2
chr16_+_2198604 0.09 ENST00000210187.6
RAB26
RAB26, member RAS oncogene family
chr11_-_34535332 0.09 ENST00000257832.2
ENST00000429939.2
ELF5
E74-like factor 5 (ets domain transcription factor)
chr10_-_14372870 0.09 ENST00000357447.2
FRMD4A
FERM domain containing 4A
chr2_-_74667612 0.09 ENST00000305557.5
ENST00000233330.6
RTKN
rhotekin
chr7_-_105517021 0.09 ENST00000318724.4
ENST00000419735.3
ATXN7L1
ataxin 7-like 1
chr6_+_30852738 0.09 ENST00000508312.1
ENST00000512336.1
DDR1
discoidin domain receptor tyrosine kinase 1
chr1_-_155271213 0.09 ENST00000342741.4
PKLR
pyruvate kinase, liver and RBC
chr8_-_142377367 0.09 ENST00000377741.3
GPR20
G protein-coupled receptor 20
chr9_-_130829588 0.09 ENST00000373078.4
NAIF1
nuclear apoptosis inducing factor 1
chr4_+_102268904 0.08 ENST00000527564.1
ENST00000529296.1
AP001816.1
Uncharacterized protein
chr16_-_56459354 0.08 ENST00000290649.5
AMFR
autocrine motility factor receptor, E3 ubiquitin protein ligase
chr9_+_133569108 0.08 ENST00000372358.5
ENST00000546165.1
ENST00000372352.3
ENST00000372351.3
ENST00000372350.3
ENST00000495699.2
EXOSC2
exosome component 2
chr1_+_26872324 0.08 ENST00000531382.1
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr17_+_3627185 0.08 ENST00000325418.4
GSG2
germ cell associated 2 (haspin)
chr2_+_191045562 0.08 ENST00000340623.4
C2orf88
chromosome 2 open reading frame 88
chr17_-_10017864 0.08 ENST00000323816.4
GAS7
growth arrest-specific 7
chr11_-_74204742 0.07 ENST00000310109.4
LIPT2
lipoyl(octanoyl) transferase 2 (putative)
chr4_+_39640787 0.07 ENST00000532680.1
RP11-539G18.2
RP11-539G18.2
chr9_+_71944241 0.07 ENST00000257515.8
FAM189A2
family with sequence similarity 189, member A2
chr12_+_68042517 0.07 ENST00000393555.3
DYRK2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr16_+_58059470 0.07 ENST00000219271.3
MMP15
matrix metallopeptidase 15 (membrane-inserted)
chr12_+_53443680 0.07 ENST00000314250.6
ENST00000451358.1
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr2_+_27237615 0.07 ENST00000458529.1
ENST00000402218.1
MAPRE3
microtubule-associated protein, RP/EB family, member 3
chr5_+_175298573 0.07 ENST00000512824.1
CPLX2
complexin 2
chr6_-_31612808 0.07 ENST00000438149.1
BAG6
BCL2-associated athanogene 6
chr4_-_41216473 0.07 ENST00000513140.1
APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr4_-_102268708 0.07 ENST00000525819.1
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr18_+_13217965 0.06 ENST00000587905.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chrX_-_107019181 0.06 ENST00000315660.4
ENST00000372384.2
ENST00000502650.1
ENST00000506724.1
TSC22D3
TSC22 domain family, member 3
chr1_+_100111479 0.06 ENST00000263174.4
PALMD
palmdelphin
chrX_+_153029633 0.06 ENST00000538966.1
ENST00000361971.5
ENST00000538776.1
ENST00000538543.1
PLXNB3
plexin B3
chr11_-_1619524 0.06 ENST00000412090.1
KRTAP5-2
keratin associated protein 5-2
chr15_-_88799661 0.06 ENST00000360948.2
ENST00000357724.2
ENST00000355254.2
ENST00000317501.3
NTRK3
neurotrophic tyrosine kinase, receptor, type 3
chr16_-_17564738 0.06 ENST00000261381.6
XYLT1
xylosyltransferase I
chrY_+_16634483 0.06 ENST00000382872.1
NLGN4Y
neuroligin 4, Y-linked
chr22_-_31885514 0.06 ENST00000397525.1
EIF4ENIF1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr17_+_7792101 0.05 ENST00000358181.4
ENST00000330494.7
CHD3
chromodomain helicase DNA binding protein 3
chr1_+_156163880 0.05 ENST00000359511.4
ENST00000423538.2
SLC25A44
solute carrier family 25, member 44
chr1_+_15802594 0.05 ENST00000375910.3
CELA2B
chymotrypsin-like elastase family, member 2B
chrX_+_591524 0.05 ENST00000554971.1
ENST00000381575.1
SHOX
short stature homeobox
chr17_-_15165854 0.05 ENST00000395936.1
ENST00000395938.2
PMP22
peripheral myelin protein 22

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0060738 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908) positive regulation of immature T cell proliferation in thymus(GO:0033092) right lung development(GO:0060458) primary prostatic bud elongation(GO:0060516) epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738)
0.2 0.6 GO:0014724 regulation of twitch skeletal muscle contraction(GO:0014724) regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448)
0.2 0.5 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.2 0.9 GO:0033591 response to L-ascorbic acid(GO:0033591)
0.1 0.4 GO:0098582 innate vocalization behavior(GO:0098582)
0.1 0.4 GO:0070846 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.1 0.2 GO:0021569 rhombomere 3 development(GO:0021569)
0.1 0.2 GO:2001037 tongue muscle cell differentiation(GO:0035981) positive regulation of skeletal muscle fiber differentiation(GO:1902811) regulation of tongue muscle cell differentiation(GO:2001035) positive regulation of tongue muscle cell differentiation(GO:2001037)
0.1 0.2 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.1 0.3 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1 0.2 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.1 0.2 GO:0035054 embryonic heart tube anterior/posterior pattern specification(GO:0035054)
0.0 0.2 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.0 0.7 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.2 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.0 0.2 GO:0006669 sphinganine-1-phosphate biosynthetic process(GO:0006669)
0.0 0.1 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.0 0.6 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.3 GO:0009644 response to high light intensity(GO:0009644)
0.0 0.2 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.3 GO:0007320 insemination(GO:0007320)
0.0 0.1 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.0 0.1 GO:0014859 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.0 0.3 GO:0033690 positive regulation of osteoblast proliferation(GO:0033690)
0.0 0.2 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.1 GO:0003335 corneocyte development(GO:0003335)
0.0 0.2 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.2 GO:0070236 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 0.2 GO:0046618 drug export(GO:0046618)
0.0 0.1 GO:0048691 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.0 0.1 GO:1903033 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
0.0 0.5 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.2 GO:0003433 chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)
0.0 0.3 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.1 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885) regulation of osteoclast proliferation(GO:0090289)
0.0 0.1 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0 0.1 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.0 0.1 GO:0000255 allantoin metabolic process(GO:0000255) creatinine metabolic process(GO:0046449)
0.0 0.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.1 GO:0071034 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043) polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.0 0.0 GO:0061386 closure of optic fissure(GO:0061386)
0.0 0.3 GO:0002097 tRNA wobble base modification(GO:0002097)
0.0 0.2 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.0 GO:1904616 regulation of actin filament binding(GO:1904529) negative regulation of actin filament binding(GO:1904530) regulation of actin binding(GO:1904616) negative regulation of actin binding(GO:1904617)
0.0 0.3 GO:2000009 negative regulation of protein localization to cell surface(GO:2000009)
0.0 0.2 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0032185 septin cytoskeleton organization(GO:0032185)
0.0 0.0 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 0.3 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.6 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.2 GO:1990403 embryonic brain development(GO:1990403)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0070931 Golgi-associated vesicle lumen(GO:0070931)
0.1 0.6 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.2 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 0.9 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 0.1 GO:0045160 myosin I complex(GO:0045160)
0.0 0.7 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.6 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 1.1 GO:0045095 keratin filament(GO:0045095)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.1 GO:0005827 polar microtubule(GO:0005827)
0.0 0.4 GO:0031528 microvillus membrane(GO:0031528)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 1.3 GO:0043237 laminin-1 binding(GO:0043237)
0.1 0.4 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.1 0.4 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.1 0.2 GO:0032093 SAM domain binding(GO:0032093)
0.1 0.4 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.0 0.2 GO:0015307 drug:proton antiporter activity(GO:0015307)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.2 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 0.2 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.2 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.2 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.2 GO:0043426 MRF binding(GO:0043426)
0.0 0.2 GO:0070568 guanylyltransferase activity(GO:0070568)
0.0 0.3 GO:0008526 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.0 0.2 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.0 0.3 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.2 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.0 0.1 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.0 0.2 GO:0071253 connexin binding(GO:0071253)
0.0 0.7 GO:0005521 lamin binding(GO:0005521)
0.0 0.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.2 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.0 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.0 0.3 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.3 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.1 GO:1904288 BAT3 complex binding(GO:1904288)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.9 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.6 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.5 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.2 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.2 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.2 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.3 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 1.3 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)