ISMARA results: SMAD1

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SMAD1

Z-value: 2.64

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Transcription factors associated with SMAD1

Gene Symbol	Gene ID	Gene Info
SMAD1 Ensembl NCBI GeneCards UniProt	ENSG00000170365.5	SMAD family member 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SMAD1	hg19_v2_chr4_+_146403912_146403972	0.49	3.3e-01	Click!

Activity profile of SMAD1 motif

Sorted Z-values of SMAD1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_-_43835582 Show fit	2.44	ENST00000595748.1	CTC-490G23.2 Ensembl NCBI GeneCards UniProt Show fit	CTC-490G23.2
chr14_-_105420241 Show fit	2.12	ENST00000557457.1	AHNAK2 Ensembl NCBI GeneCards UniProt Show fit	AHNAK nucleoprotein 2
chr2_-_152118276 Show fit	1.80	ENST00000409092.1	RBM43 Ensembl NCBI GeneCards UniProt Show fit	RNA binding motif protein 43
chr1_+_2121228 Show fit	1.58	ENST00000597060.1	AL590822.2 Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein; cDNA FLJ36608 fis, clone TRACH2015824
chr16_+_29127282 Show fit	1.49	ENST00000562902.1	RP11-426C22.5 Ensembl NCBI GeneCards UniProt Show fit	RP11-426C22.5
chr19_+_56813305 Show fit	1.44	ENST00000593151.1	AC006116.20 Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein
chr2_-_27531313 Show fit	1.36	ENST00000296099.2	UCN Ensembl NCBI GeneCards UniProt Show fit	urocortin
chr2_+_102608306 Show fit	1.36	ENST00000332549.3	IL1R2 Ensembl NCBI GeneCards UniProt Show fit	interleukin 1 receptor, type II
chr19_-_56056888 Show fit	1.35	ENST00000592464.1 ENST00000420723.3	SBK3 Ensembl NCBI GeneCards UniProt Show fit	SH3 domain binding kinase family, member 3
chr4_+_1714548 Show fit	1.34	ENST00000605571.1	RP11-572O17.1 Ensembl NCBI GeneCards UniProt Show fit	RP11-572O17.1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	4.5	GO:1901750	leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.1	3.4	GO:1902857	positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.2	2.8	GO:0001778	plasma membrane repair(GO:0001778)
0.1	2.6	GO:0015991	ATP hydrolysis coupled proton transport(GO:0015991)
0.2	2.5	GO:0006689	ganglioside catabolic process(GO:0006689)
0.1	2.4	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.1	2.3	GO:0016226	iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1	2.3	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	2.3	GO:0002279	mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303)
0.5	2.0	GO:0050712	negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)

Showing 1 to 10 of 1,023 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.8	GO:0043202	lysosomal lumen(GO:0043202)
0.1	5.8	GO:0043034	costamere(GO:0043034)
0.0	3.8	GO:0005796	Golgi lumen(GO:0005796)
0.1	3.5	GO:0002102	podosome(GO:0002102)
0.0	3.3	GO:0001726	ruffle(GO:0001726)
0.4	2.8	GO:0097361	CIA complex(GO:0097361)
0.0	2.8	GO:0016328	lateral plasma membrane(GO:0016328)
0.0	2.6	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	2.5	GO:0097610	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1	2.4	GO:0031105	septin complex(GO:0031105)

Showing 1 to 10 of 322 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.6	GO:0017137	Rab GTPase binding(GO:0017137)
0.3	4.5	GO:0036374	glutathione hydrolase activity(GO:0036374)
0.0	3.2	GO:0017124	SH3 domain binding(GO:0017124)
0.1	3.0	GO:0070064	proline-rich region binding(GO:0070064)
0.1	2.6	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.2	2.4	GO:0003960	NADPH:quinone reductase activity(GO:0003960)
0.0	2.4	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1	2.3	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	2.3	GO:0030332	cyclin binding(GO:0030332)
0.0	2.3	GO:0008307	structural constituent of muscle(GO:0008307)

Showing 1 to 10 of 574 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.6	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	4.2	PID TRAIL PATHWAY	TRAIL signaling pathway
0.1	3.2	PID ARF 3PATHWAY	Arf1 pathway
0.1	3.1	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	3.0	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	2.8	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	2.8	PID P53 REGULATION PATHWAY	p53 pathway
0.0	2.5	PID MTOR 4PATHWAY	mTOR signaling pathway
0.0	2.2	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.0	2.2	PID ILK PATHWAY	Integrin-linked kinase signaling

Showing 1 to 10 of 81 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.4	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1	4.3	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.2	3.3	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0	3.1	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.1	2.7	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	2.7	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.1	2.3	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	2.3	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.0	2.2	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	2.1	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)

Showing 1 to 10 of 121 entries

Results for SMAD1

Z-value: 2.64

Motif logo

Transcription factors associated with SMAD1

Activity-expression correlation:

Activity profile of SMAD1 motif

Sorted Z-values of SMAD1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: