Project
A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
Navigation
Downloads
Results for SIN3A_CHD1
Z-value: 2.22
Motif logo
Transcription factors associated with SIN3A_CHD1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CHD1 | hg19_v2_chr5_-_98262240_98262240 | 0.79 | 6.1e-02 | Click! |
| SIN3A | hg19_v2_chr15_-_75743991_75744011 | -0.71 | 1.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_+_45771420 Show fit | 2.02 |
ENST00000578982.1
|
TBK1 binding protein 1 |
|
| chr3_-_88108192 Show fit | 2.00 |
ENST00000309534.6
|
CGG triplet repeat binding protein 1 |
|
| chr7_+_77166592 Show fit | 1.43 |
ENST00000248594.6
|
protein tyrosine phosphatase, non-receptor type 12 |
|
| chr19_-_17622269 Show fit | 1.41 |
ENST00000595116.1
|
CTD-3131K8.2 |
|
| chr3_+_19988885 Show fit | 1.39 |
ENST00000422242.1
|
RAB5A, member RAS oncogene family |
|
| chr7_-_139876734 Show fit | 1.35 |
ENST00000006967.5
|
lysine (K)-specific demethylase 7A |
|
| chr2_-_174828892 Show fit | 1.34 |
ENST00000418194.2
|
Sp3 transcription factor |
|
| chr5_+_98264867 Show fit | 1.32 |
ENST00000513175.1
|
CTD-2007H13.3 |
|
| chr13_-_31039375 Show fit | 1.30 |
ENST00000399494.1
|
high mobility group box 1 |
|
| chr16_+_53164956 Show fit | 1.28 |
ENST00000563410.1
|
chromodomain helicase DNA binding protein 9 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SIN3A_CHD1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.5 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
| 0.2 | 3.0 | GO:0060613 | fat pad development(GO:0060613) |
| 0.1 | 2.8 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 0.1 | 2.7 | GO:2000587 | negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587) |
| 0.0 | 2.4 | GO:0070936 | protein K48-linked ubiquitination(GO:0070936) |
| 0.0 | 2.3 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.3 | 2.1 | GO:0043353 | enucleate erythrocyte differentiation(GO:0043353) |
| 0.2 | 2.1 | GO:0043249 | erythrocyte maturation(GO:0043249) |
| 0.1 | 2.1 | GO:0045634 | regulation of melanocyte differentiation(GO:0045634) |
| 0.2 | 2.0 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.1 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.0 | 4.8 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 4.0 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.0 | 3.1 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.0 | 2.7 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 2.5 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 2.4 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.1 | 2.2 | GO:0097227 | sperm annulus(GO:0097227) |
| 0.0 | 2.2 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 2.1 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.1 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.2 | 6.0 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.1 | 5.0 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 4.5 | GO:0019208 | phosphatase regulator activity(GO:0019208) |
| 0.1 | 4.2 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.0 | 3.9 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 3.0 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.2 | 2.9 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.0 | 2.9 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.2 | 2.6 | GO:0002151 | G-quadruplex RNA binding(GO:0002151) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.1 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 4.3 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 4.1 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 2.7 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 2.7 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 2.7 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 2.6 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 2.6 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 2.3 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 2.2 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.8 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 4.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 3.6 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.1 | 3.5 | REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES | Genes involved in MAPK targets/ Nuclear events mediated by MAP kinases |
| 0.1 | 3.3 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 3.2 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 3.1 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 3.1 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.2 | 2.9 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.0 | 2.6 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |