Project
A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
Navigation
Downloads
Results for SHOX2_HOXC5
Z-value: 1.45
Motif logo
Transcription factors associated with SHOX2_HOXC5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXC5 | hg19_v2_chr12_+_54426637_54426637 | 0.94 | 5.9e-03 | Click! |
| SHOX2 | hg19_v2_chr3_-_157823839_157824078 | -0.82 | 4.3e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_6779326 Show fit | 1.69 |
ENST00000417112.1
|
RP11-554I8.2 |
|
| chr11_-_104916034 Show fit | 1.26 |
ENST00000528513.1
ENST00000375706.2 ENST00000375704.3 |
caspase recruitment domain family, member 16 |
|
| chr3_-_12587055 Show fit | 1.19 |
ENST00000564146.3
|
chromosome 3 open reading frame 83 |
|
| chr6_+_161123270 Show fit | 1.18 |
ENST00000366924.2
ENST00000308192.9 ENST00000418964.1 |
plasminogen |
|
| chr12_-_64062583 Show fit | 1.12 |
ENST00000542209.1
|
dpy-19-like 2 (C. elegans) |
|
| chr21_-_19858196 Show fit | 1.11 |
ENST00000422787.1
|
transmembrane protease, serine 15 |
|
| chr6_-_170151603 Show fit | 1.10 |
ENST00000366774.3
|
t-complex-associated-testis-expressed 3 |
|
| chr16_+_53412368 Show fit | 1.08 |
ENST00000565189.1
|
RP11-44F14.2 |
|
| chr12_-_70093111 Show fit | 1.05 |
ENST00000548658.1
ENST00000476098.1 ENST00000331471.4 ENST00000393365.1 |
bestrophin 3 |
|
| chr2_-_87248975 Show fit | 1.01 |
ENST00000409310.2
ENST00000355705.3 |
plasminogen-like B1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SHOX2_HOXC5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.8 | GO:0071494 | cellular response to UV-C(GO:0071494) |
| 0.1 | 1.6 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.4 | 1.3 | GO:0002590 | regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) |
| 0.4 | 1.2 | GO:0051919 | positive regulation of fibrinolysis(GO:0051919) |
| 0.1 | 1.2 | GO:0018211 | protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406) |
| 0.0 | 1.2 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 0.2 | 1.1 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.0 | 1.1 | GO:0072643 | interferon-gamma secretion(GO:0072643) |
| 0.1 | 1.0 | GO:0034372 | very-low-density lipoprotein particle remodeling(GO:0034372) |
| 0.3 | 0.9 | GO:0030505 | inorganic diphosphate transport(GO:0030505) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.9 | GO:0097179 | protease inhibitor complex(GO:0097179) |
| 0.0 | 1.5 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.2 | 1.3 | GO:1990357 | terminal web(GO:1990357) |
| 0.0 | 1.3 | GO:0090665 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.4 | 1.2 | GO:0044279 | other organism cell membrane(GO:0044218) other organism membrane(GO:0044279) |
| 0.1 | 1.0 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 1.0 | GO:0030286 | dynein complex(GO:0030286) |
| 0.0 | 0.9 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.1 | 0.8 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.1 | 0.8 | GO:0042587 | glycogen granule(GO:0042587) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | GO:0089720 | caspase binding(GO:0089720) |
| 0.1 | 1.4 | GO:0030169 | low-density lipoprotein particle binding(GO:0030169) |
| 0.0 | 1.4 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.3 | 1.3 | GO:0004583 | dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583) |
| 0.4 | 1.2 | GO:1904854 | proteasome core complex binding(GO:1904854) |
| 0.1 | 1.1 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.1 | 1.1 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.0 | 1.1 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.2 | 1.0 | GO:0023024 | MHC class I protein complex binding(GO:0023024) |
| 0.0 | 1.0 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.3 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.2 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 0.7 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 0.7 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 0.5 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 0.2 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 1.4 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 1.2 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 1.2 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 1.2 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 1.2 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.1 | 1.0 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 1.0 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 0.8 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.0 | 0.7 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |