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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for RXRG
Z-value: 2.17
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Transcription factors associated with RXRG
Network of associatons between targets according to the STRING database.
First level regulatory network of RXRG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.3 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 0.7 | 2.1 | GO:0006117 | acetaldehyde metabolic process(GO:0006117) |
| 0.2 | 1.7 | GO:0000430 | regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432) |
| 0.3 | 1.6 | GO:0045903 | positive regulation of translational fidelity(GO:0045903) |
| 0.3 | 1.6 | GO:0032954 | regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490) |
| 0.2 | 1.6 | GO:0016080 | synaptic vesicle targeting(GO:0016080) |
| 0.0 | 1.6 | GO:0033572 | transferrin transport(GO:0033572) |
| 0.5 | 1.5 | GO:0070446 | cellular response to caloric restriction(GO:0061433) negative regulation of oligodendrocyte progenitor proliferation(GO:0070446) |
| 0.0 | 1.5 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
| 0.4 | 1.4 | GO:0071348 | cellular response to interleukin-11(GO:0071348) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.4 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.4 | 2.2 | GO:0009368 | endopeptidase Clp complex(GO:0009368) |
| 0.0 | 2.2 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.7 | 2.1 | GO:0035525 | NF-kappaB p50/p65 complex(GO:0035525) |
| 0.0 | 2.0 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 1.9 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 1.7 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.0 | 1.7 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.0 | 1.7 | GO:0043679 | axon terminus(GO:0043679) |
| 0.1 | 1.5 | GO:0072687 | meiotic spindle(GO:0072687) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.3 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.2 | 2.6 | GO:0071532 | ankyrin repeat binding(GO:0071532) |
| 0.1 | 2.6 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.2 | 1.7 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 0.0 | 1.7 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.2 | 1.6 | GO:1990932 | 5.8S rRNA binding(GO:1990932) |
| 0.0 | 1.6 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.5 | 1.5 | GO:0046970 | NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970) |
| 0.1 | 1.5 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.1 | 1.4 | GO:0071837 | HMG box domain binding(GO:0071837) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.0 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 2.1 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 2.0 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 1.9 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 1.5 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 1.5 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 1.3 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 1.3 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 1.2 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 1.1 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.5 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.1 | 2.5 | REACTOME REGULATED PROTEOLYSIS OF P75NTR | Genes involved in Regulated proteolysis of p75NTR |
| 0.0 | 2.3 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.0 | 2.3 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 1.9 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.0 | 1.6 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.0 | 1.5 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |
| 0.2 | 1.4 | REACTOME SIGNALING BY NOTCH2 | Genes involved in Signaling by NOTCH2 |
| 0.1 | 1.3 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 1.3 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |