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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for RUNX3_BCL11A

Z-value: 0.83

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Transcription factors associated with RUNX3_BCL11A

Gene Symbol Gene ID Gene Info
RUNX3
ENSG00000020633.14 RUNX family transcription factor 3
BCL11A
ENSG00000119866.16 BAF chromatin remodeling complex subunit BCL11A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BCL11Ahg19_v2_chr2_-_60780702_607807420.891.9e-02Click!
RUNX3hg19_v2_chr1_-_25256368_25256476-0.147.9e-01Click!

Activity profile of RUNX3_BCL11A motif

Sorted Z-values of RUNX3_BCL11A motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_73780852 0.99 ENST00000589666.1
UNK
unkempt family zinc finger
chr11_-_1606513 0.92 ENST00000382171.2
KRTAP5-1
keratin associated protein 5-1
chr1_+_239882842 0.75 ENST00000448020.1
CHRM3
cholinergic receptor, muscarinic 3
chr1_+_156211753 0.54 ENST00000368272.4
BGLAP
bone gamma-carboxyglutamate (gla) protein
chr12_-_58145889 0.53 ENST00000547853.1
CDK4
cyclin-dependent kinase 4
chr7_-_84121858 0.50 ENST00000448879.1
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr1_-_168513229 0.47 ENST00000367819.2
XCL2
chemokine (C motif) ligand 2
chr6_+_159071015 0.38 ENST00000360448.3
SYTL3
synaptotagmin-like 3
chr17_+_75316336 0.36 ENST00000591934.1
SEPT9
septin 9
chr1_-_206945830 0.36 ENST00000423557.1
IL10
interleukin 10
chr17_-_67057047 0.35 ENST00000495634.1
ENST00000453985.2
ENST00000585714.1
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr14_+_64680854 0.34 ENST00000458046.2
SYNE2
spectrin repeat containing, nuclear envelope 2
chrX_-_19688475 0.34 ENST00000541422.1
SH3KBP1
SH3-domain kinase binding protein 1
chr17_-_2169425 0.33 ENST00000570606.1
ENST00000354901.4
SMG6
SMG6 nonsense mediated mRNA decay factor
chr7_+_45067265 0.33 ENST00000474617.1
CCM2
cerebral cavernous malformation 2
chr17_-_36884451 0.33 ENST00000595377.1
AC006449.1
NS5ATP13TP1; Uncharacterized protein
chr1_+_110453462 0.32 ENST00000488198.1
CSF1
colony stimulating factor 1 (macrophage)
chr6_+_45296048 0.32 ENST00000465038.2
ENST00000352853.5
ENST00000541979.1
ENST00000371438.1
RUNX2
runt-related transcription factor 2
chr19_-_13900972 0.32 ENST00000397557.1
AC008686.1
Uncharacterized protein
chr3_+_187957646 0.31 ENST00000457242.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr11_+_62475130 0.31 ENST00000294117.5
GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr5_+_131993856 0.30 ENST00000304506.3
IL13
interleukin 13
chr1_+_23695680 0.28 ENST00000454117.1
ENST00000335648.3
ENST00000518821.1
ENST00000437367.2
C1orf213
chromosome 1 open reading frame 213
chr3_+_49977894 0.27 ENST00000433811.1
RBM6
RNA binding motif protein 6
chrX_+_37639264 0.27 ENST00000378588.4
CYBB
cytochrome b-245, beta polypeptide
chrX_-_128788914 0.27 ENST00000429967.1
ENST00000307484.6
APLN
apelin
chr11_-_65548265 0.27 ENST00000532090.2
AP5B1
adaptor-related protein complex 5, beta 1 subunit
chr6_+_31514622 0.26 ENST00000376146.4
NFKBIL1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr1_-_94147385 0.26 ENST00000260502.6
BCAR3
breast cancer anti-estrogen resistance 3
chr1_+_110453203 0.26 ENST00000357302.4
ENST00000344188.5
ENST00000329608.6
CSF1
colony stimulating factor 1 (macrophage)
chr1_+_12524965 0.25 ENST00000471923.1
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr1_+_110453608 0.24 ENST00000369801.1
CSF1
colony stimulating factor 1 (macrophage)
chr13_+_28527647 0.24 ENST00000567234.1
LINC00543
long intergenic non-protein coding RNA 543
chr19_-_51875894 0.24 ENST00000600427.1
ENST00000595217.1
ENST00000221978.5
NKG7
natural killer cell group 7 sequence
chr1_+_221051699 0.23 ENST00000366903.6
HLX
H2.0-like homeobox
chr15_+_86098670 0.23 ENST00000558811.1
AKAP13
A kinase (PRKA) anchor protein 13
chr4_-_84035905 0.23 ENST00000311507.4
PLAC8
placenta-specific 8
chr1_+_44889697 0.23 ENST00000443020.2
RNF220
ring finger protein 220
chr15_+_67390920 0.23 ENST00000559092.1
ENST00000560175.1
SMAD3
SMAD family member 3
chr17_+_40119801 0.23 ENST00000585452.1
CNP
2',3'-cyclic nucleotide 3' phosphodiesterase
chr6_+_15401075 0.23 ENST00000541660.1
JARID2
jumonji, AT rich interactive domain 2
chr20_+_43992094 0.23 ENST00000453003.1
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr2_+_74741569 0.22 ENST00000233638.7
TLX2
T-cell leukemia homeobox 2
chr14_+_23352374 0.21 ENST00000267396.4
ENST00000536884.1
REM2
RAS (RAD and GEM)-like GTP binding 2
chrX_+_37639302 0.21 ENST00000545017.1
ENST00000536160.1
CYBB
cytochrome b-245, beta polypeptide
chr1_+_26872324 0.21 ENST00000531382.1
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chrX_+_48542168 0.21 ENST00000376701.4
WAS
Wiskott-Aldrich syndrome
chr8_-_11325047 0.20 ENST00000531804.1
FAM167A
family with sequence similarity 167, member A
chr5_+_176074388 0.19 ENST00000310032.8
ENST00000405525.2
TSPAN17
tetraspanin 17
chr10_+_17270214 0.19 ENST00000544301.1
VIM
vimentin
chr12_-_4754339 0.19 ENST00000228850.1
AKAP3
A kinase (PRKA) anchor protein 3
chr3_+_136676707 0.19 ENST00000329582.4
IL20RB
interleukin 20 receptor beta
chr3_+_141105235 0.18 ENST00000503809.1
ZBTB38
zinc finger and BTB domain containing 38
chr19_+_36203830 0.18 ENST00000262630.3
ZBTB32
zinc finger and BTB domain containing 32
chr8_+_145162629 0.18 ENST00000323662.8
KIAA1875
KIAA1875
chr12_-_96793142 0.18 ENST00000552262.1
ENST00000551816.1
ENST00000552496.1
CDK17
cyclin-dependent kinase 17
chr1_+_179051160 0.18 ENST00000367625.4
ENST00000352445.6
TOR3A
torsin family 3, member A
chr1_+_202385953 0.18 ENST00000466968.1
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr19_+_10947251 0.17 ENST00000592854.1
C19orf38
chromosome 19 open reading frame 38
chr17_+_79935418 0.17 ENST00000306729.7
ENST00000306739.4
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr8_-_102803163 0.17 ENST00000523645.1
ENST00000520346.1
ENST00000220931.6
ENST00000522448.1
ENST00000522951.1
ENST00000522252.1
ENST00000519098.1
NCALD
neurocalcin delta
chr5_+_132149017 0.17 ENST00000378693.2
SOWAHA
sosondowah ankyrin repeat domain family member A
chr6_+_31950150 0.17 ENST00000537134.1
C4A
complement component 4A (Rodgers blood group)
chr1_+_110453514 0.17 ENST00000369802.3
ENST00000420111.2
CSF1
colony stimulating factor 1 (macrophage)
chr1_+_39876151 0.16 ENST00000530275.1
KIAA0754
KIAA0754
chr1_-_207095324 0.16 ENST00000530505.1
ENST00000367091.3
ENST00000442471.2
FAIM3
Fas apoptotic inhibitory molecule 3
chr10_+_17272608 0.16 ENST00000421459.2
VIM
vimentin
chr11_+_7559485 0.15 ENST00000527790.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr17_+_73455788 0.15 ENST00000581519.1
KIAA0195
KIAA0195
chr6_+_31515337 0.15 ENST00000376148.4
ENST00000376145.4
NFKBIL1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr15_-_37392724 0.15 ENST00000424352.2
MEIS2
Meis homeobox 2
chr10_-_29811456 0.15 ENST00000535393.1
SVIL
supervillin
chr7_-_73184588 0.15 ENST00000395145.2
CLDN3
claudin 3
chr18_-_5238525 0.15 ENST00000581170.1
ENST00000579933.1
ENST00000581067.1
RP11-835E18.5
LINC00526
RP11-835E18.5
long intergenic non-protein coding RNA 526
chr19_-_10946871 0.15 ENST00000589638.1
TMED1
transmembrane emp24 protein transport domain containing 1
chr5_+_67535647 0.15 ENST00000520675.1
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr14_-_23564320 0.14 ENST00000605057.1
ACIN1
apoptotic chromatin condensation inducer 1
chr16_+_2570431 0.14 ENST00000563556.1
AMDHD2
amidohydrolase domain containing 2
chr22_-_30642728 0.14 ENST00000403987.3
LIF
leukemia inhibitory factor
chr2_+_30455016 0.14 ENST00000401506.1
ENST00000407930.2
LBH
limb bud and heart development
chrX_-_40036520 0.14 ENST00000406200.2
ENST00000378455.4
ENST00000342274.4
BCOR
BCL6 corepressor
chr12_-_71031185 0.14 ENST00000548122.1
ENST00000551525.1
ENST00000550358.1
PTPRB
protein tyrosine phosphatase, receptor type, B
chr12_-_120662499 0.14 ENST00000552550.1
PXN
paxillin
chr3_+_50126341 0.14 ENST00000347869.3
ENST00000469838.1
ENST00000404526.2
ENST00000441305.1
RBM5
RNA binding motif protein 5
chr1_+_198608146 0.13 ENST00000367376.2
ENST00000352140.3
ENST00000594404.1
ENST00000598951.1
ENST00000530727.1
ENST00000442510.2
ENST00000367367.4
ENST00000348564.6
ENST00000367364.1
ENST00000413409.2
PTPRC
protein tyrosine phosphatase, receptor type, C
chr15_-_37393406 0.13 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
MEIS2
Meis homeobox 2
chr5_-_94417186 0.13 ENST00000312216.8
ENST00000512425.1
MCTP1
multiple C2 domains, transmembrane 1
chr19_-_6415695 0.13 ENST00000594496.1
ENST00000594745.1
ENST00000600480.1
KHSRP
KH-type splicing regulatory protein
chr17_+_79935464 0.13 ENST00000581647.1
ENST00000580534.1
ENST00000579684.1
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr4_-_6474173 0.13 ENST00000382599.4
PPP2R2C
protein phosphatase 2, regulatory subunit B, gamma
chr5_+_35856951 0.13 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
IL7R
interleukin 7 receptor
chr19_+_13135439 0.13 ENST00000586873.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr2_+_33359473 0.13 ENST00000432635.1
LTBP1
latent transforming growth factor beta binding protein 1
chr17_+_7461849 0.13 ENST00000338784.4
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr11_-_128457446 0.13 ENST00000392668.4
ETS1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr2_+_97203082 0.13 ENST00000454558.2
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr5_+_148206156 0.13 ENST00000305988.4
ADRB2
adrenoceptor beta 2, surface
chr1_+_145727681 0.13 ENST00000417171.1
ENST00000451928.2
PDZK1
PDZ domain containing 1
chr11_+_86502085 0.13 ENST00000527521.1
PRSS23
protease, serine, 23
chr17_-_4545170 0.13 ENST00000576394.1
ENST00000574640.1
ALOX15
arachidonate 15-lipoxygenase
chr16_-_89785777 0.13 ENST00000561976.1
VPS9D1
VPS9 domain containing 1
chr17_+_40996590 0.13 ENST00000253799.3
ENST00000452774.2
AOC2
amine oxidase, copper containing 2 (retina-specific)
chr4_-_152147579 0.12 ENST00000304527.4
ENST00000455740.1
ENST00000424281.1
ENST00000409598.4
SH3D19
SH3 domain containing 19
chr2_-_119605253 0.12 ENST00000295206.6
EN1
engrailed homeobox 1
chr11_-_62457371 0.12 ENST00000317449.4
LRRN4CL
LRRN4 C-terminal like
chr22_+_47016277 0.12 ENST00000406902.1
GRAMD4
GRAM domain containing 4
chr7_+_139025875 0.12 ENST00000297534.6
C7orf55
chromosome 7 open reading frame 55
chr16_+_2802623 0.12 ENST00000576924.1
ENST00000575009.1
ENST00000576415.1
ENST00000571378.1
SRRM2
serine/arginine repetitive matrix 2
chr16_+_84801852 0.12 ENST00000569925.1
ENST00000567526.1
USP10
ubiquitin specific peptidase 10
chr6_-_34524093 0.12 ENST00000544425.1
SPDEF
SAM pointed domain containing ETS transcription factor
chr6_+_158733692 0.12 ENST00000367094.2
ENST00000367097.3
TULP4
tubby like protein 4
chr12_+_57916584 0.12 ENST00000546632.1
ENST00000549623.1
ENST00000431731.2
MBD6
methyl-CpG binding domain protein 6
chr5_+_133451254 0.12 ENST00000517851.1
ENST00000521639.1
ENST00000522375.1
ENST00000378560.4
ENST00000432532.2
ENST00000520958.1
ENST00000518915.1
ENST00000395023.1
TCF7
transcription factor 7 (T-cell specific, HMG-box)
chr15_+_67418047 0.12 ENST00000540846.2
SMAD3
SMAD family member 3
chr9_-_138853156 0.12 ENST00000371756.3
UBAC1
UBA domain containing 1
chr6_+_30029008 0.12 ENST00000332435.5
ENST00000376782.2
ENST00000359374.4
ENST00000376785.2
ZNRD1
zinc ribbon domain containing 1
chr19_-_50868882 0.12 ENST00000598915.1
NAPSA
napsin A aspartic peptidase
chr19_+_41257084 0.12 ENST00000601393.1
SNRPA
small nuclear ribonucleoprotein polypeptide A
chr6_-_112081113 0.12 ENST00000517419.1
FYN
FYN oncogene related to SRC, FGR, YES
chr10_+_112404132 0.12 ENST00000369519.3
RBM20
RNA binding motif protein 20
chr12_-_49245936 0.12 ENST00000308025.3
DDX23
DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
chr20_+_36405665 0.12 ENST00000373469.1
CTNNBL1
catenin, beta like 1
chr2_+_97202480 0.12 ENST00000357485.3
ARID5A
AT rich interactive domain 5A (MRF1-like)
chr5_+_176074455 0.12 ENST00000298564.10
ENST00000508164.1
ENST00000504168.1
ENST00000503045.1
ENST00000515708.1
ENST00000507471.1
TSPAN17
tetraspanin 17
chr17_-_61776522 0.11 ENST00000582055.1
LIMD2
LIM domain containing 2
chr11_+_36397528 0.11 ENST00000311599.5
ENST00000378867.3
PRR5L
proline rich 5 like
chr9_-_117160738 0.11 ENST00000448674.1
RP11-9M16.2
RP11-9M16.2
chr19_-_49496557 0.11 ENST00000323798.3
ENST00000541188.1
ENST00000544287.1
ENST00000540532.1
ENST00000263276.6
GYS1
glycogen synthase 1 (muscle)
chr1_+_179050512 0.11 ENST00000367627.3
TOR3A
torsin family 3, member A
chr6_+_157099036 0.11 ENST00000350026.5
ENST00000346085.5
ENST00000367148.1
ENST00000275248.4
ARID1B
AT rich interactive domain 1B (SWI1-like)
chr16_-_68482440 0.11 ENST00000219334.5
SMPD3
sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
chr22_-_30642782 0.11 ENST00000249075.3
LIF
leukemia inhibitory factor
chr17_-_34625719 0.11 ENST00000422211.2
ENST00000542124.1
CCL3L1
chemokine (C-C motif) ligand 3-like 1
chr1_-_157014865 0.11 ENST00000361409.2
ARHGEF11
Rho guanine nucleotide exchange factor (GEF) 11
chr4_-_57976544 0.11 ENST00000295666.4
ENST00000537922.1
IGFBP7
insulin-like growth factor binding protein 7
chr3_+_189507523 0.11 ENST00000437221.1
ENST00000392463.2
ENST00000392461.3
ENST00000449992.1
ENST00000456148.1
TP63
tumor protein p63
chr12_-_54121212 0.11 ENST00000548263.1
ENST00000430117.2
ENST00000550804.1
ENST00000549173.1
ENST00000551900.1
ENST00000546619.1
ENST00000548177.1
ENST00000549349.1
CALCOCO1
calcium binding and coiled-coil domain 1
chr9_-_123342415 0.11 ENST00000349780.4
ENST00000360190.4
ENST00000360822.3
ENST00000359309.3
CDK5RAP2
CDK5 regulatory subunit associated protein 2
chr1_+_44679370 0.11 ENST00000372290.4
DMAP1
DNA methyltransferase 1 associated protein 1
chr19_+_7580103 0.11 ENST00000596712.1
ZNF358
zinc finger protein 358
chr5_-_94417339 0.11 ENST00000429576.2
ENST00000508509.1
ENST00000510732.1
MCTP1
multiple C2 domains, transmembrane 1
chr6_+_144904334 0.11 ENST00000367526.4
UTRN
utrophin
chr3_-_196242233 0.11 ENST00000397537.2
SMCO1
single-pass membrane protein with coiled-coil domains 1
chr17_-_61777090 0.11 ENST00000578061.1
LIMD2
LIM domain containing 2
chr3_+_111260980 0.11 ENST00000438817.2
CD96
CD96 molecule
chr9_+_131799213 0.11 ENST00000358369.4
ENST00000406926.2
ENST00000277475.5
ENST00000450073.1
FAM73B
family with sequence similarity 73, member B
chr1_+_9299895 0.11 ENST00000602477.1
H6PD
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr12_-_120805872 0.11 ENST00000546985.1
MSI1
musashi RNA-binding protein 1
chr7_-_84122033 0.10 ENST00000424555.1
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr3_-_131756559 0.10 ENST00000505957.1
CPNE4
copine IV
chr3_+_9944303 0.10 ENST00000421412.1
ENST00000295980.3
IL17RE
interleukin 17 receptor E
chr5_+_137722255 0.10 ENST00000542866.1
KDM3B
lysine (K)-specific demethylase 3B
chr20_+_19870167 0.10 ENST00000440354.2
RIN2
Ras and Rab interactor 2
chr12_+_57916466 0.10 ENST00000355673.3
MBD6
methyl-CpG binding domain protein 6
chr17_-_46692287 0.10 ENST00000239144.4
HOXB8
homeobox B8
chr5_-_94417314 0.10 ENST00000505208.1
MCTP1
multiple C2 domains, transmembrane 1
chr4_+_71600063 0.10 ENST00000513597.1
RUFY3
RUN and FYVE domain containing 3
chr19_-_40786733 0.10 ENST00000486368.2
AKT2
v-akt murine thymoma viral oncogene homolog 2
chr13_-_38172863 0.10 ENST00000541481.1
ENST00000379743.4
ENST00000379742.4
ENST00000379749.4
ENST00000541179.1
ENST00000379747.4
POSTN
periostin, osteoblast specific factor
chr1_-_150978953 0.10 ENST00000493834.2
FAM63A
family with sequence similarity 63, member A
chr3_+_189507460 0.10 ENST00000434928.1
TP63
tumor protein p63
chr12_+_25205446 0.10 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
LRMP
lymphoid-restricted membrane protein
chr1_-_168464875 0.10 ENST00000422253.1
RP5-968D22.3
RP5-968D22.3
chr19_+_36208877 0.09 ENST00000420124.1
ENST00000222270.7
ENST00000341701.1
KMT2B
Histone-lysine N-methyltransferase 2B
chr1_+_155290677 0.09 ENST00000368354.3
ENST00000368352.5
RUSC1
RUN and SH3 domain containing 1
chr3_-_99569821 0.09 ENST00000487087.1
FILIP1L
filamin A interacting protein 1-like
chr17_+_19281034 0.09 ENST00000308406.5
ENST00000299612.7
MAPK7
mitogen-activated protein kinase 7
chr5_-_138780159 0.09 ENST00000512473.1
ENST00000515581.1
ENST00000515277.1
DNAJC18
DnaJ (Hsp40) homolog, subfamily C, member 18
chr6_+_42847649 0.09 ENST00000424341.2
ENST00000602561.1
RPL7L1
ribosomal protein L7-like 1
chr17_+_76037081 0.09 ENST00000588549.1
TNRC6C
trinucleotide repeat containing 6C
chr12_-_54121261 0.09 ENST00000549784.1
ENST00000262059.4
CALCOCO1
calcium binding and coiled-coil domain 1
chr14_+_85996471 0.09 ENST00000330753.4
FLRT2
fibronectin leucine rich transmembrane protein 2
chr1_-_12677714 0.09 ENST00000376223.2
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr12_-_58027002 0.09 ENST00000449184.3
B4GALNT1
beta-1,4-N-acetyl-galactosaminyl transferase 1
chrX_+_155227371 0.09 ENST00000369423.2
ENST00000540897.1
IL9R
interleukin 9 receptor
chr19_+_49496705 0.09 ENST00000595090.1
RUVBL2
RuvB-like AAA ATPase 2
chr5_-_94417562 0.09 ENST00000505465.1
MCTP1
multiple C2 domains, transmembrane 1
chr17_+_75315534 0.09 ENST00000590294.1
ENST00000329047.8
SEPT9
septin 9
chr1_-_98511756 0.09 ENST00000602984.1
ENST00000602852.1
MIR137HG
MIR137 host gene (non-protein coding)
chr1_-_25291475 0.09 ENST00000338888.3
ENST00000399916.1
RUNX3
runt-related transcription factor 3
chr1_-_161277210 0.09 ENST00000491222.2
MPZ
myelin protein zero
chr17_+_75315654 0.09 ENST00000590595.1
SEPT9
septin 9
chr5_+_131409476 0.09 ENST00000296871.2
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr7_+_18535321 0.08 ENST00000413380.1
ENST00000430454.1
HDAC9
histone deacetylase 9
chr10_-_14372870 0.08 ENST00000357447.2
FRMD4A
FERM domain containing 4A
chr5_+_145316120 0.08 ENST00000359120.4
SH3RF2
SH3 domain containing ring finger 2
chr6_+_143771934 0.08 ENST00000367592.1
PEX3
peroxisomal biogenesis factor 3
chr12_-_48226897 0.08 ENST00000434070.1
HDAC7
histone deacetylase 7
chr1_+_117544366 0.08 ENST00000256652.4
ENST00000369470.1
CD101
CD101 molecule
chrX_+_155227246 0.08 ENST00000244174.5
ENST00000424344.3
IL9R
interleukin 9 receptor
chrX_-_47509887 0.08 ENST00000247161.3
ENST00000592066.1
ENST00000376983.3
ELK1
ELK1, member of ETS oncogene family
chr19_-_10946949 0.08 ENST00000214869.2
ENST00000591695.1
TMED1
transmembrane emp24 protein transport domain containing 1
chr7_-_100844193 0.08 ENST00000440203.2
ENST00000379423.3
ENST00000223114.4
MOGAT3
monoacylglycerol O-acyltransferase 3
chr3_+_51575596 0.08 ENST00000409535.2
RAD54L2
RAD54-like 2 (S. cerevisiae)
chr15_-_78358465 0.08 ENST00000435468.1
TBC1D2B
TBC1 domain family, member 2B
chr3_-_196014520 0.08 ENST00000441879.1
ENST00000292823.2
ENST00000411591.1
ENST00000431016.1
ENST00000443555.1
PCYT1A
phosphate cytidylyltransferase 1, choline, alpha
chr11_-_67141090 0.08 ENST00000312438.7
CLCF1
cardiotrophin-like cytokine factor 1
chr11_-_67141640 0.08 ENST00000533438.1
CLCF1
cardiotrophin-like cytokine factor 1
chr11_+_65292538 0.08 ENST00000270176.5
ENST00000525364.1
ENST00000420247.2
ENST00000533862.1
ENST00000279270.6
ENST00000524944.1
SCYL1
SCY1-like 1 (S. cerevisiae)
chr8_-_60031762 0.08 ENST00000361421.1
TOX
thymocyte selection-associated high mobility group box

Network of associatons between targets according to the STRING database.

First level regulatory network of RUNX3_BCL11A

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:1902228 mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) positive regulation of microglial cell migration(GO:1904141)
0.2 0.6 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.2 0.8 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.1 0.4 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.1 0.5 GO:0033594 response to hydroxyisoflavone(GO:0033594)
0.1 0.5 GO:1904845 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.1 0.3 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.1 0.2 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 0.3 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020)
0.1 0.4 GO:1904674 positive regulation of somatic stem cell population maintenance(GO:1904674)
0.1 1.0 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 0.5 GO:1904636 response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
0.1 0.2 GO:0002625 regulation of T cell antigen processing and presentation(GO:0002625)
0.1 0.3 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.0 0.3 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.0 0.2 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
0.0 0.1 GO:0035962 response to interleukin-13(GO:0035962) cellular response to interleukin-13(GO:0035963)
0.0 0.1 GO:0002728 negative regulation of natural killer cell cytokine production(GO:0002728)
0.0 0.1 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0 0.2 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
0.0 0.2 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0 0.5 GO:0048484 enteric nervous system development(GO:0048484)
0.0 0.3 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.0 0.1 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.0 0.2 GO:0002378 immunoglobulin biosynthetic process(GO:0002378)
0.0 0.1 GO:0071733 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.0 0.1 GO:0061743 motor learning(GO:0061743)
0.0 0.1 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.3 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.0 0.1 GO:0032571 response to vitamin K(GO:0032571)
0.0 0.1 GO:1902769 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
0.0 0.2 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.0 0.0 GO:1901860 positive regulation of mitochondrial DNA metabolic process(GO:1901860)
0.0 0.2 GO:0071104 response to interleukin-9(GO:0071104)
0.0 0.1 GO:0070377 regulation of ERK5 cascade(GO:0070376) negative regulation of ERK5 cascade(GO:0070377)
0.0 0.2 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.0 0.1 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.0 0.1 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.0 0.1 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.0 0.1 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.4 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.1 GO:0050717 positive regulation of gamma-aminobutyric acid secretion(GO:0014054) NAD transport(GO:0043132) positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.0 0.1 GO:2001178 mediator complex assembly(GO:0036034) regulation of mediator complex assembly(GO:2001176) positive regulation of mediator complex assembly(GO:2001178)
0.0 0.1 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.0 0.6 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.1 GO:0048295 positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.0 0.3 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.0 0.1 GO:0043129 surfactant homeostasis(GO:0043129)
0.0 0.3 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.1 GO:0030578 PML body organization(GO:0030578)
0.0 0.2 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.0 0.1 GO:0014052 regulation of gamma-aminobutyric acid secretion(GO:0014052)
0.0 0.1 GO:0051414 response to cortisol(GO:0051414)
0.0 0.2 GO:0010454 negative regulation of cell fate commitment(GO:0010454)
0.0 0.1 GO:0097398 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.0 0.2 GO:0071394 cellular response to testosterone stimulus(GO:0071394)
0.0 0.1 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.2 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.1 GO:0097473 cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.0 0.1 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.0 0.1 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.0 0.2 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.0 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.1 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 0.2 GO:1904354 negative regulation of telomere capping(GO:1904354)
0.0 0.0 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.0 0.0 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
0.0 0.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.1 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.0 0.3 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0032279 asymmetric synapse(GO:0032279)
0.2 0.9 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 0.5 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 0.3 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.0 0.2 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.0 0.3 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.5 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.2 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.6 GO:0031105 septin complex(GO:0031105)
0.0 0.1 GO:0061574 ASAP complex(GO:0061574)
0.0 0.0 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.1 GO:0097255 R2TP complex(GO:0097255)
0.0 0.1 GO:0031932 TORC2 complex(GO:0031932) TOR complex(GO:0038201)
0.0 1.0 GO:0005844 polysome(GO:0005844)
0.0 0.4 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.1 GO:0097208 alveolar lamellar body(GO:0097208)
0.0 0.1 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.7 GO:0045095 keratin filament(GO:0045095)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 0.9 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1 0.3 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
0.1 0.3 GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113)
0.0 0.3 GO:1990254 keratin filament binding(GO:1990254)
0.0 0.3 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 0.1 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.2 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.1 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.0 0.1 GO:0047977 hepoxilin-epoxide hydrolase activity(GO:0047977)
0.0 0.1 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.0 0.1 GO:0052596 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.0 0.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.2 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.0 0.5 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.2 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.1 GO:0005124 scavenger receptor binding(GO:0005124)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0003947 (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity(GO:0003947)
0.0 0.2 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.1 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.0 GO:0004020 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.0 0.1 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.3 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.2 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.1 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.0 0.5 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.0 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.1 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.0 GO:0015439 heme-transporting ATPase activity(GO:0015439)
0.0 0.1 GO:0045569 TRAIL binding(GO:0045569)
0.0 0.0 GO:0052810 1-phosphatidylinositol-5-kinase activity(GO:0052810)
0.0 0.4 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.3 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.9 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.7 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.1 0.8 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.7 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.5 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.3 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta