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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for RUNX3_BCL11A
Z-value: 0.83
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Transcription factors associated with RUNX3_BCL11A
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BCL11A | hg19_v2_chr2_-_60780702_60780742 | 0.89 | 1.9e-02 | Click! |
| RUNX3 | hg19_v2_chr1_-_25256368_25256476 | -0.14 | 7.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_+_73780852 Show fit | 0.99 |
ENST00000589666.1
|
unkempt family zinc finger |
|
| chr11_-_1606513 Show fit | 0.92 |
ENST00000382171.2
|
keratin associated protein 5-1 |
|
| chr1_+_239882842 Show fit | 0.75 |
ENST00000448020.1
|
cholinergic receptor, muscarinic 3 |
|
| chr1_+_156211753 Show fit | 0.54 |
ENST00000368272.4
|
bone gamma-carboxyglutamate (gla) protein |
|
| chr12_-_58145889 Show fit | 0.53 |
ENST00000547853.1
|
cyclin-dependent kinase 4 |
|
| chr7_-_84121858 Show fit | 0.50 |
ENST00000448879.1
|
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A |
|
| chr1_-_168513229 Show fit | 0.47 |
ENST00000367819.2
|
chemokine (C motif) ligand 2 |
|
| chr6_+_159071015 Show fit | 0.38 |
ENST00000360448.3
|
synaptotagmin-like 3 |
|
| chr17_+_75316336 Show fit | 0.36 |
ENST00000591934.1
|
septin 9 |
|
| chr1_-_206945830 Show fit | 0.36 |
ENST00000423557.1
|
interleukin 10 |
Network of associatons between targets according to the STRING database.
First level regulatory network of RUNX3_BCL11A
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 0.2 | 0.9 | GO:1902228 | mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) positive regulation of microglial cell migration(GO:1904141) |
| 0.2 | 0.8 | GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) |
| 0.2 | 0.6 | GO:1903045 | neural crest cell migration involved in sympathetic nervous system development(GO:1903045) |
| 0.0 | 0.6 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.1 | 0.5 | GO:0033594 | response to hydroxyisoflavone(GO:0033594) |
| 0.1 | 0.5 | GO:1904845 | response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845) |
| 0.1 | 0.5 | GO:1904636 | response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) |
| 0.0 | 0.5 | GO:0048484 | enteric nervous system development(GO:0048484) |
| 0.1 | 0.4 | GO:0002874 | regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | GO:0005844 | polysome(GO:0005844) |
| 0.2 | 0.9 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.3 | 0.8 | GO:0032279 | asymmetric synapse(GO:0032279) |
| 0.0 | 0.7 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 0.6 | GO:0031105 | septin complex(GO:0031105) |
| 0.1 | 0.5 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.0 | 0.5 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.0 | 0.4 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.1 | 0.3 | GO:0000333 | telomerase catalytic core complex(GO:0000333) |
| 0.0 | 0.3 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.2 | 0.8 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
| 0.0 | 0.6 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.0 | 0.5 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.0 | 0.5 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 0.4 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 0.4 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.1 | 0.3 | GO:0005146 | leukemia inhibitory factor receptor binding(GO:0005146) |
| 0.1 | 0.3 | GO:0004113 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113) |
| 0.0 | 0.3 | GO:1990254 | keratin filament binding(GO:1990254) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.7 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.5 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.3 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.8 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 0.7 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 0.5 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 0.3 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.1 | 0.2 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |