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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for RUNX1_RUNX2
Z-value: 1.34
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Transcription factors associated with RUNX1_RUNX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RUNX1 | hg19_v2_chr21_-_36259445_36259519 | 0.84 | 3.6e-02 | Click! |
| RUNX2 | hg19_v2_chr6_+_45296391_45296464 | -0.68 | 1.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr21_-_36421401 Show fit | 0.94 |
ENST00000486278.2
|
runt-related transcription factor 1 |
|
| chr11_-_1606513 Show fit | 0.86 |
ENST00000382171.2
|
keratin associated protein 5-1 |
|
| chr6_-_152623231 Show fit | 0.80 |
ENST00000540663.1
ENST00000537033.1 |
spectrin repeat containing, nuclear envelope 1 |
|
| chr12_-_58145889 Show fit | 0.78 |
ENST00000547853.1
|
cyclin-dependent kinase 4 |
|
| chr17_+_73629500 Show fit | 0.78 |
ENST00000375215.3
|
small integral membrane protein 5 |
|
| chr17_+_40274756 Show fit | 0.72 |
ENST00000355067.3
|
heat shock protein, alpha-crystallin-related, B9 |
|
| chr17_+_73780852 Show fit | 0.71 |
ENST00000589666.1
|
unkempt family zinc finger |
|
| chr11_+_62475130 Show fit | 0.69 |
ENST00000294117.5
|
guanine nucleotide binding protein (G protein), gamma 3 |
|
| chr1_+_179051160 Show fit | 0.67 |
ENST00000367625.4
ENST00000352445.6 |
torsin family 3, member A |
|
| chr14_+_100531615 Show fit | 0.65 |
ENST00000392920.3
|
Enah/Vasp-like |
Network of associatons between targets according to the STRING database.
First level regulatory network of RUNX1_RUNX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.4 | GO:1904636 | response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) |
| 0.1 | 1.3 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.0 | 1.1 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.1 | 1.0 | GO:0023021 | termination of signal transduction(GO:0023021) |
| 0.1 | 1.0 | GO:0090292 | nuclear matrix anchoring at nuclear membrane(GO:0090292) |
| 0.1 | 1.0 | GO:1901748 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
| 0.1 | 0.9 | GO:0015889 | cobalamin transport(GO:0015889) |
| 0.1 | 0.8 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 0.1 | 0.8 | GO:0030259 | lipid glycosylation(GO:0030259) |
| 0.1 | 0.8 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 1.4 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.2 | 1.1 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.0 | 1.0 | GO:0031105 | septin complex(GO:0031105) |
| 0.0 | 1.0 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 1.0 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.1 | 0.8 | GO:0071144 | SMAD2-SMAD3 protein complex(GO:0071144) |
| 0.0 | 0.8 | GO:0042599 | lamellar body(GO:0042599) |
| 0.0 | 0.7 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.0 | 0.7 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 1.1 | GO:0003951 | NAD+ kinase activity(GO:0003951) |
| 0.1 | 1.0 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 0.1 | 0.9 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.0 | 0.9 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 0.9 | GO:0005521 | lamin binding(GO:0005521) |
| 0.1 | 0.8 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.1 | 0.8 | GO:0005280 | hydrogen:amino acid symporter activity(GO:0005280) |
| 0.1 | 0.8 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.0 | 0.8 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.5 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 1.5 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.4 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.1 | 1.3 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 1.3 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.0 | 1.3 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.2 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.9 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.0 | 0.9 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 0.7 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 1.6 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 1.4 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 1.3 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 1.1 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 0.9 | REACTOME ADP SIGNALLING THROUGH P2RY12 | Genes involved in ADP signalling through P2Y purinoceptor 12 |
| 0.0 | 0.9 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 0.7 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.0 | 0.7 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.0 | 0.7 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |