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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for RORC

Z-value: 0.38

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Transcription factors associated with RORC

Gene Symbol Gene ID Gene Info
RORC
ENSG00000143365.12 RAR related orphan receptor C

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RORChg19_v2_chr1_-_151804314_151804348-0.582.3e-01Click!

Activity profile of RORC motif

Sorted Z-values of RORC motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_7698599 0.40 ENST00000311069.5
PCP2
Purkinje cell protein 2
chr17_-_59940705 0.37 ENST00000577913.1
BRIP1
BRCA1 interacting protein C-terminal helicase 1
chr15_+_31508174 0.25 ENST00000559292.2
ENST00000557928.1
RP11-16E12.1
RP11-16E12.1
chrX_+_69501943 0.22 ENST00000509895.1
ENST00000374473.2
ENST00000276066.4
RAB41
RAB41, member RAS oncogene family
chr17_-_46623441 0.18 ENST00000330070.4
HOXB2
homeobox B2
chr4_-_120243545 0.16 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr7_-_128415844 0.14 ENST00000249389.2
OPN1SW
opsin 1 (cone pigments), short-wave-sensitive
chr11_-_69867159 0.14 ENST00000528507.1
RP11-626H12.2
RP11-626H12.2
chr22_-_32022280 0.14 ENST00000442379.1
PISD
phosphatidylserine decarboxylase
chr12_+_56623827 0.14 ENST00000424625.1
ENST00000419753.1
ENST00000454355.2
ENST00000417965.1
ENST00000436633.1
SLC39A5
solute carrier family 39 (zinc transporter), member 5
chr19_-_7697857 0.13 ENST00000598935.1
PCP2
Purkinje cell protein 2
chr3_+_187461442 0.13 ENST00000450760.1
RP11-211G3.2
RP11-211G3.2
chr1_-_150207017 0.12 ENST00000369119.3
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr4_+_85504075 0.11 ENST00000295887.5
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr6_-_111927062 0.10 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr12_+_56624436 0.09 ENST00000266980.4
ENST00000437277.1
SLC39A5
solute carrier family 39 (zinc transporter), member 5
chr4_-_159094194 0.09 ENST00000592057.1
ENST00000585682.1
ENST00000393807.5
FAM198B
family with sequence similarity 198, member B
chr1_+_159796534 0.09 ENST00000289707.5
SLAMF8
SLAM family member 8
chr8_-_95449155 0.09 ENST00000481490.2
FSBP
fibrinogen silencer binding protein
chr8_+_71485681 0.09 ENST00000391684.1
AC120194.1
AC120194.1
chr3_-_65583561 0.08 ENST00000460329.2
MAGI1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr2_-_148778323 0.08 ENST00000440042.1
ENST00000535373.1
ENST00000540442.1
ENST00000536575.1
ORC4
origin recognition complex, subunit 4
chr19_+_39759154 0.07 ENST00000331982.5
IFNL2
interferon, lambda 2
chr12_+_93964158 0.06 ENST00000549206.1
SOCS2
suppressor of cytokine signaling 2
chr3_+_160559931 0.05 ENST00000464260.1
ENST00000295839.9
PPM1L
protein phosphatase, Mg2+/Mn2+ dependent, 1L
chr19_+_12780512 0.05 ENST00000242796.4
WDR83
WD repeat domain 83
chr19_+_1269324 0.05 ENST00000589710.1
ENST00000588230.1
ENST00000413636.2
ENST00000586472.1
ENST00000589686.1
ENST00000444172.2
ENST00000587323.1
ENST00000320936.5
ENST00000587896.1
ENST00000589235.1
ENST00000591659.1
CIRBP
cold inducible RNA binding protein
chr10_-_105845674 0.04 ENST00000353479.5
ENST00000369733.3
COL17A1
collagen, type XVII, alpha 1
chr1_+_67632083 0.04 ENST00000347310.5
ENST00000371002.1
IL23R
interleukin 23 receptor
chr7_+_20686946 0.04 ENST00000443026.2
ENST00000406935.1
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr16_-_69385681 0.04 ENST00000288025.3
TMED6
transmembrane emp24 protein transport domain containing 6
chr3_+_185304059 0.04 ENST00000427465.2
SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr19_-_49140692 0.04 ENST00000222122.5
DBP
D site of albumin promoter (albumin D-box) binding protein
chr3_-_117716418 0.04 ENST00000484092.1
RP11-384F7.2
RP11-384F7.2
chr2_+_160590469 0.04 ENST00000409591.1
MARCH7
membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
chr3_+_45986511 0.03 ENST00000458629.1
ENST00000457814.1
CXCR6
chemokine (C-X-C motif) receptor 6
chr1_+_205197304 0.03 ENST00000358024.3
TMCC2
transmembrane and coiled-coil domain family 2
chr3_-_45957088 0.03 ENST00000539217.1
LZTFL1
leucine zipper transcription factor-like 1
chr10_-_103578182 0.03 ENST00000439817.1
MGEA5
meningioma expressed antigen 5 (hyaluronidase)
chr16_-_67514982 0.03 ENST00000565835.1
ENST00000540149.1
ENST00000290949.3
ATP6V0D1
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chr16_-_1821496 0.02 ENST00000564628.1
ENST00000563498.1
NME3
NME/NM23 nucleoside diphosphate kinase 3
chr6_+_89855765 0.02 ENST00000275072.4
PM20D2
peptidase M20 domain containing 2
chr12_+_13061894 0.02 ENST00000540125.1
GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr2_+_162016804 0.02 ENST00000392749.2
ENST00000440506.1
TANK
TRAF family member-associated NFKB activator
chr7_-_141541221 0.02 ENST00000350549.3
ENST00000438520.1
PRSS37
protease, serine, 37
chr13_+_109248500 0.02 ENST00000356711.2
MYO16
myosin XVI
chr19_-_39735646 0.02 ENST00000413851.2
IFNL3
interferon, lambda 3
chr19_-_8567478 0.02 ENST00000255612.3
PRAM1
PML-RARA regulated adaptor molecule 1
chr2_+_162016916 0.02 ENST00000405852.1
TANK
TRAF family member-associated NFKB activator
chr2_+_162016827 0.02 ENST00000429217.1
ENST00000406287.1
ENST00000402568.1
TANK
TRAF family member-associated NFKB activator
chr3_-_45957534 0.02 ENST00000536047.1
LZTFL1
leucine zipper transcription factor-like 1
chr10_-_103578162 0.02 ENST00000361464.3
ENST00000357797.5
ENST00000370094.3
MGEA5
meningioma expressed antigen 5 (hyaluronidase)
chr10_-_121296045 0.02 ENST00000392865.1
RGS10
regulator of G-protein signaling 10
chr18_-_23671139 0.02 ENST00000579061.1
ENST00000542420.2
SS18
synovial sarcoma translocation, chromosome 18
chr11_-_47616210 0.02 ENST00000302514.3
C1QTNF4
C1q and tumor necrosis factor related protein 4
chr12_+_56414795 0.02 ENST00000431367.2
IKZF4
IKAROS family zinc finger 4 (Eos)
chr7_+_112063192 0.01 ENST00000005558.4
IFRD1
interferon-related developmental regulator 1
chr7_-_43965937 0.01 ENST00000455877.1
ENST00000223341.7
ENST00000447717.3
ENST00000426198.1
URGCP
upregulator of cell proliferation
chr6_+_44094627 0.01 ENST00000259746.9
TMEM63B
transmembrane protein 63B
chr20_-_33732952 0.01 ENST00000541621.1
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr17_-_48785216 0.01 ENST00000285243.6
ANKRD40
ankyrin repeat domain 40
chr8_+_124780672 0.01 ENST00000521166.1
ENST00000334705.7
FAM91A1
family with sequence similarity 91, member A1
chr7_+_20687017 0.01 ENST00000258738.6
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr7_+_97736197 0.01 ENST00000297293.5
LMTK2
lemur tyrosine kinase 2
chr14_-_23451467 0.01 ENST00000555074.1
ENST00000361265.4
RP11-298I3.5
AJUBA
RP11-298I3.5
ajuba LIM protein
chr14_+_23025534 0.01 ENST00000557595.1
AE000662.92
Uncharacterized protein
chr1_-_145826450 0.01 ENST00000462900.2
GPR89A
G protein-coupled receptor 89A
chrX_-_110655391 0.00 ENST00000356915.2
ENST00000356220.3
DCX
doublecortin
chr1_+_154540246 0.00 ENST00000368476.3
CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr1_-_149908710 0.00 ENST00000439741.2
ENST00000361405.6
ENST00000406732.3
MTMR11
myotubularin related protein 11
chr3_+_185303962 0.00 ENST00000296257.5
SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr17_+_47439733 0.00 ENST00000507337.1
RP11-1079K10.3
RP11-1079K10.3
chrX_-_102531717 0.00 ENST00000372680.1
TCEAL5
transcription elongation factor A (SII)-like 5

Network of associatons between targets according to the STRING database.

First level regulatory network of RORC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0000706 meiotic DNA double-strand break processing(GO:0000706) double-strand break repair involved in meiotic recombination(GO:1990918)
0.1 0.2 GO:0021569 rhombomere 3 development(GO:0021569)
0.0 0.2 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
0.0 0.0 GO:1903567 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.0 0.0 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 GO:0072536 interleukin-23 receptor complex(GO:0072536)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142) phosphatidate cytidylyltransferase activity(GO:0004605)
0.0 0.1 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.0 0.0 GO:0042019 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks