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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for RFX7_RFX4_RFX1
Z-value: 1.16
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Transcription factors associated with RFX7_RFX4_RFX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RFX1 | hg19_v2_chr19_-_14117074_14117141 | -0.87 | 2.5e-02 | Click! |
| RFX4 | hg19_v2_chr12_+_107078474_107078533 | -0.68 | 1.4e-01 | Click! |
| RFX7 | hg19_v2_chr15_-_56535464_56535521 | 0.41 | 4.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RFX7_RFX4_RFX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.6 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.1 | 3.3 | GO:0035020 | regulation of Rac protein signal transduction(GO:0035020) |
| 0.0 | 2.6 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.2 | 2.3 | GO:1902412 | regulation of mitotic cytokinesis(GO:1902412) |
| 0.1 | 1.8 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.0 | 1.5 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.1 | 1.2 | GO:2000286 | receptor internalization involved in canonical Wnt signaling pathway(GO:2000286) |
| 0.1 | 1.2 | GO:0030043 | actin filament fragmentation(GO:0030043) |
| 0.1 | 1.2 | GO:0010826 | negative regulation of centrosome duplication(GO:0010826) |
| 0.2 | 1.0 | GO:0035617 | stress granule disassembly(GO:0035617) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.0 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 3.1 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.1 | 2.2 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.1 | 1.8 | GO:0000235 | astral microtubule(GO:0000235) aster(GO:0005818) |
| 0.0 | 1.7 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.1 | 1.6 | GO:0031045 | dense core granule(GO:0031045) |
| 0.0 | 1.1 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 1.0 | GO:0036038 | MKS complex(GO:0036038) |
| 0.2 | 0.9 | GO:0005879 | axonemal microtubule(GO:0005879) |
| 0.0 | 0.8 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | GO:0031005 | filamin binding(GO:0031005) |
| 0.1 | 1.0 | GO:0070568 | guanylyltransferase activity(GO:0070568) |
| 0.0 | 1.0 | GO:0010485 | H4 histone acetyltransferase activity(GO:0010485) |
| 0.0 | 0.9 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.2 | 0.7 | GO:0004582 | dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582) |
| 0.1 | 0.7 | GO:0043515 | kinetochore binding(GO:0043515) |
| 0.0 | 0.7 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.2 | 0.6 | GO:0071566 | UFM1 activating enzyme activity(GO:0071566) |
| 0.1 | 0.6 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 0.0 | 0.6 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 0.7 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 0.7 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 0.6 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 0.5 | REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS | Genes involved in NRIF signals cell death from the nucleus |
| 0.0 | 0.5 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.0 | 0.4 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.0 | 0.4 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 0.3 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.0 | 0.3 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |