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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for RFX3_RFX2
Z-value: 1.27
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Transcription factors associated with RFX3_RFX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RFX2 | hg19_v2_chr19_-_6110457_6110472 | 0.76 | 8.2e-02 | Click! |
| RFX3 | hg19_v2_chr9_-_3525968_3526016 | -0.72 | 1.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RFX3_RFX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.5 | GO:1901663 | ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.1 | 1.3 | GO:0010663 | positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666) |
| 0.0 | 1.0 | GO:0045648 | positive regulation of erythrocyte differentiation(GO:0045648) |
| 0.0 | 0.9 | GO:0035082 | axoneme assembly(GO:0035082) |
| 0.1 | 0.8 | GO:2001166 | regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168) |
| 0.0 | 0.8 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968) |
| 0.0 | 0.8 | GO:0015886 | heme transport(GO:0015886) |
| 0.0 | 0.8 | GO:0034198 | cellular response to amino acid starvation(GO:0034198) |
| 0.1 | 0.7 | GO:1904491 | protein localization to ciliary transition zone(GO:1904491) |
| 0.0 | 0.7 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.1 | 1.4 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.3 | 0.8 | GO:0005674 | transcription factor TFIIF complex(GO:0005674) |
| 0.1 | 0.8 | GO:0033503 | HULC complex(GO:0033503) |
| 0.0 | 0.7 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
| 0.0 | 0.7 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.0 | 0.7 | GO:0036038 | MKS complex(GO:0036038) |
| 0.1 | 0.6 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.0 | 0.5 | GO:0034709 | methylosome(GO:0034709) |
| 0.0 | 0.5 | GO:0035102 | PRC1 complex(GO:0035102) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.0 | 1.0 | GO:0044390 | ubiquitin-like protein conjugating enzyme binding(GO:0044390) |
| 0.1 | 0.8 | GO:0019211 | phosphatase activator activity(GO:0019211) |
| 0.0 | 0.8 | GO:0070513 | death domain binding(GO:0070513) |
| 0.0 | 0.8 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.1 | 0.7 | GO:0046624 | sphingolipid transporter activity(GO:0046624) |
| 0.1 | 0.6 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.1 | 0.6 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.0 | 0.6 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.0 | 0.6 | GO:0003688 | DNA replication origin binding(GO:0003688) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 0.7 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 0.5 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 0.5 | PID ARF 3PATHWAY | Arf1 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 1.1 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.0 | 1.0 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.0 | 0.6 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.0 | 0.5 | REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE | Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle |
| 0.0 | 0.5 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 0.4 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.0 | 0.4 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 0.3 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 0.2 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |