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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for RELA
Z-value: 1.73
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Transcription factors associated with RELA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RELA | hg19_v2_chr11_-_65430554_65430579 | -0.59 | 2.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_74964904 Show fit | 2.44 |
ENST00000508487.2
|
chemokine (C-X-C motif) ligand 2 |
|
| chr11_+_34642656 Show fit | 2.39 |
ENST00000257831.3
ENST00000450654.2 |
ets homologous factor |
|
| chr2_-_163175133 Show fit | 2.39 |
ENST00000421365.2
ENST00000263642.2 |
interferon induced with helicase C domain 1 |
|
| chr4_-_74904398 Show fit | 2.31 |
ENST00000296026.4
|
chemokine (C-X-C motif) ligand 3 |
|
| chr14_-_35873856 Show fit | 2.25 |
ENST00000553342.1
ENST00000216797.5 ENST00000557140.1 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
|
| chr6_+_138188351 Show fit | 2.12 |
ENST00000421450.1
|
tumor necrosis factor, alpha-induced protein 3 |
|
| chr2_+_228678550 Show fit | 1.96 |
ENST00000409189.3
ENST00000358813.4 |
chemokine (C-C motif) ligand 20 |
|
| chr2_-_191885686 Show fit | 1.94 |
ENST00000432058.1
|
signal transducer and activator of transcription 1, 91kDa |
|
| chr20_-_62203808 Show fit | 1.89 |
ENST00000467148.1
|
helicase with zinc finger 2, transcriptional coactivator |
|
| chr4_-_74864386 Show fit | 1.83 |
ENST00000296027.4
|
chemokine (C-X-C motif) ligand 5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of RELA
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.7 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 1.2 | 5.0 | GO:0034344 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 1.6 | 4.9 | GO:2000349 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070425) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070433) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of CD40 signaling pathway(GO:2000349) |
| 0.1 | 4.8 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.0 | 2.5 | GO:0050885 | neuromuscular process controlling balance(GO:0050885) |
| 0.4 | 2.2 | GO:0070427 | nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427) |
| 0.2 | 2.2 | GO:0070424 | regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) |
| 0.1 | 2.2 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
| 0.3 | 2.1 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.7 | 2.0 | GO:0042222 | interleukin-1 biosynthetic process(GO:0042222) regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.4 | 2.0 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.0 | 2.0 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 1.9 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.2 | 1.8 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 1.7 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.1 | 1.4 | GO:0060091 | kinocilium(GO:0060091) |
| 0.1 | 1.3 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 0.9 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.3 | 0.8 | GO:0070762 | nuclear pore transmembrane ring(GO:0070762) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 10.6 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.1 | 5.3 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.3 | 5.1 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.0 | 4.6 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.0 | 3.0 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
| 0.1 | 2.7 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 2.5 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.1 | 2.4 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.3 | 2.1 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.7 | 2.0 | GO:0031731 | CCR6 chemokine receptor binding(GO:0031731) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 8.0 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.2 | 5.9 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 3.0 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.1 | 2.6 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 2.6 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.2 | 2.0 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.1 | 1.9 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.5 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 1.1 | PID IL23 PATHWAY | IL23-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 13.3 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 7.8 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.1 | 5.3 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.2 | 4.9 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.2 | 4.0 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 2.2 | REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.2 | 2.1 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.1 | 1.9 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.2 | 1.8 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.0 | 1.3 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |