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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for RARA
Z-value: 1.26
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Transcription factors associated with RARA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RARA | hg19_v2_chr17_+_38474489_38474548 | -0.72 | 1.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RARA
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | GO:0034587 | piRNA metabolic process(GO:0034587) |
| 0.0 | 1.3 | GO:0071044 | histone mRNA catabolic process(GO:0071044) |
| 0.1 | 1.1 | GO:0072520 | seminiferous tubule development(GO:0072520) |
| 0.0 | 1.1 | GO:0001522 | pseudouridine synthesis(GO:0001522) |
| 0.0 | 1.1 | GO:0036120 | cellular response to platelet-derived growth factor stimulus(GO:0036120) |
| 0.3 | 1.0 | GO:0006391 | transcription initiation from mitochondrial promoter(GO:0006391) |
| 0.2 | 1.0 | GO:0006781 | succinyl-CoA pathway(GO:0006781) |
| 0.0 | 1.0 | GO:0001516 | prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457) |
| 0.0 | 1.0 | GO:0001937 | negative regulation of endothelial cell proliferation(GO:0001937) |
| 0.0 | 0.9 | GO:0006363 | termination of RNA polymerase I transcription(GO:0006363) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | GO:0060293 | P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293) |
| 0.0 | 1.4 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.2 | 1.1 | GO:0034991 | nuclear meiotic cohesin complex(GO:0034991) |
| 0.0 | 1.1 | GO:0098563 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.2 | 1.0 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.2 | 1.0 | GO:0017102 | methionyl glutamyl tRNA synthetase complex(GO:0017102) |
| 0.1 | 1.0 | GO:0000120 | RNA polymerase I transcription factor complex(GO:0000120) |
| 0.1 | 0.8 | GO:0034464 | BBSome(GO:0034464) |
| 0.0 | 0.8 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.0 | 0.8 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0008171 | O-methyltransferase activity(GO:0008171) |
| 0.0 | 1.4 | GO:0016896 | 3'-5'-exoribonuclease activity(GO:0000175) exoribonuclease activity, producing 5'-phosphomonoesters(GO:0016896) |
| 0.0 | 1.2 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.1 | 1.1 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.2 | 1.0 | GO:0004492 | methylmalonyl-CoA decarboxylase activity(GO:0004492) |
| 0.2 | 1.0 | GO:0070363 | mitochondrial light strand promoter sense binding(GO:0070363) |
| 0.2 | 1.0 | GO:0004775 | succinate-CoA ligase (ADP-forming) activity(GO:0004775) |
| 0.0 | 1.0 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.1 | 0.9 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.0 | 0.9 | GO:0008536 | Ran GTPase binding(GO:0008536) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 1.3 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.1 | 1.0 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.9 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 0.9 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.7 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 0.6 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.3 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 0.2 | PID IL3 PATHWAY | IL3-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.1 | 1.6 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.0 | 1.3 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.0 | 1.1 | REACTOME RNA POL I TRANSCRIPTION INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.0 | 1.1 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 1.0 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 1.0 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 1.0 | REACTOME RNA POL I RNA POL III AND MITOCHONDRIAL TRANSCRIPTION | Genes involved in RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription |
| 0.0 | 0.9 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 0.9 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |