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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for RAD21_SMC3
Z-value: 1.08
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Transcription factors associated with RAD21_SMC3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RAD21 | hg19_v2_chr8_-_117886563_117886605 | -0.63 | 1.8e-01 | Click! |
| SMC3 | hg19_v2_chr10_+_112327425_112327516 | -0.56 | 2.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_109642799 Show fit | 1.13 |
ENST00000602755.1
|
small Cajal body-specific RNA 2 |
|
| chr9_-_134615326 Show fit | 1.00 |
ENST00000438647.1
|
Rap guanine nucleotide exchange factor (GEF) 1 |
|
| chr2_+_11273179 Show fit | 0.94 |
ENST00000381585.3
ENST00000405022.3 |
chromosome 2 open reading frame 50 |
|
| chrX_-_27417088 Show fit | 0.86 |
ENST00000608735.1
ENST00000422048.1 |
RP11-268G12.1 |
|
| chr11_+_73675873 Show fit | 0.85 |
ENST00000537753.1
ENST00000542350.1 |
DnaJ (Hsp40) homolog, subfamily B, member 13 |
|
| chr3_+_50192457 Show fit | 0.80 |
ENST00000414301.1
ENST00000450338.1 |
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F |
|
| chr4_-_175041663 Show fit | 0.79 |
ENST00000503140.1
|
RP11-148L24.1 |
|
| chr6_+_31105426 Show fit | 0.76 |
ENST00000547221.1
|
psoriasis susceptibility 1 candidate 1 |
|
| chr14_-_75079294 Show fit | 0.74 |
ENST00000556359.1
|
latent transforming growth factor beta binding protein 2 |
|
| chr7_-_27219632 Show fit | 0.72 |
ENST00000470747.4
|
Uncharacterized protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of RAD21_SMC3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | GO:0046339 | diacylglycerol metabolic process(GO:0046339) |
| 0.1 | 1.6 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.0 | 1.3 | GO:0090140 | regulation of mitochondrial fission(GO:0090140) |
| 0.1 | 1.0 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
| 0.2 | 0.9 | GO:1904158 | axonemal central apparatus assembly(GO:1904158) |
| 0.1 | 0.9 | GO:0036486 | trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) neural crest cell migration involved in autonomic nervous system development(GO:1901166) |
| 0.0 | 0.9 | GO:1902018 | negative regulation of cilium assembly(GO:1902018) |
| 0.0 | 0.9 | GO:0043949 | regulation of cAMP-mediated signaling(GO:0043949) |
| 0.2 | 0.8 | GO:1990502 | dense core granule maturation(GO:1990502) |
| 0.1 | 0.7 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 1.4 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.0 | 1.4 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.1 | 0.7 | GO:0044352 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 0.0 | 0.7 | GO:0005861 | troponin complex(GO:0005861) |
| 0.2 | 0.6 | GO:0097233 | lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233) |
| 0.1 | 0.6 | GO:0097255 | R2TP complex(GO:0097255) |
| 0.0 | 0.6 | GO:0045179 | apical cortex(GO:0045179) |
| 0.0 | 0.6 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.0 | 0.6 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.1 | 1.2 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.1 | 1.1 | GO:0060002 | plus-end directed microfilament motor activity(GO:0060002) |
| 0.0 | 1.0 | GO:0019841 | retinol binding(GO:0019841) |
| 0.0 | 0.9 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.0 | 0.9 | GO:0008171 | O-methyltransferase activity(GO:0008171) |
| 0.0 | 0.8 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.0 | 0.7 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.0 | 0.7 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
| 0.0 | 0.7 | GO:0030552 | cAMP binding(GO:0030552) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.5 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.0 | 1.3 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 1.1 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.0 | 1.1 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.0 | 1.0 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 0.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.5 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.5 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 0.5 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | REACTOME ARMS MEDIATED ACTIVATION | Genes involved in ARMS-mediated activation |
| 0.0 | 1.1 | REACTOME FRS2 MEDIATED CASCADE | Genes involved in FRS2-mediated cascade |
| 0.0 | 1.0 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.8 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 0.7 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.0 | 0.6 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.0 | 0.6 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 0.6 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.0 | 0.6 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 0.6 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |