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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PRDM4

Z-value: 0.52

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Transcription factors associated with PRDM4

Gene Symbol Gene ID Gene Info
PRDM4
ENSG00000110851.7 PR/SET domain 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PRDM4hg19_v2_chr12_-_108154705_1081547760.749.5e-02Click!

Activity profile of PRDM4 motif

Sorted Z-values of PRDM4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_53636125 0.37 ENST00000601493.1
ENST00000599261.1
ENST00000597503.1
ENST00000500065.4
ENST00000243643.4
ENST00000594011.1
ENST00000455735.2
ENST00000595193.1
ENST00000448501.1
ENST00000421033.1
ENST00000440291.1
ENST00000595813.1
ENST00000600574.1
ENST00000596051.1
ENST00000601110.1
ZNF415
zinc finger protein 415
chr22_-_39636914 0.36 ENST00000381551.4
PDGFB
platelet-derived growth factor beta polypeptide
chr10_+_88728189 0.29 ENST00000416348.1
ADIRF
adipogenesis regulatory factor
chr4_+_667307 0.28 ENST00000506838.1
MYL5
myosin, light chain 5, regulatory
chr7_+_90893783 0.27 ENST00000287934.2
FZD1
frizzled family receptor 1
chr14_-_24732738 0.25 ENST00000558074.1
ENST00000560226.1
TGM1
transglutaminase 1
chr20_-_49639631 0.23 ENST00000424171.1
ENST00000439216.1
ENST00000371571.4
KCNG1
potassium voltage-gated channel, subfamily G, member 1
chr1_+_27113963 0.18 ENST00000430292.1
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr6_-_32160622 0.16 ENST00000487761.1
ENST00000375040.3
GPSM3
G-protein signaling modulator 3
chr1_+_171750776 0.16 ENST00000458517.1
ENST00000362019.3
ENST00000367737.5
ENST00000361735.3
METTL13
methyltransferase like 13
chr10_-_105212141 0.16 ENST00000369788.3
CALHM2
calcium homeostasis modulator 2
chr12_+_50794947 0.16 ENST00000552445.1
LARP4
La ribonucleoprotein domain family, member 4
chr14_-_74462922 0.16 ENST00000553284.1
ENTPD5
ectonucleoside triphosphate diphosphohydrolase 5
chr2_+_219264466 0.15 ENST00000273062.2
CTDSP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr1_+_6511651 0.15 ENST00000434576.1
ESPN
espin
chr1_-_43232649 0.14 ENST00000372526.2
ENST00000236040.4
ENST00000296388.5
ENST00000397054.3
LEPRE1
leucine proline-enriched proteoglycan (leprecan) 1
chr19_-_35264089 0.14 ENST00000588760.1
ENST00000329285.8
ENST00000587354.2
ZNF599
zinc finger protein 599
chr16_+_88636875 0.14 ENST00000569435.1
ZC3H18
zinc finger CCCH-type containing 18
chr17_+_42634844 0.14 ENST00000315323.3
FZD2
frizzled family receptor 2
chr5_+_159343688 0.13 ENST00000306675.3
ADRA1B
adrenoceptor alpha 1B
chr2_+_219264762 0.13 ENST00000452977.1
CTDSP1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr5_-_78281623 0.12 ENST00000521117.1
ARSB
arylsulfatase B
chr16_+_88636789 0.11 ENST00000301011.5
ENST00000452588.2
ZC3H18
zinc finger CCCH-type containing 18
chr7_+_143078652 0.11 ENST00000354434.4
ENST00000449423.2
ZYX
zyxin
chr6_-_24721054 0.11 ENST00000378119.4
C6orf62
chromosome 6 open reading frame 62
chr7_+_143079000 0.10 ENST00000392910.2
ZYX
zyxin
chr2_+_234296792 0.10 ENST00000409813.3
DGKD
diacylglycerol kinase, delta 130kDa
chr11_-_85393886 0.10 ENST00000534224.1
CREBZF
CREB/ATF bZIP transcription factor
chr19_+_42724423 0.09 ENST00000301215.3
ENST00000597945.1
ZNF526
zinc finger protein 526
chr1_+_27114589 0.09 ENST00000431541.1
ENST00000449950.2
ENST00000374145.1
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr16_+_29823427 0.09 ENST00000358758.7
ENST00000567659.1
ENST00000572820.1
PRRT2
proline-rich transmembrane protein 2
chr4_+_667686 0.08 ENST00000505477.1
MYL5
myosin, light chain 5, regulatory
chr5_+_145317356 0.08 ENST00000511217.1
SH3RF2
SH3 domain containing ring finger 2
chr12_+_15475462 0.08 ENST00000543886.1
ENST00000348962.2
PTPRO
protein tyrosine phosphatase, receptor type, O
chr1_+_222910625 0.07 ENST00000360827.2
FAM177B
family with sequence similarity 177, member B
chr14_+_64565442 0.07 ENST00000553308.1
SYNE2
spectrin repeat containing, nuclear envelope 2
chr20_+_62697564 0.07 ENST00000458442.1
TCEA2
transcription elongation factor A (SII), 2
chr16_+_15068916 0.06 ENST00000455313.2
PDXDC1
pyridoxal-dependent decarboxylase domain containing 1
chr16_+_15068831 0.06 ENST00000535621.2
ENST00000566426.1
PDXDC1
pyridoxal-dependent decarboxylase domain containing 1
chr1_+_151043070 0.06 ENST00000368918.3
ENST00000368917.1
GABPB2
GA binding protein transcription factor, beta subunit 2
chr1_+_54359854 0.06 ENST00000361921.3
ENST00000322679.6
ENST00000532493.1
ENST00000525202.1
ENST00000524406.1
ENST00000388876.3
DIO1
deiodinase, iodothyronine, type I
chr19_-_11639910 0.06 ENST00000588998.1
ENST00000586149.1
ECSIT
ECSIT signalling integrator
chr5_-_180688105 0.06 ENST00000327767.4
TRIM52
tripartite motif containing 52
chrX_+_115567767 0.06 ENST00000371900.4
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr19_-_11639931 0.06 ENST00000592312.1
ENST00000590480.1
ENST00000585318.1
ENST00000252440.7
ENST00000417981.2
ENST00000270517.7
ECSIT
ECSIT signalling integrator
chr17_+_7788104 0.05 ENST00000380358.4
CHD3
chromodomain helicase DNA binding protein 3
chr15_+_74287035 0.05 ENST00000395132.2
ENST00000268059.6
ENST00000354026.6
ENST00000268058.3
ENST00000565898.1
ENST00000569477.1
ENST00000569965.1
ENST00000567543.1
ENST00000436891.3
ENST00000435786.2
ENST00000564428.1
ENST00000359928.4
PML
promyelocytic leukemia
chr20_-_61569227 0.05 ENST00000266070.4
ENST00000395335.2
ENST00000266071.5
DIDO1
death inducer-obliterator 1
chr14_+_24025345 0.05 ENST00000557630.1
THTPA
thiamine triphosphatase
chr20_-_61569296 0.05 ENST00000370371.4
DIDO1
death inducer-obliterator 1
chr5_-_78281775 0.04 ENST00000396151.3
ENST00000565165.1
ARSB
arylsulfatase B
chr16_+_29823552 0.04 ENST00000300797.6
PRRT2
proline-rich transmembrane protein 2
chr14_+_24025194 0.04 ENST00000404535.3
ENST00000288014.6
THTPA
thiamine triphosphatase
chr5_+_102455853 0.04 ENST00000515845.1
ENST00000321521.9
ENST00000507921.1
PPIP5K2
diphosphoinositol pentakisphosphate kinase 2
chr15_-_66797172 0.03 ENST00000569438.1
ENST00000569696.1
ENST00000307961.6
RPL4
ribosomal protein L4
chr19_+_41117770 0.03 ENST00000601032.1
LTBP4
latent transforming growth factor beta binding protein 4
chr3_+_148709310 0.03 ENST00000484197.1
ENST00000492285.2
ENST00000461191.1
GYG1
glycogenin 1
chr9_+_139560197 0.03 ENST00000371698.3
EGFL7
EGF-like-domain, multiple 7
chr19_+_50180317 0.03 ENST00000534465.1
PRMT1
protein arginine methyltransferase 1
chr10_+_123923105 0.03 ENST00000368999.1
TACC2
transforming, acidic coiled-coil containing protein 2
chrX_-_73072534 0.03 ENST00000429829.1
XIST
X inactive specific transcript (non-protein coding)
chr9_+_96338647 0.03 ENST00000359246.4
PHF2
PHD finger protein 2
chr4_+_2451700 0.02 ENST00000506607.1
RP11-503N18.3
Uncharacterized protein
chr3_+_148709128 0.02 ENST00000345003.4
ENST00000296048.6
ENST00000483267.1
GYG1
glycogenin 1
chr11_-_67188642 0.02 ENST00000546202.1
ENST00000542876.1
PPP1CA
protein phosphatase 1, catalytic subunit, alpha isozyme
chr2_+_233734994 0.02 ENST00000331342.2
C2orf82
chromosome 2 open reading frame 82
chr16_+_29674540 0.02 ENST00000436527.1
ENST00000360121.3
ENST00000449759.1
SPN
QPRT
sialophorin
quinolinate phosphoribosyltransferase
chr20_+_61569463 0.02 ENST00000266069.3
GID8
GID complex subunit 8
chr1_+_27114418 0.02 ENST00000078527.4
PIGV
phosphatidylinositol glycan anchor biosynthesis, class V
chr16_+_15068955 0.02 ENST00000396410.4
ENST00000569715.1
ENST00000450288.2
PDXDC1
pyridoxal-dependent decarboxylase domain containing 1
chr5_+_140261703 0.01 ENST00000409494.1
ENST00000289272.2
PCDHA13
protocadherin alpha 13
chr11_+_8040739 0.01 ENST00000534099.1
TUB
tubby bipartite transcription factor
chr12_+_15475331 0.01 ENST00000281171.4
PTPRO
protein tyrosine phosphatase, receptor type, O
chr5_-_102455801 0.00 ENST00000508629.1
ENST00000399004.2
GIN1
gypsy retrotransposon integrase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of PRDM4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0090677 metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936)
0.1 0.3 GO:0035425 autocrine signaling(GO:0035425)
0.0 0.1 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.0 0.3 GO:0045229 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.0 0.3 GO:2001023 cellular response to cisplatin(GO:0072719) regulation of response to drug(GO:2001023)
0.0 0.1 GO:0061580 colon epithelial cell migration(GO:0061580)
0.0 0.1 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0 0.1 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.0 0.1 GO:0003150 muscular septum morphogenesis(GO:0003150)
0.0 0.1 GO:0030046 parallel actin filament bundle assembly(GO:0030046)
0.0 0.3 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0031501 mannosyltransferase complex(GO:0031501)
0.0 0.3 GO:1990909 Wnt signalosome(GO:1990909)
0.0 0.4 GO:0005859 muscle myosin complex(GO:0005859)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.0 0.2 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
0.0 0.1 GO:0050333 thiamin-triphosphatase activity(GO:0050333)
0.0 0.1 GO:0004936 alpha-adrenergic receptor activity(GO:0004936)
0.0 0.1 GO:0003943 N-acetylgalactosamine-4-sulfatase activity(GO:0003943)
0.0 0.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.4 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.2 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.1 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID WNT SIGNALING PATHWAY Wnt signaling network