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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PRDM1

Z-value: 1.50

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Transcription factors associated with PRDM1

Gene Symbol Gene ID Gene Info
ENSG00000057657.10 PR/SET domain 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PRDM1hg19_v2_chr6_+_106535455_1065356370.796.3e-02Click!

Activity profile of PRDM1 motif

Sorted Z-values of PRDM1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_131746575 1.55 ENST00000337752.2
ENST00000378947.3
ENST00000407797.1
chromosome 5 open reading frame 56
chr16_-_67970990 1.31 ENST00000358514.4
proteasome (prosome, macropain) subunit, beta type, 10
chr10_-_81203972 1.28 ENST00000372333.3
zinc finger, CCHC domain containing 24
chr2_-_36779411 1.18 ENST00000406220.1
Uncharacterized protein
chr7_-_105332084 1.13 ENST00000472195.1
ataxin 7-like 1
chr21_+_17909594 1.09 ENST00000441820.1
ENST00000602280.1
long intergenic non-protein coding RNA 478
chr12_-_86650077 1.02 ENST00000552808.2
ENST00000547225.1
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr6_-_121655850 0.83 ENST00000422369.1
TBC1 domain family, member 32
chr12_+_43086018 0.80 ENST00000550177.1
RP11-25I15.3
chr5_-_159766528 0.77 ENST00000505287.2
cyclin J-like
chr15_+_85144217 0.75 ENST00000540936.1
ENST00000448803.2
ENST00000546275.1
ENST00000546148.1
ENST00000442073.3
ENST00000334141.3
ENST00000358472.3
ENST00000502939.2
ENST00000379358.3
ENST00000327179.6
zinc finger and SCAN domain containing 2
chr2_+_239756671 0.74 ENST00000448943.2
twist family bHLH transcription factor 2
chr1_+_207262881 0.73 ENST00000451804.2
complement component 4 binding protein, beta
chr7_+_134832808 0.72 ENST00000275767.3
transmembrane protein 140
chrX_-_63005405 0.72 ENST00000374878.1
ENST00000437457.2
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr12_+_94656297 0.69 ENST00000545312.1
plexin C1
chr3_+_8543393 0.69 ENST00000157600.3
ENST00000415597.1
ENST00000535732.1
LIM and cysteine-rich domains 1
chr4_+_186990298 0.65 ENST00000296795.3
ENST00000513189.1
toll-like receptor 3
chr8_+_39770803 0.64 ENST00000518237.1
indoleamine 2,3-dioxygenase 1
chr7_-_86848933 0.64 ENST00000423734.1
transmembrane protein 243, mitochondrial
chr3_-_64431146 0.62 ENST00000569824.1
ENST00000485770.1
prickle homolog 2 (Drosophila)
RP11-14D22.2
chr13_-_95364389 0.61 ENST00000376945.2
SRY (sex determining region Y)-box 21
chr1_-_8483723 0.60 ENST00000476556.1
arginine-glutamic acid dipeptide (RE) repeats
chr7_-_3083472 0.60 ENST00000356408.3
caspase recruitment domain family, member 11
chr17_+_46908350 0.59 ENST00000258947.3
ENST00000509507.1
ENST00000448105.2
ENST00000570513.1
ENST00000509415.1
ENST00000513119.1
ENST00000416445.2
ENST00000508679.1
ENST00000505071.1
calcium binding and coiled-coil domain 2
chr12_-_71003568 0.58 ENST00000547715.1
ENST00000451516.2
ENST00000538708.1
ENST00000550857.1
ENST00000261266.5
protein tyrosine phosphatase, receptor type, B
chr3_+_69915363 0.57 ENST00000451708.1
microphthalmia-associated transcription factor
chr7_-_111424462 0.56 ENST00000437129.1
dedicator of cytokinesis 4
chr22_-_31688431 0.56 ENST00000402249.3
ENST00000443175.1
ENST00000215912.5
ENST00000441972.1
phosphoinositide-3-kinase interacting protein 1
chr8_-_9009079 0.56 ENST00000519699.1
protein phosphatase 1, regulatory subunit 3B
chr20_+_388679 0.56 ENST00000356286.5
ENST00000475269.1
RanBP-type and C3HC4-type zinc finger containing 1
chr4_-_100140331 0.54 ENST00000407820.2
ENST00000394897.1
ENST00000508558.1
ENST00000394899.2
alcohol dehydrogenase 6 (class V)
chr20_+_388791 0.54 ENST00000441733.1
ENST00000353660.3
RanBP-type and C3HC4-type zinc finger containing 1
chr20_+_388935 0.54 ENST00000382181.2
ENST00000400247.3
RanBP-type and C3HC4-type zinc finger containing 1
chr8_+_9009202 0.54 ENST00000518496.1
Uncharacterized protein
chr17_+_7211656 0.53 ENST00000416016.2
eukaryotic translation initiation factor 5A
chr6_+_106535455 0.53 ENST00000424894.1
PR domain containing 1, with ZNF domain
chr6_-_33282024 0.53 ENST00000475304.1
ENST00000489157.1
TAP binding protein (tapasin)
chr3_+_8543561 0.52 ENST00000397386.3
LIM and cysteine-rich domains 1
chr16_-_88851618 0.51 ENST00000301015.9
piezo-type mechanosensitive ion channel component 1
chr10_-_44880491 0.50 ENST00000374426.2
ENST00000395795.4
ENST00000395794.2
ENST00000374429.2
ENST00000395793.3
ENST00000343575.6
chemokine (C-X-C motif) ligand 12
chr14_-_69263043 0.50 ENST00000408913.2
ZFP36 ring finger protein-like 1
chr1_+_212782012 0.50 ENST00000341491.4
ENST00000366985.1
activating transcription factor 3
chr3_+_8543533 0.48 ENST00000454244.1
LIM and cysteine-rich domains 1
chr14_-_69262947 0.47 ENST00000557086.1
ZFP36 ring finger protein-like 1
chr14_-_69262789 0.47 ENST00000557022.1
ZFP36 ring finger protein-like 1
chr5_-_94417186 0.46 ENST00000312216.8
ENST00000512425.1
multiple C2 domains, transmembrane 1
chr12_-_118498958 0.46 ENST00000315436.3
WD repeat and SOCS box containing 2
chr22_-_31688381 0.45 ENST00000487265.2
phosphoinositide-3-kinase interacting protein 1
chr15_-_72565340 0.45 ENST00000568360.1
poly (ADP-ribose) polymerase family, member 6
chr1_-_161014731 0.43 ENST00000368020.1
upstream transcription factor 1
chr2_+_145780662 0.42 ENST00000423031.1
testis expressed 41 (non-protein coding)
chr6_-_33282163 0.42 ENST00000434618.2
ENST00000456592.2
TAP binding protein (tapasin)
chr22_+_39436862 0.41 ENST00000381565.2
ENST00000452957.2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chr5_-_66942617 0.41 ENST00000507298.1
RP11-83M16.5
chr11_-_47736896 0.41 ENST00000525123.1
ENST00000528244.1
ENST00000532595.1
ENST00000529154.1
ENST00000530969.1
ATP/GTP binding protein-like 2
chr12_-_118498911 0.40 ENST00000544233.1
WD repeat and SOCS box containing 2
chr5_-_94417339 0.40 ENST00000429576.2
ENST00000508509.1
ENST00000510732.1
multiple C2 domains, transmembrane 1
chr18_+_3466248 0.39 ENST00000581029.1
ENST00000581442.1
ENST00000579007.1
RP11-838N2.4
chr19_+_34287751 0.38 ENST00000590771.1
ENST00000589786.1
ENST00000284006.6
ENST00000588881.1
potassium channel tetramerization domain containing 15
chr5_-_94417314 0.38 ENST00000505208.1
multiple C2 domains, transmembrane 1
chr11_+_64323156 0.38 ENST00000377585.3
solute carrier family 22 (organic anion/urate transporter), member 11
chr6_-_33281979 0.38 ENST00000426633.2
ENST00000467025.1
TAP binding protein (tapasin)
chr22_-_36635225 0.38 ENST00000529194.1
apolipoprotein L, 2
chr12_+_25205446 0.38 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
lymphoid-restricted membrane protein
chr3_-_114343039 0.36 ENST00000481632.1
zinc finger and BTB domain containing 20
chr4_-_111558135 0.36 ENST00000394598.2
ENST00000394595.3
paired-like homeodomain 2
chr16_+_31085714 0.36 ENST00000300850.5
ENST00000564189.1
ENST00000428260.1
zinc finger protein 646
chr4_+_183065793 0.35 ENST00000512480.1
teneurin transmembrane protein 3
chrX_+_123095860 0.35 ENST00000428941.1
stromal antigen 2
chr17_+_6659354 0.35 ENST00000574907.1
XIAP associated factor 1
chr8_+_77593448 0.35 ENST00000521891.2
zinc finger homeobox 4
chr8_+_77593474 0.35 ENST00000455469.2
ENST00000050961.6
zinc finger homeobox 4
chr8_+_97506033 0.35 ENST00000518385.1
syndecan 2
chr20_-_52612705 0.34 ENST00000434986.2
breast carcinoma amplified sequence 1
chr4_-_48782259 0.34 ENST00000507711.1
ENST00000358350.4
ENST00000537810.1
ENST00000264319.7
FRY-like
chr8_-_79717163 0.34 ENST00000520269.1
interleukin 7
chr4_+_146403912 0.33 ENST00000507367.1
ENST00000394092.2
ENST00000515385.1
SMAD family member 1
chr11_-_796197 0.33 ENST00000530360.1
ENST00000528606.1
ENST00000320230.5
solute carrier family 25 (mitochondrial carrier: glutamate), member 22
chr2_-_145275828 0.33 ENST00000392861.2
ENST00000409211.1
zinc finger E-box binding homeobox 2
chr8_-_29120580 0.33 ENST00000524189.1
kinesin family member 13B
chr1_+_151372010 0.32 ENST00000290541.6
proteasome (prosome, macropain) subunit, beta type, 4
chr4_-_153303658 0.32 ENST00000296555.5
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr7_-_111424506 0.32 ENST00000450156.1
ENST00000494651.2
dedicator of cytokinesis 4
chr15_+_75491213 0.32 ENST00000360639.2
chromosome 15 open reading frame 39
chr6_-_10412600 0.32 ENST00000379608.3
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr19_+_24009879 0.31 ENST00000354585.4
ribosomal protein SA pseudogene 58
chr6_+_31540056 0.31 ENST00000418386.2
lymphotoxin alpha
chr13_+_24144796 0.31 ENST00000403372.2
tumor necrosis factor receptor superfamily, member 19
chr17_-_43339474 0.31 ENST00000331780.4
spermatogenesis associated 32
chr14_-_69262916 0.31 ENST00000553375.1
ZFP36 ring finger protein-like 1
chr16_+_84801852 0.30 ENST00000569925.1
ENST00000567526.1
ubiquitin specific peptidase 10
chr16_+_20685815 0.30 ENST00000561584.1
acyl-CoA synthetase medium-chain family member 3
chr1_+_17906970 0.29 ENST00000375415.1
Rho guanine nucleotide exchange factor (GEF) 10-like
chr5_+_92919043 0.29 ENST00000327111.3
nuclear receptor subfamily 2, group F, member 1
chr10_+_122610853 0.29 ENST00000604585.1
WD repeat domain 11
chr3_+_69915385 0.28 ENST00000314589.5
microphthalmia-associated transcription factor
chr12_+_94542459 0.28 ENST00000258526.4
plexin C1
chr6_-_28220002 0.27 ENST00000377294.2
zinc finger with KRAB and SCAN domains 4
chr8_-_142012169 0.27 ENST00000517453.1
protein tyrosine kinase 2
chr14_-_23479331 0.26 ENST00000397377.1
ENST00000397379.3
ENST00000406429.2
ENST00000341470.4
ENST00000555998.1
ENST00000397376.2
ENST00000553675.1
ENST00000553931.1
ENST00000555575.1
ENST00000553958.1
ENST00000555098.1
ENST00000556419.1
ENST00000553606.1
ENST00000299088.6
ENST00000554179.1
ENST00000397382.4
chromosome 14 open reading frame 93
chr10_-_82049424 0.26 ENST00000372213.3
methionine adenosyltransferase I, alpha
chr7_-_122526499 0.25 ENST00000412584.2
Ca++-dependent secretion activator 2
chrX_-_154563889 0.25 ENST00000369449.2
ENST00000321926.4
chloride intracellular channel 2
chr13_-_33924755 0.25 ENST00000439831.1
ENST00000567873.1
StAR-related lipid transfer (START) domain containing 13
chr4_+_142558078 0.24 ENST00000529613.1
interleukin 15
chr11_+_64323428 0.24 ENST00000377581.3
solute carrier family 22 (organic anion/urate transporter), member 11
chrX_+_123095890 0.24 ENST00000435215.1
stromal antigen 2
chr15_-_37393406 0.24 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
Meis homeobox 2
chr22_+_41697520 0.24 ENST00000352645.4
zinc finger CCCH-type containing 7B
chr2_-_145275228 0.23 ENST00000427902.1
ENST00000409487.3
ENST00000470879.1
ENST00000435831.1
zinc finger E-box binding homeobox 2
chr3_+_185046676 0.23 ENST00000428617.1
ENST00000443863.1
mitogen-activated protein kinase kinase kinase 13
chr12_+_51318513 0.23 ENST00000332160.4
methyltransferase like 7A
chr16_+_50775971 0.23 ENST00000311559.9
ENST00000564326.1
ENST00000566206.1
cylindromatosis (turban tumor syndrome)
chr6_-_29527702 0.23 ENST00000377050.4
ubiquitin D
chr16_-_3930724 0.23 ENST00000262367.5
CREB binding protein
chr12_-_57504975 0.23 ENST00000553397.1
ENST00000556259.1
signal transducer and activator of transcription 6, interleukin-4 induced
chr3_+_47422485 0.23 ENST00000431726.1
ENST00000456221.1
ENST00000265562.4
protein tyrosine phosphatase, non-receptor type 23
chr6_-_138820624 0.22 ENST00000343505.5
NHS-like 1
chrX_-_118826784 0.22 ENST00000394616.4
septin 6
chr5_+_86563636 0.22 ENST00000274376.6
RAS p21 protein activator (GTPase activating protein) 1
chr1_-_153919128 0.22 ENST00000361217.4
DENN/MADD domain containing 4B
chr2_+_179184955 0.21 ENST00000315022.2
oxysterol binding protein-like 6
chr8_-_56986768 0.21 ENST00000523936.1
ribosomal protein S20
chr4_-_146859787 0.21 ENST00000508784.1
zinc finger protein 827
chr6_-_41909191 0.20 ENST00000512426.1
ENST00000372987.4
cyclin D3
chr8_-_116681221 0.20 ENST00000395715.3
trichorhinophalangeal syndrome I
chr12_-_120189900 0.20 ENST00000546026.1
citron (rho-interacting, serine/threonine kinase 21)
chr11_+_71709938 0.20 ENST00000393705.4
ENST00000337131.5
ENST00000531053.1
ENST00000404792.1
interleukin 18 binding protein
chr11_+_28129795 0.20 ENST00000406787.3
ENST00000342303.5
ENST00000403099.1
ENST00000407364.3
methyltransferase like 15
chr20_+_30946106 0.19 ENST00000375687.4
ENST00000542461.1
additional sex combs like 1 (Drosophila)
chr9_-_69229650 0.19 ENST00000416428.1
COBW domain containing 6
chr1_-_221915418 0.19 ENST00000323825.3
ENST00000366899.3
dual specificity phosphatase 10
chr3_+_51977294 0.19 ENST00000498510.1
poly (ADP-ribose) polymerase family, member 3
chr6_-_44400720 0.19 ENST00000595057.1
AL133262.1
chr1_-_151735937 0.19 ENST00000368829.3
ENST00000368830.3
mitochondrial ribosomal protein L9
chr15_-_37392086 0.18 ENST00000561208.1
Meis homeobox 2
chr22_-_36635598 0.18 ENST00000454728.1
apolipoprotein L, 2
chr1_+_110453462 0.18 ENST00000488198.1
colony stimulating factor 1 (macrophage)
chr3_+_107241882 0.18 ENST00000416476.2
bobby sox homolog (Drosophila)
chr8_-_29120604 0.18 ENST00000521515.1
kinesin family member 13B
chr1_+_28099700 0.18 ENST00000440806.2
syntaxin 12
chr17_-_26695013 0.17 ENST00000555059.2
Homeobox protein SEBOX
chr4_-_100242549 0.17 ENST00000305046.8
ENST00000394887.3
alcohol dehydrogenase 1B (class I), beta polypeptide
chr11_+_93861993 0.17 ENST00000227638.3
ENST00000436171.2
pannexin 1
chr11_-_72432950 0.17 ENST00000426523.1
ENST00000429686.1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr7_+_95401877 0.16 ENST00000524053.1
ENST00000324972.6
ENST00000537881.1
ENST00000437599.1
ENST00000359388.4
ENST00000413338.1
dynein, cytoplasmic 1, intermediate chain 1
chr9_+_137533615 0.16 ENST00000371817.3
collagen, type V, alpha 1
chr11_+_64008443 0.16 ENST00000309366.4
FK506 binding protein 2, 13kDa
chrX_-_118827113 0.16 ENST00000394617.2
septin 6
chr12_-_86650045 0.15 ENST00000604798.1
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr6_+_53659746 0.15 ENST00000370888.1
leucine rich repeat containing 1
chr9_+_84304628 0.15 ENST00000437181.1
RP11-154D17.1
chr3_+_119013185 0.15 ENST00000264245.4
Rho GTPase activating protein 31
chr6_-_112575912 0.15 ENST00000522006.1
ENST00000230538.7
ENST00000519932.1
laminin, alpha 4
chr22_-_36556821 0.15 ENST00000531095.1
ENST00000397293.2
ENST00000349314.2
apolipoprotein L, 3
chr1_+_11832179 0.15 ENST00000312793.5
chromosome 1 open reading frame 167
chr6_-_137113604 0.15 ENST00000359015.4
mitogen-activated protein kinase kinase kinase 5
chr19_+_34287174 0.15 ENST00000587559.1
ENST00000588637.1
potassium channel tetramerization domain containing 15
chr13_+_24144509 0.14 ENST00000248484.4
tumor necrosis factor receptor superfamily, member 19
chr13_+_108921977 0.14 ENST00000430559.1
ENST00000375887.4
tumor necrosis factor (ligand) superfamily, member 13b
chr12_+_51317788 0.14 ENST00000550502.1
methyltransferase like 7A
chr6_-_99797522 0.14 ENST00000389677.5
failed axon connections homolog (Drosophila)
chr1_-_44497024 0.14 ENST00000372306.3
ENST00000372310.3
ENST00000475075.2
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr5_+_140430979 0.13 ENST00000306549.3
protocadherin beta 1
chr1_+_2985760 0.13 ENST00000378391.2
ENST00000514189.1
ENST00000270722.5
PR domain containing 16
chrX_-_106362013 0.12 ENST00000372487.1
ENST00000372479.3
ENST00000203616.8
RNA binding motif protein 41
chr2_+_166150541 0.12 ENST00000283256.6
sodium channel, voltage-gated, type II, alpha subunit
chr6_-_112575838 0.12 ENST00000455073.1
laminin, alpha 4
chr11_+_64323098 0.12 ENST00000301891.4
solute carrier family 22 (organic anion/urate transporter), member 11
chr21_+_43933946 0.11 ENST00000352133.2
solute carrier family 37 (glucose-6-phosphate transporter), member 1
chr8_-_116680833 0.11 ENST00000220888.5
trichorhinophalangeal syndrome I
chr9_+_133454943 0.11 ENST00000319725.9
far upstream element (FUSE) binding protein 3
chr1_+_2985726 0.11 ENST00000511072.1
ENST00000378398.3
ENST00000441472.2
ENST00000442529.2
PR domain containing 16
chr17_+_74372662 0.11 ENST00000591651.1
ENST00000545180.1
sphingosine kinase 1
chr1_+_110453203 0.11 ENST00000357302.4
ENST00000344188.5
ENST00000329608.6
colony stimulating factor 1 (macrophage)
chr5_+_73109339 0.11 ENST00000296799.4
Rho guanine nucleotide exchange factor (GEF) 28
chr6_-_10413112 0.11 ENST00000465858.1
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr22_-_36635563 0.11 ENST00000451256.2
apolipoprotein L, 2
chrX_+_114874727 0.11 ENST00000543070.1
plastin 3
chr8_+_134203303 0.11 ENST00000519433.1
ENST00000517423.1
ENST00000377863.2
ENST00000220856.6
WNT1 inducible signaling pathway protein 1
chr22_-_36635684 0.10 ENST00000358502.5
apolipoprotein L, 2
chr4_+_152020715 0.10 ENST00000274065.4
ribosomal protein S3A
chr5_+_76506706 0.10 ENST00000340978.3
ENST00000346042.3
ENST00000264917.5
ENST00000342343.4
ENST00000333194.4
phosphodiesterase 8B
chr5_-_59481406 0.10 ENST00000546160.1
phosphodiesterase 4D, cAMP-specific
chr4_-_140544386 0.10 ENST00000561977.1
RP11-308D13.3
chr10_+_18429606 0.10 ENST00000324631.7
ENST00000352115.6
ENST00000377328.1
calcium channel, voltage-dependent, beta 2 subunit
chr19_+_49977818 0.09 ENST00000594009.1
ENST00000595510.1
fms-related tyrosine kinase 3 ligand
chr1_+_164600184 0.09 ENST00000482110.1
pre-B-cell leukemia homeobox 1
chrX_-_133930285 0.09 ENST00000486347.1
ENST00000343004.5
family with sequence similarity 122B
chr11_+_64008525 0.09 ENST00000449942.2
FK506 binding protein 2, 13kDa
chr18_+_18943554 0.09 ENST00000580732.2
growth regulation by estrogen in breast cancer-like
chr19_+_17186577 0.09 ENST00000595618.1
ENST00000594824.1
myosin IXB
chr5_-_64064508 0.09 ENST00000513458.4
SREK1-interacting protein 1
chr11_+_128563652 0.08 ENST00000527786.2
Fli-1 proto-oncogene, ETS transcription factor
chr8_-_116681686 0.08 ENST00000519815.1
trichorhinophalangeal syndrome I
chr17_+_3379284 0.08 ENST00000263080.2
aspartoacylase
chr1_+_156737292 0.07 ENST00000271526.4
ENST00000353233.3
papillary renal cell carcinoma (translocation-associated)
chr8_-_23540402 0.07 ENST00000523261.1
ENST00000380871.4
NK3 homeobox 1
chr12_+_6561190 0.07 ENST00000544021.1
ENST00000266556.7
TAP binding protein-like

Network of associatons between targets according to the STRING database.

First level regulatory network of PRDM1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0050822 peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823)
0.3 1.7 GO:0097403 cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
0.2 1.0 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.2 0.9 GO:0002678 positive regulation of chronic inflammatory response(GO:0002678)
0.2 0.5 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.2 0.5 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.2 0.5 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.2 0.5 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.2 1.6 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.2 0.7 GO:0034344 microglial cell activation involved in immune response(GO:0002282) type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.1 0.9 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.1 0.6 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.1 0.7 GO:0015747 urate transport(GO:0015747)
0.1 0.4 GO:0003409 optic cup structural organization(GO:0003409) oculomotor nerve morphogenesis(GO:0021622) oculomotor nerve formation(GO:0021623)
0.1 0.7 GO:0045959 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959)
0.1 0.4 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.1 0.4 GO:0021763 subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) superior vena cava morphogenesis(GO:0060578)
0.1 0.2 GO:1990108 protein linear deubiquitination(GO:1990108)
0.1 0.3 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 0.2 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.1 0.3 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.1 0.6 GO:0061373 mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.4 GO:0000432 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.1 1.7 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 0.5 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1 0.2 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.1 0.3 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.1 0.2 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.1 0.5 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.1 0.2 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.3 GO:0008218 bioluminescence(GO:0008218)
0.0 0.2 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.0 0.4 GO:0006216 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0 0.2 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.0 0.2 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.0 0.7 GO:0006069 ethanol oxidation(GO:0006069)
0.0 0.1 GO:0045062 extrathymic T cell selection(GO:0045062)
0.0 0.5 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 0.1 GO:0046521 sphingoid catabolic process(GO:0046521)
0.0 0.6 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.2 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.0 0.2 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 0.2 GO:0051106 positive regulation of DNA ligation(GO:0051106)
0.0 0.3 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.1 GO:0006533 aspartate catabolic process(GO:0006533)
0.0 0.3 GO:1990504 dense core granule exocytosis(GO:1990504)
0.0 0.2 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.2 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.1 GO:0002590 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590)
0.0 0.6 GO:0098792 xenophagy(GO:0098792)
0.0 0.2 GO:0070842 aggresome assembly(GO:0070842)
0.0 0.2 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.0 0.2 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.0 0.3 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.3 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 0.9 GO:0030318 melanocyte differentiation(GO:0030318)
0.0 1.0 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.0 0.3 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.4 GO:0097264 self proteolysis(GO:0097264)
0.0 0.1 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885)
0.0 0.0 GO:0060129 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) regulation of calcium-independent cell-cell adhesion(GO:0051040) thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.0 0.1 GO:0031296 B cell costimulation(GO:0031296)
0.0 0.3 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.1 GO:2000836 androgen secretion(GO:0035935) regulation of androgen secretion(GO:2000834) positive regulation of androgen secretion(GO:2000836)
0.0 0.1 GO:0007402 ganglion mother cell fate determination(GO:0007402)
0.0 0.7 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.0 0.1 GO:1904879 membrane depolarization during atrial cardiac muscle cell action potential(GO:0098912) positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 0.3 GO:0002360 T cell lineage commitment(GO:0002360)
0.0 0.1 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.1 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0071797 LUBAC complex(GO:0071797)
0.2 1.3 GO:0042825 TAP complex(GO:0042825)
0.2 0.5 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.1 1.1 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 0.4 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.1 0.4 GO:0005940 septin ring(GO:0005940) septin collar(GO:0032173)
0.1 0.6 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 0.2 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.3 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.6 GO:0042587 glycogen granule(GO:0042587)
0.0 0.4 GO:0016589 NURF complex(GO:0016589)
0.0 0.5 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.6 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.3 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.0 0.1 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 0.7 GO:0036020 endolysosome membrane(GO:0036020)
0.0 0.9 GO:0032420 stereocilium(GO:0032420)
0.0 0.6 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.3 GO:0071141 SMAD protein complex(GO:0071141)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.3 1.3 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433)
0.2 0.6 GO:0033754 indoleamine 2,3-dioxygenase activity(GO:0033754)
0.1 1.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 0.6 GO:0008267 poly-glutamine tract binding(GO:0008267)
0.1 0.7 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.1 0.7 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 0.4 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.1 1.7 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 0.2 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.8 GO:0008035 high-density lipoprotein particle binding(GO:0008035)
0.0 0.3 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 1.0 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.1 GO:0030626 U12 snRNA binding(GO:0030626)
0.0 0.5 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.3 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 1.1 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.3 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.3 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.0 0.2 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.0 0.5 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.5 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.2 GO:0043426 MRF binding(GO:0043426)
0.0 0.5 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.4 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.3 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.1 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.0 0.2 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.6 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.2 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.0 0.1 GO:0015526 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0 0.2 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 0.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.9 GO:0070888 E-box binding(GO:0070888)
0.0 0.1 GO:0004882 androgen receptor activity(GO:0004882)
0.0 0.1 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.5 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.1 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.2 GO:0070628 proteasome binding(GO:0070628)
0.0 0.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.5 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 1.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.3 PID ALK2 PATHWAY ALK2 signaling events
0.0 1.3 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.6 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.7 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.4 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.7 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.7 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 1.2 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 1.0 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.7 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.6 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.7 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.5 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.5 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.2 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.3 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.5 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation