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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for PRDM1
Z-value: 1.50
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Transcription factors associated with PRDM1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PRDM1 | hg19_v2_chr6_+_106535455_106535637 | 0.79 | 6.3e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_131746575 Show fit | 1.55 |
ENST00000337752.2
ENST00000378947.3 ENST00000407797.1 |
chromosome 5 open reading frame 56 |
|
| chr16_-_67970990 Show fit | 1.31 |
ENST00000358514.4
|
proteasome (prosome, macropain) subunit, beta type, 10 |
|
| chr10_-_81203972 Show fit | 1.28 |
ENST00000372333.3
|
zinc finger, CCHC domain containing 24 |
|
| chr2_-_36779411 Show fit | 1.18 |
ENST00000406220.1
|
Uncharacterized protein |
|
| chr7_-_105332084 Show fit | 1.13 |
ENST00000472195.1
|
ataxin 7-like 1 |
|
| chr21_+_17909594 Show fit | 1.09 |
ENST00000441820.1
ENST00000602280.1 |
long intergenic non-protein coding RNA 478 |
|
| chr12_-_86650077 Show fit | 1.02 |
ENST00000552808.2
ENST00000547225.1 |
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative) |
|
| chr6_-_121655850 Show fit | 0.83 |
ENST00000422369.1
|
TBC1 domain family, member 32 |
|
| chr12_+_43086018 Show fit | 0.80 |
ENST00000550177.1
|
RP11-25I15.3 |
|
| chr5_-_159766528 Show fit | 0.77 |
ENST00000505287.2
|
cyclin J-like |
Network of associatons between targets according to the STRING database.
First level regulatory network of PRDM1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.7 | GO:0097403 | cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545) |
| 0.1 | 1.7 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.2 | 1.6 | GO:0097039 | protein linear polyubiquitination(GO:0097039) |
| 0.4 | 1.3 | GO:0050822 | peptide stabilization(GO:0050822) peptide antigen stabilization(GO:0050823) |
| 0.2 | 1.0 | GO:0043553 | negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.0 | 1.0 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 0.2 | 0.9 | GO:0002678 | positive regulation of chronic inflammatory response(GO:0002678) |
| 0.1 | 0.9 | GO:1904694 | negative regulation of vascular smooth muscle contraction(GO:1904694) |
| 0.0 | 0.9 | GO:0030318 | melanocyte differentiation(GO:0030318) |
| 0.2 | 0.7 | GO:0034344 | microglial cell activation involved in immune response(GO:0002282) type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) positive regulation of interferon-alpha biosynthetic process(GO:0045356) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.6 | GO:0071797 | LUBAC complex(GO:0071797) |
| 0.2 | 1.3 | GO:0042825 | TAP complex(GO:0042825) |
| 0.1 | 1.1 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 0.9 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 0.7 | GO:0036020 | endolysosome membrane(GO:0036020) |
| 0.1 | 0.6 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.0 | 0.6 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.0 | 0.6 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.0 | 0.6 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.2 | 0.5 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.3 | 1.3 | GO:0015433 | peptide antigen-transporting ATPase activity(GO:0015433) |
| 0.1 | 1.2 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.0 | 1.2 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 1.1 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.3 | 1.0 | GO:0036313 | phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313) |
| 0.0 | 1.0 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.0 | 0.9 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 0.8 | GO:0008035 | high-density lipoprotein particle binding(GO:0008035) |
| 0.1 | 0.7 | GO:0004024 | alcohol dehydrogenase activity, zinc-dependent(GO:0004024) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.7 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.6 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 0.3 | PID ALK2 PATHWAY | ALK2 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | REACTOME DESTABILIZATION OF MRNA BY BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
| 0.0 | 1.2 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 1.0 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.0 | 0.7 | REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR | Genes involved in Trafficking and processing of endosomal TLR |
| 0.0 | 0.7 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.0 | 0.7 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.0 | 0.7 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 0.7 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 0.6 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.0 | 0.5 | REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | Genes involved in Downstream signal transduction |