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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for PPARG
Z-value: 0.83
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Transcription factors associated with PPARG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PPARG | hg19_v2_chr3_+_12329358_12329393 | -0.71 | 1.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_49661037 Show fit | 0.63 |
ENST00000427978.2
|
transient receptor potential cation channel, subfamily M, member 4 |
|
| chr19_+_49660997 Show fit | 0.52 |
ENST00000598691.1
ENST00000252826.5 |
transient receptor potential cation channel, subfamily M, member 4 |
|
| chr19_+_544034 Show fit | 0.52 |
ENST00000592501.1
ENST00000264553.3 |
granzyme M (lymphocyte met-ase 1) |
|
| chr19_-_1592828 Show fit | 0.51 |
ENST00000592012.1
|
methyl-CpG binding domain protein 3 |
|
| chr19_-_51587502 Show fit | 0.50 |
ENST00000156499.2
ENST00000391802.1 |
kallikrein-related peptidase 14 |
|
| chr11_-_62439727 Show fit | 0.43 |
ENST00000528862.1
|
chromosome 11 open reading frame 48 |
|
| chr19_+_49661079 Show fit | 0.42 |
ENST00000355712.5
|
transient receptor potential cation channel, subfamily M, member 4 |
|
| chr9_+_140119618 Show fit | 0.40 |
ENST00000359069.2
|
chromosome 9 open reading frame 169 |
|
| chr3_+_195447738 Show fit | 0.38 |
ENST00000447234.2
ENST00000320736.6 ENST00000436408.1 |
mucin 20, cell surface associated |
|
| chr14_-_100841794 Show fit | 0.33 |
ENST00000556295.1
ENST00000554820.1 |
tryptophanyl-tRNA synthetase |
Network of associatons between targets according to the STRING database.
First level regulatory network of PPARG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.6 | GO:1904199 | positive regulation of regulation of vascular smooth muscle cell membrane depolarization(GO:1904199) regulation of vascular smooth muscle cell membrane depolarization(GO:1990736) |
| 0.1 | 0.8 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
| 0.0 | 0.7 | GO:0006346 | methylation-dependent chromatin silencing(GO:0006346) |
| 0.0 | 0.5 | GO:0007320 | insemination(GO:0007320) |
| 0.0 | 0.5 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.0 | 0.5 | GO:1904380 | endoplasmic reticulum mannose trimming(GO:1904380) |
| 0.1 | 0.4 | GO:0070426 | positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434) |
| 0.0 | 0.4 | GO:0051533 | positive regulation of NFAT protein import into nucleus(GO:0051533) |
| 0.0 | 0.4 | GO:0035542 | regulation of SNARE complex assembly(GO:0035542) |
| 0.0 | 0.4 | GO:0048012 | hepatocyte growth factor receptor signaling pathway(GO:0048012) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | GO:0034706 | sodium channel complex(GO:0034706) |
| 0.0 | 0.7 | GO:0090545 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.0 | 0.5 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.1 | 0.4 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
| 0.0 | 0.4 | GO:0033263 | CORVET complex(GO:0033263) |
| 0.0 | 0.4 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.1 | 0.3 | GO:0002133 | polycystin complex(GO:0002133) |
| 0.0 | 0.3 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.0 | 0.3 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.1 | 0.2 | GO:0071547 | piP-body(GO:0071547) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | GO:0005227 | calcium activated cation channel activity(GO:0005227) |
| 0.1 | 0.8 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 0.0 | 0.7 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.0 | 0.5 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.0 | 0.4 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 0.0 | 0.4 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.0 | 0.4 | GO:0005041 | low-density lipoprotein receptor activity(GO:0005041) |
| 0.1 | 0.3 | GO:0044549 | GTP cyclohydrolase binding(GO:0044549) |
| 0.1 | 0.3 | GO:0015307 | drug:proton antiporter activity(GO:0015307) |
| 0.0 | 0.3 | GO:1904288 | BAT3 complex binding(GO:1904288) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 0.8 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 0.3 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.0 | 0.3 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.0 | 0.2 | REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.0 | 0.2 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.0 | 0.2 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.0 | 0.1 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |