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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for POU6F2

Z-value: 0.53

Motif logo

Transcription factors associated with POU6F2

Gene Symbol Gene ID Gene Info
ENSG00000106536.15 POU class 6 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU6F2hg19_v2_chr7_+_39017504_390175980.711.1e-01Click!

Activity profile of POU6F2 motif

Sorted Z-values of POU6F2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_106697974 0.82 ENST00000553039.1
cytoskeleton-associated protein 4
chr1_+_193028717 0.39 ENST00000415442.2
ENST00000506303.1
TROVE domain family, member 2
chr14_+_59100774 0.38 ENST00000556859.1
ENST00000421793.1
dishevelled-binding antagonist of beta-catenin 1
chr17_+_73539232 0.33 ENST00000580925.1
lethal giant larvae homolog 2 (Drosophila)
chr11_+_12302492 0.32 ENST00000533534.1
MICAL C-terminal like
chr10_+_77056181 0.29 ENST00000526759.1
ENST00000533822.1
ZNF503 antisense RNA 1
chr8_-_90769422 0.25 ENST00000524190.1
ENST00000523859.1
RP11-37B2.1
chr17_-_46716647 0.20 ENST00000608940.1
RP11-357H14.17
chr15_+_58702742 0.20 ENST00000356113.6
ENST00000414170.3
lipase, hepatic
chr14_+_32798547 0.20 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
A kinase (PRKA) anchor protein 6
chr4_+_110749143 0.20 ENST00000317735.4
retinal pigment epithelium-derived rhodopsin homolog
chr17_-_2117600 0.19 ENST00000572369.1
SMG6 nonsense mediated mRNA decay factor
chrX_+_86772787 0.19 ENST00000373114.4
kelch-like family member 4
chr9_-_13165457 0.19 ENST00000542239.1
ENST00000538841.1
ENST00000433359.2
multiple PDZ domain protein
chr1_+_62439037 0.18 ENST00000545929.1
InaD-like (Drosophila)
chrX_+_10031499 0.18 ENST00000454666.1
WWC family member 3
chr9_-_110251836 0.17 ENST00000374672.4
Kruppel-like factor 4 (gut)
chr1_-_159832438 0.16 ENST00000368100.1
V-set and immunoglobulin domain containing 8
chr8_+_77593474 0.15 ENST00000455469.2
ENST00000050961.6
zinc finger homeobox 4
chr5_-_111093081 0.14 ENST00000453526.2
ENST00000509427.1
neuronal regeneration related protein
chrX_+_86772707 0.14 ENST00000373119.4
kelch-like family member 4
chr7_+_129015484 0.14 ENST00000490911.1
adenosylhomocysteinase-like 2
chr1_+_44514040 0.14 ENST00000431800.1
ENST00000437643.1
RP5-1198O20.4
chr9_+_131902346 0.13 ENST00000432124.1
ENST00000435305.1
protein phosphatase 2A activator, regulatory subunit 4
chr15_-_37393406 0.13 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
Meis homeobox 2
chr17_-_71223839 0.13 ENST00000579872.1
ENST00000580032.1
family with sequence similarity 104, member A
chr19_+_9203855 0.13 ENST00000429566.3
olfactory receptor, family 1, subfamily M, member 1
chr4_+_78829479 0.13 ENST00000504901.1
mitochondrial ribosomal protein L1
chr19_-_38344165 0.13 ENST00000592714.1
ENST00000587395.1
AC016582.2
chr2_+_7118755 0.12 ENST00000433456.1
ring finger protein 144A
chr3_+_141105705 0.12 ENST00000513258.1
zinc finger and BTB domain containing 38
chr1_+_19967014 0.12 ENST00000428975.1
neuroblastoma 1, DAN family BMP antagonist
chr9_+_130853715 0.11 ENST00000373066.5
ENST00000432073.2
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
chr5_-_140998481 0.11 ENST00000518047.1
diaphanous-related formin 1
chr8_+_77593448 0.11 ENST00000521891.2
zinc finger homeobox 4
chr13_-_30160925 0.11 ENST00000450494.1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr5_-_139726181 0.11 ENST00000507104.1
ENST00000230990.6
heparin-binding EGF-like growth factor
chr8_-_142012169 0.10 ENST00000517453.1
protein tyrosine kinase 2
chr9_+_109625378 0.10 ENST00000277225.5
ENST00000457913.1
ENST00000472574.1
zinc finger protein 462
chrX_-_13835147 0.10 ENST00000493677.1
ENST00000355135.2
glycoprotein M6B
chr11_-_63439013 0.10 ENST00000398868.3
atlastin GTPase 3
chr15_+_101402041 0.10 ENST00000558475.1
ENST00000558641.1
ENST00000559673.1
RP11-66B24.1
chr3_+_159557637 0.10 ENST00000445224.2
schwannomin interacting protein 1
chr22_-_32767017 0.10 ENST00000400234.1
RFPL3 antisense
chr13_-_110438914 0.09 ENST00000375856.3
insulin receptor substrate 2
chr7_-_55620433 0.09 ENST00000418904.1
vesicular, overexpressed in cancer, prosurvival protein 1
chr11_-_129062093 0.09 ENST00000310343.9
Rho GTPase activating protein 32
chr8_-_42396185 0.09 ENST00000518717.1
solute carrier family 20 (phosphate transporter), member 2
chr15_-_74421477 0.09 ENST00000514871.1
HCG2004779; Uncharacterized protein
chr7_+_141478242 0.09 ENST00000247881.2
taste receptor, type 2, member 4
chr2_-_8715616 0.08 ENST00000418358.1
AC011747.3
chr3_+_189507523 0.08 ENST00000437221.1
ENST00000392463.2
ENST00000392461.3
ENST00000449992.1
ENST00000456148.1
tumor protein p63
chr6_-_33160231 0.08 ENST00000395194.1
ENST00000457788.1
ENST00000341947.2
ENST00000357486.1
ENST00000374714.1
ENST00000374713.1
ENST00000395197.1
ENST00000374712.1
ENST00000361917.1
ENST00000374708.4
collagen, type XI, alpha 2
chr5_-_140998616 0.08 ENST00000389054.3
ENST00000398562.2
ENST00000389057.5
ENST00000398566.3
ENST00000398557.4
ENST00000253811.6
diaphanous-related formin 1
chr6_-_111804905 0.08 ENST00000358835.3
ENST00000435970.1
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr11_+_7598239 0.08 ENST00000525597.1
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr11_-_31531121 0.08 ENST00000532287.1
ENST00000526776.1
ENST00000534812.1
ENST00000529749.1
ENST00000278200.1
ENST00000530023.1
ENST00000533642.1
IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chrX_-_21676442 0.08 ENST00000379499.2
kelch-like family member 34
chr11_+_47293795 0.08 ENST00000422579.1
MAP-kinase activating death domain
chr4_+_175204818 0.07 ENST00000503780.1
centrosomal protein 44kDa
chr2_-_70780572 0.07 ENST00000450929.1
transforming growth factor, alpha
chr22_+_20905269 0.07 ENST00000457322.1
mediator complex subunit 15
chr16_-_54962625 0.07 ENST00000559432.1
colorectal neoplasia differentially expressed (non-protein coding)
chr11_+_107461804 0.07 ENST00000531234.1
ELMO/CED-12 domain containing 1
chr7_+_129015671 0.07 ENST00000466993.1
adenosylhomocysteinase-like 2
chr4_-_22444733 0.07 ENST00000508133.1
G protein-coupled receptor 125
chr16_+_53133070 0.07 ENST00000565832.1
chromodomain helicase DNA binding protein 9
chr10_+_18549645 0.07 ENST00000396576.2
calcium channel, voltage-dependent, beta 2 subunit
chr5_+_137722255 0.07 ENST00000542866.1
lysine (K)-specific demethylase 3B
chr12_+_15699286 0.07 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
protein tyrosine phosphatase, receptor type, O
chrX_+_107288239 0.07 ENST00000217957.5
V-set and immunoglobulin domain containing 1
chr18_-_24129367 0.06 ENST00000408011.3
potassium channel tetramerization domain containing 1
chr15_+_75080883 0.06 ENST00000567571.1
c-src tyrosine kinase
chr14_-_69261310 0.06 ENST00000336440.3
ZFP36 ring finger protein-like 1
chr11_+_31531291 0.06 ENST00000350638.5
ENST00000379163.5
ENST00000395934.2
elongator acetyltransferase complex subunit 4
chrX_+_107288197 0.06 ENST00000415430.3
V-set and immunoglobulin domain containing 1
chr3_+_141106458 0.06 ENST00000509883.1
zinc finger and BTB domain containing 38
chr18_+_44812072 0.06 ENST00000598649.1
ENST00000586905.2
CTD-2130O13.1
chr12_+_121131970 0.06 ENST00000535656.1
malectin
chr5_-_124082279 0.06 ENST00000513986.1
zinc finger protein 608
chr4_+_40198527 0.06 ENST00000381799.5
ras homolog family member H
chr12_-_30887948 0.06 ENST00000433722.2
caprin family member 2
chr14_-_73360796 0.05 ENST00000556509.1
ENST00000541685.1
ENST00000546183.1
D4, zinc and double PHD fingers, family 3
chr8_+_22424551 0.05 ENST00000523348.1
sorbin and SH3 domain containing 3
chr1_+_10271674 0.05 ENST00000377086.1
kinesin family member 1B
chr17_-_47786375 0.05 ENST00000511657.1
solute carrier family 35, member B1
chr6_-_133035185 0.05 ENST00000367928.4
vanin 1
chr12_-_71031185 0.05 ENST00000548122.1
ENST00000551525.1
ENST00000550358.1
protein tyrosine phosphatase, receptor type, B
chr15_+_93443419 0.05 ENST00000557381.1
ENST00000420239.2
chromodomain helicase DNA binding protein 2
chr7_+_115862858 0.05 ENST00000393481.2
testis derived transcript (3 LIM domains)
chr11_-_71823715 0.05 ENST00000545944.1
ENST00000502597.2
anaphase promoting complex subunit 15
chr6_+_4087664 0.05 ENST00000430835.2
chromosome 6 open reading frame 201
chr20_+_56136136 0.05 ENST00000319441.4
ENST00000543666.1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr7_-_73038867 0.05 ENST00000313375.3
ENST00000354613.1
ENST00000395189.1
ENST00000453275.1
MLX interacting protein-like
chr5_-_36301984 0.05 ENST00000502994.1
ENST00000515759.1
ENST00000296604.3
RAN binding protein 3-like
chr5_+_159343688 0.05 ENST00000306675.3
adrenoceptor alpha 1B
chr9_-_34729457 0.05 ENST00000378788.3
family with sequence similarity 205, member A
chr1_-_204329013 0.05 ENST00000272203.3
ENST00000414478.1
pleckstrin homology domain containing, family A member 6
chr7_-_5465045 0.05 ENST00000399434.2
trinucleotide repeat containing 18
chr4_-_175204765 0.04 ENST00000513696.1
ENST00000503293.1
F-box protein 8
chr14_+_32798462 0.04 ENST00000280979.4
A kinase (PRKA) anchor protein 6
chr11_-_93583697 0.04 ENST00000409977.1
V-set and transmembrane domain containing 5
chr11_+_128563652 0.04 ENST00000527786.2
Fli-1 proto-oncogene, ETS transcription factor
chr12_+_94551874 0.04 ENST00000551850.1
plexin C1
chr13_-_95131923 0.04 ENST00000377028.5
ENST00000446125.1
dopachrome tautomerase
chrX_-_30877837 0.04 ENST00000378930.3
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr15_+_67390920 0.04 ENST00000559092.1
ENST00000560175.1
SMAD family member 3
chr15_-_33447055 0.04 ENST00000559047.1
ENST00000561249.1
formin 1
chr16_-_4852915 0.04 ENST00000322048.7
rogdi homolog (Drosophila)
chr4_-_74486217 0.04 ENST00000335049.5
ENST00000307439.5
Ras association (RalGDS/AF-6) domain family member 6
chr3_-_57199397 0.04 ENST00000296318.7
interleukin 17 receptor D
chr20_+_42187608 0.04 ENST00000373100.1
serum/glucocorticoid regulated kinase 2
chr10_-_92681033 0.04 ENST00000371697.3
ankyrin repeat domain 1 (cardiac muscle)
chr1_-_2458026 0.04 ENST00000435556.3
ENST00000378466.3
pantothenate kinase 4
chr20_+_58515417 0.03 ENST00000360816.3
family with sequence similarity 217, member B
chr12_-_15815626 0.03 ENST00000540613.1
epidermal growth factor receptor pathway substrate 8
chr7_+_129007964 0.03 ENST00000460109.1
ENST00000474594.1
ENST00000446212.1
adenosylhomocysteinase-like 2
chr15_+_96869165 0.03 ENST00000421109.2
nuclear receptor subfamily 2, group F, member 2
chr17_+_12569472 0.03 ENST00000343344.4
myocardin
chr1_-_234667504 0.03 ENST00000421207.1
ENST00000435574.1
RP5-855F14.1
chr17_+_4613918 0.03 ENST00000574954.1
ENST00000346341.2
ENST00000572457.1
ENST00000381488.6
ENST00000412477.3
ENST00000571428.1
ENST00000575877.1
arrestin, beta 2
chr11_+_45918092 0.03 ENST00000395629.2
mitogen-activated protein kinase 8 interacting protein 1
chr6_-_138866823 0.03 ENST00000342260.5
NHS-like 1
chr3_+_189507460 0.03 ENST00000434928.1
tumor protein p63
chr1_+_46379254 0.03 ENST00000372008.2
microtubule associated serine/threonine kinase 2
chr20_+_42187682 0.03 ENST00000373092.3
ENST00000373077.1
serum/glucocorticoid regulated kinase 2
chr7_+_116660246 0.03 ENST00000434836.1
ENST00000393443.1
ENST00000465133.1
ENST00000477742.1
ENST00000393447.4
ENST00000393444.3
suppression of tumorigenicity 7
chr11_-_70672645 0.02 ENST00000423696.2
SH3 and multiple ankyrin repeat domains 2
chr3_-_11610255 0.02 ENST00000424529.2
vestigial like 4 (Drosophila)
chr2_-_158300556 0.02 ENST00000264192.3
cytohesin 1 interacting protein
chr5_+_136070614 0.02 ENST00000502421.1
CTB-1I21.1
chr11_+_101918153 0.02 ENST00000434758.2
ENST00000526781.1
ENST00000534360.1
chromosome 11 open reading frame 70
chrX_-_19988382 0.02 ENST00000356980.3
ENST00000379687.3
ENST00000379682.4
chromosome X open reading frame 23
chr9_-_21482312 0.02 ENST00000448696.3
interferon, epsilon
chr6_-_74231444 0.02 ENST00000331523.2
ENST00000356303.2
eukaryotic translation elongation factor 1 alpha 1
chr2_+_128403439 0.02 ENST00000544369.1
G protein-coupled receptor 17
chr17_-_33390667 0.02 ENST00000378516.2
ENST00000268850.7
ENST00000394597.2
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr10_-_75415825 0.02 ENST00000394810.2
synaptopodin 2-like
chr20_-_45035223 0.02 ENST00000450812.1
ENST00000290246.6
ENST00000439931.2
ENST00000396391.1
engulfment and cell motility 2
chr4_-_109541610 0.02 ENST00000510212.1
RPL34 antisense RNA 1 (head to head)
chr6_-_155635583 0.02 ENST00000367166.4
transcription factor B1, mitochondrial
chr2_+_128403720 0.02 ENST00000272644.3
G protein-coupled receptor 17
chr21_+_17792672 0.02 ENST00000602620.1
long intergenic non-protein coding RNA 478
chr3_-_127541194 0.02 ENST00000453507.2
monoglyceride lipase
chr6_+_151646800 0.02 ENST00000354675.6
A kinase (PRKA) anchor protein 12
chr5_-_96478466 0.02 ENST00000274382.4
Lix1 homolog (chicken)
chr4_-_74486347 0.02 ENST00000342081.3
Ras association (RalGDS/AF-6) domain family member 6
chr12_-_71031220 0.02 ENST00000334414.6
protein tyrosine phosphatase, receptor type, B
chr17_+_4613776 0.01 ENST00000269260.2
arrestin, beta 2
chr4_-_66536057 0.01 ENST00000273854.3
EPH receptor A5
chr9_-_79520989 0.01 ENST00000376713.3
ENST00000376718.3
ENST00000428286.1
prune homolog 2 (Drosophila)
chr11_-_71823266 0.01 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
anaphase promoting complex subunit 15
chr17_+_18086392 0.01 ENST00000541285.1
alkB, alkylation repair homolog 5 (E. coli)
chr1_-_21606013 0.01 ENST00000357071.4
endothelin converting enzyme 1
chr5_+_67586465 0.01 ENST00000336483.5
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr6_+_130339710 0.01 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
l(3)mbt-like 3 (Drosophila)
chr10_-_21186144 0.01 ENST00000377119.1
nebulette
chr11_-_71823796 0.01 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
anaphase promoting complex subunit 15
chr11_-_36619771 0.01 ENST00000311485.3
ENST00000527033.1
ENST00000532616.1
recombination activating gene 2
chr2_+_102721023 0.01 ENST00000409589.1
ENST00000409329.1
interleukin 1 receptor, type I
chr5_-_134914673 0.01 ENST00000512158.1
chemokine (C-X-C motif) ligand 14
chr8_+_119294456 0.01 ENST00000366457.2
Uncharacterized protein
chr12_-_89746173 0.01 ENST00000308385.6
dual specificity phosphatase 6
chr17_-_19290117 0.01 ENST00000497081.2
microfibrillar-associated protein 4
chr21_+_33671160 0.00 ENST00000303645.5
melanocortin 2 receptor accessory protein
chr2_+_29001711 0.00 ENST00000418910.1
protein phosphatase 1, catalytic subunit, beta isozyme
chr2_+_44502630 0.00 ENST00000410056.3
ENST00000409741.1
ENST00000409229.3
solute carrier family 3 (amino acid transporter heavy chain), member 1
chrX_+_43515467 0.00 ENST00000338702.3
ENST00000542639.1
monoamine oxidase A
chr2_+_138721850 0.00 ENST00000329366.4
ENST00000280097.3
histamine N-methyltransferase
chr3_-_45838011 0.00 ENST00000358525.4
ENST00000413781.1
solute carrier family 6 (proline IMINO transporter), member 20
chr14_+_39583427 0.00 ENST00000308317.6
ENST00000396249.2
ENST00000250379.8
ENST00000534684.2
ENST00000527381.1
gem (nuclear organelle) associated protein 2

Network of associatons between targets according to the STRING database.

First level regulatory network of POU6F2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
0.0 0.2 GO:1904995 regulation of muscle hyperplasia(GO:0014738) negative regulation of muscle hyperplasia(GO:0014740) negative regulation of leukocyte adhesion to vascular endothelial cell(GO:1904995) negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.0 0.2 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.2 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.1 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.0 0.1 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0 0.1 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.0 0.1 GO:0051541 elastin metabolic process(GO:0051541)
0.0 0.2 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.0 0.0 GO:1904640 response to methionine(GO:1904640)
0.0 0.1 GO:0060023 soft palate development(GO:0060023)
0.0 0.0 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.0 0.2 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.1 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.0 0.1 GO:1904647 response to rotenone(GO:1904647)
0.0 0.1 GO:1903826 arginine transmembrane transport(GO:1903826)
0.0 0.1 GO:0072334 UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334)
0.0 0.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.2 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.1 GO:1901545 cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
0.0 0.1 GO:0051612 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.0 0.7 GO:0042599 lamellar body(GO:0042599)
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.4 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.1 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.1 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.2 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.2 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0 0.3 GO:0030620 U2 snRNA binding(GO:0030620)
0.0 0.2 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.0 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.0 0.0 GO:0031859 platelet activating factor receptor binding(GO:0031859)
0.0 0.1 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 0.3 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.1 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.0 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0 0.1 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.0 0.1 GO:0016015 morphogen activity(GO:0016015)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME OPSINS Genes involved in Opsins