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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for POU5F1_POU2F3
Z-value: 1.43
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Transcription factors associated with POU5F1_POU2F3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU5F1 | hg19_v2_chr6_-_31138439_31138475 | 0.39 | 4.4e-01 | Click! |
| POU2F3 | hg19_v2_chr11_+_120110863_120110908 | 0.16 | 7.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_35658007 Show fit | 2.35 |
ENST00000602361.1
|
RNA component of mitochondrial RNA processing endoribonuclease |
|
| chr11_+_313503 Show fit | 1.32 |
ENST00000528780.1
ENST00000328221.5 |
interferon induced transmembrane protein 1 |
|
| chr12_+_113344811 Show fit | 1.30 |
ENST00000551241.1
ENST00000553185.1 ENST00000550689.1 |
2'-5'-oligoadenylate synthetase 1, 40/46kDa |
|
| chr12_+_113344582 Show fit | 1.29 |
ENST00000202917.5
ENST00000445409.2 ENST00000452357.2 |
2'-5'-oligoadenylate synthetase 1, 40/46kDa |
|
| chr12_+_113344755 Show fit | 1.27 |
ENST00000550883.1
|
2'-5'-oligoadenylate synthetase 1, 40/46kDa |
|
| chr12_-_7245125 Show fit | 1.21 |
ENST00000542285.1
ENST00000540610.1 |
complement component 1, r subcomponent |
|
| chr1_-_27701307 Show fit | 1.19 |
ENST00000270879.4
ENST00000354982.2 |
ficolin (collagen/fibrinogen domain containing) 3 |
|
| chr12_-_7245152 Show fit | 1.05 |
ENST00000542220.2
|
complement component 1, r subcomponent |
|
| chr6_+_27114861 Show fit | 1.02 |
ENST00000377459.1
|
histone cluster 1, H2ah |
|
| chr12_-_7245080 Show fit | 1.01 |
ENST00000541042.1
ENST00000540242.1 |
complement component 1, r subcomponent |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU5F1_POU2F3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.2 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.1 | 4.7 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.2 | 2.3 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 0.2 | 2.3 | GO:0035290 | trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) neural crest cell migration involved in autonomic nervous system development(GO:1901166) |
| 0.0 | 1.5 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.2 | 1.2 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
| 0.1 | 1.1 | GO:0030223 | neutrophil differentiation(GO:0030223) |
| 0.1 | 1.0 | GO:0003322 | pancreatic A cell development(GO:0003322) |
| 0.2 | 0.9 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 0.0 | 0.9 | GO:0010390 | histone monoubiquitination(GO:0010390) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.8 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 0.7 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 0.6 | GO:0032585 | multivesicular body membrane(GO:0032585) |
| 0.0 | 0.6 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.0 | 0.5 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.0 | 0.4 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.1 | 0.3 | GO:1990923 | PET complex(GO:1990923) |
| 0.0 | 0.3 | GO:0000798 | nuclear cohesin complex(GO:0000798) |
| 0.0 | 0.3 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.0 | 0.3 | GO:0061700 | GATOR2 complex(GO:0061700) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.4 | 4.8 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.1 | 2.3 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.1 | 2.3 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.0 | 1.1 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 0.8 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 0.6 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.0 | 0.6 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 0.6 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 0.5 | GO:0055100 | adiponectin binding(GO:0055100) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.4 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 1.2 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 0.7 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 0.6 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 0.6 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.0 | 0.2 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 0.1 | PID IL5 PATHWAY | IL5-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.0 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.0 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.1 | 0.9 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.0 | 0.8 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 0.7 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 0.7 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.6 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.5 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.0 | 0.4 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 0.4 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |