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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for POU3F2
Z-value: 2.83
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Transcription factors associated with POU3F2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU3F2 | hg19_v2_chr6_+_99282570_99282591 | -0.08 | 8.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU3F2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 8.1 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 1.4 | 5.4 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
| 0.1 | 3.8 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 3.7 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.3 | 3.6 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.6 | 3.2 | GO:0006203 | dGTP catabolic process(GO:0006203) |
| 0.1 | 3.1 | GO:0009452 | 7-methylguanosine RNA capping(GO:0009452) RNA capping(GO:0036260) |
| 0.4 | 3.0 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.0 | 2.7 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.4 | 2.6 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.1 | GO:0044215 | other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) |
| 0.0 | 5.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.4 | 4.9 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.2 | 3.4 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 3.4 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 3.0 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.2 | 2.8 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.1 | 2.8 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.1 | 2.5 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 2.5 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.1 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.0 | 5.5 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.0 | 4.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.4 | 3.1 | GO:0032554 | purine deoxyribonucleotide binding(GO:0032554) |
| 0.4 | 3.0 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.0 | 3.0 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 2.4 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.8 | 2.3 | GO:0086057 | voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057) |
| 0.3 | 2.3 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
| 0.1 | 2.3 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 3.5 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 3.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 2.8 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 2.6 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.1 | 2.3 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 2.1 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 1.8 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 1.8 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.8 | PID CD40 PATHWAY | CD40/CD40L signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.0 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 4.6 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 4.4 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.0 | 3.9 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 3.5 | REACTOME MRNA CAPPING | Genes involved in mRNA Capping |
| 0.0 | 3.0 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 2.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 2.8 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.1 | 2.8 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 2.8 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |