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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for POU2F2_POU3F1
Z-value: 1.39
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Transcription factors associated with POU2F2_POU3F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU2F2 | hg19_v2_chr19_-_42636543_42636607 | -0.38 | 4.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_228645796 Show fit | 3.49 |
ENST00000369160.2
|
histone cluster 3, H2bb |
|
| chr6_-_26124138 Show fit | 1.85 |
ENST00000314332.5
ENST00000396984.1 |
histone cluster 1, H2bc |
|
| chr17_+_19091325 Show fit | 1.84 |
ENST00000584923.1
|
small nucleolar RNA, C/D box 3A |
|
| chr1_+_149858461 Show fit | 1.15 |
ENST00000331380.2
|
histone cluster 2, H2ac |
|
| chr7_-_27153454 Show fit | 1.12 |
ENST00000522456.1
|
homeobox A3 |
|
| chr1_-_149783914 Show fit | 1.11 |
ENST00000369167.1
ENST00000427880.2 ENST00000545683.1 |
histone cluster 2, H2bf |
|
| chr6_-_26043885 Show fit | 1.02 |
ENST00000357905.2
|
histone cluster 1, H2bb |
|
| chr17_-_7832753 Show fit | 1.01 |
ENST00000303790.2
|
potassium voltage-gated channel, shaker-related subfamily, beta member 3 |
|
| chr6_-_27775694 Show fit | 0.96 |
ENST00000377401.2
|
histone cluster 1, H2bl |
|
| chr6_+_26217159 Show fit | 0.96 |
ENST00000303910.2
|
histone cluster 1, H2ae |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU2F2_POU3F1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.6 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.2 | 2.2 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.2 | 1.3 | GO:0000710 | meiotic mismatch repair(GO:0000710) |
| 0.1 | 1.1 | GO:0010159 | specification of organ position(GO:0010159) |
| 0.2 | 1.0 | GO:0036343 | psychomotor behavior(GO:0036343) |
| 0.0 | 0.9 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
| 0.2 | 0.7 | GO:1904059 | regulation of locomotor rhythm(GO:1904059) |
| 0.0 | 0.7 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.0 | 0.7 | GO:0016973 | poly(A)+ mRNA export from nucleus(GO:0016973) |
| 0.0 | 0.7 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.8 | GO:0000786 | nucleosome(GO:0000786) |
| 0.2 | 0.9 | GO:0032301 | MutSalpha complex(GO:0032301) |
| 0.0 | 0.7 | GO:0000346 | transcription export complex(GO:0000346) |
| 0.0 | 0.6 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.0 | 0.5 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.1 | 0.4 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) |
| 0.0 | 0.4 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.0 | 0.3 | GO:0042583 | chromaffin granule(GO:0042583) |
| 0.0 | 0.2 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.0 | 0.2 | GO:0005638 | lamin filament(GO:0005638) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.8 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.1 | 1.2 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 1.0 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.2 | 0.9 | GO:0032143 | single thymine insertion binding(GO:0032143) |
| 0.0 | 0.7 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.0 | 0.7 | GO:0001530 | lipopolysaccharide binding(GO:0001530) |
| 0.1 | 0.6 | GO:0070095 | fructose-6-phosphate binding(GO:0070095) |
| 0.1 | 0.6 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 0.0 | 0.5 | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) |
| 0.0 | 0.5 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 0.2 | PID IL5 PATHWAY | IL5-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.8 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 1.0 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.7 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 0.6 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.0 | 0.6 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 0.4 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.0 | 0.2 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.0 | 0.2 | REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.0 | 0.2 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |