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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for PLAGL1
Z-value: 4.66
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Transcription factors associated with PLAGL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PLAGL1 | hg19_v2_chr6_-_144385698_144385742 | 0.75 | 8.6e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_74212073 Show fit | 6.40 |
ENST00000441217.1
|
AC073046.25 |
|
| chr19_+_2249308 Show fit | 3.32 |
ENST00000592877.1
ENST00000221496.4 |
anti-Mullerian hormone |
|
| chr1_-_21948906 Show fit | 2.83 |
ENST00000374761.2
ENST00000599760.1 |
RAP1 GTPase activating protein |
|
| chr20_-_62168672 Show fit | 2.82 |
ENST00000217185.2
|
protein tyrosine kinase 6 |
|
| chr19_+_51815102 Show fit | 2.76 |
ENST00000270642.8
|
IgLON family member 5 |
|
| chr17_-_79304150 Show fit | 2.73 |
ENST00000574093.1
|
transmembrane protein 105 |
|
| chr14_-_21566731 Show fit | 2.72 |
ENST00000360947.3
|
zinc finger protein 219 |
|
| chr5_+_667759 Show fit | 2.70 |
ENST00000594226.1
|
Uncharacterized protein |
|
| chr16_-_1429010 Show fit | 2.67 |
ENST00000513783.1
|
unkempt family zinc finger-like |
|
| chr20_-_62168714 Show fit | 2.67 |
ENST00000542869.1
|
protein tyrosine kinase 6 |
Network of associatons between targets according to the STRING database.
First level regulatory network of PLAGL1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.6 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
| 0.2 | 6.4 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 1.0 | 6.2 | GO:0015887 | biotin transport(GO:0015878) pantothenate transmembrane transport(GO:0015887) |
| 0.2 | 6.0 | GO:0060575 | intestinal epithelial cell differentiation(GO:0060575) |
| 0.2 | 5.9 | GO:0036150 | phosphatidylserine acyl-chain remodeling(GO:0036150) |
| 0.2 | 5.1 | GO:0070734 | histone H3-K27 methylation(GO:0070734) |
| 0.1 | 5.1 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 0.7 | 5.0 | GO:0097473 | cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473) |
| 0.1 | 4.8 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.3 | 4.7 | GO:0048702 | embryonic neurocranium morphogenesis(GO:0048702) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.0 | GO:0042641 | actomyosin(GO:0042641) |
| 0.0 | 15.5 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 14.4 | GO:0001726 | ruffle(GO:0001726) |
| 0.0 | 14.4 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 12.2 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 11.3 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.1 | 10.3 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.1 | 8.2 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 8.1 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 6.3 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.1 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 12.0 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.2 | 8.7 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.1 | 7.4 | GO:0042162 | telomeric DNA binding(GO:0042162) |
| 0.1 | 7.4 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.1 | 6.6 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.8 | 6.2 | GO:0008523 | sodium-dependent multivitamin transmembrane transporter activity(GO:0008523) |
| 0.1 | 6.2 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.3 | 6.1 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.2 | 6.1 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.3 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.2 | 12.1 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.2 | 10.7 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 9.5 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 9.5 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.1 | 8.1 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.0 | 7.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 7.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 7.0 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 7.0 | NABA COLLAGENS | Genes encoding collagen proteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.6 | REACTOME SIGNALING BY PDGF | Genes involved in Signaling by PDGF |
| 0.1 | 10.5 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 10.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 9.9 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 8.8 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 8.1 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.4 | 7.8 | REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.1 | 7.5 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.3 | 6.8 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.1 | 6.7 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |