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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for PKNOX1_TGIF2
Z-value: 1.01
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Transcription factors associated with PKNOX1_TGIF2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TGIF2 | hg19_v2_chr20_+_35202909_35203075 | 0.70 | 1.2e-01 | Click! |
| PKNOX1 | hg19_v2_chr21_+_44394620_44394737 | 0.07 | 8.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PKNOX1_TGIF2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.4 | GO:0045959 | regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) |
| 0.1 | 1.0 | GO:0023021 | termination of signal transduction(GO:0023021) |
| 0.0 | 0.6 | GO:0038180 | nerve growth factor signaling pathway(GO:0038180) |
| 0.2 | 0.5 | GO:0002728 | negative regulation of natural killer cell cytokine production(GO:0002728) |
| 0.1 | 0.5 | GO:2001300 | lipoxin metabolic process(GO:2001300) |
| 0.1 | 0.4 | GO:0098582 | innate vocalization behavior(GO:0098582) |
| 0.0 | 0.4 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.1 | 0.3 | GO:0002426 | immunoglobulin production in mucosal tissue(GO:0002426) |
| 0.1 | 0.3 | GO:1903414 | spleen trabecula formation(GO:0060345) iron cation export(GO:1903414) ferrous iron export(GO:1903988) |
| 0.1 | 0.3 | GO:0032972 | regulation of muscle filament sliding speed(GO:0032972) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0042599 | lamellar body(GO:0042599) |
| 0.0 | 0.4 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.0 | 0.3 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.0 | 0.2 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 0.2 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.0 | 0.2 | GO:0070531 | BRCA1-A complex(GO:0070531) |
| 0.0 | 0.1 | GO:0043291 | RAVE complex(GO:0043291) |
| 0.0 | 0.1 | GO:0009328 | phenylalanine-tRNA ligase complex(GO:0009328) |
| 0.0 | 0.1 | GO:0097425 | smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425) |
| 0.0 | 0.1 | GO:0097255 | R2TP complex(GO:0097255) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.0 | 0.6 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.0 | 0.6 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.1 | 0.5 | GO:0016404 | 15-hydroxyprostaglandin dehydrogenase (NAD+) activity(GO:0016404) |
| 0.1 | 0.4 | GO:0022851 | GABA-gated chloride ion channel activity(GO:0022851) |
| 0.0 | 0.4 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.1 | 0.3 | GO:0047225 | acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0047225) |
| 0.1 | 0.3 | GO:0097689 | iron channel activity(GO:0097689) |
| 0.0 | 0.3 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 0.1 | 0.2 | GO:0019808 | polyamine binding(GO:0019808) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.0 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.0 | 0.6 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 1.2 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 0.7 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 0.6 | REACTOME ARMS MEDIATED ACTIVATION | Genes involved in ARMS-mediated activation |
| 0.0 | 0.4 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 0.3 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 0.2 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.0 | 0.2 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 0.1 | REACTOME ANDROGEN BIOSYNTHESIS | Genes involved in Androgen biosynthesis |