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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PITX2

Z-value: 0.42

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Transcription factors associated with PITX2

Gene Symbol Gene ID Gene Info
PITX2
ENSG00000164093.11 paired like homeodomain 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PITX2hg19_v2_chr4_-_111544207_1115442400.901.5e-02Click!

Activity profile of PITX2 motif

Sorted Z-values of PITX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_79495397 0.23 ENST00000417245.2
ENST00000334850.7
FSCN2
fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)
chr3_-_49837254 0.19 ENST00000412678.2
ENST00000343366.4
ENST00000487256.1
CDHR4
cadherin-related family member 4
chr2_-_65659762 0.16 ENST00000440972.1
SPRED2
sprouty-related, EVH1 domain containing 2
chr8_+_123875624 0.13 ENST00000534247.1
ZHX2
zinc fingers and homeoboxes 2
chr6_-_111804905 0.12 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr4_+_70916119 0.11 ENST00000246896.3
ENST00000511674.1
HTN1
histatin 1
chr6_-_138893661 0.10 ENST00000427025.2
NHSL1
NHS-like 1
chr1_+_180875711 0.09 ENST00000434447.1
RP11-46A10.2
RP11-46A10.2
chr5_-_64920115 0.09 ENST00000381018.3
ENST00000274327.7
TRIM23
tripartite motif containing 23
chr3_+_158787041 0.08 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr4_-_68620053 0.08 ENST00000420975.2
ENST00000226413.4
GNRHR
gonadotropin-releasing hormone receptor
chr16_-_15736345 0.08 ENST00000549219.1
KIAA0430
KIAA0430
chr19_-_49843539 0.07 ENST00000602554.1
ENST00000358234.4
CTC-301O7.4
CTC-301O7.4
chr10_-_75193308 0.07 ENST00000299432.2
MSS51
MSS51 mitochondrial translational activator
chr15_+_41221536 0.07 ENST00000249749.5
DLL4
delta-like 4 (Drosophila)
chrX_-_21676442 0.07 ENST00000379499.2
KLHL34
kelch-like family member 34
chr17_-_4643114 0.07 ENST00000293778.6
CXCL16
chemokine (C-X-C motif) ligand 16
chr6_-_53013620 0.07 ENST00000259803.7
GCM1
glial cells missing homolog 1 (Drosophila)
chr4_-_36245561 0.07 ENST00000506189.1
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr9_-_110251836 0.06 ENST00000374672.4
KLF4
Kruppel-like factor 4 (gut)
chr17_-_4643161 0.05 ENST00000574412.1
CXCL16
chemokine (C-X-C motif) ligand 16
chr16_-_12070468 0.05 ENST00000538896.1
RP11-166B2.1
Putative NPIP-like protein LOC729978
chr4_+_126237554 0.05 ENST00000394329.3
FAT4
FAT atypical cadherin 4
chr12_+_6949964 0.05 ENST00000541978.1
ENST00000435982.2
GNB3
guanine nucleotide binding protein (G protein), beta polypeptide 3
chr17_+_4643337 0.05 ENST00000592813.1
ZMYND15
zinc finger, MYND-type containing 15
chrX_+_15767971 0.05 ENST00000479740.1
ENST00000454127.2
CA5B
carbonic anhydrase VB, mitochondrial
chr6_-_33297013 0.04 ENST00000453407.1
DAXX
death-domain associated protein
chr17_+_4643300 0.04 ENST00000433935.1
ZMYND15
zinc finger, MYND-type containing 15
chr9_+_34458771 0.04 ENST00000437363.1
ENST00000242317.4
DNAI1
dynein, axonemal, intermediate chain 1
chr19_-_51893827 0.04 ENST00000574814.1
CTD-2616J11.4
chromosome 19 open reading frame 84
chr9_-_8857776 0.04 ENST00000481079.1
PTPRD
protein tyrosine phosphatase, receptor type, D
chr8_-_42360015 0.04 ENST00000522707.1
SLC20A2
solute carrier family 20 (phosphate transporter), member 2
chr17_-_10633535 0.04 ENST00000341871.3
TMEM220
transmembrane protein 220
chr1_+_205538165 0.04 ENST00000536357.1
MFSD4
major facilitator superfamily domain containing 4
chr2_+_201994569 0.03 ENST00000457277.1
CFLAR
CASP8 and FADD-like apoptosis regulator
chr3_-_191000172 0.03 ENST00000427544.2
UTS2B
urotensin 2B
chrM_+_9207 0.03 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr6_+_35310391 0.03 ENST00000337400.2
ENST00000311565.4
ENST00000540939.1
PPARD
peroxisome proliferator-activated receptor delta
chr1_-_31230650 0.02 ENST00000294507.3
LAPTM5
lysosomal protein transmembrane 5
chr9_-_131486367 0.02 ENST00000372663.4
ENST00000406904.2
ENST00000452105.1
ENST00000372672.2
ENST00000372667.5
ZDHHC12
zinc finger, DHHC-type containing 12
chr4_+_146560245 0.02 ENST00000541599.1
MMAA
methylmalonic aciduria (cobalamin deficiency) cblA type
chr22_-_30234218 0.02 ENST00000307790.3
ENST00000542393.1
ENST00000397771.2
ASCC2
activating signal cointegrator 1 complex subunit 2
chr11_-_75017734 0.02 ENST00000532525.1
ARRB1
arrestin, beta 1
chr6_+_35310312 0.02 ENST00000448077.2
ENST00000360694.3
ENST00000418635.2
ENST00000444397.1
PPARD
peroxisome proliferator-activated receptor delta
chr17_-_46657473 0.01 ENST00000332503.5
HOXB4
homeobox B4
chr3_+_119421849 0.01 ENST00000273390.5
ENST00000463700.1
MAATS1
MYCBP-associated, testis expressed 1
chr1_+_2407754 0.01 ENST00000419816.2
ENST00000378486.3
ENST00000378488.3
ENST00000288766.5
PLCH2
phospholipase C, eta 2
chr1_-_98515395 0.01 ENST00000424528.2
MIR137HG
MIR137 host gene (non-protein coding)
chr7_-_128415844 0.01 ENST00000249389.2
OPN1SW
opsin 1 (cone pigments), short-wave-sensitive
chr9_-_127358087 0.01 ENST00000475178.1
NR6A1
nuclear receptor subfamily 6, group A, member 1
chr22_-_39096661 0.01 ENST00000216039.5
JOSD1
Josephin domain containing 1
chr16_-_5116025 0.01 ENST00000472572.3
ENST00000315997.5
ENST00000422873.1
ENST00000350219.4
C16orf89
chromosome 16 open reading frame 89
chrX_-_6146876 0.01 ENST00000381095.3
NLGN4X
neuroligin 4, X-linked
chr9_-_95166841 0.01 ENST00000262551.4
OGN
osteoglycin
chr13_-_95131923 0.01 ENST00000377028.5
ENST00000446125.1
DCT
dopachrome tautomerase
chr6_-_41673552 0.00 ENST00000419574.1
ENST00000445214.1
TFEB
transcription factor EB
chrX_-_48931648 0.00 ENST00000376386.3
ENST00000376390.4
PRAF2
PRA1 domain family, member 2
chr11_+_61522844 0.00 ENST00000265460.5
MYRF
myelin regulatory factor
chr7_-_122840015 0.00 ENST00000194130.2
SLC13A1
solute carrier family 13 (sodium/sulfate symporter), member 1
chr18_-_47017956 0.00 ENST00000584895.1
ENST00000332968.6
ENST00000580210.1
ENST00000579408.1
RPL17-C18orf32
RPL17
RPL17-C18orf32 readthrough
ribosomal protein L17
chr8_-_27462822 0.00 ENST00000522098.1
CLU
clusterin
chr2_+_120770581 0.00 ENST00000263713.5
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chr6_+_43215727 0.00 ENST00000304139.5
TTBK1
tau tubulin kinase 1
chr19_+_2476116 0.00 ENST00000215631.4
ENST00000587345.1
GADD45B
growth arrest and DNA-damage-inducible, beta
chr7_-_122339162 0.00 ENST00000340112.2
RNF133
ring finger protein 133

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0060018 astrocyte fate commitment(GO:0060018)
0.0 0.1 GO:1904995 regulation of muscle hyperplasia(GO:0014738) negative regulation of muscle hyperplasia(GO:0014740) negative regulation of leukocyte adhesion to vascular endothelial cell(GO:1904995) negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.0 0.1 GO:0097210 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.0 0.0 GO:0072738 response to diamide(GO:0072737) cellular response to diamide(GO:0072738)
0.0 0.1 GO:0061074 regulation of neural retina development(GO:0061074) negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0016035 zeta DNA polymerase complex(GO:0016035)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0004968 gonadotropin-releasing hormone receptor activity(GO:0004968)
0.0 0.1 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors