ISMARA results: PITX1

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for PITX1

Z-value: 3.32

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Transcription factors associated with PITX1

Gene Symbol	Gene ID	Gene Info
PITX1 Ensembl NCBI GeneCards UniProt	ENSG00000069011.11	paired like homeodomain 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PITX1	hg19_v2_chr5_-_134369973_134369988	0.90	1.5e-02	Click!

Activity profile of PITX1 motif

Sorted Z-values of PITX1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_-_58204128 Show fit	5.01	ENST00000597520.1	AC004017.1 Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein
chr11_+_107650219 Show fit	3.52	ENST00000398067.1	AP001024.1 Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein
chr1_-_213020991 Show fit	2.91	ENST00000332912.3	C1orf227 Ensembl NCBI GeneCards UniProt Show fit	chromosome 1 open reading frame 227
chr4_-_185776854 Show fit	2.86	ENST00000511703.1	RP11-701P16.5 Ensembl NCBI GeneCards UniProt Show fit	RP11-701P16.5
chr12_-_66317967 Show fit	2.66	ENST00000601398.1	AC090673.2 Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein
chr19_-_2085323 Show fit	2.60	ENST00000591638.1	MOB3A Ensembl NCBI GeneCards UniProt Show fit	MOB kinase activator 3A
chr19_-_13900972 Show fit	2.50	ENST00000397557.1	AC008686.1 Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein
chr1_+_161185032 Show fit	2.42	ENST00000367992.3 ENST00000289902.1	FCER1G Ensembl NCBI GeneCards UniProt Show fit	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
chr20_-_46041046 Show fit	2.32	ENST00000437920.1	RP1-148H17.1 Ensembl NCBI GeneCards UniProt Show fit	RP1-148H17.1
chr7_+_99724317 Show fit	2.21	ENST00000398075.2 ENST00000421390.1	MBLAC1 Ensembl NCBI GeneCards UniProt Show fit	metallo-beta-lactamase domain containing 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	6.0	GO:0036149	phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.1	3.9	GO:0006735	NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0	2.8	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0	2.7	GO:0030032	lamellipodium assembly(GO:0030032)
0.5	2.6	GO:0046203	spermidine catabolic process(GO:0046203)
0.4	2.6	GO:0036016	response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016)
0.1	2.6	GO:0045859	regulation of protein kinase activity(GO:0045859)
0.0	2.6	GO:0045599	negative regulation of fat cell differentiation(GO:0045599)
0.1	2.5	GO:0023041	neuronal signal transduction(GO:0023041)
0.8	2.4	GO:0001812	positive regulation of type I hypersensitivity(GO:0001812) positive regulation of mast cell cytokine production(GO:0032765) mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)

Showing 1 to 10 of 503 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.5	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.0	4.1	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2	3.4	GO:0000813	ESCRT I complex(GO:0000813)
0.0	3.3	GO:0043202	lysosomal lumen(GO:0043202)
0.1	3.2	GO:0031229	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0	3.1	GO:0030131	clathrin adaptor complex(GO:0030131)
0.0	2.8	GO:0001726	ruffle(GO:0001726)
0.0	2.4	GO:0002102	podosome(GO:0002102)
0.1	2.2	GO:0045277	respiratory chain complex IV(GO:0045277)
0.0	1.9	GO:0042383	sarcolemma(GO:0042383)

Showing 1 to 10 of 196 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.0	GO:0035591	signaling adaptor activity(GO:0035591)
0.3	4.4	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	3.6	GO:0043130	ubiquitin binding(GO:0043130)
0.0	3.4	GO:0004004	ATP-dependent RNA helicase activity(GO:0004004)
0.0	3.0	GO:0016279	protein-lysine N-methyltransferase activity(GO:0016279)
0.0	2.8	GO:0019902	phosphatase binding(GO:0019902)
0.7	2.7	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.5	2.7	GO:0019863	IgE binding(GO:0019863)
0.9	2.6	GO:0034038	deoxyhypusine synthase activity(GO:0034038)
0.0	2.5	GO:0004177	aminopeptidase activity(GO:0004177)

Showing 1 to 10 of 341 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
4.7	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
3.0	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
2.7	PID IL3 PATHWAY	IL3-mediated signaling events
2.7	PID P53 REGULATION PATHWAY	p53 pathway
2.6	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
2.6	PID P73PATHWAY	p73 transcription factor network
2.5	PID FOXM1 PATHWAY	FOXM1 transcription factor network
2.5	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
1.9	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
1.8	PID IGF1 PATHWAY	IGF1 pathway

Showing 1 to 10 of 57 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	6.1	REACTOME ACYL CHAIN REMODELLING OF PI	Genes involved in Acyl chain remodelling of PI
0.1	5.0	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.1	4.8	REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.2	4.6	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.1	2.7	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.1	2.6	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1	2.6	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.0	2.5	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1	2.4	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.1	2.2	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling

Showing 1 to 10 of 102 entries

Results for PITX1

Z-value: 3.32

Motif logo

Transcription factors associated with PITX1

Activity-expression correlation:

Activity profile of PITX1 motif

Sorted Z-values of PITX1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: