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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for PAX8
Z-value: 1.21
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Transcription factors associated with PAX8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PAX8 | hg19_v2_chr2_-_114036488_114036527 | 0.59 | 2.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_24126350 Show fit | 1.21 |
ENST00000378491.4
ENST00000378478.1 ENST00000378477.2 |
neurensin 1 |
|
| chr6_+_131571535 Show fit | 1.16 |
ENST00000474850.2
|
A kinase (PRKA) anchor protein 7 |
|
| chr14_-_57197224 Show fit | 1.02 |
ENST00000554597.1
ENST00000556696.1 |
Uncharacterized protein |
|
| chr15_-_29745003 Show fit | 0.90 |
ENST00000560082.1
|
family with sequence similarity 189, member A1 |
|
| chr11_-_9482010 Show fit | 0.88 |
ENST00000596206.1
|
LOC644656 protein; Uncharacterized protein |
|
| chr19_+_35630926 Show fit | 0.87 |
ENST00000588081.1
ENST00000589121.1 |
FXYD domain containing ion transport regulator 1 |
|
| chrX_-_153141783 Show fit | 0.85 |
ENST00000458029.1
|
L1 cell adhesion molecule |
|
| chr22_-_20138302 Show fit | 0.72 |
ENST00000540078.1
ENST00000439765.2 |
uncharacterized protein LOC388849 |
|
| chr4_+_123653807 Show fit | 0.72 |
ENST00000314218.3
ENST00000542236.1 |
Bardet-Biedl syndrome 12 |
|
| chr9_-_116837249 Show fit | 0.66 |
ENST00000466610.2
|
alpha-1-microglobulin/bikunin precursor |
Network of associatons between targets according to the STRING database.
First level regulatory network of PAX8
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | GO:0042755 | eating behavior(GO:0042755) |
| 0.2 | 1.2 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
| 0.0 | 1.2 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.0 | 1.2 | GO:0045773 | positive regulation of axon extension(GO:0045773) |
| 0.1 | 0.9 | GO:0010734 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
| 0.1 | 0.8 | GO:0003025 | regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) vagus nerve development(GO:0021564) |
| 0.2 | 0.7 | GO:1904897 | regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922) |
| 0.1 | 0.7 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
| 0.1 | 0.6 | GO:0072695 | negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695) |
| 0.0 | 0.6 | GO:0050832 | defense response to fungus(GO:0050832) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 1.3 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.0 | 0.9 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 0.9 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 0.6 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.0 | 0.4 | GO:0060091 | kinocilium(GO:0060091) |
| 0.1 | 0.3 | GO:0044279 | other organism cell membrane(GO:0044218) other organism membrane(GO:0044279) |
| 0.1 | 0.2 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.0 | 0.2 | GO:0097524 | sperm plasma membrane(GO:0097524) |
| 0.0 | 0.2 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.2 | 1.2 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 0.0 | 1.2 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.0 | 0.8 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.2 | 0.7 | GO:0019862 | IgA binding(GO:0019862) |
| 0.0 | 0.7 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.1 | 0.6 | GO:0016936 | galactoside binding(GO:0016936) |
| 0.0 | 0.6 | GO:0098505 | G-rich strand telomeric DNA binding(GO:0098505) |
| 0.0 | 0.5 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.1 | 0.4 | GO:1901375 | acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.0 | 0.6 | ST G ALPHA S PATHWAY | G alpha s Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 1.2 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 0.6 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.0 | 0.6 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 0.5 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.0 | 0.5 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 0.4 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.0 | 0.3 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 0.2 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |