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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for PAX5
Z-value: 0.97
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Transcription factors associated with PAX5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PAX5 | hg19_v2_chr9_-_37034028_37034157 | -0.36 | 4.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_-_34662651 Show fit | 0.92 |
ENST00000259631.4
|
chemokine (C-C motif) ligand 27 |
|
| chr11_+_107650219 Show fit | 0.79 |
ENST00000398067.1
|
Uncharacterized protein |
|
| chr6_-_41701898 Show fit | 0.57 |
ENST00000433032.1
|
transcription factor EB |
|
| chr1_-_17676070 Show fit | 0.54 |
ENST00000602074.1
|
Uncharacterized protein |
|
| chr8_-_1922789 Show fit | 0.53 |
ENST00000521498.1
|
RP11-439C15.4 |
|
| chr2_-_27531313 Show fit | 0.52 |
ENST00000296099.2
|
urocortin |
|
| chr1_-_161059380 Show fit | 0.51 |
ENST00000368012.3
|
poliovirus receptor-related 4 |
|
| chr5_+_133842243 Show fit | 0.48 |
ENST00000515627.2
|
AC005355.2 |
|
| chr17_+_73539232 Show fit | 0.47 |
ENST00000580925.1
|
lethal giant larvae homolog 2 (Drosophila) |
|
| chr17_+_80317121 Show fit | 0.45 |
ENST00000333437.4
|
testis expressed 19 |
Network of associatons between targets according to the STRING database.
First level regulatory network of PAX5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0010761 | fibroblast migration(GO:0010761) |
| 0.0 | 0.8 | GO:0031572 | G2 DNA damage checkpoint(GO:0031572) |
| 0.0 | 0.7 | GO:0032688 | negative regulation of interferon-beta production(GO:0032688) |
| 0.0 | 0.7 | GO:0007191 | adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191) |
| 0.0 | 0.7 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome(GO:0048025) |
| 0.0 | 0.7 | GO:0032418 | lysosome localization(GO:0032418) |
| 0.2 | 0.6 | GO:0002432 | granuloma formation(GO:0002432) |
| 0.1 | 0.6 | GO:1904158 | axonemal central apparatus assembly(GO:1904158) |
| 0.0 | 0.6 | GO:0001675 | acrosome assembly(GO:0001675) |
| 0.0 | 0.6 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | GO:0097525 | spliceosomal snRNP complex(GO:0097525) |
| 0.0 | 1.5 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 1.2 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.0 | 0.9 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.1 | 0.8 | GO:0043196 | varicosity(GO:0043196) |
| 0.0 | 0.8 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 0.7 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.0 | 0.7 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.0 | 0.6 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.0 | 0.6 | GO:0097539 | ciliary transition fiber(GO:0097539) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 1.0 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.0 | 1.0 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.2 | 0.8 | GO:0031728 | CCR3 chemokine receptor binding(GO:0031728) |
| 0.0 | 0.8 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 0.0 | 0.8 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.0 | 0.8 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.1 | 0.7 | GO:0005412 | glucose:sodium symporter activity(GO:0005412) |
| 0.0 | 0.7 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.6 | GO:0038064 | collagen receptor activity(GO:0038064) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 1.1 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 1.0 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.0 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.9 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.9 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 0.8 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 0.8 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 0.7 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.0 | 0.7 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 1.2 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 1.2 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 1.0 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.8 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 0.8 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.7 | REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION | Genes involved in RORA Activates Circadian Expression |
| 0.0 | 0.7 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 0.7 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 0.6 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |