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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for OTX2_CRX

Z-value: 0.67

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Transcription factors associated with OTX2_CRX

Gene Symbol Gene ID Gene Info
OTX2
ENSG00000165588.12 orthodenticle homeobox 2
CRX
ENSG00000105392.11 cone-rod homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CRXhg19_v2_chr19_+_48325097_483252110.404.3e-01Click!

Activity profile of OTX2_CRX motif

Sorted Z-values of OTX2_CRX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_86999516 0.43 ENST00000521564.1
ATP6V0D2
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
chrX_+_69488174 0.43 ENST00000480877.2
ENST00000307959.8
ARR3
arrestin 3, retinal (X-arrestin)
chr17_+_4643337 0.43 ENST00000592813.1
ZMYND15
zinc finger, MYND-type containing 15
chr8_-_25281747 0.40 ENST00000421054.2
GNRH1
gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
chr17_-_4689727 0.40 ENST00000328739.5
ENST00000354194.4
VMO1
vitelline membrane outer layer 1 homolog (chicken)
chrX_+_69488155 0.39 ENST00000374495.3
ARR3
arrestin 3, retinal (X-arrestin)
chr3_+_111393659 0.38 ENST00000477665.1
PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr2_+_219472637 0.36 ENST00000417849.1
PLCD4
phospholipase C, delta 4
chr17_+_4643300 0.31 ENST00000433935.1
ZMYND15
zinc finger, MYND-type containing 15
chr22_-_41258074 0.26 ENST00000307221.4
DNAJB7
DnaJ (Hsp40) homolog, subfamily B, member 7
chr17_-_4643114 0.25 ENST00000293778.6
CXCL16
chemokine (C-X-C motif) ligand 16
chr15_-_44092295 0.25 ENST00000249714.3
ENST00000299969.6
ENST00000319327.6
SERINC4
serine incorporator 4
chr14_-_70040339 0.25 ENST00000599174.1
CCDC177
Homo sapiens coiled-coil domain containing 177 (CCDC177), mRNA.
chr17_+_74536115 0.23 ENST00000592014.1
PRCD
progressive rod-cone degeneration
chr1_+_180897269 0.23 ENST00000367587.1
KIAA1614
KIAA1614
chr11_+_20044096 0.23 ENST00000533917.1
NAV2
neuron navigator 2
chr18_-_64271316 0.22 ENST00000540086.1
ENST00000580157.1
CDH19
cadherin 19, type 2
chr16_-_58004992 0.20 ENST00000564448.1
ENST00000251102.8
ENST00000311183.4
CNGB1
cyclic nucleotide gated channel beta 1
chr9_+_82188077 0.20 ENST00000425506.1
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr3_+_111393501 0.20 ENST00000393934.3
PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr14_-_101034811 0.18 ENST00000553553.1
BEGAIN
brain-enriched guanylate kinase-associated
chrX_-_101771645 0.18 ENST00000289373.4
TMSB15A
thymosin beta 15a
chr17_-_40264692 0.16 ENST00000591220.1
ENST00000251642.3
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr6_-_33297013 0.15 ENST00000453407.1
DAXX
death-domain associated protein
chr17_-_48207157 0.15 ENST00000330175.4
ENST00000503131.1
SAMD14
sterile alpha motif domain containing 14
chr11_-_8680383 0.15 ENST00000299550.6
TRIM66
tripartite motif containing 66
chr2_-_14541060 0.15 ENST00000418420.1
ENST00000417751.1
LINC00276
long intergenic non-protein coding RNA 276
chr11_+_61248583 0.15 ENST00000432063.2
ENST00000338608.2
PPP1R32
protein phosphatase 1, regulatory subunit 32
chr13_+_36050881 0.15 ENST00000537702.1
NBEA
neurobeachin
chr17_-_4643161 0.14 ENST00000574412.1
CXCL16
chemokine (C-X-C motif) ligand 16
chr17_-_46692457 0.14 ENST00000468443.1
HOXB8
homeobox B8
chr9_-_35754253 0.14 ENST00000436428.2
MSMP
microseminoprotein, prostate associated
chr18_-_56985776 0.14 ENST00000587244.1
CPLX4
complexin 4
chr20_-_18774614 0.14 ENST00000412553.1
LINC00652
long intergenic non-protein coding RNA 652
chr5_-_149324306 0.14 ENST00000255266.5
PDE6A
phosphodiesterase 6A, cGMP-specific, rod, alpha
chr4_+_124571409 0.13 ENST00000514823.1
ENST00000511919.1
ENST00000508111.1
RP11-93L9.1
long intergenic non-protein coding RNA 1091
chr15_+_41221536 0.13 ENST00000249749.5
DLL4
delta-like 4 (Drosophila)
chr3_-_137851220 0.13 ENST00000236709.3
A4GNT
alpha-1,4-N-acetylglucosaminyltransferase
chr10_-_21806759 0.13 ENST00000444772.3
SKIDA1
SKI/DACH domain containing 1
chr10_-_76868931 0.13 ENST00000372700.3
ENST00000473072.2
ENST00000491677.2
ENST00000607131.1
ENST00000372702.3
DUSP13
dual specificity phosphatase 13
chr14_-_57197224 0.12 ENST00000554597.1
ENST00000556696.1
RP11-1085N6.3
Uncharacterized protein
chr12_-_86650077 0.12 ENST00000552808.2
ENST00000547225.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr19_-_42931567 0.12 ENST00000244289.4
LIPE
lipase, hormone-sensitive
chr19_-_55866061 0.12 ENST00000588572.2
ENST00000593184.1
ENST00000589467.1
COX6B2
cytochrome c oxidase subunit VIb polypeptide 2 (testis)
chr15_+_33603147 0.12 ENST00000415757.3
ENST00000389232.4
RYR3
ryanodine receptor 3
chr3_-_45838011 0.12 ENST00000358525.4
ENST00000413781.1
SLC6A20
solute carrier family 6 (proline IMINO transporter), member 20
chr12_+_53693812 0.12 ENST00000549488.1
C12orf10
chromosome 12 open reading frame 10
chr10_+_24528108 0.11 ENST00000438429.1
KIAA1217
KIAA1217
chr11_+_124735282 0.10 ENST00000397801.1
ROBO3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr16_+_58010339 0.10 ENST00000290871.5
ENST00000441824.2
TEPP
testis, prostate and placenta expressed
chr12_+_53693466 0.10 ENST00000267103.5
ENST00000548632.1
C12orf10
chromosome 12 open reading frame 10
chr5_-_524445 0.10 ENST00000514375.1
ENST00000264938.3
SLC9A3
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
chr9_+_116298778 0.10 ENST00000462143.1
RGS3
regulator of G-protein signaling 3
chr6_+_100054606 0.10 ENST00000369215.4
PRDM13
PR domain containing 13
chr6_+_148593425 0.10 ENST00000367469.1
SASH1
SAM and SH3 domain containing 1
chrX_-_100129128 0.10 ENST00000372960.4
ENST00000372964.1
ENST00000217885.5
NOX1
NADPH oxidase 1
chr1_+_200863949 0.10 ENST00000413687.2
C1orf106
chromosome 1 open reading frame 106
chr9_-_95244781 0.09 ENST00000375544.3
ENST00000375543.1
ENST00000395538.3
ENST00000450139.2
ASPN
asporin
chr3_-_45837959 0.09 ENST00000353278.4
ENST00000456124.2
SLC6A20
solute carrier family 6 (proline IMINO transporter), member 20
chr2_+_183943464 0.09 ENST00000354221.4
DUSP19
dual specificity phosphatase 19
chr3_-_186262166 0.09 ENST00000307944.5
CRYGS
crystallin, gamma S
chr14_-_67981916 0.09 ENST00000357461.2
TMEM229B
transmembrane protein 229B
chr2_+_219472488 0.09 ENST00000450993.2
PLCD4
phospholipase C, delta 4
chr4_-_102268628 0.09 ENST00000323055.6
ENST00000512215.1
ENST00000394854.3
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr3_-_48229846 0.09 ENST00000302506.3
ENST00000351231.3
ENST00000437972.1
CDC25A
cell division cycle 25A
chr19_-_55866104 0.09 ENST00000326529.4
COX6B2
cytochrome c oxidase subunit VIb polypeptide 2 (testis)
chr1_+_153651078 0.09 ENST00000368680.3
NPR1
natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
chr11_-_130184555 0.09 ENST00000525842.1
ZBTB44
zinc finger and BTB domain containing 44
chr1_-_39395165 0.09 ENST00000372985.3
RHBDL2
rhomboid, veinlet-like 2 (Drosophila)
chr19_+_48325097 0.09 ENST00000221996.7
ENST00000539067.1
CRX
cone-rod homeobox
chr1_+_167298281 0.09 ENST00000367862.5
POU2F1
POU class 2 homeobox 1
chr16_+_8715536 0.09 ENST00000563958.1
ENST00000381920.3
ENST00000564554.1
METTL22
methyltransferase like 22
chr6_-_88001706 0.08 ENST00000369576.2
GJB7
gap junction protein, beta 7, 25kDa
chr11_-_130184470 0.08 ENST00000357899.4
ENST00000397753.1
ZBTB44
zinc finger and BTB domain containing 44
chrX_+_15767971 0.08 ENST00000479740.1
ENST00000454127.2
CA5B
carbonic anhydrase VB, mitochondrial
chr2_-_55237484 0.08 ENST00000394609.2
RTN4
reticulon 4
chr9_-_16253112 0.08 ENST00000380683.1
C9orf92
chromosome 9 open reading frame 92
chrX_-_21676442 0.08 ENST00000379499.2
KLHL34
kelch-like family member 34
chr4_-_15661474 0.08 ENST00000509314.1
ENST00000503196.1
FBXL5
F-box and leucine-rich repeat protein 5
chr5_+_173316341 0.08 ENST00000520867.1
ENST00000334035.5
CPEB4
cytoplasmic polyadenylation element binding protein 4
chr12_+_133757995 0.08 ENST00000536435.2
ENST00000228289.5
ENST00000541211.2
ENST00000500625.3
ENST00000539248.2
ENST00000542711.2
ENST00000536899.2
ENST00000542986.2
ENST00000537565.1
ENST00000541975.2
ZNF268
zinc finger protein 268
chr1_+_164528437 0.08 ENST00000485769.1
PBX1
pre-B-cell leukemia homeobox 1
chrX_+_123095860 0.08 ENST00000428941.1
STAG2
stromal antigen 2
chrY_+_16634483 0.08 ENST00000382872.1
NLGN4Y
neuroligin 4, Y-linked
chrX_+_123095890 0.08 ENST00000435215.1
STAG2
stromal antigen 2
chr6_+_106535455 0.07 ENST00000424894.1
PRDM1
PR domain containing 1, with ZNF domain
chr2_+_171640291 0.07 ENST00000409885.1
ERICH2
glutamate-rich 2
chr10_-_116418053 0.07 ENST00000277895.5
ABLIM1
actin binding LIM protein 1
chr6_-_88411911 0.07 ENST00000257787.5
AKIRIN2
akirin 2
chr3_+_50649302 0.07 ENST00000446044.1
MAPKAPK3
mitogen-activated protein kinase-activated protein kinase 3
chr7_-_33080506 0.07 ENST00000381626.2
ENST00000409467.1
ENST00000449201.1
NT5C3A
5'-nucleotidase, cytosolic IIIA
chr5_-_150138061 0.07 ENST00000521533.1
ENST00000424236.1
DCTN4
dynactin 4 (p62)
chr1_-_161014731 0.07 ENST00000368020.1
USF1
upstream transcription factor 1
chr7_-_97881429 0.07 ENST00000420697.1
ENST00000379795.3
ENST00000415086.1
ENST00000542604.1
ENST00000447648.2
TECPR1
tectonin beta-propeller repeat containing 1
chr11_-_47198380 0.07 ENST00000419701.2
ENST00000526342.1
ENST00000528444.1
ENST00000530596.1
ENST00000525398.1
ENST00000319543.6
ENST00000426335.2
ENST00000527927.1
ENST00000525314.1
ARFGAP2
ADP-ribosylation factor GTPase activating protein 2
chr10_-_74114714 0.07 ENST00000338820.3
ENST00000394903.2
ENST00000444643.2
DNAJB12
DnaJ (Hsp40) homolog, subfamily B, member 12
chr14_-_67981870 0.07 ENST00000555994.1
TMEM229B
transmembrane protein 229B
chr4_+_110769258 0.06 ENST00000594814.1
LRIT3
leucine-rich repeat, immunoglobulin-like and transmembrane domains 3
chr1_+_209757051 0.06 ENST00000009105.1
ENST00000423146.1
ENST00000361322.2
CAMK1G
calcium/calmodulin-dependent protein kinase IG
chr3_-_65583561 0.06 ENST00000460329.2
MAGI1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr17_-_9808887 0.06 ENST00000226193.5
RCVRN
recoverin
chr2_+_66662510 0.06 ENST00000272369.9
ENST00000407092.2
MEIS1
Meis homeobox 1
chr11_+_72975578 0.06 ENST00000393592.2
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr15_-_74495188 0.06 ENST00000563965.1
ENST00000395105.4
STRA6
stimulated by retinoic acid 6
chr18_+_29769978 0.06 ENST00000269202.6
ENST00000581447.1
MEP1B
meprin A, beta
chr11_-_111794446 0.06 ENST00000527950.1
CRYAB
crystallin, alpha B
chr2_-_136873735 0.06 ENST00000409817.1
CXCR4
chemokine (C-X-C motif) receptor 4
chr11_+_72975559 0.06 ENST00000349767.2
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr3_+_4535025 0.06 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr4_+_154125565 0.06 ENST00000338700.5
TRIM2
tripartite motif containing 2
chr6_-_111804905 0.06 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr9_-_13279563 0.06 ENST00000541718.1
MPDZ
multiple PDZ domain protein
chr19_-_44124019 0.06 ENST00000300811.3
ZNF428
zinc finger protein 428
chr11_-_71751715 0.06 ENST00000535947.1
NUMA1
nuclear mitotic apparatus protein 1
chr16_+_81272287 0.05 ENST00000425577.2
ENST00000564552.1
BCMO1
beta-carotene 15,15'-monooxygenase 1
chr5_-_41510656 0.05 ENST00000377801.3
PLCXD3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr1_-_117664317 0.05 ENST00000256649.4
ENST00000369464.3
ENST00000485032.1
TRIM45
tripartite motif containing 45
chr19_+_2476116 0.05 ENST00000215631.4
ENST00000587345.1
GADD45B
growth arrest and DNA-damage-inducible, beta
chr3_-_49058479 0.05 ENST00000440857.1
DALRD3
DALR anticodon binding domain containing 3
chr4_-_153601136 0.05 ENST00000504064.1
ENST00000304385.3
TMEM154
transmembrane protein 154
chr5_-_41510725 0.05 ENST00000328457.3
PLCXD3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr3_-_170626376 0.05 ENST00000487522.1
ENST00000474417.1
EIF5A2
eukaryotic translation initiation factor 5A2
chr11_+_72975524 0.05 ENST00000540342.1
ENST00000542092.1
P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr6_-_30658745 0.05 ENST00000376420.5
ENST00000376421.5
NRM
nurim (nuclear envelope membrane protein)
chr6_+_35310391 0.05 ENST00000337400.2
ENST00000311565.4
ENST00000540939.1
PPARD
peroxisome proliferator-activated receptor delta
chr19_+_7710774 0.05 ENST00000602355.1
STXBP2
syntaxin binding protein 2
chr2_-_200320768 0.05 ENST00000428695.1
SATB2
SATB homeobox 2
chr17_+_68100989 0.05 ENST00000585558.1
ENST00000392670.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chrX_-_6146876 0.05 ENST00000381095.3
NLGN4X
neuroligin 4, X-linked
chr21_+_34915337 0.05 ENST00000290239.6
ENST00000381692.2
ENST00000300278.4
ENST00000381679.4
SON
SON DNA binding protein
chr2_+_66662690 0.04 ENST00000488550.1
MEIS1
Meis homeobox 1
chr1_+_18957500 0.04 ENST00000375375.3
PAX7
paired box 7
chr17_-_43210580 0.04 ENST00000538093.1
ENST00000590644.1
PLCD3
phospholipase C, delta 3
chr19_-_44123734 0.04 ENST00000598676.1
ZNF428
zinc finger protein 428
chr12_-_9913489 0.04 ENST00000228434.3
ENST00000536709.1
CD69
CD69 molecule
chr9_-_131486367 0.04 ENST00000372663.4
ENST00000406904.2
ENST00000452105.1
ENST00000372672.2
ENST00000372667.5
ZDHHC12
zinc finger, DHHC-type containing 12
chr1_-_146082633 0.04 ENST00000605317.1
ENST00000604938.1
ENST00000339388.5
NBPF11
neuroblastoma breakpoint family, member 11
chr17_-_46692287 0.04 ENST00000239144.4
HOXB8
homeobox B8
chr10_+_118349920 0.04 ENST00000531984.1
PNLIPRP1
pancreatic lipase-related protein 1
chr3_-_149388682 0.04 ENST00000475579.1
WWTR1
WW domain containing transcription regulator 1
chr10_-_21186144 0.04 ENST00000377119.1
NEBL
nebulette
chr5_+_133451254 0.04 ENST00000517851.1
ENST00000521639.1
ENST00000522375.1
ENST00000378560.4
ENST00000432532.2
ENST00000520958.1
ENST00000518915.1
ENST00000395023.1
TCF7
transcription factor 7 (T-cell specific, HMG-box)
chr14_-_95236551 0.04 ENST00000238558.3
GSC
goosecoid homeobox
chr3_-_47950745 0.04 ENST00000429422.1
MAP4
microtubule-associated protein 4
chr10_-_104178857 0.04 ENST00000020673.5
PSD
pleckstrin and Sec7 domain containing
chr15_-_34610962 0.04 ENST00000290209.5
SLC12A6
solute carrier family 12 (potassium/chloride transporter), member 6
chr6_-_139613269 0.04 ENST00000358430.3
TXLNB
taxilin beta
chr18_+_616711 0.04 ENST00000579494.1
CLUL1
clusterin-like 1 (retinal)
chr14_-_22005343 0.04 ENST00000327430.3
SALL2
spalt-like transcription factor 2
chr2_-_61765315 0.04 ENST00000406957.1
ENST00000401558.2
XPO1
exportin 1 (CRM1 homolog, yeast)
chr12_-_66275350 0.04 ENST00000536648.1
RP11-366L20.2
Uncharacterized protein
chr18_-_43678241 0.04 ENST00000593152.2
ENST00000589252.1
ENST00000590665.1
ENST00000398752.6
ATP5A1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
chr14_+_88471468 0.04 ENST00000267549.3
GPR65
G protein-coupled receptor 65
chr6_+_35310312 0.04 ENST00000448077.2
ENST00000360694.3
ENST00000418635.2
ENST00000444397.1
PPARD
peroxisome proliferator-activated receptor delta
chr17_+_74536164 0.04 ENST00000586148.1
PRCD
progressive rod-cone degeneration
chrX_-_10588595 0.04 ENST00000423614.1
ENST00000317552.4
MID1
midline 1 (Opitz/BBB syndrome)
chr2_+_128175997 0.03 ENST00000234071.3
ENST00000429925.1
ENST00000442644.1
ENST00000453608.2
PROC
protein C (inactivator of coagulation factors Va and VIIIa)
chr5_-_41794313 0.03 ENST00000512084.1
OXCT1
3-oxoacid CoA transferase 1
chr20_-_31124186 0.03 ENST00000375678.3
C20orf112
chromosome 20 open reading frame 112
chr11_-_71753188 0.03 ENST00000543009.1
NUMA1
nuclear mitotic apparatus protein 1
chrM_+_9207 0.03 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr14_-_58894332 0.03 ENST00000395159.2
TIMM9
translocase of inner mitochondrial membrane 9 homolog (yeast)
chrX_-_153363188 0.03 ENST00000303391.6
MECP2
methyl CpG binding protein 2 (Rett syndrome)
chr15_+_58430567 0.03 ENST00000536493.1
AQP9
aquaporin 9
chr6_-_154567984 0.03 ENST00000517438.1
IPCEF1
interaction protein for cytohesin exchange factors 1
chr7_+_93535866 0.03 ENST00000429473.1
ENST00000430875.1
ENST00000428834.1
GNGT1
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
chr8_+_54764346 0.03 ENST00000297313.3
ENST00000344277.6
RGS20
regulator of G-protein signaling 20
chr1_-_231560790 0.03 ENST00000366641.3
EGLN1
egl-9 family hypoxia-inducible factor 1
chr17_+_12626199 0.03 ENST00000609971.1
AC005358.1
AC005358.1
chr2_-_65659762 0.03 ENST00000440972.1
SPRED2
sprouty-related, EVH1 domain containing 2
chr12_+_7941989 0.03 ENST00000229307.4
NANOG
Nanog homeobox
chrX_+_46772065 0.03 ENST00000455411.1
PHF16
jade family PHD finger 3
chr9_-_139361503 0.03 ENST00000453963.1
SEC16A
SEC16 homolog A (S. cerevisiae)
chr3_-_149095652 0.03 ENST00000305366.3
TM4SF1
transmembrane 4 L six family member 1
chr1_-_13452656 0.03 ENST00000376132.3
PRAMEF13
PRAME family member 13
chr10_-_48390973 0.03 ENST00000224600.4
RBP3
retinol binding protein 3, interstitial
chr7_+_28452130 0.03 ENST00000357727.2
CREB5
cAMP responsive element binding protein 5
chr15_+_79603404 0.03 ENST00000299705.5
TMED3
transmembrane emp24 protein transport domain containing 3
chr1_-_26633480 0.03 ENST00000450041.1
UBXN11
UBX domain protein 11
chrX_+_123097014 0.03 ENST00000394478.1
STAG2
stromal antigen 2
chr22_+_41258250 0.03 ENST00000544094.1
XPNPEP3
X-prolyl aminopeptidase (aminopeptidase P) 3, putative
chr3_+_63953415 0.03 ENST00000484332.1
ATXN7
ataxin 7
chr12_-_53189892 0.03 ENST00000309505.3
ENST00000417996.2
KRT3
keratin 3
chr1_+_244816371 0.03 ENST00000263831.7
DESI2
desumoylating isopeptidase 2
chr6_+_31554826 0.03 ENST00000376089.2
ENST00000396112.2
LST1
leukocyte specific transcript 1
chr17_-_43209862 0.03 ENST00000322765.5
PLCD3
phospholipase C, delta 3
chr11_+_128563652 0.03 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr6_+_150920999 0.02 ENST00000367328.1
ENST00000367326.1
PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr7_-_111424462 0.02 ENST00000437129.1
DOCK4
dedicator of cytokinesis 4
chr9_+_12693336 0.02 ENST00000381137.2
ENST00000388918.5
TYRP1
tyrosinase-related protein 1
chr11_-_111783595 0.02 ENST00000528628.1
CRYAB
crystallin, alpha B
chr1_+_202431859 0.02 ENST00000391959.3
ENST00000367270.4
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr2_+_85822857 0.02 ENST00000306368.4
ENST00000414390.1
ENST00000456023.1
RNF181
ring finger protein 181
chr3_-_9291063 0.02 ENST00000383836.3
SRGAP3
SLIT-ROBO Rho GTPase activating protein 3
chr1_+_144989309 0.02 ENST00000596396.1
AL590452.1
Uncharacterized protein
chr1_-_94586651 0.02 ENST00000535735.1
ENST00000370225.3
ABCA4
ATP-binding cassette, sub-family A (ABC1), member 4
chrM_+_8527 0.02 ENST00000361899.2
MT-ATP6
mitochondrially encoded ATP synthase 6
chr4_+_129730839 0.02 ENST00000511647.1
PHF17
jade family PHD finger 1
chr18_-_70532906 0.02 ENST00000299430.2
ENST00000397929.1
NETO1
neuropilin (NRP) and tolloid (TLL)-like 1
chr1_-_241799232 0.02 ENST00000366553.1
CHML
choroideremia-like (Rab escort protein 2)

Network of associatons between targets according to the STRING database.

First level regulatory network of OTX2_CRX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1990637 response to prolactin(GO:1990637) regulation of ovarian follicle development(GO:2000354)
0.1 0.2 GO:0072737 response to diamide(GO:0072737) cellular response to diamide(GO:0072738)
0.0 0.2 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.0 0.1 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.0 0.1 GO:0046022 positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0 0.2 GO:0003025 regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) vagus nerve development(GO:0021564)
0.0 0.1 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.0 0.1 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.0 0.1 GO:1903588 regulation of neural retina development(GO:0061074) negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.0 0.4 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 0.1 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.0 0.2 GO:0015824 proline transport(GO:0015824)
0.0 0.1 GO:0046532 regulation of photoreceptor cell differentiation(GO:0046532)
0.0 0.2 GO:0015825 L-serine transport(GO:0015825)
0.0 0.2 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.1 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.0 0.2 GO:0035641 locomotory exploration behavior(GO:0035641)
0.0 0.2 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.0 0.1 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) regulation of protein autoubiquitination(GO:1902498)
0.0 0.4 GO:0007035 vacuolar acidification(GO:0007035)
0.0 0.1 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.0 GO:0016571 histone methylation(GO:0016571)
0.0 0.1 GO:0071286 cellular response to magnesium ion(GO:0071286)
0.0 0.1 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.0 0.2 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.0 GO:1904823 pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 0.4 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.1 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.7 GO:0001917 photoreceptor inner segment(GO:0001917)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0002046 opsin binding(GO:0002046)
0.0 0.4 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.2 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 0.1 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.0 0.1 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.0 0.1 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.2 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.0 0.1 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.1 GO:0008665 2'-phosphotransferase activity(GO:0008665)
0.0 0.2 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.4 GO:0008009 chemokine activity(GO:0008009)
0.0 0.0 GO:0015254 pyrimidine nucleobase transmembrane transporter activity(GO:0005350) glycerol channel activity(GO:0015254)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.2 PID RHODOPSIN PATHWAY Visual signal transduction: Rods

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.4 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion