ISMARA results: OTP_PHOX2B_LHX1_LMX1A_LHX5

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Z-value: 0.84

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Transcription factors associated with OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Gene Symbol	Gene ID	Gene Info
OTP Ensembl NCBI GeneCards UniProt	ENSG00000171540.6	orthopedia homeobox
PHOX2B Ensembl NCBI GeneCards UniProt	ENSG00000109132.5	paired like homeobox 2B
LHX1 Ensembl NCBI GeneCards UniProt	ENSG00000132130.7	LIM homeobox 1
LMX1A Ensembl NCBI GeneCards UniProt	ENSG00000162761.10	LIM homeobox transcription factor 1 alpha
LHX5 Ensembl NCBI GeneCards UniProt	ENSG00000089116.3	LIM homeobox 5
HOXC4 Ensembl NCBI GeneCards UniProt	ENSG00000198353.6	homeobox C4
HOXC4 Ensembl NCBI GeneCards UniProt	ENSG00000273266.1	homeobox C4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXC4	hg19_v2_chr12_+_54447637_54447661	0.67	1.5e-01	Click!
LHX1	hg19_v2_chr17_+_35294075_35294102	-0.15	7.7e-01	Click!
OTP	hg19_v2_chr5_-_76935513_76935513	0.11	8.3e-01	Click!

Activity profile of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Sorted Z-values of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_-_327537 Show fit	1.49	ENST00000602735.1	IFITM3 Ensembl NCBI GeneCards UniProt Show fit	interferon induced transmembrane protein 3
chr14_+_20187174 Show fit	1.27	ENST00000557414.1	OR4N2 Ensembl NCBI GeneCards UniProt Show fit	olfactory receptor, family 4, subfamily N, member 2
chr10_+_91152303 Show fit	0.79	ENST00000371804.3	IFIT1 Ensembl NCBI GeneCards UniProt Show fit	interferon-induced protein with tetratricopeptide repeats 1
chr17_+_1674982 Show fit	0.71	ENST00000572048.1 ENST00000573763.1	SERPINF1 Ensembl NCBI GeneCards UniProt Show fit	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr5_-_126409159 Show fit	0.68	ENST00000607731.1 ENST00000535381.1 ENST00000296662.5 ENST00000509733.3	C5orf63 Ensembl NCBI GeneCards UniProt Show fit	chromosome 5 open reading frame 63
chr11_-_121986923 Show fit	0.48	ENST00000560104.1	BLID Ensembl NCBI GeneCards UniProt Show fit	BH3-like motif containing, cell death inducer
chr1_+_66820058 Show fit	0.46	ENST00000480109.2	PDE4B Ensembl NCBI GeneCards UniProt Show fit	phosphodiesterase 4B, cAMP-specific
chr10_+_94451574 Show fit	0.43	ENST00000492654.2	HHEX Ensembl NCBI GeneCards UniProt Show fit	hematopoietically expressed homeobox
chr19_-_36304201 Show fit	0.42	ENST00000301175.3	PRODH2 Ensembl NCBI GeneCards UniProt Show fit	proline dehydrogenase (oxidase) 2
chr2_+_182850551 Show fit	0.41	ENST00000452904.1 ENST00000409137.3 ENST00000280295.3	PPP1R1C Ensembl NCBI GeneCards UniProt Show fit	protein phosphatase 1, regulatory (inhibitor) subunit 1C

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.5	GO:0046597	negative regulation of viral entry into host cell(GO:0046597)
0.0	1.3	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.2	0.8	GO:0051097	negative regulation of helicase activity(GO:0051097)
0.0	0.8	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.1	0.7	GO:0071279	cellular response to cobalt ion(GO:0071279)
0.1	0.6	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.0	0.5	GO:1901898	negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1	0.4	GO:0010621	negative regulation of transcription by transcription factor localization(GO:0010621) gall bladder development(GO:0061010)
0.1	0.4	GO:0010133	proline catabolic process to glutamate(GO:0010133)
0.1	0.3	GO:0002416	IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)

Showing 1 to 10 of 44 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.7	GO:0043203	axon hillock(GO:0043203)
0.0	0.6	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.5	GO:0000930	gamma-tubulin complex(GO:0000930)
0.1	0.3	GO:0018444	translation release factor complex(GO:0018444)
0.0	0.3	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.0	0.2	GO:0002177	manchette(GO:0002177)
0.0	0.2	GO:0061617	MICOS complex(GO:0061617)
0.0	0.2	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	0.2	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.2	GO:0044233	ER-mitochondrion membrane contact site(GO:0044233)

Showing 1 to 10 of 18 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.3	GO:0004984	olfactory receptor activity(GO:0004984)
0.1	0.8	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1	0.4	GO:0004657	proline dehydrogenase activity(GO:0004657)
0.0	0.4	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.1	0.3	GO:0019770	IgG receptor activity(GO:0019770)
0.0	0.3	GO:0046790	virion binding(GO:0046790)
0.0	0.3	GO:0008131	primary amine oxidase activity(GO:0008131)
0.0	0.3	GO:0003747	translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0	0.3	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.3	GO:0070403	NAD+ binding(GO:0070403)

Showing 1 to 10 of 32 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
2.3	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
1.3	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.6	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.3	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.3	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.3	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.2	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle

Showing 1 to 7 of 7 entries

Results for OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Z-value: 0.84

Motif logo

Transcription factors associated with OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Activity-expression correlation:

Activity profile of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Sorted Z-values of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP:REACTOME category: