Project

A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

Navigation
Downloads

Results for OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Z-value: 0.84

Motif logo

logo of logo of logo of logo of logo of logo of

Transcription factors associated with OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Gene Symbol Gene ID Gene Info
OTP
ENSG00000171540.6 orthopedia homeobox
PHOX2B
ENSG00000109132.5 paired like homeobox 2B
LHX1
ENSG00000132130.7 LIM homeobox 1
LMX1A
ENSG00000162761.10 LIM homeobox transcription factor 1 alpha
LHX5
ENSG00000089116.3 LIM homeobox 5
HOXC4
ENSG00000198353.6 homeobox C4
HOXC4
ENSG00000273266.1 homeobox C4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXC4hg19_v2_chr12_+_54447637_544476610.671.5e-01Click!
LHX1hg19_v2_chr17_+_35294075_35294102-0.157.7e-01Click!
OTPhg19_v2_chr5_-_76935513_769355130.118.3e-01Click!

Activity profile of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Sorted Z-values of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_327537 1.49 ENST00000602735.1
IFITM3
interferon induced transmembrane protein 3
chr14_+_20187174 1.27 ENST00000557414.1
OR4N2
olfactory receptor, family 4, subfamily N, member 2
chr10_+_91152303 0.79 ENST00000371804.3
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr17_+_1674982 0.71 ENST00000572048.1
ENST00000573763.1
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr5_-_126409159 0.68 ENST00000607731.1
ENST00000535381.1
ENST00000296662.5
ENST00000509733.3
C5orf63
chromosome 5 open reading frame 63
chr11_-_121986923 0.48 ENST00000560104.1
BLID
BH3-like motif containing, cell death inducer
chr1_+_66820058 0.46 ENST00000480109.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chr10_+_94451574 0.43 ENST00000492654.2
HHEX
hematopoietically expressed homeobox
chr19_-_36304201 0.42 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr2_+_182850551 0.41 ENST00000452904.1
ENST00000409137.3
ENST00000280295.3
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr2_+_182850743 0.40 ENST00000409702.1
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr3_-_191000172 0.39 ENST00000427544.2
UTS2B
urotensin 2B
chr1_+_152178320 0.39 ENST00000429352.1
RP11-107M16.2
RP11-107M16.2
chr16_-_1538765 0.38 ENST00000447419.2
ENST00000440447.2
PTX4
pentraxin 4, long
chr3_+_138340049 0.38 ENST00000464668.1
FAIM
Fas apoptotic inhibitory molecule
chr4_+_113568207 0.37 ENST00000511529.1
LARP7
La ribonucleoprotein domain family, member 7
chr12_+_12510352 0.36 ENST00000298571.6
LOH12CR1
loss of heterozygosity, 12, chromosomal region 1
chr16_-_30122717 0.36 ENST00000566613.1
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr17_-_38821373 0.34 ENST00000394052.3
KRT222
keratin 222
chr6_-_41039567 0.33 ENST00000468811.1
OARD1
O-acyl-ADP-ribose deacylase 1
chr4_+_155484103 0.33 ENST00000302068.4
FGB
fibrinogen beta chain
chr4_+_155484155 0.31 ENST00000509493.1
FGB
fibrinogen beta chain
chr7_+_5465382 0.30 ENST00000609130.1
RP11-1275H24.2
RP11-1275H24.2
chr8_-_90769422 0.29 ENST00000524190.1
ENST00000523859.1
RP11-37B2.1
RP11-37B2.1
chrX_+_43515467 0.29 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr3_-_122283424 0.28 ENST00000477522.2
ENST00000360356.2
PARP9
poly (ADP-ribose) polymerase family, member 9
chr6_+_130339710 0.28 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
L3MBTL3
l(3)mbt-like 3 (Drosophila)
chr2_-_37068530 0.27 ENST00000593798.1
AC007382.1
Uncharacterized protein
chr4_-_39033963 0.26 ENST00000381938.3
TMEM156
transmembrane protein 156
chr12_-_112123524 0.26 ENST00000327551.6
BRAP
BRCA1 associated protein
chr12_+_104337515 0.25 ENST00000550595.1
HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chrX_+_51486481 0.25 ENST00000340438.4
GSPT2
G1 to S phase transition 2
chr2_+_152214098 0.24 ENST00000243347.3
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr12_+_78359999 0.24 ENST00000550503.1
NAV3
neuron navigator 3
chr7_+_133812052 0.23 ENST00000285928.2
LRGUK
leucine-rich repeats and guanylate kinase domain containing
chr6_+_26440700 0.23 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chr7_-_101272576 0.22 ENST00000223167.4
MYL10
myosin, light chain 10, regulatory
chr17_+_19091325 0.22 ENST00000584923.1
SNORD3A
small nucleolar RNA, C/D box 3A
chr8_-_124741451 0.22 ENST00000520519.1
ANXA13
annexin A13
chr17_+_48823975 0.21 ENST00000513969.1
ENST00000503728.1
LUC7L3
LUC7-like 3 (S. cerevisiae)
chr19_+_50016411 0.21 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr1_+_62439037 0.21 ENST00000545929.1
INADL
InaD-like (Drosophila)
chr10_-_99030395 0.20 ENST00000355366.5
ENST00000371027.1
ARHGAP19
Rho GTPase activating protein 19
chr3_+_23851928 0.20 ENST00000467766.1
ENST00000424381.1
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr2_-_43266680 0.20 ENST00000425212.1
ENST00000422351.1
ENST00000449766.1
AC016735.2
AC016735.2
chr12_-_54653313 0.20 ENST00000550411.1
ENST00000439541.2
CBX5
chromobox homolog 5
chrX_+_84258832 0.20 ENST00000373173.2
APOOL
apolipoprotein O-like
chr18_-_32870148 0.20 ENST00000589178.1
ENST00000333206.5
ENST00000592278.1
ENST00000592211.1
ENST00000420878.3
ENST00000383091.2
ENST00000586922.2
ZSCAN30
RP11-158H5.7
zinc finger and SCAN domain containing 30
RP11-158H5.7
chr4_+_95128748 0.19 ENST00000359052.4
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr14_-_54425475 0.18 ENST00000559642.1
BMP4
bone morphogenetic protein 4
chr12_+_64798095 0.18 ENST00000332707.5
XPOT
exportin, tRNA
chr4_+_76481258 0.17 ENST00000311623.4
ENST00000435974.2
C4orf26
chromosome 4 open reading frame 26
chr6_+_155334780 0.17 ENST00000538270.1
ENST00000535231.1
TIAM2
T-cell lymphoma invasion and metastasis 2
chr18_+_47087390 0.17 ENST00000583083.1
LIPG
lipase, endothelial
chr5_+_179135246 0.17 ENST00000508787.1
CANX
calnexin
chr7_+_138915102 0.17 ENST00000486663.1
UBN2
ubinuclein 2
chr7_-_87342564 0.17 ENST00000265724.3
ENST00000416177.1
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chrX_-_21676442 0.17 ENST00000379499.2
KLHL34
kelch-like family member 34
chr11_-_107729504 0.16 ENST00000265836.7
SLC35F2
solute carrier family 35, member F2
chr4_-_177116772 0.16 ENST00000280191.2
SPATA4
spermatogenesis associated 4
chr11_+_5710919 0.16 ENST00000379965.3
ENST00000425490.1
TRIM22
tripartite motif containing 22
chr2_+_191221240 0.16 ENST00000409027.1
ENST00000458193.1
INPP1
inositol polyphosphate-1-phosphatase
chr4_+_119809984 0.16 ENST00000307142.4
ENST00000448416.2
ENST00000429713.2
SYNPO2
synaptopodin 2
chr9_-_99540328 0.16 ENST00000223428.4
ENST00000375231.1
ENST00000374641.3
ZNF510
zinc finger protein 510
chr2_-_40680578 0.16 ENST00000455476.1
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr16_-_66583994 0.15 ENST00000564917.1
TK2
thymidine kinase 2, mitochondrial
chr3_+_139063372 0.15 ENST00000478464.1
MRPS22
mitochondrial ribosomal protein S22
chr12_-_118796971 0.15 ENST00000542902.1
TAOK3
TAO kinase 3
chr1_+_117544366 0.15 ENST00000256652.4
ENST00000369470.1
CD101
CD101 molecule
chr11_+_35222629 0.15 ENST00000526553.1
CD44
CD44 molecule (Indian blood group)
chr4_+_86525299 0.15 ENST00000512201.1
ARHGAP24
Rho GTPase activating protein 24
chr17_+_57233087 0.15 ENST00000578777.1
ENST00000577457.1
ENST00000582995.1
PRR11
proline rich 11
chr11_+_71934962 0.15 ENST00000543234.1
INPPL1
inositol polyphosphate phosphatase-like 1
chr3_-_141747950 0.14 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr2_-_74618907 0.14 ENST00000421392.1
ENST00000437375.1
DCTN1
dynactin 1
chrM_+_14741 0.14 ENST00000361789.2
MT-CYB
mitochondrially encoded cytochrome b
chrX_+_10126488 0.14 ENST00000380829.1
ENST00000421085.2
ENST00000454850.1
CLCN4
chloride channel, voltage-sensitive 4
chr16_-_28634874 0.14 ENST00000395609.1
ENST00000350842.4
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr3_+_44840679 0.13 ENST00000425755.1
KIF15
kinesin family member 15
chr3_-_141719195 0.13 ENST00000397991.4
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr1_-_212965104 0.13 ENST00000422588.2
ENST00000366975.6
ENST00000366977.3
ENST00000366976.1
NSL1
NSL1, MIS12 kinetochore complex component
chr17_+_68164752 0.13 ENST00000535240.1
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr19_-_36001113 0.13 ENST00000434389.1
DMKN
dermokine
chr5_+_89770664 0.13 ENST00000503973.1
ENST00000399107.1
POLR3G
polymerase (RNA) III (DNA directed) polypeptide G (32kD)
chr12_+_4130143 0.13 ENST00000543206.1
RP11-320N7.2
RP11-320N7.2
chr9_-_26947220 0.12 ENST00000520884.1
PLAA
phospholipase A2-activating protein
chr8_+_1919481 0.12 ENST00000518539.2
KBTBD11-OT1
KBTBD11 overlapping transcript 1 (non-protein coding)
chr5_+_66300446 0.12 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr1_+_212965170 0.12 ENST00000532324.1
ENST00000366974.4
ENST00000530441.1
ENST00000526641.1
ENST00000531963.1
ENST00000366973.4
ENST00000526997.1
ENST00000488246.2
TATDN3
TatD DNase domain containing 3
chr17_-_19015945 0.11 ENST00000573866.2
SNORD3D
small nucleolar RNA, C/D box 3D
chr11_-_107729287 0.11 ENST00000375682.4
SLC35F2
solute carrier family 35, member F2
chr4_+_158493642 0.11 ENST00000507108.1
ENST00000455598.1
ENST00000509450.1
RP11-364P22.1
RP11-364P22.1
chr18_-_47018869 0.11 ENST00000583036.1
ENST00000580261.1
RPL17
ribosomal protein L17
chr19_-_44388116 0.11 ENST00000587539.1
ZNF404
zinc finger protein 404
chr12_+_26164645 0.11 ENST00000542004.1
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr21_-_15583165 0.10 ENST00000536861.1
LIPI
lipase, member I
chr4_+_26324474 0.10 ENST00000514675.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr15_+_69857515 0.10 ENST00000559477.1
RP11-279F6.1
RP11-279F6.1
chr4_+_119810134 0.10 ENST00000434046.2
SYNPO2
synaptopodin 2
chr12_-_10282742 0.10 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chr3_+_138340067 0.09 ENST00000479848.1
FAIM
Fas apoptotic inhibitory molecule
chr5_+_89770696 0.09 ENST00000504930.1
ENST00000514483.1
POLR3G
polymerase (RNA) III (DNA directed) polypeptide G (32kD)
chr3_+_45927994 0.09 ENST00000357632.2
ENST00000395963.2
CCR9
chemokine (C-C motif) receptor 9
chr18_-_47018897 0.09 ENST00000418495.1
RPL17
ribosomal protein L17
chr16_-_66583701 0.09 ENST00000527800.1
ENST00000525974.1
ENST00000563369.2
TK2
thymidine kinase 2, mitochondrial
chr3_-_33686925 0.09 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
CLASP2
cytoplasmic linker associated protein 2
chr7_-_64023441 0.09 ENST00000309683.6
ZNF680
zinc finger protein 680
chr17_-_42992856 0.09 ENST00000588316.1
ENST00000435360.2
ENST00000586793.1
ENST00000588735.1
ENST00000588037.1
ENST00000592320.1
ENST00000253408.5
GFAP
glial fibrillary acidic protein
chr9_-_26947453 0.09 ENST00000397292.3
PLAA
phospholipase A2-activating protein
chr10_-_28571015 0.09 ENST00000375719.3
ENST00000375732.1
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr12_+_75784850 0.08 ENST00000550916.1
ENST00000435775.1
ENST00000378689.2
ENST00000378692.3
ENST00000320460.4
ENST00000547164.1
GLIPR1L2
GLI pathogenesis-related 1 like 2
chr1_+_151253991 0.08 ENST00000443959.1
ZNF687
zinc finger protein 687
chr18_+_47087055 0.08 ENST00000577628.1
LIPG
lipase, endothelial
chr10_-_25304889 0.08 ENST00000483339.2
ENKUR
enkurin, TRPC channel interacting protein
chr9_-_215744 0.08 ENST00000382387.2
C9orf66
chromosome 9 open reading frame 66
chr20_-_50418947 0.08 ENST00000371539.3
SALL4
spalt-like transcription factor 4
chr7_+_107224364 0.08 ENST00000491150.1
BCAP29
B-cell receptor-associated protein 29
chr12_+_41136144 0.08 ENST00000548005.1
ENST00000552248.1
CNTN1
contactin 1
chr20_-_33735070 0.08 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr11_+_114168085 0.08 ENST00000541754.1
NNMT
nicotinamide N-methyltransferase
chr4_+_26344754 0.08 ENST00000515573.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr3_+_20081515 0.07 ENST00000263754.4
KAT2B
K(lysine) acetyltransferase 2B
chrX_-_71458802 0.07 ENST00000373657.1
ENST00000334463.3
ERCC6L
excision repair cross-complementing rodent repair deficiency, complementation group 6-like
chr2_-_136678123 0.07 ENST00000422708.1
DARS
aspartyl-tRNA synthetase
chr3_-_185538849 0.07 ENST00000421047.2
IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr10_-_75415825 0.07 ENST00000394810.2
SYNPO2L
synaptopodin 2-like
chr1_+_160370344 0.07 ENST00000368061.2
VANGL2
VANGL planar cell polarity protein 2
chr4_+_87857538 0.07 ENST00000511442.1
AFF1
AF4/FMR2 family, member 1
chr2_+_202047843 0.07 ENST00000272879.5
ENST00000374650.3
ENST00000346817.5
ENST00000313728.7
ENST00000448480.1
CASP10
caspase 10, apoptosis-related cysteine peptidase
chr7_-_87856280 0.07 ENST00000490437.1
ENST00000431660.1
SRI
sorcin
chr12_+_28410128 0.07 ENST00000381259.1
ENST00000381256.1
CCDC91
coiled-coil domain containing 91
chr15_+_93443419 0.07 ENST00000557381.1
ENST00000420239.2
CHD2
chromodomain helicase DNA binding protein 2
chr18_-_51751132 0.07 ENST00000256429.3
MBD2
methyl-CpG binding domain protein 2
chr7_-_87856303 0.07 ENST00000394641.3
SRI
sorcin
chr12_+_64798826 0.07 ENST00000540203.1
XPOT
exportin, tRNA
chr4_-_170948361 0.07 ENST00000393702.3
MFAP3L
microfibrillar-associated protein 3-like
chr19_+_50016610 0.07 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr13_-_81801115 0.06 ENST00000567258.1
LINC00564
long intergenic non-protein coding RNA 564
chr8_+_132952112 0.06 ENST00000520362.1
ENST00000519656.1
EFR3A
EFR3 homolog A (S. cerevisiae)
chr4_-_185275104 0.06 ENST00000317596.3
RP11-290F5.2
RP11-290F5.2
chrX_-_106243294 0.06 ENST00000255495.7
MORC4
MORC family CW-type zinc finger 4
chr3_+_12329397 0.06 ENST00000397015.2
PPARG
peroxisome proliferator-activated receptor gamma
chr6_+_125304502 0.06 ENST00000519799.1
ENST00000368414.2
ENST00000359704.2
RNF217
ring finger protein 217
chr17_+_48823896 0.06 ENST00000511974.1
LUC7L3
LUC7-like 3 (S. cerevisiae)
chr17_-_64225508 0.06 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr17_-_45266542 0.06 ENST00000531206.1
ENST00000527547.1
ENST00000446365.2
ENST00000575483.1
ENST00000066544.3
CDC27
cell division cycle 27
chr2_-_191115229 0.06 ENST00000409820.2
ENST00000410045.1
HIBCH
3-hydroxyisobutyryl-CoA hydrolase
chr1_+_12806141 0.06 ENST00000288048.5
C1orf158
chromosome 1 open reading frame 158
chr20_+_22034809 0.06 ENST00000449427.1
RP11-125P18.1
RP11-125P18.1
chr2_-_231860596 0.06 ENST00000441063.1
ENST00000434094.1
ENST00000418330.1
ENST00000457803.1
ENST00000414876.1
ENST00000446741.1
ENST00000426904.1
AC105344.2
SPATA3 antisense RNA 1 (head to head)
chrX_-_106243451 0.06 ENST00000355610.4
ENST00000535534.1
MORC4
MORC family CW-type zinc finger 4
chr7_+_73868120 0.06 ENST00000265755.3
GTF2IRD1
GTF2I repeat domain containing 1
chr17_-_6524159 0.06 ENST00000589033.1
KIAA0753
KIAA0753
chr8_+_104384616 0.06 ENST00000520337.1
CTHRC1
collagen triple helix repeat containing 1
chr7_+_73868439 0.06 ENST00000424337.2
GTF2IRD1
GTF2I repeat domain containing 1
chr15_+_101417919 0.05 ENST00000561338.1
ALDH1A3
aldehyde dehydrogenase 1 family, member A3
chr13_+_103459704 0.05 ENST00000602836.1
BIVM-ERCC5
BIVM-ERCC5 readthrough
chr4_-_76944621 0.05 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr3_+_12329358 0.05 ENST00000309576.6
PPARG
peroxisome proliferator-activated receptor gamma
chr11_-_8857248 0.05 ENST00000534248.1
ENST00000530959.1
ENST00000531578.1
ENST00000533225.1
ST5
suppression of tumorigenicity 5
chr1_-_92371839 0.05 ENST00000370399.2
TGFBR3
transforming growth factor, beta receptor III
chr3_-_122233723 0.05 ENST00000493510.1
ENST00000344337.6
ENST00000476916.1
ENST00000465882.1
KPNA1
karyopherin alpha 1 (importin alpha 5)
chr5_-_53115506 0.05 ENST00000511953.1
ENST00000504552.1
CTD-2081C10.1
CTD-2081C10.1
chr14_-_21994337 0.05 ENST00000537235.1
ENST00000450879.2
SALL2
spalt-like transcription factor 2
chr1_-_92952433 0.05 ENST00000294702.5
GFI1
growth factor independent 1 transcription repressor
chr2_+_27886330 0.05 ENST00000326019.6
SLC4A1AP
solute carrier family 4 (anion exchanger), member 1, adaptor protein
chr2_-_8715616 0.05 ENST00000418358.1
AC011747.3
AC011747.3
chr1_+_180601139 0.05 ENST00000367590.4
ENST00000367589.3
XPR1
xenotropic and polytropic retrovirus receptor 1
chr8_-_62602327 0.05 ENST00000445642.3
ENST00000517847.2
ENST00000389204.4
ENST00000517661.1
ENST00000517903.1
ENST00000522603.1
ENST00000522349.1
ENST00000522835.1
ENST00000541428.1
ENST00000518306.1
ASPH
aspartate beta-hydroxylase
chr3_+_69812877 0.05 ENST00000457080.1
ENST00000328528.6
MITF
microphthalmia-associated transcription factor
chr17_+_12569472 0.05 ENST00000343344.4
MYOCD
myocardin
chr21_+_17909594 0.05 ENST00000441820.1
ENST00000602280.1
LINC00478
long intergenic non-protein coding RNA 478
chr3_+_130569429 0.05 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr17_+_66511540 0.05 ENST00000588188.2
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr15_-_75748115 0.05 ENST00000360439.4
SIN3A
SIN3 transcription regulator family member A
chr1_-_101360374 0.05 ENST00000535414.1
EXTL2
exostosin-like glycosyltransferase 2
chr4_+_186990298 0.05 ENST00000296795.3
ENST00000513189.1
TLR3
toll-like receptor 3
chr17_+_18086392 0.05 ENST00000541285.1
ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
chr22_+_17956618 0.04 ENST00000262608.8
CECR2
cat eye syndrome chromosome region, candidate 2
chr7_-_143599207 0.04 ENST00000355951.2
ENST00000479870.1
ENST00000478172.1
FAM115A
family with sequence similarity 115, member A
chr7_+_129932974 0.04 ENST00000445470.2
ENST00000222482.4
ENST00000492072.1
ENST00000473956.1
ENST00000493259.1
ENST00000486598.1
CPA4
carboxypeptidase A4
chr12_-_12674032 0.04 ENST00000298573.4
DUSP16
dual specificity phosphatase 16
chr3_-_151034734 0.04 ENST00000260843.4
GPR87
G protein-coupled receptor 87
chr7_-_150020750 0.04 ENST00000539352.1
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr11_-_107729887 0.04 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr3_+_157154578 0.04 ENST00000295927.3
PTX3
pentraxin 3, long
chr14_+_102276132 0.04 ENST00000350249.3
ENST00000557621.1
ENST00000556946.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr3_-_33686743 0.04 ENST00000333778.6
ENST00000539981.1
CLASP2
cytoplasmic linker associated protein 2
chr1_-_101360205 0.04 ENST00000450240.1
EXTL2
exostosin-like glycosyltransferase 2
chr7_-_37488547 0.04 ENST00000453399.1
ELMO1
engulfment and cell motility 1
chr8_-_95487331 0.04 ENST00000336148.5
RAD54B
RAD54 homolog B (S. cerevisiae)
chr3_+_69812701 0.04 ENST00000472437.1
MITF
microphthalmia-associated transcription factor
chr7_+_102553430 0.04 ENST00000339431.4
ENST00000249377.4
LRRC17
leucine rich repeat containing 17
chr14_+_102276209 0.04 ENST00000445439.3
ENST00000334743.5
ENST00000557095.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr4_+_5527117 0.04 ENST00000505296.1
C4orf6
chromosome 4 open reading frame 6
chr14_+_67831576 0.04 ENST00000555876.1
EIF2S1
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
chr12_-_10282836 0.04 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A
C-type lectin domain family 7, member A
chr14_-_51027838 0.04 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr7_-_150020578 0.03 ENST00000478393.1
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr20_-_34117447 0.03 ENST00000246199.2
ENST00000424444.1
ENST00000374345.4
ENST00000444723.1
C20orf173
chromosome 20 open reading frame 173

Network of associatons between targets according to the STRING database.

First level regulatory network of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.1 0.4 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621) gall bladder development(GO:0061010)
0.1 0.7 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.1 0.3 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.1 0.3 GO:0031247 actin rod assembly(GO:0031247)
0.1 0.3 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.1 0.3 GO:0010983 regulation of high-density lipoprotein particle clearance(GO:0010982) positive regulation of high-density lipoprotein particle clearance(GO:0010983)
0.1 0.4 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 0.6 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 1.5 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 0.2 GO:0046092 deoxycytidine metabolic process(GO:0046092)
0.0 0.2 GO:0072200 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.0 0.5 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.1 GO:2000230 regulation of cholesterol transporter activity(GO:0060694) negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.0 0.1 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.1 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.0 0.3 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 1.3 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.1 GO:0060490 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.0 0.2 GO:1901297 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.2 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.1 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 0.3 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.2 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.0 0.3 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.1 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0 0.1 GO:1903575 cornified envelope assembly(GO:1903575)
0.0 0.1 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.0 0.1 GO:0060166 olfactory pit development(GO:0060166)
0.0 0.8 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.0 0.1 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0 0.1 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.0 0.1 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 0.0 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.0 0.1 GO:0036511 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.0 0.2 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 0.1 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.0 0.0 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.0 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.0 0.0 GO:0097503 sialylation(GO:0097503)
0.0 0.0 GO:0034344 microglial cell activation involved in immune response(GO:0002282) type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.0 0.0 GO:0045209 MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209)
0.0 0.1 GO:0034699 transforming growth factor beta receptor complex assembly(GO:0007181) response to luteinizing hormone(GO:0034699) vasculogenesis involved in coronary vascular morphogenesis(GO:0060979)
0.0 0.1 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0018444 translation release factor complex(GO:0018444)
0.0 0.6 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0005873 plus-end kinesin complex(GO:0005873)
0.0 0.7 GO:0043203 axon hillock(GO:0043203)
0.0 0.2 GO:0002177 manchette(GO:0002177)
0.0 0.1 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 0.2 GO:0061617 MICOS complex(GO:0061617)
0.0 0.1 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.2 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.1 GO:0060187 cell pole(GO:0060187)
0.0 0.1 GO:0044326 dendritic spine neck(GO:0044326)
0.0 0.5 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.0 GO:0043614 multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993) astrocyte end-foot(GO:0097450) glial limiting end-foot(GO:0097451)
0.0 0.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.1 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.1 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.2 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.1 0.8 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 0.3 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.2 GO:0016005 phospholipase A2 activator activity(GO:0016005)
0.0 0.2 GO:0004137 deoxycytidine kinase activity(GO:0004137)
0.0 0.1 GO:0035248 alpha-1,4-N-acetylgalactosaminyltransferase activity(GO:0035248)
0.0 0.3 GO:0046790 virion binding(GO:0046790)
0.0 0.3 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.3 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.2 GO:0052829 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829)
0.0 0.2 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.0 1.3 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.3 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 0.2 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.2 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.4 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.1 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.0 0.1 GO:0030760 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.0 0.1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 0.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.1 GO:0070123 transforming growth factor beta receptor activity, type III(GO:0070123)
0.0 0.1 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.0 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.1 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.1 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.2 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.1 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.0 0.1 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 0.1 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.3 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.2 GO:0000150 recombinase activity(GO:0000150)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 1.3 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 2.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.3 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.3 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.2 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle