ISMARA results: OLIG2_NEUROD1

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for OLIG2_NEUROD1_ATOH1

Z-value: 1.18

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Transcription factors associated with OLIG2_NEUROD1_ATOH1

Gene Symbol	Gene ID	Gene Info
OLIG2 Ensembl NCBI GeneCards UniProt	ENSG00000205927.4	oligodendrocyte transcription factor 2
NEUROD1 Ensembl NCBI GeneCards UniProt	ENSG00000162992.3	neuronal differentiation 1
ATOH1 Ensembl NCBI GeneCards UniProt	ENSG00000172238.3	atonal bHLH transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NEUROD1	hg19_v2_chr2_-_182545603_182545603	-0.82	4.4e-02	Click!
OLIG2	hg19_v2_chr21_+_34398153_34398250	-0.31	5.5e-01	Click!

Activity profile of OLIG2_NEUROD1_ATOH1 motif

Sorted Z-values of OLIG2_NEUROD1_ATOH1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_58145889 Show fit	2.14	ENST00000547853.1	CDK4 Ensembl NCBI GeneCards UniProt Show fit	cyclin-dependent kinase 4
chr8_-_135522425 Show fit	2.02	ENST00000521673.1	ZFAT Ensembl NCBI GeneCards UniProt Show fit	zinc finger and AT hook domain containing
chr3_-_52486841 Show fit	1.21	ENST00000496590.1	TNNC1 Ensembl NCBI GeneCards UniProt Show fit	troponin C type 1 (slow)
chr5_-_159766528 Show fit	1.20	ENST00000505287.2	CCNJL Ensembl NCBI GeneCards UniProt Show fit	cyclin J-like
chr12_-_13105081 Show fit	1.18	ENST00000541128.1	GPRC5D Ensembl NCBI GeneCards UniProt Show fit	G protein-coupled receptor, family C, group 5, member D
chr19_+_41222998 Show fit	0.96	ENST00000263370.2	ITPKC Ensembl NCBI GeneCards UniProt Show fit	inositol-trisphosphate 3-kinase C
chr16_+_83932684 Show fit	0.92	ENST00000262430.4	MLYCD Ensembl NCBI GeneCards UniProt Show fit	malonyl-CoA decarboxylase
chr3_-_52869205 Show fit	0.92	ENST00000446157.2	MUSTN1 Ensembl NCBI GeneCards UniProt Show fit	musculoskeletal, embryonic nuclear protein 1
chr5_-_180632147 Show fit	0.88	ENST00000274773.7	TRIM7 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 7
chr17_+_45286706 Show fit	0.86	ENST00000393450.1 ENST00000572303.1	MYL4 Ensembl NCBI GeneCards UniProt Show fit	myosin, light chain 4, alkali; atrial, embryonic

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of OLIG2_NEUROD1_ATOH1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.7	GO:1904637	response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
0.1	2.1	GO:0060712	spongiotrophoblast layer development(GO:0060712)
0.0	1.6	GO:0010501	RNA secondary structure unwinding(GO:0010501)
0.3	1.2	GO:0032972	regulation of muscle filament sliding speed(GO:0032972)
0.0	1.0	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.2	0.9	GO:0036115	fatty-acyl-CoA catabolic process(GO:0036115)
0.0	0.9	GO:0002026	regulation of the force of heart contraction(GO:0002026)
0.0	0.9	GO:0097435	fibril organization(GO:0097435)
0.2	0.8	GO:0036371	protein localization to T-tubule(GO:0036371)
0.0	0.8	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)

Showing 1 to 10 of 150 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	2.7	GO:0097129	cyclin D2-CDK4 complex(GO:0097129)
0.0	2.1	GO:0031672	A band(GO:0031672)
0.0	1.7	GO:0031907	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2	1.2	GO:1990584	cardiac Troponin complex(GO:1990584)
0.0	0.9	GO:0002102	podosome(GO:0002102)
0.0	0.7	GO:0000421	autophagosome membrane(GO:0000421)
0.0	0.6	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.0	0.5	GO:0001940	male pronucleus(GO:0001940)
0.0	0.5	GO:0030126	COPI vesicle coat(GO:0030126)
0.0	0.5	GO:0030056	hemidesmosome(GO:0030056)

Showing 1 to 10 of 48 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.7	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0	1.8	GO:0004004	ATP-dependent RNA helicase activity(GO:0004004)
0.0	1.5	GO:0030507	spectrin binding(GO:0030507)
0.4	1.2	GO:0033867	Fas-activated serine/threonine kinase activity(GO:0033867)
0.0	1.1	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	1.0	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1	0.9	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.1	0.9	GO:0045159	myosin II binding(GO:0045159)
0.1	0.9	GO:0038062	protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0	0.9	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)

Showing 1 to 10 of 91 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.7	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	1.1	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	1.0	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0	1.0	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	1.0	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.8	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.0	0.7	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	0.5	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	0.4	PID CONE PATHWAY	Visual signal transduction: Cones
0.0	0.3	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling

Showing 1 to 10 of 12 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Total log-likelihood	Term	Description
2.8	REACTOME G1 PHASE	Genes involved in G1 Phase
1.7	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.7	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.6	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.6	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.5	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.5	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.5	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.5	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.5	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins

Showing 1 to 10 of 19 entries

Results for OLIG2_NEUROD1_ATOH1

Z-value: 1.18

Motif logo

Transcription factors associated with OLIG2_NEUROD1_ATOH1

Activity-expression correlation:

Activity profile of OLIG2_NEUROD1_ATOH1 motif

Sorted Z-values of OLIG2_NEUROD1_ATOH1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of OLIG2_NEUROD1_ATOH1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: