ISMARA results: NRF1

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NRF1

Z-value: 1.85

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Transcription factors associated with NRF1

Gene Symbol	Gene ID	Gene Info
NRF1 Ensembl NCBI GeneCards UniProt	ENSG00000106459.10	nuclear respiratory factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NRF1	hg19_v2_chr7_+_129251531_129251601	0.17	7.4e-01	Click!

Activity profile of NRF1 motif

Sorted Z-values of NRF1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_135915146 Show fit	2.76	ENST00000473093.1	MSL2 Ensembl NCBI GeneCards UniProt Show fit	male-specific lethal 2 homolog (Drosophila)
chr12_-_127630534 Show fit	1.65	ENST00000535022.1	RP11-575F12.2 Ensembl NCBI GeneCards UniProt Show fit	RP11-575F12.2
chr2_+_17935119 Show fit	1.64	ENST00000317402.7	GEN1 Ensembl NCBI GeneCards UniProt Show fit	GEN1 Holliday junction 5' flap endonuclease
chr10_-_99185798 Show fit	1.59	ENST00000439965.2	AL355490.1 Ensembl NCBI GeneCards UniProt Show fit	LOC644215 protein; Uncharacterized protein
chr12_+_112451222 Show fit	1.56	ENST00000552052.1	ERP29 Ensembl NCBI GeneCards UniProt Show fit	endoplasmic reticulum protein 29
chr4_-_56412713 Show fit	1.55	ENST00000435527.2	CLOCK Ensembl NCBI GeneCards UniProt Show fit	clock circadian regulator
chr2_+_99758161 Show fit	1.52	ENST00000409684.1	C2ORF15 Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein C2orf15
chr1_-_229406746 Show fit	1.45	ENST00000429227.1 ENST00000436334.1	RP5-1061H20.4 Ensembl NCBI GeneCards UniProt Show fit	RP5-1061H20.4
chr5_+_162887556 Show fit	1.44	ENST00000393915.4 ENST00000432118.2 ENST00000358715.3	HMMR Ensembl NCBI GeneCards UniProt Show fit	hyaluronan-mediated motility receptor (RHAMM)
chr18_+_11103 Show fit	1.42	ENST00000575820.1 ENST00000572573.1	AP005530.1 Ensembl NCBI GeneCards UniProt Show fit	AP005530.1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NRF1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.2	GO:0016254	preassembly of GPI anchor in ER membrane(GO:0016254)
0.1	2.5	GO:0000722	telomere maintenance via recombination(GO:0000722)
0.5	2.4	GO:0043335	protein unfolding(GO:0043335)
0.1	2.3	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.2	2.1	GO:0002084	protein depalmitoylation(GO:0002084)
0.1	2.1	GO:0071786	endoplasmic reticulum tubular network organization(GO:0071786)
0.7	2.0	GO:0071139	resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140)
0.4	1.9	GO:0006203	dGTP catabolic process(GO:0006203)
0.2	1.9	GO:0035092	sperm chromatin condensation(GO:0035092)
0.6	1.8	GO:0046963	3'-phosphoadenosine 5'-phosphosulfate transport(GO:0046963) 3'-phospho-5'-adenylyl sulfate transmembrane transport(GO:1902559)

Showing 1 to 10 of 401 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	3.9	GO:0072487	MSL complex(GO:0072487)
0.3	2.3	GO:0035061	interchromatin granule(GO:0035061)
0.1	2.3	GO:0033391	chromatoid body(GO:0033391)
0.1	2.2	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0	2.1	GO:0016235	aggresome(GO:0016235)
0.1	1.9	GO:0031045	dense core granule(GO:0031045)
0.1	1.9	GO:0030992	intraciliary transport particle B(GO:0030992)
0.1	1.8	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	1.7	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
0.1	1.6	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)

Showing 1 to 10 of 170 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.9	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
0.0	3.3	GO:0051087	chaperone binding(GO:0051087)
0.2	2.2	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1	2.2	GO:0008409	5'-3' exonuclease activity(GO:0008409)
0.1	2.1	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	2.0	GO:0019003	GDP binding(GO:0019003)
0.0	1.9	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.6	1.8	GO:0046964	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.0	1.8	GO:0070888	E-box binding(GO:0070888)
0.2	1.7	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)

Showing 1 to 10 of 226 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.1	PID PLK1 PATHWAY	PLK1 signaling events
0.0	1.9	PID BARD1 PATHWAY	BARD1 signaling events
0.0	1.4	PID BMP PATHWAY	BMP receptor signaling
0.0	1.4	PID TCPTP PATHWAY	Signaling events mediated by TCPTP
0.1	1.3	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.0	1.2	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.0	0.9	PID RAC1 PATHWAY	RAC1 signaling pathway
0.0	0.9	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	0.9	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.8	PID AURORA B PATHWAY	Aurora B signaling

Showing 1 to 10 of 26 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.8	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.1	3.2	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0	2.8	REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21	Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.1	2.0	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.1	1.8	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	1.8	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	1.7	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.1	1.5	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.1	1.5	REACTOME PROCESSING OF INTRONLESS PRE MRNAS	Genes involved in Processing of Intronless Pre-mRNAs
0.0	1.5	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis

Showing 1 to 10 of 64 entries

Results for NRF1

Z-value: 1.85

Motif logo

Transcription factors associated with NRF1

Activity-expression correlation:

Activity profile of NRF1 motif

Sorted Z-values of NRF1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NRF1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: