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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for NR3C1
Z-value: 0.99
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Transcription factors associated with NR3C1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR3C1 | hg19_v2_chr5_-_142782862_142782894 | 0.83 | 4.1e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr21_-_47352477 Show fit | 2.78 |
ENST00000593412.1
|
Uncharacterized protein |
|
| chr1_-_27998689 Show fit | 2.06 |
ENST00000339145.4
ENST00000362020.4 ENST00000361157.6 |
interferon, alpha-inducible protein 6 |
|
| chr8_-_145060593 Show fit | 1.13 |
ENST00000313059.5
ENST00000524918.1 ENST00000313028.7 ENST00000525773.1 |
poly (ADP-ribose) polymerase family, member 10 |
|
| chr2_-_191878162 Show fit | 1.05 |
ENST00000540176.1
|
signal transducer and activator of transcription 1, 91kDa |
|
| chr12_-_7245125 Show fit | 0.72 |
ENST00000542285.1
ENST00000540610.1 |
complement component 1, r subcomponent |
|
| chr7_-_95225768 Show fit | 0.69 |
ENST00000005178.5
|
pyruvate dehydrogenase kinase, isozyme 4 |
|
| chr19_+_15783879 Show fit | 0.68 |
ENST00000551607.1
|
cytochrome P450, family 4, subfamily F, polypeptide 12 |
|
| chr2_+_114163945 Show fit | 0.63 |
ENST00000453673.3
|
immunoglobulin kappa variable 1/OR2-108 (non-functional) |
|
| chr4_+_9446156 Show fit | 0.62 |
ENST00000334879.1
|
defensin, beta 131 |
|
| chr1_+_218683438 Show fit | 0.62 |
ENST00000443836.1
|
chromosome 1 open reading frame 143 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR3C1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.1 | GO:0051902 | negative regulation of mitochondrial depolarization(GO:0051902) |
| 0.0 | 1.7 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.3 | 1.1 | GO:0046725 | negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) |
| 0.2 | 1.1 | GO:0010847 | regulation of chromatin assembly(GO:0010847) |
| 0.1 | 1.0 | GO:0072520 | seminiferous tubule development(GO:0072520) |
| 0.0 | 0.9 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.1 | 0.7 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
| 0.0 | 0.7 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
| 0.0 | 0.7 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
| 0.0 | 0.7 | GO:0050716 | positive regulation of interleukin-1 secretion(GO:0050716) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.2 | 1.2 | GO:0005958 | DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) |
| 0.1 | 0.8 | GO:0034991 | nuclear meiotic cohesin complex(GO:0034991) |
| 0.0 | 0.7 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.1 | 0.6 | GO:0016272 | prefoldin complex(GO:0016272) |
| 0.1 | 0.6 | GO:0030915 | Smc5-Smc6 complex(GO:0030915) |
| 0.0 | 0.6 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.0 | 0.6 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
| 0.0 | 0.6 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.0 | 0.5 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 1.2 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 1.0 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.0 | 1.0 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.2 | 0.8 | GO:0008670 | 2,4-dienoyl-CoA reductase (NADPH) activity(GO:0008670) |
| 0.0 | 0.8 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 0.8 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.2 | 0.7 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
| 0.2 | 0.5 | GO:0018685 | alkane 1-monooxygenase activity(GO:0018685) |
| 0.0 | 0.5 | GO:0016018 | cyclosporin A binding(GO:0016018) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.1 | 1.1 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.0 | 0.8 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 0.7 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.6 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.5 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 0.1 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 1.2 | REACTOME INTEGRATION OF PROVIRUS | Genes involved in Integration of provirus |
| 0.1 | 1.1 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 1.1 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 0.8 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 0.7 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 0.7 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.0 | 0.6 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 0.6 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.1 | 0.5 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |