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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NR1D1

Z-value: 0.47

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Transcription factors associated with NR1D1

Gene Symbol Gene ID Gene Info
NR1D1
ENSG00000126368.5 nuclear receptor subfamily 1 group D member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR1D1hg19_v2_chr17_-_38256973_38256990-0.786.6e-02Click!

Activity profile of NR1D1 motif

Sorted Z-values of NR1D1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_182703688 0.45 ENST00000466812.1
ENST00000487822.1
ENST00000460412.1
ENST00000469954.1
DCUN1D1
DCN1, defective in cullin neddylation 1, domain containing 1
chr7_+_64126535 0.41 ENST00000344930.3
ZNF107
zinc finger protein 107
chr17_-_59940705 0.39 ENST00000577913.1
BRIP1
BRCA1 interacting protein C-terminal helicase 1
chr19_+_21203426 0.34 ENST00000261560.5
ENST00000599548.1
ENST00000594110.1
ZNF430
zinc finger protein 430
chr19_+_38880695 0.31 ENST00000587947.1
ENST00000338502.4
SPRED3
sprouty-related, EVH1 domain containing 3
chr22_-_20138302 0.29 ENST00000540078.1
ENST00000439765.2
AC006547.14
uncharacterized protein LOC388849
chr9_+_91150016 0.26 ENST00000375854.3
ENST00000375855.3
NXNL2
nucleoredoxin-like 2
chr9_+_116343192 0.26 ENST00000471324.2
RGS3
regulator of G-protein signaling 3
chr5_-_111312622 0.26 ENST00000395634.3
NREP
neuronal regeneration related protein
chrX_+_54947229 0.23 ENST00000442098.1
ENST00000430420.1
ENST00000453081.1
ENST00000173898.7
ENST00000319167.8
ENST00000375022.4
ENST00000399736.1
ENST00000440072.1
ENST00000420798.2
ENST00000431115.1
ENST00000440759.1
ENST00000375041.2
TRO
trophinin
chr12_-_123755639 0.23 ENST00000535979.1
CDK2AP1
cyclin-dependent kinase 2 associated protein 1
chr1_-_197169672 0.22 ENST00000367405.4
ZBTB41
zinc finger and BTB domain containing 41
chr1_+_44398943 0.21 ENST00000372359.5
ENST00000414809.3
ARTN
artemin
chr7_+_94139105 0.21 ENST00000297273.4
CASD1
CAS1 domain containing 1
chr19_-_23578220 0.21 ENST00000595533.1
ENST00000397082.2
ENST00000599743.1
ENST00000300619.7
ZNF91
zinc finger protein 91
chr3_-_45957088 0.21 ENST00000539217.1
LZTFL1
leucine zipper transcription factor-like 1
chr17_-_38074842 0.20 ENST00000309481.7
GSDMB
gasdermin B
chr19_-_23433144 0.20 ENST00000418100.1
ENST00000597537.1
ENST00000597037.1
ZNF724P
zinc finger protein 724, pseudogene
chr19_-_42927251 0.18 ENST00000597001.1
LIPE
lipase, hormone-sensitive
chr19_-_58071166 0.18 ENST00000601415.1
ZNF550
zinc finger protein 550
chr6_-_135424186 0.18 ENST00000529882.1
HBS1L
HBS1-like (S. cerevisiae)
chr14_-_50999307 0.17 ENST00000013125.4
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr14_-_24733444 0.17 ENST00000560478.1
ENST00000560443.1
TGM1
transglutaminase 1
chr17_-_38074859 0.16 ENST00000520542.1
ENST00000418519.1
ENST00000394179.1
GSDMB
gasdermin B
chr10_-_105156198 0.16 ENST00000369815.1
ENST00000309579.3
ENST00000337003.4
USMG5
up-regulated during skeletal muscle growth 5 homolog (mouse)
chr1_+_110210644 0.16 ENST00000369831.2
ENST00000442650.1
ENST00000369827.3
ENST00000460717.3
ENST00000241337.4
ENST00000467579.3
ENST00000414179.2
ENST00000369829.2
GSTM2
glutathione S-transferase mu 2 (muscle)
chr17_-_72588422 0.15 ENST00000375352.1
CD300LD
CD300 molecule-like family member d
chr3_+_169755715 0.15 ENST00000355897.5
GPR160
G protein-coupled receptor 160
chr19_+_35810164 0.13 ENST00000598537.1
CD22
CD22 molecule
chr17_-_79139817 0.13 ENST00000326724.4
AATK
apoptosis-associated tyrosine kinase
chr19_+_21324863 0.12 ENST00000598331.1
ZNF431
zinc finger protein 431
chr11_-_125365435 0.11 ENST00000524435.1
FEZ1
fasciculation and elongation protein zeta 1 (zygin I)
chr10_-_8095412 0.11 ENST00000458727.1
ENST00000355358.1
RP11-379F12.3
GATA3-AS1
RP11-379F12.3
GATA3 antisense RNA 1
chr1_-_11865982 0.11 ENST00000418034.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr5_-_43313574 0.11 ENST00000325110.6
ENST00000433297.2
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr14_-_50999190 0.10 ENST00000557390.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr19_-_51220176 0.10 ENST00000359082.3
ENST00000293441.1
SHANK1
SH3 and multiple ankyrin repeat domains 1
chr7_-_100493482 0.10 ENST00000411582.1
ENST00000419336.2
ENST00000241069.5
ENST00000302913.4
ACHE
acetylcholinesterase (Yt blood group)
chr1_-_26232522 0.10 ENST00000399728.1
STMN1
stathmin 1
chr3_+_58223228 0.09 ENST00000478253.1
ENST00000295962.4
ABHD6
abhydrolase domain containing 6
chr2_+_203776937 0.09 ENST00000402905.3
ENST00000414490.1
ENST00000431787.1
ENST00000444724.1
ENST00000414857.1
ENST00000430899.1
ENST00000445120.1
ENST00000441569.1
ENST00000432024.1
ENST00000443740.1
ENST00000414439.1
ENST00000428585.1
ENST00000545253.1
ENST00000545262.1
ENST00000447539.1
ENST00000456821.2
ENST00000434998.1
ENST00000320443.8
CARF
calcium responsive transcription factor
chr9_+_136243117 0.09 ENST00000426926.2
ENST00000371957.3
C9orf96
chromosome 9 open reading frame 96
chr6_+_63921351 0.08 ENST00000370659.1
FKBP1C
FK506 binding protein 1C
chr14_+_50999744 0.08 ENST00000441560.2
ATL1
atlastin GTPase 1
chr6_+_76458990 0.08 ENST00000369977.3
MYO6
myosin VI
chr1_-_26233423 0.08 ENST00000357865.2
STMN1
stathmin 1
chr3_-_49203744 0.08 ENST00000321895.6
CCDC71
coiled-coil domain containing 71
chr17_-_74528128 0.08 ENST00000590175.1
CYGB
cytoglobin
chr12_-_110883346 0.08 ENST00000547365.1
ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr1_+_218519577 0.08 ENST00000366930.4
ENST00000366929.4
TGFB2
transforming growth factor, beta 2
chr16_-_70712229 0.08 ENST00000562883.2
MTSS1L
metastasis suppressor 1-like
chr19_+_21265028 0.08 ENST00000291770.7
ZNF714
zinc finger protein 714
chr15_-_65903407 0.07 ENST00000395644.4
ENST00000567744.1
ENST00000568573.1
ENST00000562830.1
ENST00000569491.1
ENST00000561769.1
VWA9
von Willebrand factor A domain containing 9
chr8_+_101162812 0.07 ENST00000353107.3
ENST00000522439.1
POLR2K
polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
chr2_+_63816295 0.07 ENST00000539945.1
ENST00000544381.1
MDH1
malate dehydrogenase 1, NAD (soluble)
chr4_-_21699380 0.07 ENST00000382148.3
KCNIP4
Kv channel interacting protein 4
chr15_+_65903680 0.07 ENST00000537259.1
SLC24A1
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
chr1_+_161719552 0.07 ENST00000367943.4
DUSP12
dual specificity phosphatase 12
chr16_+_4606347 0.07 ENST00000444310.4
C16orf96
chromosome 16 open reading frame 96
chr9_-_131155773 0.06 ENST00000608502.1
MIR219-2
microRNA 219-2
chr9_-_37592561 0.06 ENST00000544379.1
ENST00000377773.5
ENST00000401811.3
ENST00000321301.6
TOMM5
translocase of outer mitochondrial membrane 5 homolog (yeast)
chr7_-_37488547 0.06 ENST00000453399.1
ELMO1
engulfment and cell motility 1
chr17_+_6899366 0.06 ENST00000251535.6
ALOX12
arachidonate 12-lipoxygenase
chr19_-_19932501 0.06 ENST00000540806.2
ENST00000590766.1
ENST00000587452.1
ENST00000545006.1
ENST00000590319.1
ENST00000587461.1
ENST00000450683.2
ENST00000443905.2
ENST00000590274.1
ZNF506
CTC-559E9.4
zinc finger protein 506
CTC-559E9.4
chr6_-_27440837 0.06 ENST00000211936.6
ZNF184
zinc finger protein 184
chr19_+_21264943 0.06 ENST00000597424.1
ZNF714
zinc finger protein 714
chr3_-_52002194 0.06 ENST00000466412.1
PCBP4
poly(rC) binding protein 4
chr19_-_18995029 0.05 ENST00000596048.1
CERS1
ceramide synthase 1
chr4_+_1873155 0.05 ENST00000507820.1
ENST00000514045.1
WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr17_-_1029866 0.05 ENST00000570525.1
ABR
active BCR-related
chr3_-_117716418 0.05 ENST00000484092.1
RP11-384F7.2
RP11-384F7.2
chr19_+_22235279 0.05 ENST00000594363.1
ENST00000597927.1
ENST00000594947.1
ZNF257
zinc finger protein 257
chr1_-_26232951 0.05 ENST00000426559.2
ENST00000455785.2
STMN1
stathmin 1
chr13_+_113622757 0.05 ENST00000375604.2
MCF2L
MCF.2 cell line derived transforming sequence-like
chr1_+_159796534 0.04 ENST00000289707.5
SLAMF8
SLAM family member 8
chr7_+_64126503 0.04 ENST00000360117.3
ZNF107
zinc finger protein 107
chr9_+_101569944 0.04 ENST00000375011.3
GALNT12
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)
chrX_+_24167746 0.04 ENST00000428571.1
ENST00000539115.1
ZFX
zinc finger protein, X-linked
chr7_-_128694927 0.04 ENST00000471166.1
ENST00000265388.5
TNPO3
transportin 3
chr9_+_126773880 0.04 ENST00000373615.4
LHX2
LIM homeobox 2
chr15_-_65903512 0.04 ENST00000567923.1
VWA9
von Willebrand factor A domain containing 9
chr16_+_71392616 0.04 ENST00000349553.5
ENST00000302628.4
ENST00000562305.1
CALB2
calbindin 2
chr13_+_113622810 0.04 ENST00000397030.1
MCF2L
MCF.2 cell line derived transforming sequence-like
chr1_-_226374373 0.04 ENST00000366812.5
ACBD3
acyl-CoA binding domain containing 3
chr2_+_63816269 0.04 ENST00000432309.1
MDH1
malate dehydrogenase 1, NAD (soluble)
chr5_-_43313269 0.04 ENST00000511774.1
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr8_+_11561660 0.04 ENST00000526716.1
ENST00000335135.4
ENST00000528027.1
GATA4
GATA binding protein 4
chr6_+_31543334 0.03 ENST00000449264.2
TNF
tumor necrosis factor
chr3_+_169755919 0.03 ENST00000492492.1
GPR160
G protein-coupled receptor 160
chr2_+_63816087 0.03 ENST00000409908.1
ENST00000442225.1
ENST00000409476.1
ENST00000436321.1
MDH1
malate dehydrogenase 1, NAD (soluble)
chr6_+_76458909 0.03 ENST00000369981.3
ENST00000369985.4
MYO6
myosin VI
chr7_-_100493744 0.03 ENST00000428317.1
ENST00000441605.1
ACHE
acetylcholinesterase (Yt blood group)
chr13_+_100741269 0.02 ENST00000376286.4
ENST00000376279.3
ENST00000376285.1
PCCA
propionyl CoA carboxylase, alpha polypeptide
chrX_+_68725084 0.02 ENST00000252338.4
FAM155B
family with sequence similarity 155, member B
chr1_-_11865351 0.02 ENST00000413656.1
ENST00000376585.1
ENST00000423400.1
ENST00000431243.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr2_-_89513402 0.02 ENST00000498435.1
IGKV1-27
immunoglobulin kappa variable 1-27
chrY_+_2803322 0.02 ENST00000383052.1
ENST00000155093.3
ENST00000449237.1
ENST00000443793.1
ZFY
zinc finger protein, Y-linked
chr7_-_44229022 0.02 ENST00000403799.3
GCK
glucokinase (hexokinase 4)
chr2_+_113342163 0.02 ENST00000409719.1
CHCHD5
coiled-coil-helix-coiled-coil-helix domain containing 5
chr12_-_7125770 0.02 ENST00000261407.4
LPCAT3
lysophosphatidylcholine acyltransferase 3
chr10_+_23217006 0.01 ENST00000376528.4
ENST00000447081.1
ARMC3
armadillo repeat containing 3
chr17_-_36347030 0.01 ENST00000518551.1
TBC1D3
TBC1 domain family, member 3
chr1_+_197382957 0.01 ENST00000367397.1
CRB1
crumbs homolog 1 (Drosophila)
chr1_-_32403903 0.01 ENST00000344035.6
ENST00000356536.3
PTP4A2
protein tyrosine phosphatase type IVA, member 2
chr2_+_63816126 0.01 ENST00000454035.1
MDH1
malate dehydrogenase 1, NAD (soluble)
chr9_-_35112376 0.01 ENST00000488109.2
FAM214B
family with sequence similarity 214, member B
chr15_-_65903574 0.01 ENST00000420799.2
ENST00000313182.2
ENST00000431261.2
ENST00000442903.3
VWA9
von Willebrand factor A domain containing 9
chr16_-_18468926 0.01 ENST00000545114.1
RP11-1212A22.4
LOC339047 protein; Nuclear pore complex-interacting protein family member A3; Nuclear pore complex-interacting protein family member A5; Protein PKD1P1
chr19_+_22235310 0.01 ENST00000600162.1
ZNF257
zinc finger protein 257
chr2_-_73053126 0.01 ENST00000272427.6
ENST00000410104.1
EXOC6B
exocyst complex component 6B
chr1_+_2398876 0.01 ENST00000449969.1
PLCH2
phospholipase C, eta 2
chr1_-_154178803 0.01 ENST00000368525.3
C1orf189
chromosome 1 open reading frame 189
chr19_-_22605136 0.01 ENST00000357774.5
ENST00000601553.1
ENST00000593657.1
ZNF98
zinc finger protein 98
chr18_-_19284724 0.01 ENST00000580981.1
ENST00000289119.2
ABHD3
abhydrolase domain containing 3
chr2_+_220306745 0.01 ENST00000431523.1
ENST00000396698.1
ENST00000396695.2
SPEG
SPEG complex locus
chr1_-_6557156 0.01 ENST00000537245.1
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr13_+_113623509 0.00 ENST00000535094.2
MCF2L
MCF.2 cell line derived transforming sequence-like
chr17_-_76128488 0.00 ENST00000322914.3
TMC6
transmembrane channel-like 6
chrX_-_49089771 0.00 ENST00000376251.1
ENST00000323022.5
ENST00000376265.2
CACNA1F
calcium channel, voltage-dependent, L type, alpha 1F subunit
chr14_-_50999373 0.00 ENST00000554273.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr1_-_41131326 0.00 ENST00000372684.3
RIMS3
regulating synaptic membrane exocytosis 3
chr17_+_15637150 0.00 ENST00000578506.1
TBC1D26
TBC1 domain family, member 26
chr22_-_28316116 0.00 ENST00000415296.1
PITPNB
phosphatidylinositol transfer protein, beta

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1D1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0000706 meiotic DNA double-strand break processing(GO:0000706) double-strand break repair involved in meiotic recombination(GO:1990918)
0.1 0.2 GO:1903565 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.0 0.2 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.0 0.1 GO:0045212 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.0 0.1 GO:0050894 determination of affect(GO:0050894)
0.0 0.2 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.0 0.1 GO:0003275 apoptotic process involved in outflow tract morphogenesis(GO:0003275) uterine wall breakdown(GO:0042704) positive regulation of catagen(GO:0051795) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.0 0.2 GO:0097021 lymphocyte migration into lymphoid organs(GO:0097021)
0.0 0.2 GO:0070458 cellular detoxification of nitrogen compound(GO:0070458)
0.0 0.2 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.0 0.5 GO:0045116 protein neddylation(GO:0045116)
0.0 0.1 GO:0072720 cellular response to mycotoxin(GO:0036146) response to dithiothreitol(GO:0072720)
0.0 0.2 GO:0015074 DNA integration(GO:0015074)
0.0 0.1 GO:0071926 endocannabinoid signaling pathway(GO:0071926) regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 0.1 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 0.1 GO:0035865 cellular response to potassium ion(GO:0035865)
0.0 0.1 GO:2000490 negative regulation of hepatic stellate cell activation(GO:2000490)
0.0 0.0 GO:1901671 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925) positive regulation of translational initiation by iron(GO:0045994) positive regulation of superoxide dismutase activity(GO:1901671) positive regulation of removal of superoxide radicals(GO:1904833)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.0 0.2 GO:0047860 diiodophenylpyruvate reductase activity(GO:0047860)
0.0 0.1 GO:0060001 minus-end directed microfilament motor activity(GO:0060001)
0.0 0.2 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.1 GO:0031877 somatostatin receptor binding(GO:0031877)
0.0 0.1 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.0 0.1 GO:0047888 fatty acid peroxidase activity(GO:0047888)
0.0 0.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.5 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.3 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.2 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks