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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NOTO_VSX2_DLX2_DLX6_NKX6-1

Z-value: 0.82

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Transcription factors associated with NOTO_VSX2_DLX2_DLX6_NKX6-1

Gene Symbol Gene ID Gene Info
NOTO
ENSG00000214513.3 notochord homeobox
VSX2
ENSG00000119614.2 visual system homeobox 2
DLX2
ENSG00000115844.6 distal-less homeobox 2
DLX6
ENSG00000006377.9 distal-less homeobox 6
NKX6-1
ENSG00000163623.5 NK6 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DLX2hg19_v2_chr2_-_172967621_1729676370.901.5e-02Click!
NOTOhg19_v2_chr2_+_73429386_734293860.901.5e-02Click!
DLX6hg19_v2_chr7_+_96635277_96635301-0.562.5e-01Click!
NKX6-1hg19_v2_chr4_-_85418103_854181030.345.1e-01Click!

Activity profile of NOTO_VSX2_DLX2_DLX6_NKX6-1 motif

Sorted Z-values of NOTO_VSX2_DLX2_DLX6_NKX6-1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_39150385 1.02 ENST00000391586.1
KRTAP3-3
keratin associated protein 3-3
chr7_-_14029283 0.81 ENST00000433547.1
ENST00000405192.2
ETV1
ets variant 1
chr6_+_131571535 0.71 ENST00000474850.2
AKAP7
A kinase (PRKA) anchor protein 7
chr3_-_57233966 0.70 ENST00000473921.1
ENST00000295934.3
HESX1
HESX homeobox 1
chr17_-_77924627 0.67 ENST00000572862.1
ENST00000573782.1
ENST00000574427.1
ENST00000570373.1
ENST00000340848.7
ENST00000576768.1
TBC1D16
TBC1 domain family, member 16
chr2_+_66918558 0.64 ENST00000435389.1
ENST00000428590.1
ENST00000412944.1
AC007392.3
AC007392.3
chr19_-_7698599 0.58 ENST00000311069.5
PCP2
Purkinje cell protein 2
chr4_-_89442940 0.54 ENST00000527353.1
PIGY
phosphatidylinositol glycan anchor biosynthesis, class Y
chr2_-_99871570 0.51 ENST00000333017.2
ENST00000409679.1
ENST00000423306.1
LYG2
lysozyme G-like 2
chr1_-_159832438 0.48 ENST00000368100.1
VSIG8
V-set and immunoglobulin domain containing 8
chr20_-_60294804 0.47 ENST00000317652.1
RP11-429E11.3
Uncharacterized protein
chr1_-_234667504 0.45 ENST00000421207.1
ENST00000435574.1
RP5-855F14.1
RP5-855F14.1
chr1_-_183538319 0.40 ENST00000420553.1
ENST00000419402.1
NCF2
neutrophil cytosolic factor 2
chr19_-_56110859 0.39 ENST00000221665.3
ENST00000592585.1
FIZ1
FLT3-interacting zinc finger 1
chr7_-_84122033 0.39 ENST00000424555.1
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr4_+_3388057 0.39 ENST00000538395.1
RGS12
regulator of G-protein signaling 12
chr21_+_17909594 0.39 ENST00000441820.1
ENST00000602280.1
LINC00478
long intergenic non-protein coding RNA 478
chr12_-_28122980 0.37 ENST00000395868.3
ENST00000534890.1
PTHLH
parathyroid hormone-like hormone
chr15_+_75080883 0.36 ENST00000567571.1
CSK
c-src tyrosine kinase
chr5_+_66300464 0.35 ENST00000436277.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr17_-_78450398 0.35 ENST00000306773.4
NPTX1
neuronal pentraxin I
chr15_+_58702742 0.34 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr17_+_59489112 0.34 ENST00000335108.2
C17orf82
chromosome 17 open reading frame 82
chr4_+_139694701 0.32 ENST00000502606.1
RP11-98O2.1
RP11-98O2.1
chr17_-_39623681 0.32 ENST00000225899.3
KRT32
keratin 32
chr17_+_61151306 0.32 ENST00000580068.1
ENST00000580466.1
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr14_-_101295407 0.30 ENST00000596284.1
AL117190.2
AL117190.2
chr12_-_28123206 0.29 ENST00000542963.1
ENST00000535992.1
PTHLH
parathyroid hormone-like hormone
chrX_-_133792480 0.29 ENST00000359237.4
PLAC1
placenta-specific 1
chr3_-_12587055 0.28 ENST00000564146.3
C3orf83
chromosome 3 open reading frame 83
chr17_-_38928414 0.28 ENST00000335552.4
KRT26
keratin 26
chr5_+_137722255 0.28 ENST00000542866.1
KDM3B
lysine (K)-specific demethylase 3B
chr14_-_57197224 0.28 ENST00000554597.1
ENST00000556696.1
RP11-1085N6.3
Uncharacterized protein
chr18_+_61445205 0.28 ENST00000431370.1
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr6_+_4087664 0.26 ENST00000430835.2
C6orf201
chromosome 6 open reading frame 201
chr8_-_42358742 0.26 ENST00000517366.1
SLC20A2
solute carrier family 20 (phosphate transporter), member 2
chr1_-_36020531 0.26 ENST00000440579.1
ENST00000494948.1
KIAA0319L
KIAA0319-like
chr14_+_59100774 0.25 ENST00000556859.1
ENST00000421793.1
DACT1
dishevelled-binding antagonist of beta-catenin 1
chr9_+_12693336 0.25 ENST00000381137.2
ENST00000388918.5
TYRP1
tyrosinase-related protein 1
chr5_+_133562095 0.25 ENST00000602919.1
CTD-2410N18.3
CTD-2410N18.3
chr6_-_32157947 0.24 ENST00000375050.4
PBX2
pre-B-cell leukemia homeobox 2
chr20_+_42187608 0.24 ENST00000373100.1
SGK2
serum/glucocorticoid regulated kinase 2
chrX_+_139791917 0.23 ENST00000607004.1
ENST00000370535.3
LINC00632
long intergenic non-protein coding RNA 632
chr1_-_9953295 0.22 ENST00000377258.1
CTNNBIP1
catenin, beta interacting protein 1
chr16_-_30102547 0.22 ENST00000279386.2
TBX6
T-box 6
chr7_-_55620433 0.22 ENST00000418904.1
VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr4_+_108815402 0.22 ENST00000503385.1
SGMS2
sphingomyelin synthase 2
chr4_-_74486109 0.22 ENST00000395777.2
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr5_+_174151536 0.22 ENST00000239243.6
ENST00000507785.1
MSX2
msh homeobox 2
chr4_-_74486347 0.22 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr17_+_48243352 0.21 ENST00000344627.6
ENST00000262018.3
ENST00000543315.1
ENST00000451235.2
ENST00000511303.1
SGCA
sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
chr1_+_74701062 0.21 ENST00000326637.3
TNNI3K
TNNI3 interacting kinase
chr2_-_145188137 0.21 ENST00000440875.1
ZEB2
zinc finger E-box binding homeobox 2
chr4_+_169418195 0.21 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chr3_+_157154578 0.20 ENST00000295927.3
PTX3
pentraxin 3, long
chr9_-_16276311 0.20 ENST00000380685.1
C9orf92
chromosome 9 open reading frame 92
chr16_+_69345243 0.19 ENST00000254950.11
VPS4A
vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr12_-_118796910 0.19 ENST00000541186.1
ENST00000539872.1
TAOK3
TAO kinase 3
chr19_+_48949087 0.19 ENST00000598711.1
GRWD1
glutamate-rich WD repeat containing 1
chr17_-_48133054 0.18 ENST00000499842.1
RP11-1094H24.4
RP11-1094H24.4
chr3_-_27764190 0.18 ENST00000537516.1
EOMES
eomesodermin
chr6_+_135502501 0.18 ENST00000527615.1
ENST00000420123.2
ENST00000525369.1
ENST00000528774.1
ENST00000534121.1
ENST00000534044.1
ENST00000533624.1
MYB
v-myb avian myeloblastosis viral oncogene homolog
chr3_-_157824292 0.18 ENST00000483851.2
SHOX2
short stature homeobox 2
chr7_-_99716914 0.18 ENST00000431404.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr16_+_22501658 0.18 ENST00000415833.2
NPIPB5
nuclear pore complex interacting protein family, member B5
chr13_-_74993252 0.17 ENST00000325811.1
AL355390.1
Uncharacterized protein
chr12_+_26348246 0.17 ENST00000422622.2
SSPN
sarcospan
chr11_+_124481361 0.17 ENST00000284288.2
PANX3
pannexin 3
chr14_-_37051798 0.17 ENST00000258829.5
NKX2-8
NK2 homeobox 8
chr10_+_123951957 0.17 ENST00000514539.1
TACC2
transforming, acidic coiled-coil containing protein 2
chr7_+_99717230 0.17 ENST00000262932.3
CNPY4
canopy FGF signaling regulator 4
chrX_-_64196307 0.17 ENST00000545618.1
ZC4H2
zinc finger, C4H2 domain containing
chr20_-_50418972 0.17 ENST00000395997.3
SALL4
spalt-like transcription factor 4
chr20_-_50419055 0.17 ENST00000217086.4
SALL4
spalt-like transcription factor 4
chr20_+_42187682 0.17 ENST00000373092.3
ENST00000373077.1
SGK2
serum/glucocorticoid regulated kinase 2
chr1_-_232651312 0.16 ENST00000262861.4
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr5_+_60933634 0.16 ENST00000505642.1
C5orf64
chromosome 5 open reading frame 64
chr12_+_52695617 0.16 ENST00000293525.5
KRT86
keratin 86
chr7_-_84121858 0.16 ENST00000448879.1
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr12_-_28125638 0.16 ENST00000545234.1
PTHLH
parathyroid hormone-like hormone
chr9_+_125133315 0.16 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr6_-_161695074 0.16 ENST00000457520.2
ENST00000366906.5
ENST00000320285.4
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4
chr12_-_16761007 0.16 ENST00000354662.1
ENST00000441439.2
LMO3
LIM domain only 3 (rhombotin-like 2)
chr10_+_4828815 0.15 ENST00000533295.1
AKR1E2
aldo-keto reductase family 1, member E2
chr17_+_73539339 0.15 ENST00000581713.1
LLGL2
lethal giant larvae homolog 2 (Drosophila)
chr16_+_14280564 0.15 ENST00000572567.1
MKL2
MKL/myocardin-like 2
chr8_+_77593448 0.15 ENST00000521891.2
ZFHX4
zinc finger homeobox 4
chr12_+_26348582 0.15 ENST00000535504.1
SSPN
sarcospan
chr6_+_155538093 0.15 ENST00000462408.2
TIAM2
T-cell lymphoma invasion and metastasis 2
chr7_-_14026063 0.15 ENST00000443608.1
ENST00000438956.1
ETV1
ets variant 1
chr11_-_8290263 0.15 ENST00000428101.2
LMO1
LIM domain only 1 (rhombotin 1)
chr8_-_109799793 0.15 ENST00000297459.3
TMEM74
transmembrane protein 74
chr4_+_88571429 0.14 ENST00000339673.6
ENST00000282479.7
DMP1
dentin matrix acidic phosphoprotein 1
chr19_-_14064114 0.14 ENST00000585607.1
ENST00000538517.2
ENST00000587458.1
ENST00000538371.2
PODNL1
podocan-like 1
chr2_-_203735586 0.14 ENST00000454326.1
ENST00000432273.1
ENST00000450143.1
ENST00000411681.1
ICA1L
islet cell autoantigen 1,69kDa-like
chr1_+_28586006 0.14 ENST00000253063.3
SESN2
sestrin 2
chrX_-_73511908 0.14 ENST00000455395.1
FTX
FTX transcript, XIST regulator (non-protein coding)
chr1_-_94586651 0.13 ENST00000535735.1
ENST00000370225.3
ABCA4
ATP-binding cassette, sub-family A (ABC1), member 4
chr12_+_26348429 0.13 ENST00000242729.2
SSPN
sarcospan
chr16_-_4852915 0.13 ENST00000322048.7
ROGDI
rogdi homolog (Drosophila)
chr4_+_169418255 0.13 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr13_+_78315466 0.13 ENST00000314070.5
ENST00000462234.1
SLAIN1
SLAIN motif family, member 1
chr2_-_214016314 0.13 ENST00000434687.1
ENST00000374319.4
IKZF2
IKAROS family zinc finger 2 (Helios)
chr11_-_117747607 0.13 ENST00000540359.1
ENST00000539526.1
FXYD6
FXYD domain containing ion transport regulator 6
chr12_-_42878101 0.13 ENST00000552108.1
PRICKLE1
prickle homolog 1 (Drosophila)
chr2_-_145275828 0.13 ENST00000392861.2
ENST00000409211.1
ZEB2
zinc finger E-box binding homeobox 2
chr9_-_16253112 0.13 ENST00000380683.1
C9orf92
chromosome 9 open reading frame 92
chr15_-_53002007 0.13 ENST00000561490.1
FAM214A
family with sequence similarity 214, member A
chr10_+_24755416 0.13 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217
KIAA1217
chr7_-_27179814 0.13 ENST00000522788.1
ENST00000521779.1
HOXA3
homeobox A3
chrX_-_110655306 0.12 ENST00000371993.2
DCX
doublecortin
chr6_+_161123270 0.12 ENST00000366924.2
ENST00000308192.9
ENST00000418964.1
PLG
plasminogen
chr12_+_21207503 0.12 ENST00000545916.1
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr14_-_69261310 0.12 ENST00000336440.3
ZFP36L1
ZFP36 ring finger protein-like 1
chr14_+_56584414 0.12 ENST00000559044.1
PELI2
pellino E3 ubiquitin protein ligase family member 2
chr2_-_87248975 0.12 ENST00000409310.2
ENST00000355705.3
PLGLB1
plasminogen-like B1
chr7_+_73442422 0.12 ENST00000358929.4
ENST00000431562.1
ENST00000320492.7
ENST00000438906.1
ELN
elastin
chr11_-_117747327 0.12 ENST00000584230.1
ENST00000527429.1
ENST00000584394.1
ENST00000532984.1
FXYD6
FXYD6-FXYD2
FXYD domain containing ion transport regulator 6
FXYD6-FXYD2 readthrough
chr14_-_95236551 0.12 ENST00000238558.3
GSC
goosecoid homeobox
chr12_+_116985896 0.12 ENST00000547114.1
RP11-809C9.2
RP11-809C9.2
chr1_-_190446759 0.12 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr12_+_9066472 0.12 ENST00000538657.1
PHC1
polyhomeotic homolog 1 (Drosophila)
chr7_-_99716952 0.12 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr6_-_33160231 0.11 ENST00000395194.1
ENST00000457788.1
ENST00000341947.2
ENST00000357486.1
ENST00000374714.1
ENST00000374713.1
ENST00000395197.1
ENST00000374712.1
ENST00000361917.1
ENST00000374708.4
COL11A2
collagen, type XI, alpha 2
chr16_+_14280742 0.11 ENST00000341243.5
MKL2
MKL/myocardin-like 2
chr1_+_10509971 0.11 ENST00000320498.4
CORT
cortistatin
chrX_+_10031499 0.11 ENST00000454666.1
WWC3
WWC family member 3
chr7_-_130080977 0.11 ENST00000223208.5
CEP41
centrosomal protein 41kDa
chr1_+_168250194 0.11 ENST00000367821.3
TBX19
T-box 19
chr10_+_114710425 0.11 ENST00000352065.5
ENST00000369395.1
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr4_+_183370146 0.11 ENST00000510504.1
TENM3
teneurin transmembrane protein 3
chr7_+_23286182 0.11 ENST00000258733.4
ENST00000381990.2
ENST00000409458.3
ENST00000539136.1
ENST00000453162.2
GPNMB
glycoprotein (transmembrane) nmb
chr8_-_72268889 0.11 ENST00000388742.4
EYA1
eyes absent homolog 1 (Drosophila)
chr15_+_49715293 0.11 ENST00000267843.4
ENST00000560270.1
FGF7
fibroblast growth factor 7
chr4_-_140544386 0.10 ENST00000561977.1
RP11-308D13.3
RP11-308D13.3
chr7_+_129984630 0.10 ENST00000355388.3
ENST00000497503.1
ENST00000463587.1
ENST00000461828.1
ENST00000494311.1
ENST00000466363.2
ENST00000485477.1
ENST00000431780.2
ENST00000474905.1
CPA5
carboxypeptidase A5
chr7_-_99716940 0.10 ENST00000440225.1
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr2_+_145780662 0.10 ENST00000423031.1
TEX41
testis expressed 41 (non-protein coding)
chr19_+_48949030 0.10 ENST00000253237.5
GRWD1
glutamate-rich WD repeat containing 1
chr2_+_28618532 0.10 ENST00000545753.1
FOSL2
FOS-like antigen 2
chr6_-_22297730 0.10 ENST00000306482.1
PRL
prolactin
chr14_+_88471468 0.10 ENST00000267549.3
GPR65
G protein-coupled receptor 65
chr3_-_114790179 0.10 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr1_+_44679113 0.10 ENST00000361745.6
ENST00000446292.1
ENST00000440641.1
ENST00000436069.1
ENST00000437511.1
DMAP1
DNA methyltransferase 1 associated protein 1
chr7_+_73442487 0.10 ENST00000380575.4
ENST00000380584.4
ENST00000458204.1
ENST00000357036.5
ENST00000417091.1
ENST00000429192.1
ENST00000442310.1
ENST00000380553.4
ENST00000380576.5
ENST00000428787.1
ENST00000320399.6
ELN
elastin
chr7_-_111032971 0.10 ENST00000450877.1
IMMP2L
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chrX_+_78003204 0.10 ENST00000435339.3
ENST00000514744.1
LPAR4
lysophosphatidic acid receptor 4
chr20_+_42136308 0.10 ENST00000434666.1
ENST00000427442.2
ENST00000439769.1
ENST00000418998.1
L3MBTL1
l(3)mbt-like 1 (Drosophila)
chr2_-_216003127 0.10 ENST00000412081.1
ENST00000272895.7
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr7_+_139528952 0.10 ENST00000416849.2
ENST00000436047.2
ENST00000414508.2
ENST00000448866.1
TBXAS1
thromboxane A synthase 1 (platelet)
chr3_+_156799587 0.10 ENST00000469196.1
RP11-6F2.5
RP11-6F2.5
chr15_+_76352178 0.10 ENST00000388942.3
C15orf27
chromosome 15 open reading frame 27
chr4_+_159727272 0.10 ENST00000379346.3
FNIP2
folliculin interacting protein 2
chr18_+_46065393 0.10 ENST00000256413.3
CTIF
CBP80/20-dependent translation initiation factor
chr7_+_66800928 0.10 ENST00000430244.1
RP11-166O4.5
RP11-166O4.5
chr17_-_46690839 0.10 ENST00000498634.2
HOXB8
homeobox B8
chr1_-_25291475 0.10 ENST00000338888.3
ENST00000399916.1
RUNX3
runt-related transcription factor 3
chr1_+_206557366 0.10 ENST00000414007.1
ENST00000419187.2
SRGAP2
SLIT-ROBO Rho GTPase activating protein 2
chr12_-_86650045 0.10 ENST00000604798.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr1_-_68698222 0.09 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
WLS
wntless Wnt ligand secretion mediator
chr2_-_145275228 0.09 ENST00000427902.1
ENST00000409487.3
ENST00000470879.1
ENST00000435831.1
ZEB2
zinc finger E-box binding homeobox 2
chr17_-_46716647 0.09 ENST00000608940.1
RP11-357H14.17
RP11-357H14.17
chr12_+_49621658 0.09 ENST00000541364.1
TUBA1C
tubulin, alpha 1c
chr11_+_65554493 0.09 ENST00000335987.3
OVOL1
ovo-like zinc finger 1
chr11_-_117748138 0.09 ENST00000527717.1
FXYD6
FXYD domain containing ion transport regulator 6
chrX_-_19688475 0.09 ENST00000541422.1
SH3KBP1
SH3-domain kinase binding protein 1
chr1_+_214161272 0.09 ENST00000498508.2
ENST00000366958.4
PROX1
prospero homeobox 1
chr17_-_27418537 0.09 ENST00000408971.2
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr18_-_47792851 0.09 ENST00000398545.4
CCDC11
coiled-coil domain containing 11
chr6_-_161695042 0.09 ENST00000366908.5
ENST00000366911.5
ENST00000366905.3
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4
chr10_+_80027105 0.09 ENST00000461034.1
ENST00000476909.1
ENST00000459633.1
LINC00595
long intergenic non-protein coding RNA 595
chr21_-_35899113 0.09 ENST00000492600.1
ENST00000481448.1
ENST00000381132.2
RCAN1
regulator of calcineurin 1
chr7_-_14029515 0.09 ENST00000430479.1
ENST00000405218.2
ENST00000343495.5
ETV1
ets variant 1
chr2_+_216946589 0.09 ENST00000433112.1
ENST00000454545.1
ENST00000437356.2
ENST00000295658.4
ENST00000455479.1
ENST00000406027.2
TMEM169
transmembrane protein 169
chr7_-_99717463 0.09 ENST00000437822.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr3_-_71777824 0.09 ENST00000469524.1
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chr20_+_60174827 0.09 ENST00000543233.1
CDH4
cadherin 4, type 1, R-cadherin (retinal)
chr9_-_131486367 0.09 ENST00000372663.4
ENST00000406904.2
ENST00000452105.1
ENST00000372672.2
ENST00000372667.5
ZDHHC12
zinc finger, DHHC-type containing 12
chr16_+_89334512 0.09 ENST00000602042.1
AC137932.1
AC137932.1
chr13_-_81801115 0.09 ENST00000567258.1
LINC00564
long intergenic non-protein coding RNA 564
chr6_-_26235206 0.09 ENST00000244534.5
HIST1H1D
histone cluster 1, H1d
chr15_+_58430368 0.09 ENST00000558772.1
ENST00000219919.4
AQP9
aquaporin 9
chr19_+_56111680 0.09 ENST00000301073.3
ZNF524
zinc finger protein 524
chr15_+_58430567 0.08 ENST00000536493.1
AQP9
aquaporin 9
chr13_+_110958124 0.08 ENST00000400163.2
COL4A2
collagen, type IV, alpha 2
chr10_+_17270214 0.08 ENST00000544301.1
VIM
vimentin
chr1_-_94079648 0.08 ENST00000370247.3
BCAR3
breast cancer anti-estrogen resistance 3
chr9_+_12695702 0.08 ENST00000381136.2
TYRP1
tyrosinase-related protein 1
chr3_-_131756559 0.08 ENST00000505957.1
CPNE4
copine IV
chr9_-_139965000 0.08 ENST00000409687.3
SAPCD2
suppressor APC domain containing 2
chr9_-_123639600 0.08 ENST00000373896.3
PHF19
PHD finger protein 19
chr7_+_139529040 0.08 ENST00000455353.1
ENST00000458722.1
ENST00000411653.1
TBXAS1
thromboxane A synthase 1 (platelet)
chr1_+_202317855 0.08 ENST00000356764.2
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr6_-_9933500 0.08 ENST00000492169.1
OFCC1
orofacial cleft 1 candidate 1
chr16_-_57514277 0.08 ENST00000562008.1
ENST00000567214.1
DOK4
docking protein 4
chr2_-_224467093 0.08 ENST00000305409.2
SCG2
secretogranin II
chr12_-_28124903 0.08 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
PTHLH
parathyroid hormone-like hormone
chr1_-_31666767 0.07 ENST00000530145.1
NKAIN1
Na+/K+ transporting ATPase interacting 1
chr22_-_36236265 0.07 ENST00000414461.2
ENST00000416721.2
ENST00000449924.2
ENST00000262829.7
ENST00000397305.3
RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chrX_-_153599578 0.07 ENST00000360319.4
ENST00000344736.4
FLNA
filamin A, alpha

Network of associatons between targets according to the STRING database.

First level regulatory network of NOTO_VSX2_DLX2_DLX6_NKX6-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.1 0.5 GO:0009253 peptidoglycan metabolic process(GO:0000270) peptidoglycan catabolic process(GO:0009253)
0.1 0.3 GO:0090214 spongiotrophoblast layer developmental growth(GO:0090214)
0.1 0.2 GO:0051795 positive regulation of catagen(GO:0051795) activation of meiosis(GO:0090427)
0.1 0.2 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.1 0.2 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.1 0.2 GO:1990922 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.1 0.8 GO:0030916 otic vesicle formation(GO:0030916)
0.1 0.8 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.1 0.3 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.1 0.4 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0 0.1 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.0 0.2 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.0 0.2 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.0 1.1 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.4 GO:0060385 axonogenesis involved in innervation(GO:0060385)
0.0 0.2 GO:0015855 pyrimidine nucleobase transport(GO:0015855) purine nucleobase transmembrane transport(GO:1904823)
0.0 0.1 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.0 0.2 GO:0001878 response to yeast(GO:0001878)
0.0 0.2 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.0 0.2 GO:0060809 mesodermal to mesenchymal transition involved in gastrulation(GO:0060809)
0.0 0.3 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
0.0 0.1 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.0 0.3 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.0 0.1 GO:0061300 cerebellum vasculature development(GO:0061300)
0.0 0.0 GO:0061346 non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.0 0.2 GO:0071600 otic vesicle morphogenesis(GO:0071600)
0.0 0.1 GO:2000691 regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691)
0.0 0.1 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.0 0.1 GO:0035627 ceramide transport(GO:0035627)
0.0 0.1 GO:1901545 cellular response to raffinose(GO:0097403) response to raffinose(GO:1901545)
0.0 0.1 GO:1903414 spleen trabecula formation(GO:0060345) iron cation export(GO:1903414) ferrous iron export(GO:1903988)
0.0 0.1 GO:0021816 lamellipodium assembly involved in ameboidal cell migration(GO:0003363) extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration(GO:0021816)
0.0 0.1 GO:0044771 meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.0 0.1 GO:0060023 soft palate development(GO:0060023)
0.0 0.9 GO:0002076 osteoblast development(GO:0002076)
0.0 0.2 GO:2000172 regulation of branching morphogenesis of a nerve(GO:2000172)
0.0 0.1 GO:0060437 lung growth(GO:0060437)
0.0 0.1 GO:1904640 response to methionine(GO:1904640)
0.0 0.4 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.1 GO:0002426 immunoglobulin production in mucosal tissue(GO:0002426)
0.0 0.3 GO:0072718 response to cisplatin(GO:0072718)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.2 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.0 0.2 GO:1902730 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) myoblast fate commitment(GO:0048625) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.1 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.0 0.1 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.0 0.0 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.0 0.7 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.1 GO:0002384 hepatic immune response(GO:0002384)
0.0 0.1 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.3 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.0 GO:0034374 low-density lipoprotein particle remodeling(GO:0034374)
0.0 0.1 GO:1904247 positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
0.0 0.4 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.1 GO:0060017 parathyroid gland development(GO:0060017)
0.0 0.1 GO:0048706 embryonic skeletal system development(GO:0048706)
0.0 0.0 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.0 0.1 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501)
0.0 0.1 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.0 0.1 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 0.2 GO:0034214 protein hexamerization(GO:0034214)
0.0 0.1 GO:1905232 cellular response to L-glutamate(GO:1905232)
0.0 0.7 GO:0001919 regulation of receptor recycling(GO:0001919)
0.0 0.1 GO:0035513 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.0 GO:1902725 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723) negative regulation of satellite cell differentiation(GO:1902725)
0.0 0.4 GO:0045730 respiratory burst(GO:0045730)
0.0 0.1 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.1 GO:0035026 leading edge cell differentiation(GO:0035026)
0.0 0.0 GO:0032803 viral protein processing(GO:0019082) regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803) negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804) regulation of nerve growth factor production(GO:0032903) negative regulation of nerve growth factor production(GO:0032904) dibasic protein processing(GO:0090472)
0.0 0.1 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.1 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.0 0.1 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.0 0.1 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.0 0.1 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.5 GO:0006506 GPI anchor biosynthetic process(GO:0006506)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0044218 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.0 0.4 GO:0032010 phagolysosome(GO:0032010)
0.0 0.1 GO:0071821 FANCM-MHF complex(GO:0071821)
0.0 0.5 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.3 GO:0071953 elastic fiber(GO:0071953)
0.0 0.2 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.5 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.5 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.1 GO:0031523 Myb complex(GO:0031523)
0.0 0.9 GO:0045095 keratin filament(GO:0045095)
0.0 0.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.1 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 0.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.0 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.1 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.0 GO:0036117 hyaluranon cable(GO:0036117)
0.0 0.1 GO:0097524 sperm plasma membrane(GO:0097524)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0003796 lysozyme activity(GO:0003796)
0.1 0.2 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.1 0.2 GO:0050571 1,5-anhydro-D-fructose reductase activity(GO:0050571)
0.0 0.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 0.2 GO:0004796 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.0 0.2 GO:0015254 pyrimidine nucleobase transmembrane transporter activity(GO:0005350) glycerol channel activity(GO:0015254)
0.0 0.1 GO:1904854 proteasome core complex binding(GO:1904854)
0.0 0.1 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.0 0.3 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.2 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.1 GO:0032093 SAM domain binding(GO:0032093)
0.0 0.1 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.0 0.2 GO:0031013 troponin I binding(GO:0031013)
0.0 0.3 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.3 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.5 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.9 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.1 GO:0034040 lipid-transporting ATPase activity(GO:0034040)
0.0 0.4 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.1 GO:0097689 iron channel activity(GO:0097689)
0.0 0.7 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.1 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.0 0.1 GO:0047225 acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0047225)
0.0 0.1 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0 0.1 GO:0070728 leucine binding(GO:0070728)
0.0 0.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.1 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.4 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.3 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.0 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.0 0.3 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.1 GO:1990254 keratin filament binding(GO:1990254)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.4 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.1 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)
0.0 0.0 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.1 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.3 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.1 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.8 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.4 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins