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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NKX6-2

Z-value: 0.77

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Transcription factors associated with NKX6-2

Gene Symbol Gene ID Gene Info
NKX6-2
ENSG00000148826.6 NK6 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX6-2hg19_v2_chr10_-_134599556_1345996530.374.7e-01Click!

Activity profile of NKX6-2 motif

Sorted Z-values of NKX6-2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_172309634 1.06 ENST00000339506.3
DCAF17
DDB1 and CUL4 associated factor 17
chr14_-_98444386 0.80 ENST00000556462.1
ENST00000556138.1
C14orf64
chromosome 14 open reading frame 64
chr14_-_51027838 0.77 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr4_+_55095428 0.76 ENST00000508170.1
ENST00000512143.1
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr12_+_72061563 0.68 ENST00000551238.1
THAP2
THAP domain containing, apoptosis associated protein 2
chr9_-_70465758 0.57 ENST00000489273.1
CBWD5
COBW domain containing 5
chr1_+_79115503 0.54 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44
interferon-induced protein 44
chr4_-_140201333 0.49 ENST00000398955.1
MGARP
mitochondria-localized glutamic acid-rich protein
chr15_+_49715449 0.48 ENST00000560979.1
FGF7
fibroblast growth factor 7
chr4_+_95174445 0.46 ENST00000509418.1
SMARCAD1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
chr22_-_40929812 0.45 ENST00000422851.1
MKL1
megakaryoblastic leukemia (translocation) 1
chr8_-_42358742 0.44 ENST00000517366.1
SLC20A2
solute carrier family 20 (phosphate transporter), member 2
chr12_-_74686314 0.43 ENST00000551210.1
ENST00000515416.2
ENST00000549905.1
RP11-81H3.2
RP11-81H3.2
chr5_-_58295712 0.43 ENST00000317118.8
PDE4D
phosphodiesterase 4D, cAMP-specific
chr7_+_16828866 0.41 ENST00000597084.1
AC073333.1
Uncharacterized protein
chr12_-_94673956 0.40 ENST00000551941.1
RP11-1105G2.3
Uncharacterized protein
chr3_-_98241358 0.40 ENST00000503004.1
ENST00000506575.1
ENST00000513452.1
ENST00000515620.1
CLDND1
claudin domain containing 1
chr5_+_7373230 0.38 ENST00000500616.2
CTD-2296D1.5
CTD-2296D1.5
chr4_+_26324474 0.35 ENST00000514675.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr12_+_41136144 0.35 ENST00000548005.1
ENST00000552248.1
CNTN1
contactin 1
chr1_+_196621002 0.35 ENST00000367429.4
ENST00000439155.2
CFH
complement factor H
chrX_+_68835911 0.32 ENST00000525810.1
ENST00000527388.1
ENST00000374553.2
ENST00000374552.4
ENST00000338901.3
ENST00000524573.1
EDA
ectodysplasin A
chr2_-_211342292 0.32 ENST00000448951.1
LANCL1
LanC lantibiotic synthetase component C-like 1 (bacterial)
chr1_+_209878182 0.32 ENST00000367027.3
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr6_-_26043885 0.32 ENST00000357905.2
HIST1H2BB
histone cluster 1, H2bb
chr22_+_46476192 0.29 ENST00000443490.1
FLJ27365
hsa-mir-4763
chr2_+_200472779 0.27 ENST00000427045.1
ENST00000419243.1
AC093590.1
AC093590.1
chr10_+_6625733 0.27 ENST00000607982.1
ENST00000608526.1
PRKCQ-AS1
PRKCQ antisense RNA 1
chr1_-_110933611 0.25 ENST00000472422.2
ENST00000437429.2
SLC16A4
solute carrier family 16, member 4
chr12_-_76462713 0.25 ENST00000552056.1
NAP1L1
nucleosome assembly protein 1-like 1
chr14_+_24407940 0.24 ENST00000354854.1
DHRS4-AS1
DHRS4-AS1
chr12_+_32655110 0.23 ENST00000546442.1
ENST00000583694.1
FGD4
FYVE, RhoGEF and PH domain containing 4
chr8_+_26150628 0.23 ENST00000523925.1
ENST00000315985.7
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr1_+_70820451 0.23 ENST00000361764.4
ENST00000359875.5
ENST00000370940.5
ENST00000531950.1
ENST00000432224.1
HHLA3
HERV-H LTR-associating 3
chr22_-_29137771 0.23 ENST00000439200.1
ENST00000405598.1
ENST00000398017.2
ENST00000425190.2
ENST00000348295.3
ENST00000382578.1
ENST00000382565.1
ENST00000382566.1
ENST00000382580.2
ENST00000328354.6
CHEK2
checkpoint kinase 2
chr1_-_149858227 0.22 ENST00000369155.2
HIST2H2BE
histone cluster 2, H2be
chr1_-_200379180 0.22 ENST00000294740.3
ZNF281
zinc finger protein 281
chr2_+_118572226 0.21 ENST00000263239.2
DDX18
DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
chr10_-_115904361 0.21 ENST00000428953.1
ENST00000543782.1
C10orf118
chromosome 10 open reading frame 118
chr5_-_111091948 0.21 ENST00000447165.2
NREP
neuronal regeneration related protein
chr12_+_32655048 0.21 ENST00000427716.2
ENST00000266482.3
FGD4
FYVE, RhoGEF and PH domain containing 4
chr2_-_208030886 0.21 ENST00000426163.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr6_-_26199499 0.21 ENST00000377831.5
HIST1H3D
histone cluster 1, H3d
chr18_+_76829441 0.21 ENST00000458297.2
ATP9B
ATPase, class II, type 9B
chr1_-_110933663 0.20 ENST00000369781.4
ENST00000541986.1
ENST00000369779.4
SLC16A4
solute carrier family 16, member 4
chr6_-_160209471 0.20 ENST00000539948.1
TCP1
t-complex 1
chr17_+_57233087 0.20 ENST00000578777.1
ENST00000577457.1
ENST00000582995.1
PRR11
proline rich 11
chr1_+_244515930 0.19 ENST00000366537.1
ENST00000308105.4
C1orf100
chromosome 1 open reading frame 100
chr18_-_10701979 0.19 ENST00000538948.1
ENST00000285141.4
PIEZO2
piezo-type mechanosensitive ion channel component 2
chr2_+_218990727 0.18 ENST00000318507.2
ENST00000454148.1
CXCR2
chemokine (C-X-C motif) receptor 2
chr14_-_98444461 0.18 ENST00000499006.2
C14orf64
chromosome 14 open reading frame 64
chr8_+_42873548 0.18 ENST00000533338.1
ENST00000534420.1
HOOK3
RP11-598P20.5
hook microtubule-tethering protein 3
Uncharacterized protein
chr9_+_88556036 0.18 ENST00000361671.5
ENST00000416045.1
NAA35
N(alpha)-acetyltransferase 35, NatC auxiliary subunit
chr14_-_75530693 0.18 ENST00000555135.1
ENST00000357971.3
ENST00000553302.1
ENST00000555694.1
ENST00000238618.3
ACYP1
acylphosphatase 1, erythrocyte (common) type
chr5_+_68513622 0.17 ENST00000512880.1
ENST00000602380.1
MRPS36
mitochondrial ribosomal protein S36
chr1_+_100810575 0.17 ENST00000542213.1
CDC14A
cell division cycle 14A
chr19_+_852291 0.17 ENST00000263621.1
ELANE
elastase, neutrophil expressed
chr12_+_28410128 0.17 ENST00000381259.1
ENST00000381256.1
CCDC91
coiled-coil domain containing 91
chr10_-_73848086 0.17 ENST00000536168.1
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr14_+_88852059 0.16 ENST00000045347.7
SPATA7
spermatogenesis associated 7
chr13_+_97928395 0.16 ENST00000445661.2
MBNL2
muscleblind-like splicing regulator 2
chrX_+_135230712 0.16 ENST00000535737.1
FHL1
four and a half LIM domains 1
chr2_-_228244013 0.16 ENST00000304568.3
TM4SF20
transmembrane 4 L six family member 20
chr2_-_136678123 0.16 ENST00000422708.1
DARS
aspartyl-tRNA synthetase
chr10_-_14574705 0.16 ENST00000489100.1
FAM107B
family with sequence similarity 107, member B
chr16_-_67517716 0.16 ENST00000290953.2
AGRP
agouti related protein homolog (mouse)
chr7_-_22233442 0.16 ENST00000401957.2
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr18_+_42260059 0.15 ENST00000426838.4
SETBP1
SET binding protein 1
chr4_+_55095264 0.15 ENST00000257290.5
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr4_-_87374330 0.14 ENST00000511328.1
ENST00000503911.1
MAPK10
mitogen-activated protein kinase 10
chr5_+_31193847 0.14 ENST00000514738.1
ENST00000265071.2
CDH6
cadherin 6, type 2, K-cadherin (fetal kidney)
chr6_-_113953705 0.14 ENST00000452675.1
RP11-367G18.1
RP11-367G18.1
chr18_-_53255379 0.13 ENST00000565908.2
TCF4
transcription factor 4
chr12_+_14561422 0.13 ENST00000541056.1
ATF7IP
activating transcription factor 7 interacting protein
chr1_+_218683438 0.13 ENST00000443836.1
C1orf143
chromosome 1 open reading frame 143
chr4_+_113568207 0.13 ENST00000511529.1
LARP7
La ribonucleoprotein domain family, member 7
chr7_-_78400598 0.13 ENST00000536571.1
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr6_-_64029879 0.13 ENST00000370658.5
ENST00000485906.2
ENST00000370657.4
LGSN
lengsin, lens protein with glutamine synthetase domain
chr15_+_49715293 0.13 ENST00000267843.4
ENST00000560270.1
FGF7
fibroblast growth factor 7
chr12_+_105380073 0.13 ENST00000552951.1
ENST00000280749.5
C12orf45
chromosome 12 open reading frame 45
chr10_-_94257512 0.13 ENST00000371581.5
IDE
insulin-degrading enzyme
chr9_+_82186872 0.13 ENST00000376544.3
ENST00000376520.4
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr11_-_11374904 0.13 ENST00000528848.2
CSNK2A3
casein kinase 2, alpha 3 polypeptide
chr17_-_57232525 0.13 ENST00000583380.1
ENST00000580541.1
ENST00000578105.1
ENST00000437036.2
SKA2
spindle and kinetochore associated complex subunit 2
chr14_+_86401039 0.13 ENST00000557195.1
CTD-2341M24.1
CTD-2341M24.1
chr19_+_52772832 0.12 ENST00000593703.1
ENST00000601711.1
ENST00000599581.1
ZNF766
zinc finger protein 766
chrX_+_10124977 0.12 ENST00000380833.4
CLCN4
chloride channel, voltage-sensitive 4
chr1_-_150849208 0.12 ENST00000358595.5
ARNT
aryl hydrocarbon receptor nuclear translocator
chr16_+_21610879 0.12 ENST00000396014.4
METTL9
methyltransferase like 9
chr15_-_49103235 0.12 ENST00000380950.2
CEP152
centrosomal protein 152kDa
chr2_-_217559517 0.11 ENST00000449583.1
IGFBP5
insulin-like growth factor binding protein 5
chr11_-_8892900 0.11 ENST00000526155.1
ENST00000524757.1
ENST00000527392.1
ENST00000534665.1
ENST00000525169.1
ENST00000527516.1
ENST00000533471.1
ST5
suppression of tumorigenicity 5
chr11_-_94706705 0.11 ENST00000279839.6
CWC15
CWC15 spliceosome-associated protein homolog (S. cerevisiae)
chr7_+_77469439 0.11 ENST00000450574.1
ENST00000416283.2
ENST00000248550.7
PHTF2
putative homeodomain transcription factor 2
chr2_-_191115229 0.11 ENST00000409820.2
ENST00000410045.1
HIBCH
3-hydroxyisobutyryl-CoA hydrolase
chr1_-_109399682 0.11 ENST00000369995.3
ENST00000370001.3
AKNAD1
AKNA domain containing 1
chr1_-_110155671 0.10 ENST00000351050.3
GNAT2
guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
chr6_+_47666275 0.10 ENST00000327753.3
ENST00000283303.2
GPR115
G protein-coupled receptor 115
chr2_+_210444142 0.10 ENST00000360351.4
ENST00000361559.4
MAP2
microtubule-associated protein 2
chr1_+_85527987 0.10 ENST00000326813.8
ENST00000294664.6
ENST00000528899.1
WDR63
WD repeat domain 63
chr2_+_58655520 0.10 ENST00000455219.3
ENST00000449448.2
AC007092.1
long intergenic non-protein coding RNA 1122
chr6_-_26199471 0.10 ENST00000341023.1
HIST1H2AD
histone cluster 1, H2ad
chr21_-_36421401 0.10 ENST00000486278.2
RUNX1
runt-related transcription factor 1
chr16_+_53483983 0.09 ENST00000544545.1
RBL2
retinoblastoma-like 2 (p130)
chr7_-_112635675 0.09 ENST00000447785.1
ENST00000451962.1
AC018464.3
AC018464.3
chr1_+_78383813 0.09 ENST00000342754.5
NEXN
nexilin (F actin binding protein)
chr17_-_56494882 0.09 ENST00000584437.1
RNF43
ring finger protein 43
chr7_+_77325738 0.09 ENST00000334955.8
RSBN1L
round spermatid basic protein 1-like
chr20_-_18477862 0.09 ENST00000337227.4
RBBP9
retinoblastoma binding protein 9
chr22_+_24198890 0.09 ENST00000345044.6
SLC2A11
solute carrier family 2 (facilitated glucose transporter), member 11
chr17_-_41836153 0.09 ENST00000301691.2
SOST
sclerostin
chr2_+_202047843 0.09 ENST00000272879.5
ENST00000374650.3
ENST00000346817.5
ENST00000313728.7
ENST00000448480.1
CASP10
caspase 10, apoptosis-related cysteine peptidase
chr10_-_63995871 0.08 ENST00000315289.2
RTKN2
rhotekin 2
chr4_-_185139062 0.08 ENST00000296741.2
ENPP6
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr6_+_12290586 0.08 ENST00000379375.5
EDN1
endothelin 1
chr6_-_80247140 0.08 ENST00000392959.1
ENST00000467898.3
LCA5
Leber congenital amaurosis 5
chr18_-_52989525 0.08 ENST00000457482.3
TCF4
transcription factor 4
chr9_+_130026756 0.08 ENST00000314904.5
ENST00000373387.4
GARNL3
GTPase activating Rap/RanGAP domain-like 3
chr19_+_52772821 0.08 ENST00000439461.1
ZNF766
zinc finger protein 766
chr14_+_52164820 0.08 ENST00000554167.1
FRMD6
FERM domain containing 6
chr17_-_57232596 0.08 ENST00000581068.1
ENST00000330137.7
SKA2
spindle and kinetochore associated complex subunit 2
chr1_-_200379129 0.08 ENST00000367353.1
ZNF281
zinc finger protein 281
chr17_-_60885700 0.08 ENST00000583600.1
MARCH10
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr2_-_207024134 0.08 ENST00000457011.1
ENST00000440274.1
ENST00000432169.1
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr4_-_25865159 0.07 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr5_-_159546396 0.07 ENST00000523662.1
ENST00000456329.3
ENST00000307063.7
PWWP2A
PWWP domain containing 2A
chr14_-_27066960 0.07 ENST00000539517.2
NOVA1
neuro-oncological ventral antigen 1
chr8_-_103876965 0.07 ENST00000337198.5
AZIN1
antizyme inhibitor 1
chr1_+_210501589 0.07 ENST00000413764.2
ENST00000541565.1
HHAT
hedgehog acyltransferase
chr11_+_100558384 0.07 ENST00000524892.2
ENST00000298815.8
ARHGAP42
Rho GTPase activating protein 42
chr2_+_210444298 0.07 ENST00000445941.1
MAP2
microtubule-associated protein 2
chr11_-_126810521 0.07 ENST00000530572.1
RP11-688I9.4
RP11-688I9.4
chr6_-_53481847 0.07 ENST00000503985.1
RP1-27K12.2
RP1-27K12.2
chr5_+_68513557 0.07 ENST00000256441.4
MRPS36
mitochondrial ribosomal protein S36
chr2_-_73520667 0.07 ENST00000545030.1
ENST00000436467.2
EGR4
early growth response 4
chr6_-_56716686 0.06 ENST00000520645.1
DST
dystonin
chr7_-_92146729 0.06 ENST00000541751.1
PEX1
peroxisomal biogenesis factor 1
chr1_-_114696472 0.06 ENST00000393296.1
ENST00000369547.1
ENST00000610222.1
SYT6
synaptotagmin VI
chr9_-_77643307 0.06 ENST00000376834.3
ENST00000376830.3
C9orf41
chromosome 9 open reading frame 41
chr16_-_21442874 0.06 ENST00000534903.1
NPIPB3
nuclear pore complex interacting protein family, member B3
chr2_+_207024306 0.05 ENST00000236957.5
ENST00000392221.1
ENST00000392222.2
ENST00000445505.1
EEF1B2
eukaryotic translation elongation factor 1 beta 2
chr9_-_26892342 0.05 ENST00000535437.1
CAAP1
caspase activity and apoptosis inhibitor 1
chr14_+_52164675 0.05 ENST00000555936.1
FRMD6
FERM domain containing 6
chrX_+_35937843 0.05 ENST00000297866.5
CXorf22
chromosome X open reading frame 22
chr17_-_60885659 0.05 ENST00000311269.5
MARCH10
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
chr4_+_71384300 0.05 ENST00000504451.1
AMTN
amelotin
chr1_+_244624678 0.05 ENST00000366534.4
ENST00000366533.4
ENST00000428042.1
ENST00000366531.3
C1orf101
chromosome 1 open reading frame 101
chr22_+_29138013 0.05 ENST00000216027.3
ENST00000398941.2
HSCB
HscB mitochondrial iron-sulfur cluster co-chaperone
chr7_-_78400364 0.05 ENST00000535697.1
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr12_+_111284764 0.05 ENST00000545036.1
ENST00000308208.5
CCDC63
coiled-coil domain containing 63
chr9_+_34652164 0.04 ENST00000441545.2
ENST00000553620.1
IL11RA
interleukin 11 receptor, alpha
chr10_+_26505179 0.04 ENST00000376261.3
GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr7_-_107880508 0.04 ENST00000425651.2
NRCAM
neuronal cell adhesion molecule
chr7_-_37024665 0.04 ENST00000396040.2
ELMO1
engulfment and cell motility 1
chr14_+_76776957 0.04 ENST00000512784.1
ESRRB
estrogen-related receptor beta
chr20_+_57467204 0.04 ENST00000603546.1
GNAS
GNAS complex locus
chr12_-_28124903 0.04 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
PTHLH
parathyroid hormone-like hormone
chr1_-_32384693 0.04 ENST00000602683.1
ENST00000470404.1
PTP4A2
protein tyrosine phosphatase type IVA, member 2
chr17_-_56494908 0.04 ENST00000577716.1
RNF43
ring finger protein 43
chr10_-_73848531 0.04 ENST00000373109.2
SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr17_-_40829026 0.04 ENST00000412503.1
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr2_-_74570520 0.04 ENST00000394019.2
ENST00000346834.4
ENST00000359484.4
ENST00000423644.1
ENST00000377634.4
ENST00000436454.1
SLC4A5
solute carrier family 4 (sodium bicarbonate cotransporter), member 5
chr5_+_67586465 0.03 ENST00000336483.5
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr16_+_19422035 0.03 ENST00000381414.4
ENST00000396229.2
TMC5
transmembrane channel-like 5
chr15_-_49103184 0.03 ENST00000399334.3
ENST00000325747.5
CEP152
centrosomal protein 152kDa
chr5_+_166711804 0.03 ENST00000518659.1
ENST00000545108.1
TENM2
teneurin transmembrane protein 2
chrX_+_105937068 0.03 ENST00000324342.3
RNF128
ring finger protein 128, E3 ubiquitin protein ligase
chr12_-_133787772 0.03 ENST00000545350.1
AC226150.4
Uncharacterized protein
chr14_+_77582905 0.03 ENST00000557408.1
TMEM63C
transmembrane protein 63C
chr4_+_71384257 0.03 ENST00000339336.4
AMTN
amelotin
chr2_-_208030647 0.03 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)
chr1_+_145477060 0.03 ENST00000369308.3
LIX1L
Lix1 homolog (mouse)-like
chr21_-_36421626 0.03 ENST00000300305.3
RUNX1
runt-related transcription factor 1
chr19_+_48112371 0.03 ENST00000594866.1
GLTSCR1
glioma tumor suppressor candidate region gene 1
chr12_+_111284805 0.03 ENST00000552694.1
CCDC63
coiled-coil domain containing 63
chr2_-_207023918 0.03 ENST00000455934.2
ENST00000449699.1
ENST00000454195.1
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr18_-_12656715 0.03 ENST00000462226.1
ENST00000497844.2
ENST00000309836.5
ENST00000453447.2
SPIRE1
spire-type actin nucleation factor 1
chr17_-_40828969 0.03 ENST00000591022.1
ENST00000587627.1
ENST00000293349.6
PLEKHH3
pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
chr14_-_98444438 0.03 ENST00000512901.2
C14orf64
chromosome 14 open reading frame 64
chr8_-_57123815 0.03 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
PLAG1
pleiomorphic adenoma gene 1
chr10_+_32873190 0.03 ENST00000375025.4
C10orf68
Homo sapiens coiled-coil domain containing 7 (CCDC7), transcript variant 5, mRNA.
chr3_+_159943362 0.02 ENST00000326474.3
C3orf80
chromosome 3 open reading frame 80
chr1_-_150738261 0.02 ENST00000448301.2
ENST00000368985.3
CTSS
cathepsin S
chr5_+_155753745 0.02 ENST00000435422.3
ENST00000337851.4
ENST00000447401.1
SGCD
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
chr4_-_87374283 0.02 ENST00000361569.2
MAPK10
mitogen-activated protein kinase 10
chr14_-_27066636 0.02 ENST00000267422.7
ENST00000344429.5
ENST00000574031.1
ENST00000465357.2
ENST00000547619.1
NOVA1
neuro-oncological ventral antigen 1
chrX_-_10544942 0.02 ENST00000380779.1
MID1
midline 1 (Opitz/BBB syndrome)
chr2_+_108994466 0.02 ENST00000272452.2
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr12_-_6233828 0.02 ENST00000572068.1
ENST00000261405.5
VWF
von Willebrand factor
chr2_-_175712479 0.02 ENST00000443238.1
CHN1
chimerin 1
chr6_+_4773205 0.02 ENST00000440139.1
CDYL
chromodomain protein, Y-like
chr15_+_80364901 0.02 ENST00000560228.1
ENST00000559835.1
ENST00000559775.1
ENST00000558688.1
ENST00000560392.1
ENST00000560976.1
ENST00000558272.1
ENST00000558390.1
ZFAND6
zinc finger, AN1-type domain 6
chr2_-_207024233 0.02 ENST00000423725.1
ENST00000233190.6
NDUFS1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr2_-_175712270 0.02 ENST00000295497.7
ENST00000444394.1
CHN1
chimerin 1
chrX_+_102840408 0.02 ENST00000468024.1
ENST00000472484.1
ENST00000415568.2
ENST00000490644.1
ENST00000459722.1
ENST00000472745.1
ENST00000494801.1
ENST00000434216.2
ENST00000425011.1
TCEAL4
transcription elongation factor A (SII)-like 4
chrX_+_105936982 0.02 ENST00000418562.1
RNF128
ring finger protein 128, E3 ubiquitin protein ligase
chr1_-_186430222 0.02 ENST00000391997.2
PDC
phosducin
chr17_-_56494713 0.02 ENST00000407977.2
RNF43
ring finger protein 43
chr16_+_28565230 0.02 ENST00000317058.3
CCDC101
coiled-coil domain containing 101
chr19_+_12175596 0.01 ENST00000441304.2
ZNF844
zinc finger protein 844

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX6-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.1 0.6 GO:0060437 lung growth(GO:0060437)
0.1 0.5 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.1 0.2 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.1 0.3 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.1 0.2 GO:0042000 translocation of peptides or proteins into host(GO:0042000) translocation of peptides or proteins into host cell cytoplasm(GO:0044053) translocation of molecules into host(GO:0044417) translocation of peptides or proteins into other organism involved in symbiotic interaction(GO:0051808) translocation of molecules into other organism involved in symbiotic interaction(GO:0051836)
0.0 0.4 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.4 GO:1901297 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.4 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.2 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.0 0.2 GO:0001878 response to yeast(GO:0001878)
0.0 0.1 GO:0014734 skeletal muscle hypertrophy(GO:0014734) regulation of skeletal muscle hypertrophy(GO:1904204)
0.0 0.1 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.0 0.1 GO:1901143 insulin catabolic process(GO:1901143)
0.0 0.1 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.0 0.1 GO:0070101 nitric oxide transport(GO:0030185) positive regulation of chemokine-mediated signaling pathway(GO:0070101)
0.0 0.1 GO:0070175 positive regulation of enamel mineralization(GO:0070175)
0.0 0.2 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.4 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.8 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.2 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.0 0.2 GO:2000809 positive regulation of synaptic vesicle clustering(GO:2000809)
0.0 0.2 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 0.1 GO:2000053 regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053)
0.0 0.3 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.1 GO:0006574 valine catabolic process(GO:0006574)
0.0 0.1 GO:1902269 positive regulation of polyamine transmembrane transport(GO:1902269)
0.0 0.2 GO:0098535 de novo centriole assembly(GO:0098535)
0.0 0.4 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.1 GO:0060151 peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
0.0 0.1 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.0 0.1 GO:0003383 apical constriction(GO:0003383)
0.0 0.3 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.2 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.0 0.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.2 GO:0031417 NatC complex(GO:0031417)
0.0 0.2 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 0.2 GO:0070695 FHF complex(GO:0070695)
0.0 0.2 GO:0098536 deuterosome(GO:0098536)
0.0 1.1 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.1 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.1 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.0 0.2 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.2 GO:0060091 kinocilium(GO:0060091)
0.0 0.1 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.2 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0005018 platelet-derived growth factor alpha-receptor activity(GO:0005018)
0.1 0.3 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.0 0.4 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.1 GO:0031626 beta-endorphin binding(GO:0031626)
0.0 0.1 GO:0004356 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 0.1 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
0.0 0.8 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.2 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 0.2 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.5 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.4 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.2 GO:0019958 C-X-C chemokine binding(GO:0019958)
0.0 0.4 GO:0000150 recombinase activity(GO:0000150)
0.0 0.1 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.0 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.3 GO:0043295 glutathione binding(GO:0043295)
0.0 0.2 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.1 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.0 0.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.2 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.2 GO:0048156 tau protein binding(GO:0048156)
0.0 0.1 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2
0.0 0.4 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint