ISMARA results: NKX3-2

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NKX3-2

Z-value: 1.10

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Transcription factors associated with NKX3-2

Gene Symbol	Gene ID	Gene Info
NKX3-2 Ensembl NCBI GeneCards UniProt	ENSG00000109705.7	NK3 homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NKX3-2	hg19_v2_chr4_-_13546632_13546674	0.19	7.2e-01	Click!

Activity profile of NKX3-2 motif

Sorted Z-values of NKX3-2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_235098935 Show fit	0.78	ENST00000423175.1	RP11-443B7.1 Ensembl NCBI GeneCards UniProt Show fit	RP11-443B7.1
chr9_-_32526299 Show fit	0.60	ENST00000379882.1 ENST00000379883.2	DDX58 Ensembl NCBI GeneCards UniProt Show fit	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr9_-_32526184 Show fit	0.60	ENST00000545044.1 ENST00000379868.1	DDX58 Ensembl NCBI GeneCards UniProt Show fit	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr4_+_156824840 Show fit	0.59	ENST00000536354.2	TDO2 Ensembl NCBI GeneCards UniProt Show fit	tryptophan 2,3-dioxygenase
chr4_+_17579110 Show fit	0.57	ENST00000606142.1	LAP3 Ensembl NCBI GeneCards UniProt Show fit	leucine aminopeptidase 3
chr4_-_141348763 Show fit	0.52	ENST00000509477.1	CLGN Ensembl NCBI GeneCards UniProt Show fit	calmegin
chr17_+_4835580 Show fit	0.51	ENST00000329125.5	GP1BA Ensembl NCBI GeneCards UniProt Show fit	glycoprotein Ib (platelet), alpha polypeptide
chr17_+_38083977 Show fit	0.46	ENST00000578802.1 ENST00000578478.1 ENST00000582263.1	RP11-387H17.4 Ensembl NCBI GeneCards UniProt Show fit	RP11-387H17.4
chr12_-_68845417 Show fit	0.46	ENST00000542875.1	RP11-81H14.2 Ensembl NCBI GeneCards UniProt Show fit	RP11-81H14.2
chr7_-_56160625 Show fit	0.45	ENST00000446428.1 ENST00000432123.1 ENST00000452681.2 ENST00000537360.1	PHKG1 Ensembl NCBI GeneCards UniProt Show fit	phosphorylase kinase, gamma 1 (muscle)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX3-2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.2	GO:0034344	type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.1	1.2	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.0	1.1	GO:0007339	binding of sperm to zona pellucida(GO:0007339)
0.0	1.0	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.1	0.9	GO:0016584	nucleosome positioning(GO:0016584)
0.1	0.6	GO:0019442	tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.1	0.6	GO:0061086	negative regulation of histone H3-K27 methylation(GO:0061086)
0.1	0.5	GO:0006421	asparaginyl-tRNA aminoacylation(GO:0006421)
0.0	0.5	GO:1900028	negative regulation of ruffle assembly(GO:1900028)
0.0	0.5	GO:0036484	trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) neural crest cell migration involved in autonomic nervous system development(GO:1901166)

Showing 1 to 10 of 87 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.6	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.1	0.5	GO:0031213	RSF complex(GO:0031213)
0.1	0.5	GO:0042567	insulin-like growth factor ternary complex(GO:0042567)
0.0	0.5	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.0	0.4	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.0	0.4	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.4	GO:0061689	tricellular tight junction(GO:0061689)
0.0	0.4	GO:0000788	nuclear nucleosome(GO:0000788)
0.0	0.4	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.4	GO:0030992	intraciliary transport particle B(GO:0030992)

Showing 1 to 10 of 35 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.2	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	1.2	GO:0003727	single-stranded RNA binding(GO:0003727)
0.0	1.0	GO:0044183	protein binding involved in protein folding(GO:0044183)
0.1	0.6	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.1	0.6	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.6	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.2	0.5	GO:0008160	protein tyrosine phosphatase activator activity(GO:0008160)
0.1	0.5	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.0	0.5	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.5	GO:0008143	poly(A) binding(GO:0008143)

Showing 1 to 10 of 57 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
0.4	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.4	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.3	PID S1P S1P4 PATHWAY	S1P4 pathway

Showing 1 to 3 of 3 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.2	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.0	0.5	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.0	0.5	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	0.5	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation
0.0	0.4	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.4	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.0	0.4	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	0.4	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.4	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.0	0.3	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide

Showing 1 to 10 of 14 entries

Results for NKX3-2

Z-value: 1.10

Motif logo

Transcription factors associated with NKX3-2

Activity-expression correlation:

Activity profile of NKX3-2 motif

Sorted Z-values of NKX3-2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX3-2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: