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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NKX2-1

Z-value: 0.77

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Transcription factors associated with NKX2-1

Gene Symbol Gene ID Gene Info
NKX2-1
ENSG00000136352.13 NK2 homeobox 1

Activity profile of NKX2-1 motif

Sorted Z-values of NKX2-1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_39390212 0.50 ENST00000437828.1
SIRT2
sirtuin 2
chr20_+_825275 0.38 ENST00000541082.1
FAM110A
family with sequence similarity 110, member A
chr8_+_94752349 0.37 ENST00000391680.1
RBM12B-AS1
RBM12B antisense RNA 1
chr3_-_49837254 0.31 ENST00000412678.2
ENST00000343366.4
ENST00000487256.1
CDHR4
cadherin-related family member 4
chr8_-_144679264 0.30 ENST00000531953.1
ENST00000526133.1
EEF1D
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
chr1_-_41487383 0.29 ENST00000302946.8
ENST00000372613.2
ENST00000439569.2
ENST00000397197.2
SLFNL1
schlafen-like 1
chrX_-_30326445 0.29 ENST00000378963.1
NR0B1
nuclear receptor subfamily 0, group B, member 1
chr11_+_115498761 0.28 ENST00000424313.2
AP000997.1
AP000997.1
chr3_+_39149145 0.28 ENST00000301819.6
ENST00000431162.2
TTC21A
tetratricopeptide repeat domain 21A
chr1_-_41487415 0.27 ENST00000372611.1
SLFNL1
schlafen-like 1
chr11_-_86383650 0.26 ENST00000526944.1
ENST00000530335.1
ENST00000543262.1
ENST00000524826.1
ME3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr9_-_7800067 0.26 ENST00000358227.4
TMEM261
transmembrane protein 261
chr4_+_184826418 0.24 ENST00000308497.4
ENST00000438269.1
STOX2
storkhead box 2
chrX_-_153236819 0.24 ENST00000354233.3
HCFC1
host cell factor C1 (VP16-accessory protein)
chr20_-_56285595 0.24 ENST00000395816.3
ENST00000347215.4
PMEPA1
prostate transmembrane protein, androgen induced 1
chr9_-_97356075 0.23 ENST00000375337.3
FBP2
fructose-1,6-bisphosphatase 2
chr11_+_46193466 0.23 ENST00000533793.1
RP11-702F3.3
RP11-702F3.3
chr7_-_105332084 0.23 ENST00000472195.1
ATXN7L1
ataxin 7-like 1
chr14_+_74815116 0.22 ENST00000256362.4
VRTN
vertebrae development associated
chrX_-_153236620 0.22 ENST00000369984.4
HCFC1
host cell factor C1 (VP16-accessory protein)
chrX_-_153237258 0.22 ENST00000310441.7
HCFC1
host cell factor C1 (VP16-accessory protein)
chr19_-_36231437 0.21 ENST00000591748.1
IGFLR1
IGF-like family receptor 1
chr19_-_39390350 0.21 ENST00000447739.1
ENST00000358931.5
ENST00000407552.1
SIRT2
sirtuin 2
chr21_+_45773515 0.21 ENST00000397932.2
ENST00000300481.9
TRPM2
transient receptor potential cation channel, subfamily M, member 2
chr19_+_39390320 0.21 ENST00000576510.1
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chrX_+_22056165 0.21 ENST00000535894.1
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr21_-_36421401 0.20 ENST00000486278.2
RUNX1
runt-related transcription factor 1
chr2_+_85646054 0.20 ENST00000389938.2
SH2D6
SH2 domain containing 6
chr1_-_153538011 0.20 ENST00000368707.4
S100A2
S100 calcium binding protein A2
chr1_-_17338386 0.19 ENST00000341676.5
ENST00000452699.1
ATP13A2
ATPase type 13A2
chr8_-_38326119 0.19 ENST00000356207.5
ENST00000326324.6
FGFR1
fibroblast growth factor receptor 1
chr21_+_33671264 0.19 ENST00000339944.4
MRAP
melanocortin 2 receptor accessory protein
chr17_-_3499125 0.18 ENST00000399759.3
TRPV1
transient receptor potential cation channel, subfamily V, member 1
chr5_-_146889619 0.18 ENST00000343218.5
DPYSL3
dihydropyrimidinase-like 3
chr18_+_13382553 0.18 ENST00000586222.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr16_+_2022036 0.18 ENST00000568546.1
TBL3
transducin (beta)-like 3
chr3_+_187930719 0.18 ENST00000312675.4
LPP
LIM domain containing preferred translocation partner in lipoma
chr18_+_42260861 0.18 ENST00000282030.5
SETBP1
SET binding protein 1
chr19_+_48972459 0.18 ENST00000427476.1
CYTH2
cytohesin 2
chr12_+_25205446 0.18 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
LRMP
lymphoid-restricted membrane protein
chr8_-_80680078 0.18 ENST00000337919.5
ENST00000354724.3
HEY1
hes-related family bHLH transcription factor with YRPW motif 1
chr16_+_58533951 0.17 ENST00000566192.1
ENST00000565088.1
ENST00000568640.1
ENST00000563978.1
ENST00000569923.1
ENST00000356752.4
ENST00000563799.1
ENST00000562999.1
ENST00000570248.1
ENST00000562731.1
ENST00000568424.1
NDRG4
NDRG family member 4
chr8_+_77596014 0.17 ENST00000523885.1
ZFHX4
zinc finger homeobox 4
chr17_+_40610862 0.17 ENST00000393829.2
ENST00000546249.1
ENST00000537728.1
ENST00000264649.6
ENST00000585525.1
ENST00000343619.4
ENST00000544137.1
ENST00000589727.1
ENST00000587824.1
ATP6V0A1
ATPase, H+ transporting, lysosomal V0 subunit a1
chr6_-_149806105 0.17 ENST00000389942.5
ENST00000416573.2
ENST00000542614.1
ENST00000409806.3
ZC3H12D
zinc finger CCCH-type containing 12D
chr19_+_50148087 0.17 ENST00000601038.1
ENST00000595242.1
SCAF1
SR-related CTD-associated factor 1
chr10_-_79397547 0.17 ENST00000481070.1
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr9_-_128246769 0.16 ENST00000444226.1
MAPKAP1
mitogen-activated protein kinase associated protein 1
chr6_+_100054606 0.16 ENST00000369215.4
PRDM13
PR domain containing 13
chr16_+_66638003 0.16 ENST00000562357.1
ENST00000360086.4
ENST00000562707.1
ENST00000361909.4
ENST00000460097.1
ENST00000565666.1
CMTM3
CKLF-like MARVEL transmembrane domain containing 3
chr10_+_80027105 0.16 ENST00000461034.1
ENST00000476909.1
ENST00000459633.1
LINC00595
long intergenic non-protein coding RNA 595
chr1_+_202431859 0.16 ENST00000391959.3
ENST00000367270.4
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr16_-_67493110 0.15 ENST00000602876.1
ATP6V0D1
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chr1_-_228604328 0.15 ENST00000355586.4
ENST00000366698.2
ENST00000520264.1
ENST00000479800.1
ENST00000295033.3
TRIM17
tripartite motif containing 17
chr16_+_5121814 0.15 ENST00000262374.5
ENST00000586840.1
ALG1
ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
chr17_-_34195862 0.15 ENST00000592980.1
ENST00000587626.1
C17orf66
chromosome 17 open reading frame 66
chr15_+_76030311 0.14 ENST00000543887.1
AC019294.1
AC019294.1
chr2_+_101591314 0.14 ENST00000450763.1
NPAS2
neuronal PAS domain protein 2
chr8_-_144679602 0.14 ENST00000526710.1
EEF1D
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
chrX_+_86772787 0.14 ENST00000373114.4
KLHL4
kelch-like family member 4
chr1_+_15736359 0.14 ENST00000375980.4
EFHD2
EF-hand domain family, member D2
chrX_+_23928500 0.14 ENST00000435707.1
CXorf58
chromosome X open reading frame 58
chr17_+_61086917 0.14 ENST00000424789.2
ENST00000389520.4
TANC2
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
chr5_-_172662303 0.14 ENST00000517440.1
ENST00000329198.4
NKX2-5
NK2 homeobox 5
chr1_+_55464600 0.13 ENST00000371265.4
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr8_-_16859690 0.13 ENST00000180166.5
FGF20
fibroblast growth factor 20
chr11_-_62313090 0.13 ENST00000528508.1
ENST00000533365.1
AHNAK
AHNAK nucleoprotein
chr22_+_24999114 0.13 ENST00000412658.1
ENST00000445029.1
ENST00000419133.1
ENST00000400382.1
ENST00000438643.2
ENST00000452551.1
ENST00000400383.1
ENST00000412898.1
ENST00000400380.1
ENST00000455483.1
ENST00000430289.1
GGT1
gamma-glutamyltransferase 1
chr15_-_43029252 0.13 ENST00000563260.1
ENST00000356231.3
CDAN1
codanin 1
chr14_+_67707826 0.13 ENST00000261681.4
MPP5
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr5_-_172662230 0.12 ENST00000424406.2
NKX2-5
NK2 homeobox 5
chr7_+_99156212 0.12 ENST00000454654.1
ZNF655
zinc finger protein 655
chr19_+_48972265 0.12 ENST00000452733.2
CYTH2
cytohesin 2
chr19_+_24009879 0.12 ENST00000354585.4
RPSAP58
ribosomal protein SA pseudogene 58
chr17_-_47492236 0.12 ENST00000434917.2
ENST00000300408.3
ENST00000511832.1
ENST00000419140.2
PHB
prohibitin
chr3_+_4535025 0.12 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr7_+_150782945 0.11 ENST00000463381.1
AGAP3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr19_+_38924316 0.11 ENST00000355481.4
ENST00000360985.3
ENST00000359596.3
RYR1
ryanodine receptor 1 (skeletal)
chr17_+_46048376 0.11 ENST00000338399.4
CDK5RAP3
CDK5 regulatory subunit associated protein 3
chr12_+_6961279 0.11 ENST00000229268.8
ENST00000389231.5
ENST00000542087.1
USP5
ubiquitin specific peptidase 5 (isopeptidase T)
chr6_-_26056695 0.11 ENST00000343677.2
HIST1H1C
histone cluster 1, H1c
chr12_+_25205666 0.11 ENST00000547044.1
LRMP
lymphoid-restricted membrane protein
chr8_+_145203548 0.11 ENST00000534366.1
MROH1
maestro heat-like repeat family member 1
chr16_-_28223166 0.11 ENST00000304658.5
XPO6
exportin 6
chr17_+_38375528 0.11 ENST00000583268.1
WIPF2
WAS/WASL interacting protein family, member 2
chr11_+_66512089 0.11 ENST00000524551.1
ENST00000525908.1
ENST00000360962.4
ENST00000346672.4
ENST00000527634.1
ENST00000540737.1
C11orf80
chromosome 11 open reading frame 80
chr16_+_640055 0.10 ENST00000568586.1
ENST00000538492.1
ENST00000248139.3
RAB40C
RAB40C, member RAS oncogene family
chr16_-_18937072 0.10 ENST00000569122.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr17_-_34195889 0.10 ENST00000311880.2
C17orf66
chromosome 17 open reading frame 66
chr17_-_76778339 0.10 ENST00000591455.1
ENST00000446868.3
ENST00000361101.4
ENST00000589296.1
CYTH1
cytohesin 1
chr19_+_40477062 0.10 ENST00000455878.2
PSMC4
proteasome (prosome, macropain) 26S subunit, ATPase, 4
chr2_-_225266802 0.10 ENST00000243806.2
FAM124B
family with sequence similarity 124B
chr17_-_49198216 0.10 ENST00000262013.7
ENST00000357122.4
SPAG9
sperm associated antigen 9
chr17_+_46048471 0.10 ENST00000578018.1
ENST00000579175.1
CDK5RAP3
CDK5 regulatory subunit associated protein 3
chr20_+_30407105 0.10 ENST00000375994.2
MYLK2
myosin light chain kinase 2
chr16_-_67190152 0.09 ENST00000486556.1
TRADD
TNFRSF1A-associated via death domain
chr12_+_93772402 0.09 ENST00000546925.1
NUDT4
nudix (nucleoside diphosphate linked moiety X)-type motif 4
chr9_-_72374848 0.09 ENST00000377200.5
ENST00000340434.4
ENST00000472967.2
PTAR1
protein prenyltransferase alpha subunit repeat containing 1
chr12_+_25205568 0.09 ENST00000548766.1
ENST00000556887.1
LRMP
lymphoid-restricted membrane protein
chr3_-_52029830 0.09 ENST00000492277.1
ENST00000475248.1
ENST00000479017.1
ENST00000495383.1
ENST00000466397.1
ENST00000481629.1
RPL29
ribosomal protein L29
chr11_-_65325430 0.09 ENST00000322147.4
LTBP3
latent transforming growth factor beta binding protein 3
chr6_+_25652501 0.09 ENST00000334979.6
SCGN
secretagogin, EF-hand calcium binding protein
chr9_+_33290491 0.09 ENST00000379540.3
ENST00000379521.4
ENST00000318524.6
NFX1
nuclear transcription factor, X-box binding 1
chr11_-_65325203 0.09 ENST00000526927.1
ENST00000536982.1
LTBP3
latent transforming growth factor beta binding protein 3
chr10_-_103454876 0.09 ENST00000331272.7
FBXW4
F-box and WD repeat domain containing 4
chr2_-_31360887 0.09 ENST00000420311.2
ENST00000356174.3
ENST00000324589.5
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr1_-_38397384 0.08 ENST00000373027.1
INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr18_-_10791648 0.08 ENST00000583325.1
PIEZO2
piezo-type mechanosensitive ion channel component 2
chr17_-_47492164 0.08 ENST00000512041.2
ENST00000446735.1
ENST00000504124.1
PHB
prohibitin
chr20_+_30407151 0.08 ENST00000375985.4
MYLK2
myosin light chain kinase 2
chr1_+_228337553 0.08 ENST00000366714.2
GJC2
gap junction protein, gamma 2, 47kDa
chr2_-_133429091 0.08 ENST00000345008.6
LYPD1
LY6/PLAUR domain containing 1
chr18_+_72166564 0.08 ENST00000583216.1
ENST00000581912.1
ENST00000582589.1
CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr1_-_15735925 0.08 ENST00000427824.1
RP3-467K16.4
RP3-467K16.4
chr5_-_172662197 0.08 ENST00000521848.1
NKX2-5
NK2 homeobox 5
chr5_+_131705438 0.07 ENST00000245407.3
SLC22A5
solute carrier family 22 (organic cation/carnitine transporter), member 5
chr19_-_10679644 0.07 ENST00000393599.2
CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr17_-_1508379 0.07 ENST00000412517.3
SLC43A2
solute carrier family 43 (amino acid system L transporter), member 2
chr9_-_14313641 0.07 ENST00000380953.1
NFIB
nuclear factor I/B
chr1_+_150266256 0.07 ENST00000309092.7
ENST00000369084.5
MRPS21
mitochondrial ribosomal protein S21
chr13_-_46425865 0.07 ENST00000400405.2
SIAH3
siah E3 ubiquitin protein ligase family member 3
chr19_+_751122 0.06 ENST00000215582.6
MISP
mitotic spindle positioning
chr16_+_66638567 0.06 ENST00000567572.1
CMTM3
CKLF-like MARVEL transmembrane domain containing 3
chr16_+_57126428 0.06 ENST00000290776.8
CPNE2
copine II
chr2_+_119699864 0.06 ENST00000541757.1
ENST00000412481.1
MARCO
macrophage receptor with collagenous structure
chr7_+_150758642 0.06 ENST00000488420.1
SLC4A2
solute carrier family 4 (anion exchanger), member 2
chr11_+_66512303 0.06 ENST00000532565.2
C11orf80
chromosome 11 open reading frame 80
chr15_+_74911430 0.06 ENST00000562670.1
ENST00000564096.1
CLK3
CDC-like kinase 3
chr1_-_160232197 0.06 ENST00000419626.1
ENST00000610139.1
ENST00000475733.1
ENST00000407642.2
ENST00000368073.3
ENST00000326837.2
DCAF8
DDB1 and CUL4 associated factor 8
chr14_-_73360796 0.06 ENST00000556509.1
ENST00000541685.1
ENST00000546183.1
DPF3
D4, zinc and double PHD fingers, family 3
chr1_+_151512775 0.06 ENST00000368849.3
ENST00000392712.3
ENST00000353024.3
ENST00000368848.2
ENST00000538902.1
TUFT1
tuftelin 1
chr17_+_66521936 0.06 ENST00000592800.1
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr19_+_48958766 0.06 ENST00000342291.2
KCNJ14
potassium inwardly-rectifying channel, subfamily J, member 14
chrX_+_86772707 0.05 ENST00000373119.4
KLHL4
kelch-like family member 4
chr18_-_13915530 0.05 ENST00000327606.3
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr2_-_157189180 0.05 ENST00000539077.1
ENST00000424077.1
ENST00000426264.1
ENST00000339562.4
ENST00000421709.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr12_-_67197760 0.05 ENST00000539540.1
ENST00000540433.1
ENST00000541947.1
ENST00000538373.1
GRIP1
glutamate receptor interacting protein 1
chr12_-_102591604 0.05 ENST00000329406.4
PMCH
pro-melanin-concentrating hormone
chr20_-_22565101 0.05 ENST00000419308.2
FOXA2
forkhead box A2
chr8_+_145065705 0.05 ENST00000533044.1
GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr5_-_171615315 0.05 ENST00000176763.5
STK10
serine/threonine kinase 10
chr1_-_153599426 0.05 ENST00000392622.1
S100A13
S100 calcium binding protein A13
chr19_+_36235964 0.05 ENST00000587708.2
PSENEN
presenilin enhancer gamma secretase subunit
chr3_-_139195350 0.05 ENST00000232217.2
RBP2
retinol binding protein 2, cellular
chr9_+_133986782 0.05 ENST00000372301.2
AIF1L
allograft inflammatory factor 1-like
chr16_+_640201 0.05 ENST00000563109.1
RAB40C
RAB40C, member RAS oncogene family
chr1_-_202679535 0.05 ENST00000367268.4
SYT2
synaptotagmin II
chr2_-_230787879 0.05 ENST00000435716.1
TRIP12
thyroid hormone receptor interactor 12
chr16_+_57126482 0.05 ENST00000537605.1
ENST00000535318.2
CPNE2
copine II
chr1_+_180165672 0.04 ENST00000443059.1
QSOX1
quiescin Q6 sulfhydryl oxidase 1
chr12_+_60058458 0.04 ENST00000548610.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr8_-_144679296 0.04 ENST00000317198.6
EEF1D
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
chr2_-_225266711 0.04 ENST00000389874.3
FAM124B
family with sequence similarity 124B
chr1_-_25291475 0.04 ENST00000338888.3
ENST00000399916.1
RUNX3
runt-related transcription factor 3
chr5_+_140430979 0.04 ENST00000306549.3
PCDHB1
protocadherin beta 1
chr17_+_46048497 0.04 ENST00000583352.1
CDK5RAP3
CDK5 regulatory subunit associated protein 3
chr17_+_4613918 0.04 ENST00000574954.1
ENST00000346341.2
ENST00000572457.1
ENST00000381488.6
ENST00000412477.3
ENST00000571428.1
ENST00000575877.1
ARRB2
arrestin, beta 2
chr16_-_28222797 0.04 ENST00000569951.1
ENST00000565698.1
XPO6
exportin 6
chrX_-_70473957 0.04 ENST00000373984.3
ENST00000314425.5
ENST00000373982.1
ZMYM3
zinc finger, MYM-type 3
chr16_+_12995614 0.04 ENST00000423335.2
SHISA9
shisa family member 9
chr14_-_74892805 0.04 ENST00000331628.3
ENST00000554953.1
SYNDIG1L
synapse differentiation inducing 1-like
chr12_+_13349711 0.04 ENST00000538364.1
ENST00000396301.3
EMP1
epithelial membrane protein 1
chr8_+_145065521 0.04 ENST00000534791.1
GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr16_-_58663720 0.04 ENST00000564557.1
ENST00000569240.1
ENST00000441024.2
ENST00000569020.1
ENST00000317147.5
CNOT1
CCR4-NOT transcription complex, subunit 1
chr15_+_77287426 0.04 ENST00000558012.1
ENST00000267939.5
ENST00000379595.3
PSTPIP1
proline-serine-threonine phosphatase interacting protein 1
chr1_-_92952433 0.04 ENST00000294702.5
GFI1
growth factor independent 1 transcription repressor
chr22_+_24891210 0.03 ENST00000382760.2
UPB1
ureidopropionase, beta
chr8_+_37654693 0.03 ENST00000412232.2
GPR124
G protein-coupled receptor 124
chr10_+_102222798 0.03 ENST00000343737.5
WNT8B
wingless-type MMTV integration site family, member 8B
chr2_+_119699742 0.03 ENST00000327097.4
MARCO
macrophage receptor with collagenous structure
chr8_-_67341208 0.03 ENST00000499642.1
RP11-346I3.4
RP11-346I3.4
chr12_-_10978957 0.03 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chr18_+_56806701 0.03 ENST00000587834.1
SEC11C
SEC11 homolog C (S. cerevisiae)
chr4_+_144354644 0.03 ENST00000512843.1
GAB1
GRB2-associated binding protein 1
chr6_-_75828774 0.03 ENST00000493109.2
COL12A1
collagen, type XII, alpha 1
chr8_-_114389353 0.03 ENST00000343508.3
CSMD3
CUB and Sushi multiple domains 3
chr1_+_214163033 0.03 ENST00000607425.1
PROX1
prospero homeobox 1
chr3_+_184056614 0.03 ENST00000453072.1
FAM131A
family with sequence similarity 131, member A
chr1_+_32930647 0.03 ENST00000609129.1
ZBTB8B
zinc finger and BTB domain containing 8B
chr6_-_71012773 0.03 ENST00000370496.3
ENST00000357250.6
COL9A1
collagen, type IX, alpha 1
chr17_-_42466864 0.03 ENST00000353281.4
ENST00000262407.5
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
chrX_-_70474377 0.03 ENST00000373978.1
ENST00000373981.1
ZMYM3
zinc finger, MYM-type 3
chr7_-_27224842 0.02 ENST00000517402.1
HOXA11
homeobox A11
chr1_-_182369751 0.02 ENST00000367565.1
TEDDM1
transmembrane epididymal protein 1
chr3_+_187930429 0.02 ENST00000420410.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr8_-_28747424 0.02 ENST00000523436.1
ENST00000397363.4
ENST00000521777.1
ENST00000520184.1
ENST00000521022.1
INTS9
integrator complex subunit 9
chr15_-_33360085 0.02 ENST00000334528.9
FMN1
formin 1
chr3_-_114790179 0.02 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr2_+_128848740 0.02 ENST00000375990.3
UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr16_+_66638616 0.02 ENST00000564060.1
ENST00000565922.1
CMTM3
CKLF-like MARVEL transmembrane domain containing 3
chr1_-_175712829 0.02 ENST00000367674.2
TNR
tenascin R
chr15_-_94614049 0.02 ENST00000556447.1
ENST00000555772.1
CTD-3049M7.1
CTD-3049M7.1
chr10_+_82300575 0.02 ENST00000313455.4
SH2D4B
SH2 domain containing 4B
chr7_-_27224795 0.02 ENST00000006015.3
HOXA11
homeobox A11
chrX_-_110655306 0.01 ENST00000371993.2
DCX
doublecortin
chr21_+_45432174 0.01 ENST00000380221.3
ENST00000291574.4
TRAPPC10
trafficking protein particle complex 10
chr16_+_1359138 0.01 ENST00000325437.5
UBE2I
ubiquitin-conjugating enzyme E2I
chr16_+_28303804 0.01 ENST00000341901.4
SBK1
SH3 domain binding kinase 1
chr20_-_45142154 0.01 ENST00000347606.4
ENST00000457685.2
ZNF334
zinc finger protein 334
chr10_-_129691195 0.01 ENST00000368671.3
CLRN3
clarin 3

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0070446 cellular response to caloric restriction(GO:0061433) negative regulation of oligodendrocyte progenitor proliferation(GO:0070446)
0.2 0.7 GO:0019046 release from viral latency(GO:0019046)
0.1 0.3 GO:0060927 Purkinje myocyte differentiation(GO:0003168) cardiac pacemaker cell fate commitment(GO:0060927) atrioventricular node cell fate commitment(GO:0060929)
0.1 0.2 GO:0005986 sucrose biosynthetic process(GO:0005986)
0.1 0.2 GO:1904351 negative regulation of protein catabolic process in the vacuole(GO:1904351) negative regulation of lysosomal protein catabolic process(GO:1905166)
0.1 0.2 GO:1903465 vacuolar phosphate transport(GO:0007037) positive regulation of mitotic cell cycle DNA replication(GO:1903465) positive regulation of parathyroid hormone secretion(GO:2000830)
0.0 0.2 GO:0045917 positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0 0.2 GO:1901594 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.0 0.2 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.0 0.2 GO:1904383 response to sodium phosphate(GO:1904383)
0.0 0.2 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.0 0.2 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.0 0.2 GO:0072592 oxygen metabolic process(GO:0072592)
0.0 0.1 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.3 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.2 GO:0032971 regulation of muscle filament sliding(GO:0032971)
0.0 0.1 GO:0060730 regulation of intestinal epithelial structure maintenance(GO:0060730)
0.0 0.2 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.4 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.1 GO:0051866 general adaptation syndrome(GO:0051866)
0.0 0.2 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.0 0.3 GO:0030238 male sex determination(GO:0030238)
0.0 0.3 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 0.1 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.0 0.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.1 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.0 0.4 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0045013 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.0 0.2 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0 0.1 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.0 0.0 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.0 0.1 GO:0019344 cysteine biosynthetic process(GO:0019344)
0.0 0.2 GO:0032196 transposition(GO:0032196)
0.0 0.2 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.1 GO:0010644 cell communication by electrical coupling(GO:0010644)
0.0 0.1 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.0 0.0 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.0 0.1 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0 0.0 GO:0002194 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.2 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.0 0.5 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.7 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.1 GO:1990425 ryanodine receptor complex(GO:1990425)
0.0 0.3 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.3 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.3 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 0.0 GO:0005595 collagen type XII trimer(GO:0005595)
0.0 0.2 GO:0032591 dendritic spine membrane(GO:0032591)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.1 0.2 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.1 0.3 GO:0010736 serum response element binding(GO:0010736)
0.1 0.2 GO:0031783 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.1 0.2 GO:0004803 transposase activity(GO:0004803)
0.0 0.2 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.7 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0 0.3 GO:0004473 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.0 0.2 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.0 0.2 GO:1903135 cupric ion binding(GO:1903135)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.1 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.0 0.1 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.2 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.0 0.2 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.0 0.1 GO:0015199 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.3 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.3 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.1 GO:0102008 cytosolic dipeptidase activity(GO:0102008)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.2 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.2 GO:0015278 calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0 0.0 GO:0031859 platelet activating factor receptor binding(GO:0031859)
0.0 0.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.1 GO:1903763 gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.0 0.0 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.3 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1