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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for NFKB2
Z-value: 1.02
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Transcription factors associated with NFKB2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFKB2 | hg19_v2_chr10_+_104154229_104154354 | 0.06 | 9.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_149411860 Show fit | 0.70 |
ENST00000486744.1
|
KRAB-A domain containing 1 |
|
| chr2_+_232575168 Show fit | 0.63 |
ENST00000440384.1
|
prothymosin, alpha |
|
| chr4_-_74904398 Show fit | 0.61 |
ENST00000296026.4
|
chemokine (C-X-C motif) ligand 3 |
|
| chr17_-_34207295 Show fit | 0.50 |
ENST00000463941.1
ENST00000293272.3 |
chemokine (C-C motif) ligand 5 |
|
| chr4_-_169239921 Show fit | 0.45 |
ENST00000514995.1
ENST00000393743.3 |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 |
|
| chr16_-_28192360 Show fit | 0.44 |
ENST00000570033.1
|
exportin 6 |
|
| chr4_-_74864386 Show fit | 0.40 |
ENST00000296027.4
|
chemokine (C-X-C motif) ligand 5 |
|
| chr14_-_24616426 Show fit | 0.39 |
ENST00000216802.5
|
proteasome (prosome, macropain) activator subunit 2 (PA28 beta) |
|
| chr4_+_74735102 Show fit | 0.39 |
ENST00000395761.3
|
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
|
| chr6_-_31138439 Show fit | 0.38 |
ENST00000259915.8
|
POU class 5 homeobox 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFKB2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | GO:0090023 | positive regulation of neutrophil chemotaxis(GO:0090023) |
| 0.2 | 0.5 | GO:0033634 | positive regulation of cell-cell adhesion mediated by integrin(GO:0033634) |
| 0.1 | 0.5 | GO:0009137 | purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181) |
| 0.1 | 0.5 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 0.0 | 0.5 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.1 | 0.4 | GO:0009786 | regulation of asymmetric cell division(GO:0009786) |
| 0.1 | 0.4 | GO:0015688 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) |
| 0.1 | 0.4 | GO:0018094 | protein polyglycylation(GO:0018094) |
| 0.0 | 0.4 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.1 | 0.3 | GO:1903971 | mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) positive regulation of microglial cell migration(GO:1904141) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.0 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.0 | 1.0 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.1 | 0.3 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.0 | 0.3 | GO:0031501 | mannosyltransferase complex(GO:0031501) |
| 0.1 | 0.2 | GO:0036117 | hyaluranon cable(GO:0036117) |
| 0.0 | 0.2 | GO:0097169 | AIM2 inflammasome complex(GO:0097169) |
| 0.0 | 0.2 | GO:0070435 | Shc-EGFR complex(GO:0070435) |
| 0.0 | 0.2 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.0 | 0.2 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.0 | 0.2 | GO:0042612 | MHC class I protein complex(GO:0042612) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.1 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.1 | 1.0 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.1 | 0.5 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) |
| 0.0 | 0.5 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.0 | 0.5 | GO:0017110 | nucleoside-diphosphatase activity(GO:0017110) |
| 0.1 | 0.4 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.1 | 0.4 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.0 | 0.4 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.1 | 0.3 | GO:0004584 | dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584) |
| 0.1 | 0.3 | GO:0070736 | protein-glycine ligase activity, initiating(GO:0070736) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 0.6 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.4 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.2 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 1.0 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.0 | 0.3 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 0.3 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.0 | 0.2 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |