ISMARA results: NFKB1

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NFKB1

Z-value: 1.10

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Transcription factors associated with NFKB1

Gene Symbol	Gene ID	Gene Info
NFKB1 Ensembl NCBI GeneCards UniProt	ENSG00000109320.7	nuclear factor kappa B subunit 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFKB1	hg19_v2_chr4_+_103423055_103423112	0.74	9.6e-02	Click!

Activity profile of NFKB1 motif

Sorted Z-values of NFKB1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_+_74212073 Show fit	1.32	ENST00000441217.1	AC073046.25 Ensembl NCBI GeneCards UniProt Show fit	AC073046.25
chr11_-_64570624 Show fit	1.30	ENST00000439069.1	MAP4K2 Ensembl NCBI GeneCards UniProt Show fit	mitogen-activated protein kinase kinase kinase kinase 2
chr15_+_76352178 Show fit	0.95	ENST00000388942.3	C15orf27 Ensembl NCBI GeneCards UniProt Show fit	chromosome 15 open reading frame 27
chr5_+_35852797 Show fit	0.93	ENST00000508941.1	IL7R Ensembl NCBI GeneCards UniProt Show fit	interleukin 7 receptor
chr3_-_111852061 Show fit	0.89	ENST00000488580.1 ENST00000460387.2 ENST00000484193.1 ENST00000487901.1	GCSAM Ensembl NCBI GeneCards UniProt Show fit	germinal center-associated, signaling and motility
chr12_-_62997214 Show fit	0.88	ENST00000408887.2	C12orf61 Ensembl NCBI GeneCards UniProt Show fit	chromosome 12 open reading frame 61
chr14_-_103589246 Show fit	0.87	ENST00000558224.1 ENST00000560742.1	LINC00677 Ensembl NCBI GeneCards UniProt Show fit	long intergenic non-protein coding RNA 677
chr20_+_1115821 Show fit	0.86	ENST00000435720.1	PSMF1 Ensembl NCBI GeneCards UniProt Show fit	proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
chr19_+_41222998 Show fit	0.82	ENST00000263370.2	ITPKC Ensembl NCBI GeneCards UniProt Show fit	inositol-trisphosphate 3-kinase C
chr10_+_104154229 Show fit	0.76	ENST00000428099.1 ENST00000369966.3	NFKB2 Ensembl NCBI GeneCards UniProt Show fit	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NFKB1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.0	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.1	1.5	GO:0019264	glycine biosynthetic process from serine(GO:0019264)
0.2	1.4	GO:2001151	regulation of renal water transport(GO:2001151) positive regulation of renal water transport(GO:2001153)
0.3	1.2	GO:0098582	innate vocalization behavior(GO:0098582)
0.1	1.2	GO:0021564	regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) vagus nerve development(GO:0021564)
0.4	1.1	GO:0070446	cellular response to caloric restriction(GO:0061433) negative regulation of oligodendrocyte progenitor proliferation(GO:0070446)
0.2	1.1	GO:0044501	modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.2	1.1	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.1	1.1	GO:0050884	neuromuscular process controlling posture(GO:0050884)
0.0	1.1	GO:0071577	zinc II ion transmembrane transport(GO:0071577)

Showing 1 to 10 of 128 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.7	GO:0032587	ruffle membrane(GO:0032587)
0.1	1.5	GO:0070552	BRISC complex(GO:0070552)
0.1	1.4	GO:0005677	chromatin silencing complex(GO:0005677)
0.0	1.2	GO:0005614	interstitial matrix(GO:0005614)
0.2	0.9	GO:1990682	CSF1-CSF1R complex(GO:1990682)
0.0	0.9	GO:0005839	proteasome core complex(GO:0005839)
0.0	0.9	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.1	0.8	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1	0.7	GO:0043196	varicosity(GO:0043196)
0.0	0.7	GO:0036449	microtubule minus-end(GO:0036449)

Showing 1 to 10 of 36 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.7	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1	1.5	GO:0004793	glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.2	1.4	GO:0042577	lipid phosphatase activity(GO:0042577)
0.1	1.4	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.4	1.1	GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0	1.1	GO:0070628	proteasome binding(GO:0070628)
0.0	1.1	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.0	1.1	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.2	0.9	GO:0004917	interleukin-7 receptor activity(GO:0004917)
0.1	0.9	GO:0005157	macrophage colony-stimulating factor receptor binding(GO:0005157)

Showing 1 to 10 of 78 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.8	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.0	1.4	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	1.4	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.0	0.9	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	0.6	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.6	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	0.4	PID FGF PATHWAY	FGF signaling pathway
0.1	0.3	PID IL23 PATHWAY	IL23-mediated signaling events
0.0	0.3	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta

Showing 1 to 9 of 9 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.7	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	1.6	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.1	1.5	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	1.1	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.0	0.9	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0	0.8	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.0	0.8	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	0.6	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.6	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0	0.6	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse

Showing 1 to 10 of 18 entries

Results for NFKB1

Z-value: 1.10

Motif logo

Transcription factors associated with NFKB1

Activity-expression correlation:

Activity profile of NFKB1 motif

Sorted Z-values of NFKB1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NFKB1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: