ISMARA results: NFIX

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NFIX_NFIB

Z-value: 2.68

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Transcription factors associated with NFIX_NFIB

Gene Symbol	Gene ID	Gene Info
NFIX Ensembl NCBI GeneCards UniProt	ENSG00000008441.12	nuclear factor I X
NFIB Ensembl NCBI GeneCards UniProt	ENSG00000147862.10	nuclear factor I B

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFIB	hg19_v2_chr9_-_14314066_14314075	0.67	1.5e-01	Click!
NFIX	hg19_v2_chr19_+_13134772_13134846	0.55	2.6e-01	Click!

Activity profile of NFIX_NFIB motif

Sorted Z-values of NFIX_NFIB motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_53207842 Show fit	2.45	ENST00000458244.2	KRT4 Ensembl NCBI GeneCards UniProt Show fit	keratin 4
chr2_+_159651821 Show fit	2.18	ENST00000309950.3 ENST00000409042.1	DAPL1 Ensembl NCBI GeneCards UniProt Show fit	death associated protein-like 1
chr11_+_47608198 Show fit	1.91	ENST00000356737.2 ENST00000538490.1	FAM180B Ensembl NCBI GeneCards UniProt Show fit	family with sequence similarity 180, member B
chr5_-_99870932 Show fit	1.44	ENST00000504833.1	CTD-2001C12.1 Ensembl NCBI GeneCards UniProt Show fit	CTD-2001C12.1
chr2_+_20866424 Show fit	1.44	ENST00000272224.3	GDF7 Ensembl NCBI GeneCards UniProt Show fit	growth differentiation factor 7
chr12_-_58145889 Show fit	1.41	ENST00000547853.1	CDK4 Ensembl NCBI GeneCards UniProt Show fit	cyclin-dependent kinase 4
chr15_+_41062159 Show fit	1.38	ENST00000344320.6	C15orf62 Ensembl NCBI GeneCards UniProt Show fit	chromosome 15 open reading frame 62
chr1_-_39407467 Show fit	1.27	ENST00000540558.1	RHBDL2 Ensembl NCBI GeneCards UniProt Show fit	rhomboid, veinlet-like 2 (Drosophila)
chr2_-_132589601 Show fit	1.27	ENST00000437330.1	AC103564.7 Ensembl NCBI GeneCards UniProt Show fit	AC103564.7
chr12_-_71003568 Show fit	1.26	ENST00000547715.1 ENST00000451516.2 ENST00000538708.1 ENST00000550857.1 ENST00000261266.5	PTPRB Ensembl NCBI GeneCards UniProt Show fit	protein tyrosine phosphatase, receptor type, B

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NFIX_NFIB

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.3	GO:0070268	cornification(GO:0070268)
0.0	3.3	GO:0010507	negative regulation of autophagy(GO:0010507)
0.3	2.9	GO:0072592	oxygen metabolic process(GO:0072592)
0.1	2.9	GO:0006751	glutathione catabolic process(GO:0006751)
0.1	2.6	GO:0003334	keratinocyte development(GO:0003334)
0.0	2.6	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0	2.2	GO:0030032	lamellipodium assembly(GO:0030032)
0.1	2.1	GO:0051894	positive regulation of focal adhesion assembly(GO:0051894)
0.1	2.0	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.1	2.0	GO:0046341	CDP-diacylglycerol metabolic process(GO:0046341)

Showing 1 to 10 of 1,056 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.4	GO:0030055	cell-substrate junction(GO:0030055)
0.0	2.6	GO:0019867	outer membrane(GO:0019867)
0.0	2.5	GO:0031228	intrinsic component of Golgi membrane(GO:0031228)
0.0	2.4	GO:0002102	podosome(GO:0002102)
0.1	2.3	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	2.3	GO:0045095	keratin filament(GO:0045095)
0.1	2.2	GO:0005677	chromatin silencing complex(GO:0005677)
0.0	2.2	GO:0032587	ruffle membrane(GO:0032587)
0.1	2.1	GO:0005614	interstitial matrix(GO:0005614)
0.0	2.1	GO:0042641	actomyosin(GO:0042641)

Showing 1 to 10 of 315 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.5	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.1	2.8	GO:0070513	death domain binding(GO:0070513)
0.0	2.6	GO:0017137	Rab GTPase binding(GO:0017137)
0.1	2.5	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	2.5	GO:0004712	protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1	2.3	GO:0036374	glutathione hydrolase activity(GO:0036374)
0.1	2.3	GO:0017049	GTP-Rho binding(GO:0017049)
0.1	2.2	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1	2.1	GO:0038062	protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0	2.0	GO:0051015	actin filament binding(GO:0051015)

Showing 1 to 10 of 637 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.0	PID RAC1 PATHWAY	RAC1 signaling pathway
0.0	4.2	PID ILK PATHWAY	Integrin-linked kinase signaling
0.1	4.1	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	3.9	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	3.6	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	3.0	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	2.9	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	2.5	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.1	2.3	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	2.2	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases

Showing 1 to 10 of 91 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.6	REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0	4.1	REACTOME GAB1 SIGNALOSOME	Genes involved in GAB1 signalosome
0.0	3.9	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0	3.0	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.1	2.6	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.1	2.5	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	2.5	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.1	2.2	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1	2.0	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1	1.8	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway

Showing 1 to 10 of 134 entries

Results for NFIX_NFIB

Z-value: 2.68

Motif logo

Transcription factors associated with NFIX_NFIB

Activity-expression correlation:

Activity profile of NFIX_NFIB motif

Sorted Z-values of NFIX_NFIB motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NFIX_NFIB

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: