ISMARA results: NFE2L1

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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for NFE2L1

Z-value: 1.72

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Transcription factors associated with NFE2L1

Gene Symbol	Gene ID	Gene Info
NFE2L1 Ensembl NCBI GeneCards UniProt	ENSG00000082641.11	nuclear factor, erythroid 2 like 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFE2L1	hg19_v2_chr17_+_46131912_46131952	0.80	5.4e-02	Click!

Activity profile of NFE2L1 motif

Sorted Z-values of NFE2L1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_-_128246769 Show fit	1.72	ENST00000444226.1	MAPKAP1 Ensembl NCBI GeneCards UniProt Show fit	mitogen-activated protein kinase associated protein 1
chr6_-_170151603 Show fit	1.22	ENST00000366774.3	TCTE3 Ensembl NCBI GeneCards UniProt Show fit	t-complex-associated-testis-expressed 3
chr2_+_159651821 Show fit	1.13	ENST00000309950.3 ENST00000409042.1	DAPL1 Ensembl NCBI GeneCards UniProt Show fit	death associated protein-like 1
chr1_-_183538319 Show fit	1.12	ENST00000420553.1 ENST00000419402.1	NCF2 Ensembl NCBI GeneCards UniProt Show fit	neutrophil cytosolic factor 2
chr11_+_63137251 Show fit	1.04	ENST00000310969.4 ENST00000279178.3	SLC22A9 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 22 (organic anion transporter), member 9
chr6_+_13272904 Show fit	1.02	ENST00000379335.3 ENST00000379329.1	PHACTR1 Ensembl NCBI GeneCards UniProt Show fit	phosphatase and actin regulator 1
chr3_-_172019686 Show fit	1.00	ENST00000596321.1	AC092964.2 Ensembl NCBI GeneCards UniProt Show fit	Uncharacterized protein
chr8_+_94752349 Show fit	0.92	ENST00000391680.1	RBM12B-AS1 Ensembl NCBI GeneCards UniProt Show fit	RBM12B antisense RNA 1
chr10_-_10504285 Show fit	0.92	ENST00000602311.1	RP11-271F18.4 Ensembl NCBI GeneCards UniProt Show fit	RP11-271F18.4
chr14_+_24779340 Show fit	0.85	ENST00000533293.1 ENST00000543919.1	LTB4R2 Ensembl NCBI GeneCards UniProt Show fit	leukotriene B4 receptor 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NFE2L1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.7	GO:0030950	establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.3	1.3	GO:0061737	leukotriene signaling pathway(GO:0061737)
0.2	1.2	GO:1990414	replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1	1.2	GO:0030473	nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration(GO:0021817) nuclear migration along microtubule(GO:0030473)
0.0	1.1	GO:0045730	respiratory burst(GO:0045730)
0.0	1.1	GO:0034198	cellular response to amino acid starvation(GO:0034198)
0.1	1.0	GO:0051012	microtubule sliding(GO:0051012)
0.1	1.0	GO:0015747	urate transport(GO:0015747)
0.0	1.0	GO:0005979	regulation of glycogen biosynthetic process(GO:0005979) regulation of glucan biosynthetic process(GO:0010962)
0.0	1.0	GO:0007099	centriole replication(GO:0007099)

Showing 1 to 10 of 156 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.1	GO:0031932	TORC2 complex(GO:0031932)
0.1	2.1	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	1.2	GO:0030286	dynein complex(GO:0030286)
0.1	1.1	GO:0032010	phagolysosome(GO:0032010)
0.1	0.9	GO:0035749	myelin sheath adaxonal region(GO:0035749)
0.0	0.9	GO:0016592	mediator complex(GO:0016592)
0.2	0.8	GO:1990796	photoreceptor cell terminal bouton(GO:1990796)
0.0	0.8	GO:0071011	precatalytic spliceosome(GO:0071011)
0.2	0.7	GO:0034685	integrin alphav-beta6 complex(GO:0034685)
0.1	0.7	GO:1990876	cytoplasmic side of nuclear pore(GO:1990876)

Showing 1 to 10 of 60 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.0	GO:0003774	motor activity(GO:0003774)
0.1	1.7	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.3	1.3	GO:0004974	leukotriene B4 receptor activity(GO:0001632) leukotriene receptor activity(GO:0004974)
0.0	1.3	GO:0005521	lamin binding(GO:0005521)
0.1	1.2	GO:0009378	four-way junction helicase activity(GO:0009378)
0.1	1.1	GO:0016176	superoxide-generating NADPH oxidase activity(GO:0016175) superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1	1.1	GO:0070513	death domain binding(GO:0070513)
0.0	1.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.1	1.0	GO:0015143	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0	1.0	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)

Showing 1 to 10 of 104 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.8	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	1.7	PID RAC1 PATHWAY	RAC1 signaling pathway
0.0	0.9	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	0.8	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	0.7	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	0.7	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.5	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	0.4	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	0.4	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.1	0.3	PID IL23 PATHWAY	IL23-mediated signaling events

Showing 1 to 10 of 13 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.1	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	1.7	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.1	1.3	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.0	1.3	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0	1.2	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	1.2	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.1	0.9	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.0	0.6	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.6	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation
0.0	0.5	REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	Genes involved in FGFR2c ligand binding and activation

Showing 1 to 10 of 29 entries

Results for NFE2L1

Z-value: 1.72

Motif logo

Transcription factors associated with NFE2L1

Activity-expression correlation:

Activity profile of NFE2L1 motif

Sorted Z-values of NFE2L1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NFE2L1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: