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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for NFATC2_NFATC3
Z-value: 1.21
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Transcription factors associated with NFATC2_NFATC3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFATC3 | hg19_v2_chr16_+_68119440_68119561 | 0.67 | 1.5e-01 | Click! |
| NFATC2 | hg19_v2_chr20_-_50179368_50179392 | 0.16 | 7.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_-_85969774 Show fit | 1.76 |
ENST00000598933.1
|
RP11-542M13.3 |
|
| chr2_+_20650796 Show fit | 1.42 |
ENST00000448241.1
|
AC023137.2 |
|
| chrX_-_15683147 Show fit | 1.14 |
ENST00000380342.3
|
transmembrane protein 27 |
|
| chr6_+_148593425 Show fit | 0.87 |
ENST00000367469.1
|
SAM and SH3 domain containing 1 |
|
| chr6_-_13290684 Show fit | 0.80 |
ENST00000606393.1
|
RP1-257A7.5 |
|
| chr14_+_32476072 Show fit | 0.76 |
ENST00000556949.1
|
Uncharacterized protein |
|
| chrX_+_152683780 Show fit | 0.65 |
ENST00000338647.5
|
ZFP92 zinc finger protein |
|
| chr19_+_36346734 Show fit | 0.63 |
ENST00000586102.3
|
kin of IRRE like 2 (Drosophila) |
|
| chr5_+_35852797 Show fit | 0.62 |
ENST00000508941.1
|
interleukin 7 receptor |
|
| chr17_+_6900201 Show fit | 0.55 |
ENST00000480801.1
|
arachidonate 12-lipoxygenase |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFATC2_NFATC3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | GO:0035542 | regulation of SNARE complex assembly(GO:0035542) |
| 0.1 | 0.9 | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) |
| 0.1 | 0.7 | GO:2000402 | negative regulation of lymphocyte migration(GO:2000402) |
| 0.0 | 0.7 | GO:0014877 | response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 0.1 | 0.6 | GO:2001301 | lipoxin biosynthetic process(GO:2001301) lipoxin A4 metabolic process(GO:2001302) lipoxin A4 biosynthetic process(GO:2001303) |
| 0.1 | 0.6 | GO:0042699 | follicle-stimulating hormone signaling pathway(GO:0042699) |
| 0.1 | 0.6 | GO:0051552 | flavone metabolic process(GO:0051552) |
| 0.1 | 0.6 | GO:0003056 | regulation of vascular smooth muscle contraction(GO:0003056) |
| 0.0 | 0.6 | GO:0001915 | negative regulation of T cell mediated cytotoxicity(GO:0001915) |
| 0.2 | 0.5 | GO:1990654 | sebum secreting cell proliferation(GO:1990654) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.1 | 0.7 | GO:0036057 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.0 | 0.7 | GO:0070938 | contractile ring(GO:0070938) |
| 0.0 | 0.7 | GO:0043034 | costamere(GO:0043034) |
| 0.0 | 0.6 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.0 | 0.5 | GO:0043220 | Schmidt-Lanterman incisure(GO:0043220) |
| 0.0 | 0.4 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.0 | 0.4 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.0 | 0.4 | GO:0045180 | basal cortex(GO:0045180) |
| 0.0 | 0.4 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.1 | GO:0008241 | peptidyl-dipeptidase activity(GO:0008241) |
| 0.0 | 0.9 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.0 | 0.8 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.0 | 0.8 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 0.7 | GO:0005227 | calcium activated cation channel activity(GO:0005227) |
| 0.2 | 0.6 | GO:0031896 | V2 vasopressin receptor binding(GO:0031896) |
| 0.2 | 0.6 | GO:0004917 | interleukin-7 receptor activity(GO:0004917) |
| 0.1 | 0.6 | GO:0047977 | linoleate 13S-lipoxygenase activity(GO:0016165) hepoxilin-epoxide hydrolase activity(GO:0047977) |
| 0.0 | 0.6 | GO:0045159 | myosin II binding(GO:0045159) |
| 0.0 | 0.6 | GO:0035256 | G-protein coupled glutamate receptor binding(GO:0035256) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 0.7 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 0.7 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.6 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 0.5 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.4 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 0.4 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.0 | 0.3 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.2 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 0.2 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 0.7 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 0.6 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 0.6 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.5 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 0.0 | 0.5 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 0.4 | REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |
| 0.0 | 0.4 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 0.4 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 0.4 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |