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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for MYBL2
Z-value: 1.70
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Transcription factors associated with MYBL2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYBL2 | hg19_v2_chr20_+_42295745_42295797 | -0.82 | 4.5e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_27998689 Show fit | 3.84 |
ENST00000339145.4
ENST00000362020.4 ENST00000361157.6 |
interferon, alpha-inducible protein 6 |
|
| chr1_-_235098935 Show fit | 3.14 |
ENST00000423175.1
|
RP11-443B7.1 |
|
| chr4_+_89299994 Show fit | 1.62 |
ENST00000264346.7
|
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 |
|
| chr1_-_235098861 Show fit | 1.48 |
ENST00000458044.1
|
RP11-443B7.1 |
|
| chr4_+_89299885 Show fit | 1.45 |
ENST00000380265.5
ENST00000273960.3 |
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 |
|
| chr12_-_57081940 Show fit | 1.32 |
ENST00000436399.2
|
prostaglandin E synthase 3 (cytosolic) |
|
| chr4_-_141348789 Show fit | 1.10 |
ENST00000414773.1
|
calmegin |
|
| chr2_-_47403642 Show fit | 1.05 |
ENST00000456319.1
ENST00000409563.1 ENST00000272298.7 |
calmodulin 2 (phosphorylase kinase, delta) |
|
| chr1_+_91966384 Show fit | 0.93 |
ENST00000430031.2
ENST00000234626.6 |
cell division cycle 7 |
|
| chr16_+_50059182 Show fit | 0.91 |
ENST00000562576.1
|
CTD nuclear envelope phosphatase 1 regulatory subunit 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MYBL2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.8 | GO:0051902 | negative regulation of mitochondrial depolarization(GO:0051902) |
| 0.1 | 2.3 | GO:0007339 | binding of sperm to zona pellucida(GO:0007339) |
| 0.1 | 2.1 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 0.2 | 1.8 | GO:0009212 | dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) |
| 0.0 | 1.6 | GO:0035306 | positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307) |
| 0.2 | 1.5 | GO:0000727 | double-strand break repair via break-induced replication(GO:0000727) |
| 0.1 | 1.5 | GO:0033750 | ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753) |
| 0.3 | 1.3 | GO:0036228 | protein targeting to nuclear inner membrane(GO:0036228) |
| 0.1 | 1.2 | GO:0000712 | resolution of meiotic recombination intermediates(GO:0000712) |
| 0.1 | 1.2 | GO:1903800 | positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.3 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.4 | 1.9 | GO:0032301 | MutSalpha complex(GO:0032301) |
| 0.0 | 1.7 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.1 | 1.4 | GO:0045495 | P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293) |
| 0.1 | 1.3 | GO:0044613 | nuclear pore central transport channel(GO:0044613) |
| 0.0 | 1.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.2 | 1.1 | GO:0098536 | deuterosome(GO:0098536) |
| 0.0 | 1.1 | GO:0071141 | SMAD protein complex(GO:0071141) |
| 0.0 | 1.1 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.1 | 1.0 | GO:0030915 | Smc5-Smc6 complex(GO:0030915) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.0 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.4 | 2.2 | GO:0050220 | prostaglandin-E synthase activity(GO:0050220) |
| 0.4 | 1.9 | GO:0032143 | single thymine insertion binding(GO:0032143) |
| 0.0 | 1.8 | GO:0008171 | O-methyltransferase activity(GO:0008171) |
| 0.0 | 1.8 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.1 | 1.5 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
| 0.0 | 1.3 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 1.3 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.0 | 1.3 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.1 | 1.2 | GO:0035500 | MH2 domain binding(GO:0035500) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 1.7 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 1.6 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.1 | 1.4 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.0 | 1.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 0.9 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 0.8 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 0.7 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 0.6 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 0.5 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.8 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 2.7 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.0 | 2.1 | REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS | Genes involved in Activation of ATR in response to replication stress |
| 0.1 | 1.6 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.1 | 1.4 | REACTOME REGULATION OF IFNG SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.0 | 1.4 | REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE | Genes involved in p53-Dependent G1 DNA Damage Response |
| 0.0 | 1.0 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.0 | 1.0 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 0.0 | 1.0 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 1.0 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |