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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for MLX_USF2_USF1_PAX2
Z-value: 1.56
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Transcription factors associated with MLX_USF2_USF1_PAX2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000108788.7 | MAX dimerization protein MLX | |
| ENSG00000105698.11 | upstream transcription factor 2, c-fos interacting | |
| ENSG00000158773.10 | upstream transcription factor 1 | |
| ENSG00000075891.17 | paired box 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| USF1 | hg19_v2_chr1_-_161015663_161015694 | -0.91 | 1.3e-02 | Click! |
| MLX | hg19_v2_chr17_+_40719073_40719092 | -0.71 | 1.1e-01 | Click! |
| USF2 | hg19_v2_chr19_+_35759968_35760042 | -0.60 | 2.1e-01 | Click! |
| PAX2 | hg19_v2_chr10_+_102505468_102505546 | -0.60 | 2.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_87865262 Show fit | 2.01 |
ENST00000369577.3
ENST00000518845.1 ENST00000339907.4 ENST00000496806.2 |
zinc finger protein 292 |
|
| chr12_-_49463620 Show fit | 1.92 |
ENST00000550675.1
|
Ras homolog enriched in brain like 1 |
|
| chr6_+_151773583 Show fit | 1.77 |
ENST00000545879.1
|
chromosome 6 open reading frame 211 |
|
| chr8_+_126103921 Show fit | 1.69 |
ENST00000523741.1
|
non-SMC element 2, MMS21 homolog (S. cerevisiae) |
|
| chr2_+_46926326 Show fit | 1.64 |
ENST00000394861.2
|
suppressor of cytokine signaling 5 |
|
| chr14_-_54955721 Show fit | 1.63 |
ENST00000554908.1
|
glia maturation factor, beta |
|
| chr3_+_112280857 Show fit | 1.55 |
ENST00000492406.1
ENST00000468642.1 |
solute carrier family 35, member A5 |
|
| chr4_-_47465666 Show fit | 1.48 |
ENST00000381571.4
|
COMM domain containing 8 |
|
| chr11_-_18343725 Show fit | 1.48 |
ENST00000531848.1
|
Hermansky-Pudlak syndrome 5 |
|
| chr1_+_150254936 Show fit | 1.44 |
ENST00000447007.1
ENST00000369095.1 ENST00000369094.1 |
chromosome 1 open reading frame 51 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MLX_USF2_USF1_PAX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.5 | GO:1902963 | regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) |
| 0.0 | 2.8 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.3 | 2.7 | GO:0045629 | negative regulation of T-helper 2 cell differentiation(GO:0045629) |
| 0.5 | 2.3 | GO:0034184 | positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184) |
| 0.3 | 2.2 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 0.3 | 2.2 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 0.2 | 2.2 | GO:1990034 | cellular response to corticosterone stimulus(GO:0071386) calcium ion export from cell(GO:1990034) |
| 0.1 | 2.2 | GO:0048262 | determination of dorsal/ventral asymmetry(GO:0048262) |
| 0.1 | 2.2 | GO:0070816 | phosphorylation of RNA polymerase II C-terminal domain(GO:0070816) |
| 0.1 | 2.2 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 3.6 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 0.1 | 3.4 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.7 | 2.9 | GO:0031084 | BLOC-2 complex(GO:0031084) |
| 0.3 | 2.3 | GO:0030915 | Smc5-Smc6 complex(GO:0030915) |
| 0.1 | 2.2 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.2 | 2.1 | GO:0033503 | HULC complex(GO:0033503) |
| 0.2 | 2.1 | GO:0000439 | core TFIIH complex(GO:0000439) |
| 0.1 | 2.1 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.3 | 1.9 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
| 0.1 | 1.9 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.6 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.1 | 3.2 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 2.8 | GO:0019789 | SUMO transferase activity(GO:0019789) |
| 0.2 | 2.6 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.0 | 2.6 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 2.5 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 2.3 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.1 | 2.3 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.4 | 2.1 | GO:0019776 | Atg8 ligase activity(GO:0019776) |
| 0.2 | 2.1 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 2.9 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 2.4 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 1.9 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.8 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 1.7 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 1.7 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.1 | 1.3 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 1.2 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.2 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.6 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 4.1 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 3.5 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 0.0 | 2.4 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.1 | 2.3 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.1 | 2.2 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.1 | 2.2 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.0 | 1.7 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 1.7 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 1.6 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |