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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for MEF2C
Z-value: 0.85
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Transcription factors associated with MEF2C
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_65837090 Show fit | 0.87 |
ENST00000529036.1
|
Uncharacterized protein |
|
| chr8_+_101349823 Show fit | 0.76 |
ENST00000519566.1
|
KB-1991G8.1 |
|
| chr17_+_7758374 Show fit | 0.59 |
ENST00000301599.6
ENST00000574668.1 |
transmembrane protein 88 |
|
| chrX_+_153046456 Show fit | 0.47 |
ENST00000393786.3
ENST00000370104.1 ENST00000370108.3 ENST00000370101.3 ENST00000430541.1 ENST00000370100.1 |
SRSF protein kinase 3 |
|
| chr3_+_193853927 Show fit | 0.45 |
ENST00000232424.3
|
hes family bHLH transcription factor 1 |
|
| chr3_+_8543393 Show fit | 0.44 |
ENST00000157600.3
ENST00000415597.1 ENST00000535732.1 |
LIM and cysteine-rich domains 1 |
|
| chr9_-_102582155 Show fit | 0.40 |
ENST00000427039.1
|
RP11-554F20.1 |
|
| chr21_+_17909594 Show fit | 0.40 |
ENST00000441820.1
ENST00000602280.1 |
long intergenic non-protein coding RNA 478 |
|
| chr1_-_206945830 Show fit | 0.40 |
ENST00000423557.1
|
interleukin 10 |
|
| chrX_+_9217932 Show fit | 0.38 |
ENST00000432442.1
|
GS1-519E5.1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of MEF2C
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.1 | 0.5 | GO:0032971 | regulation of muscle filament sliding(GO:0032971) |
| 0.1 | 0.4 | GO:0060164 | negative regulation of auditory receptor cell differentiation(GO:0045608) negative regulation of mechanoreceptor differentiation(GO:0045632) regulation of timing of neuron differentiation(GO:0060164) negative regulation of inner ear receptor cell differentiation(GO:2000981) |
| 0.1 | 0.4 | GO:0002874 | regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) |
| 0.1 | 0.4 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
| 0.1 | 0.4 | GO:1903644 | regulation of chaperone-mediated protein folding(GO:1903644) |
| 0.0 | 0.4 | GO:2000188 | regulation of cholesterol homeostasis(GO:2000188) |
| 0.1 | 0.3 | GO:0033058 | directional locomotion(GO:0033058) |
| 0.1 | 0.3 | GO:1903028 | positive regulation of opsonization(GO:1903028) |
| 0.1 | 0.3 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.3 | GO:0005863 | striated muscle myosin thick filament(GO:0005863) |
| 0.0 | 0.3 | GO:0005638 | lamin filament(GO:0005638) |
| 0.0 | 0.3 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 0.2 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.0 | 0.2 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.0 | 0.2 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 0.0 | 0.1 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.0 | 0.1 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.0 | 0.1 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.0 | 0.0 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) discoidal high-density lipoprotein particle(GO:0034365) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | GO:0031432 | titin binding(GO:0031432) |
| 0.1 | 0.4 | GO:0004619 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 0.1 | 0.3 | GO:0051373 | FATZ binding(GO:0051373) |
| 0.0 | 0.3 | GO:0008241 | peptidyl-dipeptidase activity(GO:0008241) |
| 0.0 | 0.3 | GO:0016316 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) |
| 0.0 | 0.3 | GO:0001025 | RNA polymerase III transcription factor binding(GO:0001025) |
| 0.0 | 0.3 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.0 | 0.2 | GO:0031013 | troponin I binding(GO:0031013) |
| 0.0 | 0.2 | GO:0015185 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185) |
| 0.0 | 0.2 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.0 | 0.3 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |