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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for MECOM
Z-value: 1.17
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Transcription factors associated with MECOM
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MECOM | hg19_v2_chr3_-_168864315_168864356 | 0.48 | 3.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MECOM
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.2 | 1.3 | GO:1901297 | positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068) |
| 0.1 | 1.3 | GO:2000582 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 0.2 | 1.0 | GO:0045872 | regulation of rhodopsin gene expression(GO:0007468) positive regulation of rhodopsin gene expression(GO:0045872) |
| 0.2 | 1.0 | GO:0031860 | telomeric 3' overhang formation(GO:0031860) |
| 0.1 | 0.8 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.0 | 0.8 | GO:0017121 | phospholipid scrambling(GO:0017121) |
| 0.0 | 0.7 | GO:0048023 | positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378) |
| 0.0 | 0.7 | GO:0006704 | glucocorticoid biosynthetic process(GO:0006704) |
| 0.0 | 0.6 | GO:0007253 | cytoplasmic sequestering of NF-kappaB(GO:0007253) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.1 | 1.3 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.0 | 1.3 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.1 | 1.0 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.1 | 0.8 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 0.5 | GO:0031673 | H zone(GO:0031673) |
| 0.0 | 0.5 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 0.4 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.1 | 0.3 | GO:0034753 | nuclear aryl hydrocarbon receptor complex(GO:0034753) |
| 0.0 | 0.3 | GO:0033263 | CORVET complex(GO:0033263) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.2 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.1 | 1.3 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.1 | 1.3 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.0 | 1.0 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.0 | 1.0 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.0 | 1.0 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.8 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.2 | 0.7 | GO:0003845 | 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845) |
| 0.0 | 0.6 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.0 | 0.5 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 1.0 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 0.1 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.3 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 1.0 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 1.0 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 0.8 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 0.8 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.5 | REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS | Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors |
| 0.0 | 0.5 | REACTOME STEROID HORMONES | Genes involved in Steroid hormones |
| 0.0 | 0.4 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.1 | 0.3 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |