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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for MAZ_ZNF281_GTF2F1
Z-value: 1.56
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Transcription factors associated with MAZ_ZNF281_GTF2F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF281 | hg19_v2_chr1_-_200379104_200379128 | 0.95 | 3.1e-03 | Click! |
| MAZ | hg19_v2_chr16_+_29819096_29819250 | -0.94 | 5.4e-03 | Click! |
| GTF2F1 | hg19_v2_chr19_-_6393465_6393479 | -0.72 | 1.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAZ_ZNF281_GTF2F1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.5 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.0 | 3.0 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.1 | 2.7 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 0.1 | 2.3 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 1.9 | GO:0030514 | negative regulation of BMP signaling pathway(GO:0030514) |
| 0.1 | 1.8 | GO:2000587 | negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587) |
| 0.3 | 1.7 | GO:1900224 | positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224) |
| 0.0 | 1.7 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.1 | 1.6 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
| 0.1 | 1.6 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.2 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.1 | 2.7 | GO:0016580 | Sin3 complex(GO:0016580) |
| 0.0 | 2.5 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.0 | 2.4 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.1 | 2.3 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.0 | 2.3 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 2.1 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.1 | 1.9 | GO:0097227 | sperm annulus(GO:0097227) |
| 0.0 | 1.8 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.2 | 1.6 | GO:0032444 | activin responsive factor complex(GO:0032444) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | GO:0061659 | ubiquitin-like protein ligase activity(GO:0061659) |
| 0.0 | 3.2 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 0.2 | 3.0 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.2 | 2.6 | GO:0031386 | protein tag(GO:0031386) |
| 0.1 | 2.5 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 2.4 | GO:0019208 | phosphatase regulator activity(GO:0019208) |
| 0.0 | 2.4 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.1 | 2.2 | GO:0019841 | retinol binding(GO:0019841) |
| 0.0 | 2.2 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.0 | 2.2 | GO:0030276 | clathrin binding(GO:0030276) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.0 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 4.9 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 3.7 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 2.4 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 1.6 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.1 | 1.6 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.1 | 1.4 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 1.4 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.0 | 1.3 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 1.2 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.6 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 4.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 3.4 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.2 | 2.6 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |
| 0.1 | 2.5 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.0 | 2.5 | REACTOME RNA POL I TRANSCRIPTION | Genes involved in RNA Polymerase I Transcription |
| 0.0 | 2.4 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.1 | 2.1 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.1 | 2.0 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 1.8 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |