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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for MAFB
Z-value: 1.29
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Transcription factors associated with MAFB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MAFB | hg19_v2_chr20_-_39317868_39317884 | -0.07 | 9.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAFB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.0 | 2.1 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.1 | 1.8 | GO:0071380 | cellular response to prostaglandin E stimulus(GO:0071380) |
| 0.1 | 1.7 | GO:2000587 | negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587) |
| 0.3 | 1.4 | GO:0016267 | O-glycan processing, core 1(GO:0016267) |
| 0.0 | 1.3 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.1 | 1.2 | GO:0070863 | positive regulation of protein exit from endoplasmic reticulum(GO:0070863) |
| 0.1 | 1.1 | GO:0030422 | production of siRNA involved in RNA interference(GO:0030422) |
| 0.0 | 1.1 | GO:0006378 | mRNA polyadenylation(GO:0006378) |
| 0.1 | 1.0 | GO:0006543 | glutamine catabolic process(GO:0006543) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.8 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 1.4 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.1 | 1.3 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.1 | 1.3 | GO:0030663 | COPI-coated vesicle membrane(GO:0030663) |
| 0.0 | 1.3 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.0 | 1.2 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.0 | 1.1 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.0 | 1.1 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 1.0 | GO:0034518 | mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518) |
| 0.0 | 0.9 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 2.2 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.1 | 2.0 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.1 | 1.7 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.2 | 1.6 | GO:0004957 | prostaglandin E receptor activity(GO:0004957) |
| 0.3 | 1.4 | GO:0016263 | glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263) |
| 0.0 | 1.3 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.1 | 1.1 | GO:0070883 | pre-miRNA binding(GO:0070883) |
| 0.0 | 1.0 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.2 | 0.9 | GO:0050115 | myosin-light-chain-phosphatase activity(GO:0050115) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.4 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 2.7 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.7 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 1.2 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 1.2 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.8 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.8 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 0.7 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.7 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.6 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.2 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.0 | 1.9 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.2 | 1.6 | REACTOME PROSTANOID LIGAND RECEPTORS | Genes involved in Prostanoid ligand receptors |
| 0.0 | 1.5 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 1.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.2 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 1.1 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.0 | 1.1 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.0 | 1.1 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.0 | 1.1 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |